Articles tagged "Kidney transplantation"

2018 American Transplant Congress
Th17 and NK Responses Are Differentially Induced in Renal Allografts According to Recipient Murine Cytomegalovirus Dose and Strain
M. Shimamura,¹ M. Li,² S. Boddeda,¹ B. Chen,² Q. Zeng,¹ T. Schoeb,² V. Velazquez.¹
¹Center for Vaccines and Immunity and Dept. of Pediatric Infectious Diseases, The Research Institute at Nationwide Children's Hospital and The Ohio State University, Columbus, OH; ²Depts. of Pediatric Infectious Diseases, Pathology, and Genetics, University of Alabama at Birmingham, Birmingham, AL.
Purpose: To study the impact of cytomegalovirus (CMV) recipient positive (R+) serostatus upon renal allograft injury, murine CMV (MCMV) D+/R+ kidney transplants using recipients infected…
2018 American Transplant Congress
Tissue Talks: Graft´s Histological Findings 10 Years after Belatacept or CNI
G. Mondragon-Ramirez,¹ N. Uribe-Uribe,² J. Arreola-Guerra,⁵ R. Reyes-Acevedo,⁵ M. Vilatoba,³ J. Furuzawa-Carballeda,⁴ A. Lopez-Toledo,¹ G. Mondragon-Salgado,¹ J. Alberu.³
¹Inst Mex de Trasplantes, Cuernavaca, Mexico; ²Pathology, Inst Nal de C. Médicas y Nutrición SZ, Mexico City, Mexico; ³Transplantation, Inst Nal de C. Médicas y Nutrición SZ, Mexico City, Mexico; ⁴Immunology, Inst Nal de C. Médicas y Nutrición SZ, Mexico City, Mexico; ⁵Transplantation, C Hospital Miguel Hidalgo, Aguascalientes, Mexico.
The BENEFIT study demonstrated that 7 yrs after kidney transplantation (KT), mean eGFR, patient and graft survival, were significantly higher in the belatacept group than…
2018 American Transplant Congress
Metformin Use after Kidney Transplantation: A Safe Option in Carefully Selected Patients
F. Koraishy,¹ L. Vest,¹ Z. Zhang,¹ M. Schnitzler,¹ V. Dharnidharka,² D. Axelrod,³ R. Ouseph,¹ A. Naik,⁴ N. Lam,⁵ H. Randall,¹ T. Alhamad,² D. Segev,³ D. Brennan,³ B. Kasiske,⁶ G. Hess,⁷ K. Lentine.
¹Saint Louis Univ, St. Louis; ²Washington Univ, St. Louis; ³Lahey Clinic, Burlington; ⁴Univ Michigan, Ann Arbor; ⁵Univ Alberta, Edmonton; ⁶Johns Hopkins, Baltimore; ⁷Hennepin County, Minneapolis; ⁸Symphony Health, Conshohocken.
Recent guidelines support metformin as a therapeutic option in diabetic patients with mild to moderate renal insufficiency. The frequency and outcomes of metformin use in…
2018 American Transplant Congress
T-Cell Depletion Does Not Increase the Risk of CMV Infection in Donor-Positive, Recipient-Negative Kidney Transplants Due to the Absence of Preformed CMV-Specific Cell-Mediated Immunity
M. Jarque,¹ H. Kaminski,² L. Couzi,² E. Crespo,¹ J. Déchanet-Merville,³ S. Luque,¹ N. Montero,⁴ M. Pascual,⁵ O. Manuel,^5,6 P. Merville,² O. Bestard.^1,4
¹Nephrology Lab, IDIBELL, Barcelona, Spain; ²Nephrology Dep, Hôpital Pellegrin, Bordeaux, France; ³National Center of Scientific Research, Bordeaux, France; ⁴Nephrology Dep, Bellvitge Hospital, Barcelona, Spain; ⁵Transplantation Center, Lausanne Hospital, Lausanne, Switzerland; ⁶Infectious Diseases Dep, Lausanne Hospital, Lausanne, Switzerland.
Kidney transplants (KT) with R-/D+ CMV serostatus receiving T-cell depletion induction are considered as the highest risk population for CMV infection and long-lasting prophylaxis therapy…
2018 American Transplant Congress
Prospective, Double Blind, Randomized Trial Comparing the Use of Ketorolac and Lyrica versus SOC+placebo during Live Donor Nephrectomy for Transplant
J. Campsen,¹ T. Call,² A. Rosales,¹ C. Allen,³ A. Presson,³ R. Kim.¹
¹Trasplantation and Advanced Hepatobiliary Surgery, University of Utah, Salt Lake City, UT; ²Anesthesiology, University of Utah, Salt Lake City, UT; ³Epidemiology, University of Utah, Salt Lake City, UT.
Opioid exposure is a concern after live donation (LD) for transplant. We theorized that a protocol using pregablin pre-operation to desensitize nerves followed by ketorolac…
2018 American Transplant Congress
RNA-Seq Based Analysis of Renal Allograft Biopsies Reveals Key Mediators of Interstitial Fibrosis/Tubular Atrophy
C. McEvoy,^1,2,4 E. Brennan,^1,2 A. Dorman,^2,3 D. Sadlier,^1,2 A. Konvalinka,⁴ P. Conlon,^2,3 C. Godson.^1,2
¹Diabetes Complications Research Centre, Conway Institute, School of Medicine, University College Dublin, Dublin, Ireland; ²North Dublin Renal Biobank, Dublin, Ireland; ³Beaumont Hospital & RCSI, Dublin, Ireland; ⁴University Health Network, Toronto, Canada.
Interstitial Fibrosis/Tubular Atrophy(IFTA) is the final common pathway of most progressive renal diseases and is a potent predictors of renal outcome in both native and…
2018 American Transplant Congress
Programmed Cell Death Ligand 1 (PD-L1) Expression is Associated with Subtypes of Post-Transplant Lymphoproliferative Disorders (PTLD)
N. Rodig,¹ G. Pinkus,² G. Ramos Gonzalez,³ T. Agur,¹ O. Weinberg.⁴
¹Pediatrics, Boston Children's Hospital, Boston, MA; ²Pathology, Brigham and Women's Hospital, Boston, MA; ³Surgery, Boston Children's Hospital, Boston, MA; ⁴Pathology, Boston Children's Hospital, Boston, MA.
Introduction: PD-L1 expression on select tumor cells engages the PD-1 receptor on T cells, inhibiting anti-tumor immune responses. PD-L1 has been detected in cases of…
2018 American Transplant Congress
modified DFPP Can Eliminate Donor-Reactive IgG Antibody with Preserving Fibrinogen before Kidney Transplantation
D. Iwami,¹ T. Matsumoto,² K. Hotta,¹ M. Ota,² Y. Chiba,² H. Higuchi,¹ N. Shinohara.¹
¹Renal and Genitourinary Surgery, Hokkaido University, Graduate School of Medicine, Sapporo, Hokkaido, Japan; ²Medical Engineering Center, Hokkaido University Hospital, Sapporo, Hokkaido, Japan.
BACKGROUND: Elimination of preexisting IgG antibodies against donor antigen is an important role before antibody-incompatible (i.e. ABO-incompatible and donor-specific antibody positive) kidney transplantation. Plasma exchange…
2018 American Transplant Congress
Novel Vascular Inflow Offers Renal Transplantation to Recipients with Severe Central and Peripheral Vascular Disease
S. Mao,¹ E. Giorgakis,² A. Moss,² T. Taner.¹
¹William J. von Liebig Center for Transplantation, Mayo Clinic, Rochester, MN; ²Transplantation Surgery, Mayo Clinic, Phoenix, AZ.
Background: Absence of suitable implant locations for donor renal vessels may be a major problem in patients with significant central and peripheral vascular disease. We…
2018 American Transplant Congress
Impact of KDPI and CPRA on Outcomes in Kidney Transplant Recipients
S. Sethi, R. Najjar, A. Peng, A. Vo, S. Jordan, E. Huang.
Cedars Sinai Medical Center, Los Angeles.
Introduction: The new KAS has led to a marked increase in kidney transplants among highly sensitized recipients, mostly attributable to higher allocation of low KDPI…