Articles tagged "Islets"

2016 American Transplant Congress
Validation of SUITO Index and C-Peptide/Glucose Creatinine Ratio as Convenient Tools for the Evaluation of the Short and Long-Term Islet Allograft Function.
J. Gołębiewska,¹ J. Solomina,² S. Matosz,² C. Thomas,³ L. Schenck,² K. Golab,² W. Chon,³ S. Ramachandran,² M. Tibudan,² A. Dębska-ŚLizień,¹ B. Rutkowski,¹ P. Witkowski.²
¹Department of Nephrology, Transplantology and Internal Medicine, Medical University of Gdańsk, Gdańsk, Poland; ²Department of Surgery, University of Chicago, Chicago, IL; ³Department of Medicine, University of Chicago, Chicago, IL.
Background: Mixed Meal Tolerance Test (MMTT) together with the beta-score are standard tools to evaluate beta-cell function after islet transplantation but utilization of the test…
2016 American Transplant Congress
Human Multipotent Mesenchymal Stromal Cells Improve Survival and Function of Pancreatic Islets by Cell-to-Cell Contact.
E. Montanari,¹ R. Meier,² D. Bosco,¹ R. Mahou,³ P. Morel,² J. Seebach,⁴ C. Wandrey,³ C. Gonelle-Gispert,¹ L. Bühler.²
¹University of Geneva, Geneva, Switzerland; ²Division of Digestive and Transplantation Surgery, University Hospitals of Geneva, Geneva, Switzerland; ³Institut d'Ingénierie Biologique et Institut des Sciences et Ingénierie Chimiques, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland; ⁴Division of Immunology and Allergy, University Hospitals of Geneva, Geneva, Switzerland.
Background: MSC exhibit immunomodulatory and anti-inflammatory properties. Notably, MSC were shown to preserve human islet function and to prevent cytokine-induced apoptosis. Aim: To evaluate the…
2016 American Transplant Congress
Total Pancreatectomy with Islet Autotransplantation for Chronic Pancreatitis: Considerations for Early Intervention.
J. Jolissaint,¹ L. Langman,¹ C. DeBolt,¹ A. Wang,² D. Strand,² V. Zaydfudim,¹ R. Adams,¹ K. Brayman.¹
¹Department of Surgery, University of Virginia, Charlottesville, VA; ²Department of Medicine, University of Virginia, Charlottesville, VA.
Introduction: Total pancreatectomy with islet autotransplantation (TPIAT) provides pain relief for patients with chronic pancreatitis (CP) and the potential to ameliorate the resulting endocrine insufficiency.…
2016 American Transplant Congress
High Resolution Detection of Human Pancreatic Islet Damage During and After Isolation Procedure Using MicroRNAs.
S. Prathab Balaji,¹ M. Kanak,² G. Yoshimatsu,¹ C. Chang,¹ M. Levy,² M. Lawrence,¹ P. Kim,³ N. Onaca,³ B. Naziruddin.³
¹Islet Cell Laboratory, Baylor Research Institute, Dallas, TX; ²Transplant Division, Department of Surgery, VCU Medical Center, Richmond, VA; ³Baylor Simmons Transplant Institute, Dallas, TX.
Background: Pancreatic islets are subjected to stresses throughout isolation procedures that account for considerable variation in quality and yield. Multiparameter methods are needed to monitor…
2016 American Transplant Congress
Isolating High Islet Mass Even from Alcoholic Pancreatitis Pancreases Intended for Clinical Islet Auto-Transplantation: Improved Strategies to Human Islet Isolation Technique.
A. Balamurugan, G. Loganathan, B. Tweed, W. Tucker, S. Mokshagundam, S. Williams, M. Hughes.
Surgery, Clinical Islet Cell Laboratory, Cardiovascular Innovation Insitute, Louisville, KY.
It has been reported in the literature that after pancreatic resection with planned islet auto-transplantation (IAT), islets isolated from alcoholic pancreatitis (AP) pancreases resulted in…
2016 American Transplant Congress
IgM Treatment Successfully Prevents Type 1 Diabetes by Dysregulation of Pancreatic MicroRNAs with Immunomodulatory Roles.
P. Chhabra, R. Gehrau, V. Mas, D. Bower, D. Maluf, K. Brayman.
UVA, Charlottesville.
Type 1 Diabetes (T1D) is hallmarked by beta-cells destruction. We aimed to identify specific pancreatic microRNAs (miRNA) as potential biomarkers for T1D prediction and diagnosis,…
2016 American Transplant Congress
Risk Factors for Early Readmission After Total Pancreatectomy with Islet Auto Transplantation.
R. Shahbazov,¹ N. Bashoo,² G. Yoshimatsu,² G. Saracino,² F. Azari,¹ N. Onaca,² P. Kim,² M. Levy.³
¹Charles O.Strikler Transplant Center, Department of Surgery, University of Virginia, Charlottesville, VA; ²Baylor Simmons Transplant Institute, Baylor University Medical Center, Dallas, TX; ³Transplant Division, Virginia Commonwealth University, Richmond, VA.
Introduction: Readmission after Total Pancreatectomy with Islet Auto Transplantation (TPIAT) is common, but no data is available on reasons for readmission and islet graft function.Aims:…
2016 American Transplant Congress
In Vivo and In Vitro Characterization of 1.5 mm Ba²⁺-Alginate Macro-Encapsulated Cynomolgus Monkey Islets.
M. Bochenek,¹ J. McGarrigle,¹ J. Mendoza-Elias,¹ E. Marchese,¹ M. Nourmohammadzadeh,¹ Y. Wang,¹ A. Khan,¹ M. Omami,¹ C.-C. Yeh,¹ I. Lacik,² B. Strand,³ J. Oberholzer.¹
¹Transplant Surgery, University of Iliinois at Chicago, Chicago, IL; ²Biomaterials Research, Polymer Institute of the Slovak Academy of Sciences, Bratislava, Slovakia (Slovak Republic); ³Biotechnology, Norwegian University of Science and Technology, Trondheim, Norway.
Introduction:Micro-encapsulation of islets for the treatment of Type I diabetes has shown limited efficacy in small-scale clinical trials. The lack of success may be related…
2016 American Transplant Congress
Comparison of Outcomes from Patients with Completion versus Total Pancreatectomy with Islet Autotransplantation: A Single-Institution Experience with 120 Consecutive Cases.
G. Yoshimatsu,¹ M. Takita,¹ R. Shahbazov,² M. Lawrence,¹ B. Naziruddin,³ P. Kim,³ M. Levy,⁴ N. Onaca.³
¹Islet Cell Laboratory, Baylor Research Institute, Dallas, TX; ²Department of Surgery, University of Virginia, Charlottesville, VA; ³Transplant Division, VCU Medical Center, Richmond, VA; ⁴Baylor Simmons Transplant Institute, Dallas, TX.
Introduction: Total pancreatectomy (TP) or completion pancreatectomy is considered to effectively eliminate the severe pain from refractory chronic pancreatitis, if prior procedures failed. Islet autotransplantation…
2016 American Transplant Congress
Comparison of Early Engraftment Immunobiology of Xenoislets and Alloislets in a Dual Transplant Model.
K. Samy,¹ B. Martin,² M. Song,¹ B. Collins,¹ E. Gall,¹ J. Cano,² A. Farris,² F. Leopardi,¹ A. Kirk.^1,2
¹Department of Surgery, Duke University Medical Center, Durham, NC; ²Emory University, Atlanta, GA.
Purpose: Successful implementation of neonatal porcine islet (NPI) xenotransplantation requires an understanding of the xenospecific immune elements influencing engraftment. To elucidate these early xenospecific processes,…