Articles tagged "Kidney transplantation"

2019 American Transplant Congress
REHANNA: Renal Transplants in Hepatitis C Negative Recipients with Nucleic Acid Positive Donors with Short Course Direct Acting Antiviral Prophylaxis
C. Durand, B. Barnaba, D. Brown, N. Bair, F. Naqvi, M. Bowring, D. Segev, M. Sulkowski, N. Desai
Johns Hopkins University School of Medicine, Baltimore, MD
*Purpose: To mitigate the current organ shortage and underutilization of hepatitis C-infected deceased donor (HCV D+) organs, we evaluated the use of HCV D+ kidneys…
2019 American Transplant Congress
Steadily Dropping Malignancy Rates after Pediatric Kidney Transplantation Have Now Reversed in the Most Recent Era: A Report of the North American Pediatric Renal Trials and Collaborative Studies (NAPRTCS)
V. Dharnidharka¹, C. Cramer², A. Chua³, A. Moudgil⁴, K. Martz⁵, T. Blydt-Hansen⁶, J. Smith⁷, A. Neu, on behalf of the NAPRTCS Investigators⁸
¹Washington University in St. Louis, Saint Louis, MO, ²Mayo Clinic, Rochester, MN, ³Duke University, Durham, NC, ⁴Children's National Medical Center, Washington, DC, ⁵Emmes Corporation, Rockville, MD, ⁶BC Children's Hospital, Vancouver, BC, Canada, ⁷Seattle Children's Hospital, Seattle, WA, ⁸Johns Hopkins University, Baltimore, MD
*Purpose: In general, malignancies are very rare in children, compared to older adults. The NAPRTCS registry has collected data on children receiving kidney transplants in…
2019 American Transplant Congress
Kidney Allografts Induce Systemic Tolerance of Heart Allografts and is Dependent on Foxp3+ Cells
C. Yang¹, J. Ge¹, P. S. Russell¹, J. C. Madsen¹, A. Alessandrini¹, R. B. Colvin²
¹Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, ²Department of Pathology, Massachusetts General Hospital, Boston, MA
*Purpose: We have successfully achieved cardiac allograft tolerance in both pigs and NHP by donor kidney co-transplantation. The mechanism of Kidney Induced Cardiac Allograft Tolerance…
2019 American Transplant Congress
Mortality and Morbidity in Kidney Transplant Recipients with a Failing Graft
N. N. Lam¹, D. J. Boyne², R. R. Quinn², P. C. Austin³, B. R. Hemmelgarn², P. Campbell¹, G. A. Knoll⁴, L. Tibbles², S. Yilmaz², H. Quan², P. Ravani²
¹University of Alberta, Edmonton, AB, Canada, ²University of Calgary, Calgary, AB, Canada, ³ICES, Toronto, ON, Canada, ⁴University of Ottawa, Ottawa, ON, Canada
*Purpose: Due to their history of renal disease and exposure to immunosuppression, kidney transplant recipients with a failing graft may be at higher risk of…
2019 American Transplant Congress
Safety and Efficacy of Imlifidase in Highly-Sensitized Kidney Transplant Patients: Results from a Phase 2 Study
S. C. Jordan¹, C. Legendre², N. Desai³, T. Lorant⁴, M. Bengtsson⁴, L. Laxmyr⁵, B. Lonze⁶, A. Vo¹, K. J. Wood⁷, C. Kjellman⁵, R. A. Montgomery⁶
¹Cedars-Sinai Medical Center, Los Angeles, CA, ²Hopital Necker, Paris, France, ³Johns Hopkins University, Baltimore, MD, ⁴Uppsala University, Uppsala, Sweden, ⁵Hansa Medical AB, Lund, Sweden, ⁶NYU Langone Health Transplant Institute, New York, NY, ⁷University of Oxford, Oxford, United Kingdom
*Purpose: Many patients eligible for kidney transplantation are sensitized to allo-HLA antigens and face prolonged waiting times and increased mortality. The presence of donor specific…
2019 American Transplant Congress
Tolerance Induction with Hematopoietic Stem Cells in Kidney Transplantations
K. Lee, J. Park, Y. Chung, S. Kim
Department of Surgery, Samsung Medical Center, Seoul, Korea, Republic of
*Purpose: Tolerance induction is considered to be the final goal in the field of organ transplantation. We have performed combined bone marrow and kidney transplantation…
2019 American Transplant Congress
Lifestyle Intervention in Renal Transplant Recipients: A Multicenter, Randomized Clinical Trial
E. Corpeleijn¹, G. Klaassen², D. M. Zelle², D. Dijkema³, I. van Vliet², F. J. Bemelman⁴, G. J. Navis², S. J. Bakker²
¹Department of Epidemiology, University Medical Center Groningen, Groningen, Netherlands, ²Division of Nephrology, Department of Internal Medicine, University Medical Center Groningen, Groningen, Netherlands, ³Department of Dietetics, University Medical Center Groningen, Groningen, Netherlands, ⁴Department of Nephrology, Amsterdam Medical Center, Amsterdam, Netherlands
*Purpose: Low physical activity and reduced physical functioning are common after renal transplantation, resulting in a reduced quality of life. The aim of this study…
2019 American Transplant Congress
Autoantibody Production Significantly Decreased with APRIL/BLyS Blockade in Murine Chronic Rejection Kidney Transplant Model
N. Bath, X. Ding, B. Verhoven, S. Reese, N. Wilson, A. Sukhwal, R. Redfield III
University of Wisconsin, Madison, WI
*Purpose: Chronic antibody mediated rejection (cAMR) remains a significant barrier to achieving long-term graft survival in kidney transplantation. Alloantibody production from B lymphocytes and plasma…
2019 American Transplant Congress
Machine Perfusion Allows Use of High KDPI and Prolonged Cold Ischemia Time in Deceased Donors: A Single Center Effort to Decrease Discard Rates
M. Ortigosa-Goggins, J. Gaynor, A. Mattiazzi, J. Figueiro, G. Burke, G. Ciancio, G. Guerra
Miami Transplant Institute, University of Miami, Miami, FL
*Purpose: Discard rates of deceased donor kidney transplants(DDKT)rises as the kidney donor profile index(KDPI)increases,and approaches 60%for KDPI of >85%.Pulsatile machine perfusion(MP)allows use of kidneys with…
2019 American Transplant Congress
The Collaborative Improvement and Innovation Network (COIIN): Impact on Deceased Donor Transplant Rates and Offer Acceptance Practices
A. Wey¹, S. Gustafson¹, B. Carrico², J. Foutz², K. Sisaithong³, M. McBride², D. Klassen², D. Klassen², N. Salkowski¹, B. Kasiske¹, A. Israni¹, J. Snyder¹
¹SRTR, Minneapolis, MN, ²OPTN, Richmond, VA, ³OPTN, Minneapolis, MN
*Purpose: The Organ Procurement and Transplantation Network (OPTN) completed the Collaborative Improvement and Innovation Network (COIIN), a study to increase kidney transplants by reducing risk…