Articles tagged "Kidney transplantation"

2018 American Transplant Congress
JC Virus-Associated Nephropathy in Renal Transplant Recipient
G. Huang,¹ M. Wang,² X. Chen,¹ S-.C. Yang,³ L. Chen.¹
¹Department of Organ Transplantation, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China; ²Sun Yat-sen University, Guangzhou, China; ³Department of Pathology, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Background: JC virus (JCV) inflection is more common than BK virus (BKV) in general population. But in kidney transplants, polyomavirus nephropathy (PVAN) is primarily caused…
2018 American Transplant Congress
HOPE Act Deceased Organ Donors: True and False Positive Donors
C. Durand,¹ S. Seaman,¹ M. Bowring,¹ B. Doby,¹ D. Ostrander,¹ A. Redd,¹ M. Waldram,¹ S. Huprikar,² B. Haydel,² S. Lerner,² S. Florman,² N. Turgeon,³ R. Friedman-Moraco,³ A. Massie,¹ D. Segev.¹
¹JHU, Baltimore; ²Mount Sinai, New York; ³Emory, Atlanta.
HOPE in Action is a multicenter trial designed to evaluate the safety of HIV+ to HIV+ transplantation (NCT02602262). In this trial, organs from donors with…
2018 American Transplant Congress
Rhesus-Specific Anti-Thymocyte Globulin as an Adjuvant to Costimulatory-Blockade-Based Immunotherapy
M. Mulvihill,¹ B. Ezekian,¹ Q. Gao,¹ K. Samy,¹ R. Davis,¹ F. Leopardi,¹ A. Belli,² W. Flores,² A. Buzby,² K. Reimann,² B. Collins,¹ A. Kirk.¹
¹Department of Surgery, Duke University, Durham, NC; ²MassBiologics, University of Massachusetts Medical School, Boston, MA.
Background Belatacept targets de novo alloimmune responses with minimal off target effects in renal transplantation, though adjuvant therapy is required to control costimulation-blockade resistant rejection…
2018 American Transplant Congress
Improvement in Intermediate Graft Survival among Deceased Donor Recipients in the Last Decade Due to Improvements in Outcomes of Higher KDPI Kidney Recipients
D. Keith.
Medicine, Sacred Heart Hospital, Pensacola, FL, Turkey.
Previous research by our group showed that intermediate graft survival of adult deceased donor kidney transplants between six months and three years post-transplant improved in…
2018 American Transplant Congress
Competing Risk Analysis in Renal Allograft Survival: A New Perspective to an Old Problem
M. El ters,¹ B. Smith,² F. Cosio,¹ W. Kremers.²
¹Medicine, Mayo Clinic, Rochester, MN; ²Biostatistics, Mayo Clinic, Rochester, MN.
Background:Patient and graft survival after kidney transplant (KTX) is often estimated by Kaplan-Meier censoring for competing factors, e.g.death-censored graft survival. However when the competing factor…
2018 American Transplant Congress
Outcomes and Risk Factors of Kidney Transplantation from Pediatric Donors to Adult Recipients
G. Chen, X. Liu, C. Wang, Z. Wu, C. Wang, L. Chen.
Organ Transplant Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China.
Objective To investigate the outcomes of kidney transplantation from pediatric donors to adult recipients, and explore the risk factors for DGF and graft loss after…
2018 American Transplant Congress
Having Your Cake and Eating It Too: An Aggressive Protocol for DSA Treatment Does Not Doom Patients to High Infectious Risk
A. Murthy, A. Karaballa, G. Vranic, B. Javaid, J. Moore, S. Yi, J. Verbesey, P. Abrams, S. Ghasemian, M. Cooper, A. Gilbert.
Medstar Georgetown Transplant Institute, Medstar Georgetown University Hospital, Washington, DC.
Introduction: Antibody mediated rejection (AMR) is one of the most difficult complications to treat in kidney transplantation. We previously reported on our experience with an…
2018 American Transplant Congress
The Effects of Age-Adjusted Marriage Duration on Graft Outcomes in Spousal Donor Kidney Transplantation
M. Yu,¹ J. Park,² H. Cho,¹ J. Ha,¹ C. Ahn,¹ Y. Kim,¹ H. Lee.¹
¹Seoul National University Hospital, Seoul, Korea; ²Kangwon National University Hospital, Chuncheon, Korea.
It is well known that graft survival rate in spousal donor kidney transplantation (SKT) is similar to that of living related donor kidney transplantation (LRKT)…
2018 American Transplant Congress
Belatacept-Refractory CD8⁺CD28^–CD38^hi Effector/Memory T Cells Are Targeted by mTOR Inhibition Leading to a Preferential Loss of CD40L
C. Castro Rojas,¹ A. Godarova,¹ A. Rike Shields,² R. Alloway,² M. Jordan,³ E. Woodle,² D. Hildeman.¹
¹Division of Immunobiology, Cincinnati Children's Hospital, University of Cincinnati College of Medicine, Cincinnati, OH; ²Division of Transplantation, University of Cincinnati College of Medicine, Cincinnati, OH; ³Division of Bone Marrow Transplant and Immune Deficiency, Cincinnati Children's Research Foundation, Cincinnati, OH.
Calcineurin inhibitors (CNIs) and corticosteroids (CSS) have substantial untoward side effects, most notably nephrotoxicity. Consequently, the FDA approved belatacept for maintenance immunosuppression. We recently completed…
2018 American Transplant Congress
Precision (re)Phenotyping of Histologically Stable Kidney Transplants
D. Rychkov,¹ T. Sigdel,² M. Sirota,¹ M. Sarwal.²
¹Institute for Computational Health Sciences, UCSF, San Francisco, CA; ²Department of Surgery, UCSF, San Francisco, CA.
Background: Acute Rejection (AR) is the main cause of the renal failure within one year after transplantation (tx). Its earlier diagnosis is crucial for a…