Session Time: 2:30pm-4:00pm
Presentation Time: 3:30pm-3:42pm
Location: Room 206
*Purpose: In the United States (US), kidney paired donation (KPD) networks have facilitated an increasing proportion of KTs annually, but longer-term transplant outcomes and differences in the mortality and graft failure risk between NKR and control living donor KT (LDKT) recipients have not been well described.
*Methods: Using the National Kidney Registry (NKR), the largest US KPD clearinghouse, and SRTR, we compared NKR (N=2,363) recipients to all non-NKR LDKT recipients (N=54,496) (2/2008-12/2017). We estimated the risk of death-censored graft failure (DCGF) and mortality using inverse probability of treatment weighted Cox regression.
*Results: NKR recipients were more likely to be female, African-American, older, on public insurance, have PRA>80, spend longer on dialysis, and be previous transplant recipients (all p<0.001). NKR recipients were followed for a median 3.2 years (max=10.3 years). NKR recipients had similar DCGF (log-rank p=0.2) and mortality (log-rank p=0.6) incidence compared to non-NKR recipients. After adjustment for donor, recipient, and transplant factors, there no detectable difference in DCGF [aHR: 0.99 (0.78-1.24), p=0.9] or mortality [aHR: 0.91 (0.72-1.15), p=0.4] between NKR and non-NKR LDKT recipients.
*Conclusions: Even when transplanting patients with greater risk factors for worse post-transplant outcomes, our KPD results were equivalent to national LDKT controls.
To cite this abstract in AMA style:Leeser DB, Thomas AG, Shaffer AA, Veale J, Massie AB, Cooper M, Kapur S, Kapur S, Kapur S, Turgeon N, Segev D, Waterman A, Flechner S. Kidney Paired Donation Transplant Outcomes: Experiences from the First Ten Years of the National Kidney Registry [abstract]. Am J Transplant. 2019; 19 (suppl 3). https://atcmeetingabstracts.com/abstract/kidney-paired-donation-transplant-outcomes-experiences-from-the-first-ten-years-of-the-national-kidney-registry/. Accessed February 18, 2020.
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