Articles tagged "Kidney transplantation"

2019 American Transplant Congress
The Reduced Tacrolimus Metabolism Rate and Its Association with Estimated Glomerular Filtration Rate and Interstitial Fibrosis: A Study Using Korean Organ Transplantation Registry (KOTRY) Dataset
J. Jeong¹, H. Ro², T. Koo³, J. Yang³, M. Kim⁴, S. Shin⁵, J. Park⁶, T. Ban⁷, S. Han⁸, T. Kim⁹, C. Ahn¹⁰
¹Ajou University School of Medicine, Suwon, Korea, Republic of, ²Gachon University, Incheon, Korea, Republic of, ³Seoul National University Hospital, Seoul, Korea, Republic of, ⁴Yonsei University College of Medicine, Seoul, Korea, Republic of, ⁵Asan Medical Center, Seoul, Korea, Republic of, ⁶Samsung Medical Center, Seoul, Korea, Republic of, ⁷Seoul St Mary's Hospital, Seoul, Korea, Republic of, ⁸Keimyung University School of Medicine, Daegu, Korea, Republic of, ⁹Inje University, Busan Paik Hospital, Busan, Korea, Republic of, ¹⁰Seoul National University College of Medicine, Seoul, Korea, Republic of
*Purpose: Tacrolimus is the key drug in clinical transplant, which has narrow therapeutic index. A few studies reported the association of tacrolimus metabolism rate with…
2019 American Transplant Congress
Transition from Pediatric to Adult Care of Kidney Transplant Recipients: A Retrospective Analysis of a French Monocentric Cohort
M. Mazloum¹, M. Charbit², O. Aubert¹, D. Anglicheau¹, A. Scemla¹, R. Salomon², P. Krug², C. Legendre¹, R. Sberro-Soussan¹
¹Adult Nephrology and Renal Transplantation Department, Necker Hospital, Paris, France, ²Pediatric Nephrology and Renal Transplantation Department, Necker Hospital, Paris, France
*Purpose: Transition refers to the dynamic process in which the patient is oriented from pediatric to adult care. In the field of kidney transplantation, transition…
2019 American Transplant Congress
Outcomes Analysis of U.S. Transplant Centers Performing High Volumes of Hard to Place Kidneys
Y. Qazi¹, D. Bahl², N. Mehta³, Z. Haddad⁴, M. Smogorzewski⁴
¹USC, Los Angeles, CA, ²UC Davis, Sacramento, CA, ³UC Berkeley, Berkeley, CA, ⁴Keck Medical Center At USC, Los Angeles, CA
*Purpose: Despite a growing number of patients awaiting a kidney transplant, discard rate remains significantly high. The UNOS SRTR data now provides information on all…
2019 American Transplant Congress
Accelerating Kidney Allocation: Simultaneously Expiring Offers
M. Kosztowski¹, M. Mankowski², S. Raghavan³, J. Garonzik-Wang¹, D. Axelrod⁴, D. L. Segev¹, S. E. Gentry¹
¹Johns Hopkins University, Baltimore, MD, ²King Abdullah University of Science and Technology, Thuwal, Saudi Arabia, ³University of Maryland, College Park, MD, ⁴University of Iowa, Iowa City, IA
*Purpose: Placing kidneys quickly might reduce discard. Additionally, a faster allocation system that reduces cold ischemia time would yield benefits: decreased delayed graft function, shorter…
2019 American Transplant Congress
Simultaneous Robotic Kidney Transplantation and Bariatric Surgery for Morbidly Obese Patients with End-Stage Renal Failure
P. West-Thielke, K. A. Tulla, O. T. Okoye, J. A. Almario Alvarez, M. Spaggiari, I. G. Tzvetanov, E. Benedetti
University of Illinois at Chicago, Chicago, IL
*Purpose: The purpose of this study is to evaluate the safety and efficacy of simultaneous robotic assisted kidney transplant and robotic assisted sleeve in obese…
2019 American Transplant Congress
What’s in a High Dose? An Analysis of Tacrolimus Pharmacokinetic Parameters in Rapid Metabolizers
P. West-Thielke¹, A. Maldonado², S. J. Patel³, D. R. Stevens³, U. Meier-Kriesche³, D. Brennan⁴
¹University of Illinois, Chicago, Chicago, IL, ²Vidant Medical Center, Greenville, NC, ³Veloxis Pharmaceuticals Inc., Cary, NC, ⁴Johns Hopkins University School of Medicine, Baltimore, MD
*Purpose: CYP3A5*1 expressers exhibit differences in immediate-release tacrolimus (IR-Tac) PK and require higher doses of IR-Tac to maintain therapeutic trough concentrations. LCP-Tacrolimus (LCPT) demonstrates a…
2019 American Transplant Congress
Apolipoprotein L1 Genotyping in Potential African American Living Kidney Donors
P. Gudsoorkar, M. Anand, T. Kaur, S. Shah, S. Bumb, A. Govil, B. G. Abu Jawdeh
U.Cincinnati, Cincinnati, OH
*Purpose: African Americans(AA) account for 13% of the US population, yet compose more than one third of dialysis patients. Inheriting two Apolipoprotein L1 gene (APOL1)…
2019 American Transplant Congress
Measuring and Monitoring Disparities in Access to Kidney Transplantation Associated with Being Listed for a Multi-Organ Transplant (MOT)
D. E. Stewart, C. A. Custer, A. M. Robinson, A. R. Wilk
UNOS, Richmond, VA
*Purpose: In 2018, the OPTN published a new methodology for measuring and monitoring disparities in access to deceased donor kidney (KI) transplantation (Tx) among kidney-alone…
2019 American Transplant Congress
Super-resolution Evaluation Of The Glomerular Basement Membrane Changes In The Course Of Transplant Glomerulopathy
D. Hammad, J. H. Miner, T. Alhamad, H. Suleiman
Washinton University in St. Louis, St. Louis, MO
*Purpose: Transplant Glomerulopathy (TG) is a histologic entity that affects around 20% of kidney allografts by 5 years post transplantation and results in a significant…
2019 American Transplant Congress
Conversion from Calcineurin Inhibitors to Belatacept in Kidney Recipients with Donor-Specific Anti-HLA Antibodies and Calcineurin Inhibitor Nephrotoxicity Decreases the Pathogenicity of Donor-Specific Anti-HLA Antibodies
K. Louis¹, D. Viglietti¹, D. Pievani¹, O. Aubert¹, D. Glotz¹, C. Legendre¹, A. Zeevi², A. Loupy¹, C. Lefaucheur¹
¹Paris Translational Research Center for Organ Transplantation, Paris, France, ²University of Pittsburgh Medical Center, Pittsburgh, PA
*Purpose: Switching from CNI- to Belatacept-based regimen has been associated with improved graft function in low-immunologic risk kidney recipients. We investigated the efficacy and safety…