2020 American Transplant Congress
Construction of Three-Dimensional Vascularized Functional Beta-Cells Tissues Using a Layer-by-Layer Cell Coating Technique
*Purpose: Regenerative therapy for type I Diabetes Mellitus has been expected to be a promising treatment. A subcutaneous site is an ideal candidate for stem…2020 American Transplant Congress
Can Autologous Islet Cell Transplant Be a Comparable Choice to Parenchymal Preserving Surgery for Patients with Chronic Pancreatitis with Respect to Glycemic Control?
University of North Carolina, Chapel Hill, NC
*Purpose: The aim of this study is to examine the difference in glycemic outcomes between total pancreatectomy and autologous islet cell transplant (TPAIT) and parenchymal…2020 American Transplant Congress
Alum Elicited MDSCs Delay the Rejection of Fully Mistmatched Islets in Mice
1Boston Children's Hospital, Boston, MA, 2Massachusetts General Hospital, Boston, MA
*Purpose: Myeloid derived suppressor cells (MDSCs) have been demonstrated to be critical for the induction of tumor induced T cell tolerance and have also been…2020 American Transplant Congress
Splenectomy Impedes B Cell Infiltration Associated with Rejection of Neonatal Porcine Islet Xenografts
*Purpose: Xenotransplantation has historically been frustrated by antibody-mediated rejection. Splenectomy has shown efficacy in mediating humoral immunity. We hypothesized that adding splenectomy to a clinically…2020 American Transplant Congress
CD47 Innate Immune Checkpoint Enhances Islet Engraftment Following Intraportal Transplantation by Mitigating Instant Blood Mediated Inflammatory Reaction
*Purpose: Transplantation of islets into hepatic portal vein is associated with significant islet mass loss immediate post-transplantation. Instant blood mediated inflammatory reaction (IBMIR), characterized by…2020 American Transplant Congress
The Pleural Cavity, A Novel and Clinically Relevant Site for Pancreatic Islet Transplantation
*Purpose: Islet transplantation currently provides a cure for type 1 diabetes. Hepatic infusion of islets via the portal vein is clinically accepted in human, although…2020 American Transplant Congress
Withaferin A Prolongs Islet Allograft Survival in a Mouse Transplant Model by Preventing T Lymphocyte Proliferation and Dendritic Cell Maturation
*Purpose: Chronic decline in islet graft function and toxicities imposed by immunosuppressant drugs remain as challenges to the widespread use of islet transplantation for type…2020 American Transplant Congress
Coagulation and Cd46 Transgene Modification in Neonatal Porcine Islet Xenotransplantation
Surgery, Duke University, Durham, NC
*Purpose: Vascular thrombosis is a potential cause for early intraportal xeno-islet loss. To better understand the relationship between coagulation and inflammation in early xeno-islet transplantation,…2020 American Transplant Congress
LacripepTM and its Analogs Act as Novel Interventional Agents to Promote Long-Term Islet Transplantation Outcomes
*Purpose: To study the prosecretory, prosurvival, and mitogenic effect of Lacripep™ and its analogs in enhancing islet viability, increasing insulin secretion and promoting long-term islet…2020 American Transplant Congress
Immunomodulation with FasL Presenting Biomaterials Achieves Long-Term Survival of Allogeneic Islets in the Absence of Chronic Immunosuppression in a Non-Human Primate Model
*Purpose: The full potential of islet transplantation will only be realized by the development of tolerogenic strategies that obviate the need for maintenance immunosuppressants. We…
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