Articles tagged "Islets"

2016 American Transplant Congress
NK Cells Are Required in B-Cell Dependent, Antibody Mediated Islet Transplant Tolerance.
C. Schuetz, K. Lee, L. Kojima, L. Washburn, L. Liu, W.-H. Liu, J. Kim, J. Markmann.
Dept of Surgery, Transplant Surgery Division, Massachusetts General Hospital, Boston, MA.
Immunologic tolerance to islets has been achieved in various rodent models using antibodies directed at CD45RB and Tim-1. We have shown that this tolerance mechanism…
2016 American Transplant Congress
Successful Human-to-NonHuman Primate Pancreatic Islet Intraportal Xenotransplantation Using a Human Allo-Based Immunosuppression Regimen and Its Potential Pre-Clinical Application.
J. McGarrigle,¹ M. Bochenek,¹ E. Marchese,¹ A. Khan,¹ D. Gutierrez,^1,2 A. Mikalauskaite,¹ B. McCracken,¹ M. Reedy,¹ M. Omami,¹ C.-C. Yeh,¹ M. Spaggiari,¹ M. Nourmohammadzadeh,^1,2 D. Isa,¹ S. Ghani,¹ L.-J. Wang,¹ J. Mendoza-Elias,^1,2 Y. Wang,¹ J. Oberholzer.^1,2
¹Surgery, University of Illinois at Chicago, Chicago; ²Bioengineering, University of Illinois at Chicago, Chicago.
Intraportal pancreatic islet cell transplantation is a successful treatment for type-1 diabetes (T1DM) in humans. Unfortunately, the lack of donor pancreatic organs is a major…
2016 American Transplant Congress
Prolongation of Graft Survival by Anti-TIM1 Is Specifically Mediated by IL-10+ Bregs and Is Not Dependent on IL-35 or Plasma Cell Differentiation.
Y. Zhou,^1,2 Q. Ding,¹ A. Cherukuri,¹ D. Rothstein.¹
¹Thomas E. Starzl Transplantation Institute, Departments of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA; ²School of Medicine, Tsinghua University, Beijing, China.
In B cell-deficient mice, prolonged islet allograft survival (GS) mediated by anti-TIM1 depends on transfer of IL-10 competent B cells. However, such regulatory B cells…
2016 American Transplant Congress
Validation of the Newly Developed North America Islet Donor Scoring System in the Medium Volume Islet Transplant Center.
J. Solomina,¹ S. Matosz,¹ M. Sledzinski,² J. Golebiewska,³ O. Savaril,¹ L.-J. Wang,⁴ T. Kin,⁵ K. Golab,¹ S. Ramachandran,¹ M. Tibudan,¹ L. Schenck,¹ W. Chon,⁶ C. Thomas,⁶ P. Witkowski.¹
¹Surgery, University of Chicago, Chicago, IL; ²Surgery, Medical University of Gdansk, Gdansk, Poland; ³Internal Medicine, Medical University of Gdansk, Gdansk, Poland; ⁴Surgery, University of Illinois, Chicago, IL; ⁵Surgery, University of Alberta, Edmonton, AB, Canada; ⁶Medicine, University of Chicago, Chicago, IL.
Background.North America Islet Donor Scoring (NAIDS) system has been recently developed for selection of the optimal pancreas donor based on analysis of the results from…
2016 American Transplant Congress
B Lymphocytes Prevent Transplantation Tolerance in NOD Mice by Limiting CD4 Treg Function.
B. Stocks, C. Wilson, D. Meehan, A. Marshall, D. Moore.
Pediatrics, Vanderbilt University, Nashville, TN.
IntroductionType 1 Diabetes is a significant barrier to islet transplant as grafts are subject to both alloimmunity and recurrent autoimmunity. No better is this clinical…
2016 American Transplant Congress
The IFN-Gamma-Inducible Protein (IP-10/CXCL10) Is a Promising Target to Improve Endocrine Function Following Islet Transplantation.
G. Yoshimatsu,¹ M. Kanak,² P. Balaji S,¹ C. Chang,³ C. Darden,³ M. Takita,¹ M. Lawrence,¹ B. Naziruddin.⁴
¹Islet Cell Laboratory, Baylor Research Institute, Dallas, TX; ²Transplant Division, Department of Surgery, VCU Medical Center, Richmond, VA; ³Transplant Services, Baylor Simmons Transplant Institute, Dallas, TX.
A significant mass of transplanted islets is lost very early due to an inflammatory reaction. CXCL10 is a chemokine that is highly expressed in islets…
2016 American Transplant Congress
Characterization of Human Islet Transplant Specific Exosomes in a Xenoislet Transplantation Model.
P. Vallabhajosyula, L. Korutla, M. Yu, S. Rostami, C.-X. Yuan, C. Liu, V. Korutla, S. Reddy, A. Habertheuer, A. Naji.
Department of Surgery, University of Pennsylvania, Philadelphia, PA.
Background: There is a critical need for biomarker platforms for monitoring transplant rejection. We propose that transplant tissues release donor specific exosomes into recipient blood/…
2016 American Transplant Congress
NFκB Inhibitor Withaferin A Blocks IBMIR In Vitro: miRNA 375 Analysis.
M. Kanak,¹ M. Takita,² G. Yoshimatsu,² M. Lawrence,² M. Levy,¹ B. Naziruddin.³
¹Surgery, Virginia Commonwealth University, Richmond, VA; ²Islet Tranpsplant Lab, Baylor Research Institute, Dallas, TX; ³Simmons Transplant Institute, Baylor University Medical Center, Dallas, TX.
Background: Instant Blood Mediated Inflammatory Reaction (IBMIR) has been shown to severely affect islet engraftment. We previously reported that Withaferin A (WA) can protect islets…
2016 American Transplant Congress
CXCL12 as Innovative Immune Isolating Chemokine for Microencapsulated Allo and Xeno-Transplantation in NHPs.
M. Sremac,¹ A. Saraya,¹ O. Clemente,¹ M. Penson,¹ S. Chavan,³ N. Chronos,³ C. Schuetz,² J. Lei,² J. Markmann,² T. Brauns,¹ M. Poznansky.¹
¹Infectious Disease/VIC, Massachusetts General Hospital, Boston, MA; ²Division of Transplantation, Massachusetts General Hospital, Boston, MA; ³VICapsys, Inc, Athens, GA.
Introduction The purpose of this study is to determine whether a clinical-grade alginate-microencapsulant incorporating CXCL12, can protect and sustain the function of allo and/or adult…
2016 American Transplant Congress
A Novel Microfluidic Device for Purification of Pancreatic Islet Preparations.
W. Varhue,¹ L. Langman,² D. Bowers,³ S. Peirce-Cottler,³ N. Swami,¹ K. Brayman.²
¹Electrical and Computer Engineering, University of Virginia, Charlottesville, VA; ²Surgery, University of Virginia, Charlottesville, VA; ³Biomedical Engineering, University of Virginia, Charlottesville, VA.
Purpose: Demonstrate that novel continuous flow microfluidic designs can be utilized to remove contaminating acinar tissue and sort the purified islets, based on size and…