Articles tagged "Kidney transplantation"

2018 American Transplant Congress
Sub-Clinical Acute Rejection (subAR) Detected by Both Surveillance Biopsy (SBx) and a Peripheral Blood Molecular Biomarker Correlates with De Novo Donor Specific Antibody (dnDSA) Following Kidney Transplant (KT)
R. Heilman,¹ J. Friedewald,² K. Kurian,⁵ T. Whisemant,⁵ E. Poggio,³ C. Marsh,⁵ P. Baliga,⁷ N. Bridges,⁴ J. Odim,⁴ M. Brown,⁴ D. Ikle,³ B. Armstrong,³ L. Zhao,² D. Salomon,⁵ M. Abecassis.²
¹Mayo Clinic, Phoenix; ²Northwestern University, Chicago; ³Rho Federal Systems, Chapel Hill; ⁴National Institute of Allergy and Infectious Disease, Bethesda; ⁵Scripps Health, La Jolla; ⁶Cleveland Clinic, Cleveland; ⁷Medical University of South Carolina, Charleston.
AIMWe investigated the correlation between subAR diagnosed by SBx or by a newly-defined biomarker, and the development of dnDSA.METHODS307 KT patients enrolled into a multi-center…
2018 American Transplant Congress
Patients Prioritize Waitlist Factors over Outcomes When Evaluating Kidney Transplant Centers
A. Michelson, C. Brennan, A. Mattoo, B. Kil, D. Tsapepas, S. Husain, S. Mohan.
Nephrology, Columbia University Medical Center, New York, NY.
The factors that influence transplant candidates' selection of a transplant center for waitlisting are not well understood. Further, the relative weightage of these factors has…
2018 American Transplant Congress
Late Conversion from Calcineurin Inhibitors to Belatacept is Associated with a Sustained Improvement in Kidney Allograft Function
S. Sethi, J. Choi, A. Vo, R. Najjar, A. Peng, S. Jordan, E. Huang.
Medicine/Nephrology, Cedars Sinai Medical Center, Los Angeles, CA.
Introduction: Belatacept was shown to have longer kidney graft survival and higher eGFR at 7 years than a calcineurin inhibitor (CNI)-based regimen in the BENEFIT…
2018 American Transplant Congress
Cognition after Belatacept Conversion
C. Ogbejesi, E. Cohen, K. Belfield, W. Asch.
Yale University, New Haven, CT.
Intro: Kidney Transplant Recipients (KTRs) taking calcineurin inhibitors (CNIs) can experience varying drug toxicities. Less well studied compared to the metabolic consequences, many patients report…
2018 American Transplant Congress
Variation in Living Donor Kidney Transplantation among U.S. Transplant Centers
T. Melanson,¹ M. Basu,¹ L. Plantiga,¹ S. Pastan,¹ S. Mohan,² R. Patzer.¹
¹Emory University, Atlanta; ²Columbia University, New York.
Introduction: Living donor kidney transplant (LDKTx) is the preferred treatment for patients with end-stage renal disease (ESRD) but continues to be less common than deceased…
2018 American Transplant Congress
Transplantation of Restored Kidneys from Living Related Donors after Small Renal Tumor Resection: Report of 5 Cases
Y. Ogawa,¹ S. Shiroma,² K. Kojima,² R. Mannami,² M. Mannami,² N. Mitsuhata,² M. Nishi,⁴ H. Afuso.³
¹Urology, Tokyo-West Tokushukai Hospital, Akishima, Tokyo, Japan; ²Urology, Uwajima Toikushukai Hospital, Uwajima, Ehime, Japan; ³Urology, Okinawa Chubu Tokushukai Hospital, Okinawa, Japan; ⁴Urology, Saint Martin's Hospital, Sakaide, Kagawa, Japan.
Purpose: We launched a clinical trial registered at ClinicalTrials.gov that aimed to study the utility and safety of restored kidney transplantation between family members using…
2018 American Transplant Congress
Preoperative Anemia in Transfusion Free Patients Undergoing Kidney Transplant May Be Associated with Poor Outcome
N. Kaur, A. Pita, C. Lane, M. Bhatnagar, L. Matsuoka, R. Selby, K. Dhanireddy.
Department of Surgery, University of Southern California, Los Angeles, CA.
Background: Preoperative anemia can contribute to poor outcomes in transfusion-free (TF) kidney transplants (KT). There are no established guidelines on the acceptable degree of anemia.…
2018 American Transplant Congress
Prediction of BK Viremia by Urine BK Viral Load in Renal Transplant Patients: BK Viral Load Results in Paired Urine and Plasma Samples
K. Madden,¹ C. Janitell,² S. Yang.²
¹Pathology, University of New Mexico, Albuquerque, NM; ²Microbiology, Tricore Reference Laboratories, Albuquerque, NM.
BK virus (BKV) associated nephropathy (BKVAN) affects up to 10% of renal transplant recipients, causing graft failure without intervention; a presumptive BKVAN diagnosis is made…
2018 American Transplant Congress
HOPE Act Deceased Organ Donors: True and False Positive Donors
C. Durand,¹ S. Seaman,¹ M. Bowring,¹ B. Doby,¹ D. Ostrander,¹ A. Redd,¹ M. Waldram,¹ S. Huprikar,² B. Haydel,² S. Lerner,² S. Florman,² N. Turgeon,³ R. Friedman-Moraco,³ A. Massie,¹ D. Segev.¹
¹JHU, Baltimore; ²Mount Sinai, New York; ³Emory, Atlanta.
HOPE in Action is a multicenter trial designed to evaluate the safety of HIV+ to HIV+ transplantation (NCT02602262). In this trial, organs from donors with…
2018 American Transplant Congress
Rhesus-Specific Anti-Thymocyte Globulin as an Adjuvant to Costimulatory-Blockade-Based Immunotherapy
M. Mulvihill,¹ B. Ezekian,¹ Q. Gao,¹ K. Samy,¹ R. Davis,¹ F. Leopardi,¹ A. Belli,² W. Flores,² A. Buzby,² K. Reimann,² B. Collins,¹ A. Kirk.¹
¹Department of Surgery, Duke University, Durham, NC; ²MassBiologics, University of Massachusetts Medical School, Boston, MA.
Background Belatacept targets de novo alloimmune responses with minimal off target effects in renal transplantation, though adjuvant therapy is required to control costimulation-blockade resistant rejection…