Articles tagged "Kidney transplantation"

2018 American Transplant Congress
10-Year Outcomes of Renal Transplantation from Circulatory Death Donors with Increased Terminal Creatinine
Y. Tomita, K. Iwadoh, I. Nakajima, S. Fuchinoue.
Surgery III, Tokyo Women's Medical University, Tokyo, Japan.
Background: To alleviate chronic renal graft shortages in Japan, donation after circulatory death (DCD) is an increasingly used organ resource. Organs from DCD donors with…
2018 American Transplant Congress
The Effect of Tacrolimus Trough Level and Intrapatient Variability on the Transplant Outcomes in Kidney Transplantation
J. Lee,¹ J. Lee,¹ Y. Jung,¹ D. Kim,¹ S. Song,² J. Lee,³ J. Lee,¹ M. Kim,¹ S. Kim,¹ Y. Kim,¹ B. Kim,⁴ K. Huh.¹
¹Surgery, Yonsei University College of Medicine, Seoul, Korea; ²Surgery, Ewha Womans University, School of Medicine, Seoul, Korea; ³Surgery, CHA Bundang Medical Center, CHA University, Seongnam, Korea; ⁴Internal Medicine (Nephrology), Yonsei University College of Medicine, Seoul, Korea.
Background: Tacrolimus (TAC) is the mainstay of immunosuppression for kidney transplantation (KT). Although TAC has a narrow therapeutic index, appropriate trough concentrations of TAC have…
2018 American Transplant Congress
The Infusion with a Difference: Patient Experiences with Belatacept
H. Murad, D. Malhotra, E. Cohen, W. Asch.
Yale University, New Haven, CT.
Introduction: The results of the BENEFIT trial led to the FDA approval of the novel anti-rejection agent belatacept (bela) in 2011. In addition to its…
2018 American Transplant Congress
Chronic Changes on Time Zero Living Donor Allograft Biopsy Portraits Worse Donor Renal Function
A. Nishio-Lucar,¹ J. Murphy,² A. Sites,³ H. Cathro,² A. Doyle,¹ K. Warburton,¹ A. Agarwal.⁴
¹Medicine, University of Virginia, Charlottesville, VA; ²Pathology, University of Virginia, Charlottesville, VA; ³Transplant Services, University of Virginia, Charlottesville, VA; ⁴Surgery, University of Virginia, Charlottesville, VA.
The prognostic ability of zero hour biopsy (ZHB) in renal allografts has not been fully elucidated. ZHB utility predicting living kidney donor (LKD) renal recovery…
2018 American Transplant Congress
Pinching an Inch in Kidney Transplantation: Subcutaneous Depth as a Risk Factor for Wound Complications
R. Ruiz, T. Cox, K. Wicklund, N. Jennings, N. Onaca, G. Testa, T. Anthony, H. Fernandez, J. Bayer, G. McKenna.
Baylor All Saints Medical Center, Fort Worth.
Wound complications after kidney transplant (KTx) consume valuable resources, including prolonged hospital stays and increased costs. Known risk factors include immunosuppression exposure, diabetes, and obesity…
2018 American Transplant Congress
A “Multi-Omic” Analysis of Proteome and Metabolome for Acute Rejection and PVAN in Kidney Transplantation
T. Sigdel, J. Yang, M. Sarwal.
Surgery, UCSF, San Francisco.
Background: Most effort in identifying biomarkers have used gene expression analyses. Proteomics and metabolomics are useful to identify surrogate biomarkers in monitoring transplanted kidney and…
2018 American Transplant Congress
Increased Gene Expression of TGF-b in Renal Transplant Patients with Polyomavirus BK Viremia
W. Yin.
SURGERY, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Chia I, Taiwan; School of Medicine, Tzu Chi University, Hualien, Taiwan.
Objective: We aimed to investigate the roles of cytokines during polyomavirus BK (BKV) reactivation in renal transplant patients.Materials and Methods: Fortyeight renal allograft recipients were…
2018 American Transplant Congress
TACI-Ig as a Desensitization Agent in a Rat Model of Antibody Mediated Rejection
N. Wilson,¹ B. Verhoven,² B. Boldt,² N. Bath,² X. Ding,¹ R. Redfield III.²
¹Medicine/Nephrology, University of Wisconsin, Madison, WI; ²Surgery/Transplant, University of Wisconsin, Madison, WI.
We examined the effect of APRIL/BLyS blockade on B cell lineages & donor specific antibody (DSA) in preclinical rodent model as a novel desensitization strategy.…
2018 American Transplant Congress
Pumping Donor Kidneys Reduces DGF and Improves Allograft Survival without Affecting Rejection Rates
M. Samoylova, A. Nash, T. Brennan.
Surgery, Duke University, Durham, NC.
Recent evidence suggests that hypothermic machine perfusion of donor kidneys reduces delayed graft function (DGF), but data is sparse on its effect on allograft rejection.…
2018 American Transplant Congress
Urinary Microbiome Associated with Chronic Allograft Dysfunction in Kidney Transplants
A. Israni,^1,2 A. Muthusamy,² B. Wu,³ B. Guo,³ D. Knights,⁴ G. Al-Ghalith,⁴ J. Wu,¹ W. Oetting,⁵ D. Schladt,² R. Remmel,⁵ P. Jacobson,⁵ For DeKAF Genomics & GEN03 Investigators.¹
¹Medicine, Hennepin County Medical Center, University of Minnesota (UMN), Minneapolis; ²Minneapolis Medical Research Foundation, Mpls; ³Biostatistics, UMN, Mpls; ⁴Computer Science, UMN, Mpls; ⁵College of Pharmacy, UMN, Mpls.
Background: Microbiome dysbiosis can lead to poor outcomes after kidney transplant (tx) presumably due to immune dysregulation elicited by the microbiome. We hypothesize that chronic…