Articles tagged "Kidney transplantation"

2018 American Transplant Congress
The Financial Impact of the Opioid Epidemic on Kidney Transplantation Readmissions
L. Wilson, D. Taber, N. Pilch, R. Gilbert, Z. Elmaasarani, B. O'Brien, N. Patel, P. Mauldin, S. Ball, P. Baliga, J. Fleming.
MUSC, Charleston, SC.
Research has demonstrated increased annual medical costs in patients who abuse opioids, estimated at up to $18,000 per patient and $29 billion overall in the…
2018 American Transplant Congress
Optimizing Outcomes with a Collaborative Approach after Kidney Transplant in Hepatitis C-Positive Recipients Receiving Hepatitis C-Positive Grafts
A. Ray, R. Rubin, T. Ommert, R. Cross, C. Klein.
Piedmont Transplant Institute, Piedmont Healthcare, Atlanta, GA.
PURPOSE: To evaluate the multidisciplinary approach to HCV treatment in HCV+ kidney recipients receiving HCV+ grafts. METHODS: Single center review of treatment and outcomes in…
2018 American Transplant Congress
400 Kidney Paired Donor Transplants at a Single Center; The Methodist San Antonio Experience
A. Bingaman,¹ M. Kapturczak,¹ I. Ashlagi,² C. Murphey.³
¹Methodist Specialty and Transplant Hospital, San Antonio, TX; ²Stanford University, Palo Alto, CA; ³Southwest Immunodiagnostics, San Antonio, TX.
Background: Kidney paired donation (KPD) has become the standard of care for incompatible living donor pairs. Several mature national KPD programs exist yet KPD transplants…
2018 American Transplant Congress
Unbiased Sequencing of Urine Cell-Free DNA (cfDNA) to Evaluation Urine Virome and Associated Renal Allograft Damage
D. Dadhania,¹ P. Burnham,² J. Lee,¹ C. Snopkowski,¹ C. Li,¹ S. Albakry,¹ H. Yang,¹ T. Muthukumar,¹ I. De Vlaminck,² M. Suthanthiran.¹
¹Transplantation Medicine-Nephrology, Weill Cornell Medicine, NY, NY; ²Biomedical Engineering, Cornell University, Ithaca, NY.
Intro: Virus reactivation leading to graft damage is a frequent post-kidney transplant (KTx) complication. Immunosuppressed individuals are at risk for multiple virus infections simultaneously. Current…
2018 American Transplant Congress
Cold Pulsatile Machine Perfusion versus Static Cold Storage in Kidneys from Donation after Circulatory Death: A Multi-Centre Randomised Controlled Trial
D. Summers,^1,2 L. Randle,¹ A-.M. O'Sullivan,³ R. Johnson,² D. Collett,² M. Attia,⁴ N. Ahmad,⁴ M. Clancy,⁵ M. Akyol,⁶ A. Tavakoli,⁷ N. Jamieson,³ A. Bradley,¹ C. Watson.¹
¹Cambridge University, Cambridge, United Kingdom; ²NHS Blood and Transplant, Bristol, United Kingdom; ³Cambridge University Hospitals, Cambridge, United Kingdom; ⁴Leeds Teaching Hospitals, Leeds, United Kingdom; ⁵Queen Elizabeth Hospital, Glasgow, United Kingdom; ⁶Edinburgh University, Edinburgh, United Kingdom; ⁷Manchester University Hospitals, Manchester, United Kingdom.
Introduction:Delayed graft function affects around half of all recipients of donation after circulatory death (DCD) kidneys in the UK and has a significant impact on…
2018 American Transplant Congress
Interim Results of the kSORT in the SAILOR Randomized Multicenter Trial
P. Lindner,¹ A. Shroeder,² J. Ekberg,¹ S. Hsieh,² P. Towfighi,² I. Damm,² T. Sigdel,² M. Sarwal.²
¹Sahlgrenska University Hospital, Göteborg, Sweden; ²UCSF, San Francisco.
Background: In a randomized multicenter trial of 222 renal tx recipients treated with steroid minimization and a tacrolimus, MMF based regimen, a novel gene expression…
2018 American Transplant Congress
Association of Leptin with Cystatin C in Kidney Allograft Dysfunction
A. Bera,¹ M. Watson,² N. Gana,¹ J. Karaian,¹ S. Radhakrishnan,¹ M. Subramanian,¹ D. Little,² R. Nee,² A. Chatterjee,¹ S. Rothwell,¹ H. Pollard,¹ R. Jindal,³ M. Srivastava.¹
¹Anatomy, Physiology and Genetics, USU-School of Medicine, Bethesda, MD; ²Nephrology, USU-Walter Reed, Bethesda, MD; ³Surgery, USU-Walter Reed, Bethesda, MD.
Background: Non-invasive biomarkers are needed for monitoring recipients of kidney allografts to predict acute rejection (AR). We hypothesized that protein biomarkers released from rejecting allograft…
2018 American Transplant Congress
Validation Study of Gene Expression Signatures Associated with Antibody-Mediated Rejection (ABMR) and Cell-Mediated Rejection (CMR) in Renal Allograft Biopsies (Bx) Suggests Complexity of Molecular Diagnosis for ABMR Compared to CMR
H. Zhang,¹ C. Nast,² J. Doldron,² M. Cheung,² A. Vo,³ S. Jordan,³ M. Toyoda.¹
¹Transplant Immunology Laboratory, Cedars-Sinai Medical Center, Los Angeles, CA; ²Pathology, Cedars-Sinai Medical Center, Los Angeles, CA; ³Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA.
Background: Various molecular signatures specific to ABMR and CMR based on gene expression in renal allograft Bx or peripheral blood mononuclear cells (PBMC) of renal…
2018 American Transplant Congress
Urinary Chemokine CXCL-10 in Long Term Renal Transplant Patients Associates with Urinary Tract Infections and Microvascular Damage
G. Irish,^1,2 M. Hockley,^1,2 S. Kireta,^1,2 J. Johnson,^1,2 R. Carroll.^1,2
¹Central and Northern Adelaide Renal and Transplantation Service, Royal Adelaide Hospital, Adelaide, South Australia, Australia; ²The Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, South Australia, Australia.
Non-invasive biomarkers are needed to predict rejection post kidney transplantation. In the early transplant period, urinary CXCL-9 and CXCL-10 associate with rejection. We assessed the…
2018 American Transplant Congress
The Clinical Significance of Pretransplant C1q Assay Status in Positive Crossmatch Kidney Transplantation
J. Lee,¹ D. Kim,¹ B. Park,² S. Song,³ J. Lee,⁴ Y. Jung,¹ J. Lee,¹ J. Lee,¹ B. Kim,⁵ M. Kim,¹ S. Kim,¹ Y. Kim,¹ K. Huh.¹
¹Surgery, Yonsei University College of Medicine, Seoul, Korea; ²Laboratory Medicine, Asan MEdical Center, Seoul, Korea; ³Surgery, Ewha Womans University, School of Medicine, Seoul, Korea; ⁴Surgery, CHA Bundang Medical Center, CHA University, Seongnam, Korea; ⁵Internal Medicine (Nephrology), Yonsei University College of Medicine, Seoul, Korea.
Background: Patients with a pretransplant donor-specific antibodies (DSA) are at higher risk for antibody-mediated rejection (AMR). However, not all DSA have the same pathogenetic potential.…