Articles tagged "Kidney transplantation"

2018 American Transplant Congress
Once-Daily MeltDose Tacrolimus Formulation and Renal Function in Caucasian Fast Tacrolimus Metabolizers: Does Early Identification Have an Impact in PK Sensitive Patients?
K. Budde,⁶ B. Suwelack,¹ D. Stevens,³ W. Du,⁴ C. Procaccianti,⁵ C. Maas,⁵ S. Bunnapradist.²
¹University Hospital of Münster, Münster, Germany; ²David Geffen School of Medicine at UCLA, Los Angeles; ³Veloxis Pharmaceuticals, Cary; ⁴Clinical Statistics Consulting, Norrystown; ⁵Chiesi Farmaceutici S.p.A., Parma, Italy; ⁶Charité Universitatsmedizin, Berlin, Germany.
Tacrolimus (TAC) nephrotoxicity can be seen even at low blood trough levels, with factors beyond trough levels potentially contributing. TAC fast metabolizers have higher Cmax,…
2018 American Transplant Congress
Development of Optimal Simplified Equation for Estimation of Mycophenolic Acid Exposure Following Enteric-Coated Mycophenolate Sodium Administration in Chinese Renal Transplant Recipients
W. Peng, C. Tian, Z. Chen, W. Xue, G. Wang, Q. Ye, X. Zhang, M. Gu, M. Zhao, C. Wang, C. Huang, J. Yan, W. Zhang, C. Ding, Y. Fu, S. Ye, X. Hu, R. Tan, M. Li, R. Deng, Y. Ke, W. Wu, M. Fan, J. Chen.
MyERA Study Group, Hangzhou, China.
Background: Limited sampling strategies (LSS) aids in overcoming the complexity of extensive PK sampling and supporting the calculation of mycophenolic acid (MPA) exposure. This study…
2018 American Transplant Congress
Racial/Ethnic Disparities in Living Donor Kidney Transplantation before and after the New National Kidney Allocation System
X. Zhang,¹ T. Melanson,² L. Plantinga,^3,6 M. Basu,¹ S. Pastan,^1,7 S. Mohan,^4,5 M. Garber,⁶ R. Patzer.^1,6,7
¹Department of Surgery, Emory University School of Medicine, Atlanta; ²Department of Health Policy & Management, Emory University, Atlanta; ³Department of Medicine, Emory University School of Medicine, Atlanta; ⁴School of Medicine, Columbia University, New York; ⁵Department of Epidemiology, Columbia University, New York; ⁶Department of Epidemiology, Emory University, Atlanta; ⁷Emory Transplant Center, Emory Healthcare, Atlanta.
We aimed to assess the potential unintended impact of a new national kidney allocation system (KAS) in December 2014 on living donor kidney transplant (LDKT)…
2018 American Transplant Congress
Analysis of Patient Reported Outcomes for Patients That Received Living Donor Kidney Transplants
E. Venniro,^1,2 J. Taylor.^1,2
¹Center for Transplantation, University of Rochester Medical Center, Rochester, NY; ²Division of Nephrology, University of Rochester Medical Center, Rochester, NY.
Purpose: Caring for subjective complaints is one of the most difficult aspects of any health care provider's job. These conditions in the transplant patient are…
2018 American Transplant Congress
Involvement of Additional Surgeons in Robot Assisted Kidney Transplantation Does Not Affect Surgical Outcomes, in the Context of a Structured Robotic Surgery Program. Results from a CUSUM Analysis
F. Gheza,¹ C. Di Bella,¹ P. Giulianotti,¹ J. Oberholzer,² E. Benedetti,¹ I. Tzvetanov.¹
¹Surgery, University of Illinois, Chicago, IL; ²Surgery, University of Virginia, Virginia, VA.
Robot assisted kidney transplant (RAKT) is a good option for obese recipients. Our group first performed this procedure in 2009 and nowadays the experience includes…
2018 American Transplant Congress
JC Virus-Associated Nephropathy in Renal Transplant Recipient
G. Huang,¹ M. Wang,² X. Chen,¹ S-.C. Yang,³ L. Chen.¹
¹Department of Organ Transplantation, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China; ²Sun Yat-sen University, Guangzhou, China; ³Department of Pathology, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Background: JC virus (JCV) inflection is more common than BK virus (BKV) in general population. But in kidney transplants, polyomavirus nephropathy (PVAN) is primarily caused…
2018 American Transplant Congress
HOPE Act Deceased Organ Donors: True and False Positive Donors
C. Durand,¹ S. Seaman,¹ M. Bowring,¹ B. Doby,¹ D. Ostrander,¹ A. Redd,¹ M. Waldram,¹ S. Huprikar,² B. Haydel,² S. Lerner,² S. Florman,² N. Turgeon,³ R. Friedman-Moraco,³ A. Massie,¹ D. Segev.¹
¹JHU, Baltimore; ²Mount Sinai, New York; ³Emory, Atlanta.
HOPE in Action is a multicenter trial designed to evaluate the safety of HIV+ to HIV+ transplantation (NCT02602262). In this trial, organs from donors with…
2018 American Transplant Congress
Rhesus-Specific Anti-Thymocyte Globulin as an Adjuvant to Costimulatory-Blockade-Based Immunotherapy
M. Mulvihill,¹ B. Ezekian,¹ Q. Gao,¹ K. Samy,¹ R. Davis,¹ F. Leopardi,¹ A. Belli,² W. Flores,² A. Buzby,² K. Reimann,² B. Collins,¹ A. Kirk.¹
¹Department of Surgery, Duke University, Durham, NC; ²MassBiologics, University of Massachusetts Medical School, Boston, MA.
Background Belatacept targets de novo alloimmune responses with minimal off target effects in renal transplantation, though adjuvant therapy is required to control costimulation-blockade resistant rejection…
2018 American Transplant Congress
Improvement in Intermediate Graft Survival among Deceased Donor Recipients in the Last Decade Due to Improvements in Outcomes of Higher KDPI Kidney Recipients
D. Keith.
Medicine, Sacred Heart Hospital, Pensacola, FL, Turkey.
Previous research by our group showed that intermediate graft survival of adult deceased donor kidney transplants between six months and three years post-transplant improved in…
2018 American Transplant Congress
Competing Risk Analysis in Renal Allograft Survival: A New Perspective to an Old Problem
M. El ters,¹ B. Smith,² F. Cosio,¹ W. Kremers.²
¹Medicine, Mayo Clinic, Rochester, MN; ²Biostatistics, Mayo Clinic, Rochester, MN.
Background:Patient and graft survival after kidney transplant (KTX) is often estimated by Kaplan-Meier censoring for competing factors, e.g.death-censored graft survival. However when the competing factor…