2020 American Transplant Congress
Long-Term Islet Allo- and Xenograft Survival is Promoted by Immunoglobulin M Immunotherapy
Department of Surgery, University of Virginia Health System, Charlottesville, VA
*Purpose: To investigate if islet allo- and xenotransplant rejection is mitigated by IgM immunotherapy.*Methods: a) New onset diabetic NOD mice (n=14) were treated with IgM…2020 American Transplant Congress
Long-Term Outcomes with Islet Alone and Islet-after-Kidney Transplantation for Type 1 Diabetes in the Clinical Islet Transplantation Consortium
*Purpose: Phase 3 studies of islet transplant alone (ITA; n=48) and islet-after-kidney (IAK; n=24) transplantation in type 1 diabetes complicated by severe hypoglycemic events (SHE)…2020 American Transplant Congress
Pancreas Transplant in Chronic Kidney Disease for Type 1 Diabetic Patients
*Purpose: Although both pancreas transplantation alone (PTA) and islet cell transplantation (ICT) have been associated with peri-operative declines in eGFR, the magnitude of decline is…2020 American Transplant Congress
Evaluation of US Doppler Examination of Portal Flow Dynamics in Patients with Total Pancreatectomy and Autologous Islet Cell Transplant
University of North Carolina, Chapel Hill, NC
*Purpose: The aim of this study is to evaluate US doppler flow dynamics following total pancreatectomy and autologous islet cell transplant (TPAIT) and establish any…2020 American Transplant Congress
TPIAT Outcomes in Diabetic and Non-Diabetic Patients with Chronic Pancreatitis
Virginia Commonwealth University, Richmond, VA
*Purpose: Total pancreatectomy with islet auto-transplantation (TPIAT) is becoming the standard of care for patients with severe chronic pancreatitis (CP). However, it is necessary to…2020 American Transplant Congress
Plasma Cells Are Not Necessary for Regulatory B Cells and Preventing Their Differentiation Markedly Prolongs Allograft Survival
Thomas E Starzl Transplant Institute, University of Pittsburgh, Pittsburgh, PA
*Purpose: Plasma Cells (PCs) are the primary source of circulating antibodies. PCs were reported to be the major source of B-cell lineage IL-10, and absence…2020 American Transplant Congress
Construction of Three-Dimensional Vascularized Functional Beta-Cells Tissues Using a Layer-by-Layer Cell Coating Technique
*Purpose: Regenerative therapy for type I Diabetes Mellitus has been expected to be a promising treatment. A subcutaneous site is an ideal candidate for stem…2020 American Transplant Congress
Can Autologous Islet Cell Transplant Be a Comparable Choice to Parenchymal Preserving Surgery for Patients with Chronic Pancreatitis with Respect to Glycemic Control?
University of North Carolina, Chapel Hill, NC
*Purpose: The aim of this study is to examine the difference in glycemic outcomes between total pancreatectomy and autologous islet cell transplant (TPAIT) and parenchymal…2020 American Transplant Congress
Alum Elicited MDSCs Delay the Rejection of Fully Mistmatched Islets in Mice
1Boston Children's Hospital, Boston, MA, 2Massachusetts General Hospital, Boston, MA
*Purpose: Myeloid derived suppressor cells (MDSCs) have been demonstrated to be critical for the induction of tumor induced T cell tolerance and have also been…2020 American Transplant Congress
Splenectomy Impedes B Cell Infiltration Associated with Rejection of Neonatal Porcine Islet Xenografts
*Purpose: Xenotransplantation has historically been frustrated by antibody-mediated rejection. Splenectomy has shown efficacy in mediating humoral immunity. We hypothesized that adding splenectomy to a clinically…
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