2020 American Transplant Congress
AIPCs Home to and Engraft in the Pancreas When Injected Intravenously
1Imagine Pharma, Pittsburgh, PA, 2Allegheny Health Network, Pittsburgh, PA
*Purpose: AIPCs (Activated Islet Proliferating Cells) are a recently developed cell population generated from isolated islets of mice and humans. AIPCs are over 65% CD133-,…2020 American Transplant Congress
Generation of Insulin-Producing Cells via Multiplex Epigenetic Engineering of Human Somatic Cells in 2 Weeks
*Purpose: Stem cell-derived β-cells not only promise a renewable supply of insulin-producing cells with negligible immunosuppression but may also provide a substrate for the identification…2020 American Transplant Congress
Contamination of Acinar Cells Impairs Therapeutic Effect of Islet Transplantation Due to Induction of Inflammatory Reaction in Not Only Graft Islets but Also Hepatic Parenchyma
Regenerative Medicine and Transplantation, Fukuoka University, Fukuoka City, Japan
*Purpose: Islet transplantation is a promising treatment option for type 1 diabetes. Edmonton protocol recommended that over 30 % purity of islets is essential for…2020 American Transplant Congress
Pancreatic Mesenchymal Stromal Cells (MSC) Contain a Subset of Islet Progenitor Cells Capable of Regenerating Islets and Reversing Diabetes
*Purpose: To identity islet precursor cells residing in pancreatic MSC culture preparations that contribute to islet regeneration and restoration of islet cell function in both…2020 American Transplant Congress
Beta Cell Replacement Therapy in Nonuremic Patients with Brittle T1DM Allows for Durable Long Term Insulin Independence Halting Progression of Secondary Diabetic Complications
*Purpose: Beta cell replacement therapy in form of pancreas or islet transplantation is the only effective treatment for patients suffering from hypoglycemic unawareness despite intensive…2020 American Transplant Congress
The Mechanism How the Transplanted Islets Engraft Into White Adipose Tissue
Department of Regenerative Medicine and Transplantation, Fukuoka University, Fukuoka, Japan
*Purpose: While islet transplantation is recognized as a promising therapeutic option for severe diabetes mellitus (DM), especially type 1 DM, it still faces to various…2020 American Transplant Congress
Total Pancreatectomy with Islet Autotransplantation in Diabetic and Prediabetic Patients with Intractable Chronic Pancreatitis
*Purpose: Total pancreatectomy with islet autotransplantation (TPIAT) is an effective treatment option for non-diabetic patients with intractable chronic pancreatitis. The outcome and potential benefits for…2020 American Transplant Congress
High Laminin Alpha 5 Expression is Observed in the Pancreas of Chronic Pancreatitis Patients and Correlates with Poor Autologous Islet Transplant Outcome
Baylor University Medical Ctr, Dallas, TX
*Purpose: During chronic pancreatitis (CP), the extracellular matrix (ECM) of the pancreas is destroyed by a vicious cycle of parenchymal autodigestion by digestive exocrine enzymes…2020 American Transplant Congress
Long-Term Islet Allo- and Xenograft Survival is Promoted by Immunoglobulin M Immunotherapy
Department of Surgery, University of Virginia Health System, Charlottesville, VA
*Purpose: To investigate if islet allo- and xenotransplant rejection is mitigated by IgM immunotherapy.*Methods: a) New onset diabetic NOD mice (n=14) were treated with IgM…2020 American Transplant Congress
Long-Term Outcomes with Islet Alone and Islet-after-Kidney Transplantation for Type 1 Diabetes in the Clinical Islet Transplantation Consortium
*Purpose: Phase 3 studies of islet transplant alone (ITA; n=48) and islet-after-kidney (IAK; n=24) transplantation in type 1 diabetes complicated by severe hypoglycemic events (SHE)…
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