ATC Abstracts

American Transplant Congress abstracts

  • Home
  • Meetings Archive
    • 2019 American Transplant Congress
    • 2018 American Transplant Congress
    • 2017 American Transplant Congress
    • 2016 American Transplant Congress
    • 2015 American Transplant Congress
    • 2013 American Transplant Congress
  • Keyword Index
  • Resources
    • 2016 Resources
      • 2016 Welcome Letter
      • ATC 2016 Program Planning Committees
      • ASTS Council 2015-2016
      • AST Board of Directors 2015-2016
    • 2015 Resources
      • 2015 Welcome Letter
      • ATC 2015 Program Planning Committees
      • ASTS Council 2014-2015
      • AST Board of Directors 2014-2015
      • 2015 Conference Schedule
  • Advanced Search

Effect of Induction Therapy on CD4 Cell Count Recovery Following Renal Transplantation in HIV Positive Recipients – A Single Center Experience

J. Chique Figueroa, M. Prendergast, H. Wadei, M. Mai, K. Oshel, D. Leonard.

Department of Transplantation, Mayo Clinic College of Medicine, Jacksonville, FL.

Meeting: 2018 American Transplant Congress

Abstract number: 214

Keywords: CD4, HIV virus, Induction therapy, Kidney transplantation

Session Information

Date: Monday, June 4, 2018

Session Name: Concurrent Session: Kidney Immunosuppression: Induction Therapy

Session Time: 2:30pm-4:00pm

 Presentation Time: 3:06pm-3:18pm

Location: Room 6C

Related Abstracts
  • Long Term Outcomes With Alemtuzumab Induction Therapy for Deceased and Living Renal Transplant Recipients. A Single Center Experience
  • Effect of Induction Therapy in ABO Incompatible Living-Donor Kidney Transplantation: A Single Center Experience.

The feasibility, complications and outcomes of solid organ transplantation in the HIV positive population are well documented and have had excellent outcomes with a slight increased risk of rejection but no significant increase in the risk of opportunistic infections compared to non-HIV population. Basiliximab has been typically used for induction therapy in HIV positive organ recipients, but there is a paucity of data regarding the use of lymphocyte-depleting agents, in particular Alemtuzumab, and the effect on rates of recovery of CD4 counts, rates of rejection and opportunistic infection. We present data from a single center gathered from 14 HIV renal transplant recipients from 2012 to 2017.

Induction therapy was chosen based upon perceived immunologic risk of rejection using the same determinants (level DSA, age, cancer history) as for the non-HIV population at our institution. Six patients received Alemtuzumab (average risk), 3 Basiliximab (low risk) and 4 Thymoglobulin (high risk). Baseline CD4 counts were above 200 and all patients had undetectable viral load.

Results:

RejectionSerious InfectionCreatinine mg/dlCD4 count
alemtuzumab n=7Banff1B n=1, borderline ACR n=1nocardiosis n=1, Ocular VZV n=11-2.7no data, n=3; >150, n=3, 70 after ATG tx for rejection
thymoglobulin n=4Banff1A with TMA and graft loss n=1nonemean 1.2; graft loss excluded96-206
basiliximab n=3borderline ACR n=1none0.7-1.3>200, n=3

Conclusions: Based on this small cohort, we conclude that lymphocyte depleting agents, including Alemtuzumab, are valid options for induction in HIV positive recipients undergoing renal transplantation. Regarding opportunistic infections, a case of disseminated nocardia occurred in the Alemtuzumab group only following treatment of rejection with ATG, with a downstream effect on CD4 count recovery by 12 months post transplantation. The case of shingles at 4 months when CD4 count was <100 prompted us to consider basing duration of anti-viral prophylaxis on CD4 count rather than standard duration as applied to the non-HIV positive transplant population. Overall, rates of recovery in CD4 counts were acceptable. Apart from a case of TMA that resulted in allograft loss, rejections were mild and overall graft function was acceptable.

CITATION INFORMATION: Chique Figueroa J., Prendergast M., Wadei H., Mai M., Oshel K., Leonard D. Effect of Induction Therapy on CD4 Cell Count Recovery Following Renal Transplantation in HIV Positive Recipients – A Single Center Experience Am J Transplant. 2017;17 (suppl 3).

  • Tweet
  • Email
  • Print

To cite this abstract in AMA style:

Figueroa JChique, Prendergast M, Wadei H, Mai M, Oshel K, Leonard D. Effect of Induction Therapy on CD4 Cell Count Recovery Following Renal Transplantation in HIV Positive Recipients – A Single Center Experience [abstract]. https://atcmeetingabstracts.com/abstract/effect-of-induction-therapy-on-cd4-cell-count-recovery-following-renal-transplantation-in-hiv-positive-recipients-a-single-center-experience/. Accessed December 14, 2019.

« Back to 2018 American Transplant Congress

Most Viewed Abstracts

  • This Week
  • This Month
  • All Time
  • Penis Transplantation: First U.S. Experience.
  • Evidence of a Clinically Significant Drug-Drug Interaction between Cannabidiol and Tacrolimus: A Case Report
  • Home
  • Is There a Difference Between DCD and DBD Kidney Transplantation with Similar KDPI?
  • Low GFR after Kidney Donation Is Not Chronic Kidney Disease
  • Penis Transplantation: First U.S. Experience.
  • Evidence of a Clinically Significant Drug-Drug Interaction between Cannabidiol and Tacrolimus: A Case Report
  • Is There a Difference Between DCD and DBD Kidney Transplantation with Similar KDPI?
  • Low GFR after Kidney Donation Is Not Chronic Kidney Disease
  • Tacrolimus Dose and Trough Blood Levels in a US Liver Transplant Population
  • Penis Transplantation: First U.S. Experience.
  • Is There a Difference Between DCD and DBD Kidney Transplantation with Similar KDPI?
  • Low GFR after Kidney Donation Is Not Chronic Kidney Disease
  • Evidence of a Clinically Significant Drug-Drug Interaction between Cannabidiol and Tacrolimus: A Case Report
  • Kidney Dialysis after Heart Transplantation: The Short and Long Term Outcomes

Visit Our Partner Sites

American Transplant Congress (ATC)

Visit the official site for the American Transplant Congress »

American Journal of Transplantation

The official publication for the American Society of Transplantation (AST) and the American Society of Transplant Surgeons (ASTS) »

American Society of Transplantation (AST)

An organization of more than 3000 professionals dedicated to advancing the field of transplantation. »

American Society of Transplant Surgeons (ASTS)

The society represents approximately 1,800 professionals dedicated to excellence in transplantation surgery. »

Copyright © 2013-2019 by American Society of Transplantation and the American Society of Transplant Surgeons. All rights reserved.

Privacy Policy

wiley-new-logo

loading Cancel
Post was not sent - check your email addresses!
Email check failed, please try again
Sorry, your blog cannot share posts by email.
This site uses cookies: Find out more.