Articles tagged "Islets"

2017 American Transplant Congress
Beta Cell-Specific Free Circulating DNA May Predict the Outcome After Clinical Islet Transplantation.
B. Gala-Lopez,¹ D. Neiman,² T. Kin,¹ D. O'Gorman,¹ A. Pepper,¹ A. Malcolm,¹ B. Glaser,³ R. Shemer,² Y. Dor,² J. Shapiro.¹
¹Department of Surgery, Clinical Islet Transplant Program, University of Alberta, Edmonton, AB, Canada; ²Department of Developmental Biology and Cancer Research, The Hebrew University-Hadassah Medical School, Jerusalem, Israel; ³Endocrinology and Metabolism Service, Department of Internal Medicine, Hadassah-Hebrew University Medical Center, Jerusalem, Israel
Optimizing engraftment and early survival of human beta cells after clinical islet transplantation is critical to long-term function, but there are no reliable, quantifiable measures…
2017 American Transplant Congress
The Role of Toll-Like Receptor 4 in Islet Transplantation and a Novel Method of Protection Using Chemical Surface Modification.
C. Chang,¹ G. Yoshimatsu,² B. Akinbobuyi,⁴ M. Lawrence,² R. Kane,¹ B. Naziruddin.³
¹Institute of Biomedical Studies, Baylor University, Waco, TX; ²Baylor Scott and White Research Institute, Dallas, TX; ³Baylor Simmons Transplant Institute, Dallas, TX; ⁴Department of Chemistry and Biochemistry, Baylor University, Waco, TX
Toll-like Receptor 4 (TLR4) is the canonical receptor for lipopolysaccharide (LPS), however recent evidence reveals that TLR4 also plays an important role in ischemia-reperfusion injury…
2017 American Transplant Congress
Patterns and Associated Risk Factors for Early Readmissions Post Total Pancreatectomy and Islet Auto-Transplantation(TP-IAT).
V. Kirchner, A. Bagdiwala, D. Vock, M. Bellin, G. Beilman, L. Berry, S. Chinnakotla, T. Dunn, M. Freeman, D. Sutherland, T. Pruett.
University of Minnesota, Minneapolis
Introduction: For four decades, TP-IAT has been performed to provide pain relief and preserve insulin function in patients(pts) with chronic/acute relapsing pancreatitis. Despite advances in…
2017 American Transplant Congress
Antioxidant Thermoresponsive Hydrogel as a Versatile Islets Scaffolds for Treating Type I Diabetes.
Y. Zhu,¹ X. Zhang,² G. Ameer,¹ X. Luo.²
¹McCormick School of Engineering, Northwestern University, Evanston, IL; ²Feinberg School of Medicine, Northwestern University, Chicago, IL
Introduction: Hepatic islets transplantation procedure to treat type I diabetes often results in limited islets survival presumably due to uneven islet distribution, acute inflammatory response…
2017 American Transplant Congress
Intraomental Non-Purified Islet Transplantation Isolated from DCD Donor Pancreas.
S. Wang, G. Pei, Y. Liu, Z. Wang, B. Zhang, Y. Xie, J. Wang, Z. Shen.
Transplant Center, Tianjin First Center Hospital, Tianjin, China
Objective: We have proved that omentum was a more efficient site to perform non-purified islet transplantation with more safety in Beagle dog islet auto-transplantation model.…
2017 American Transplant Congress
Cibinetide (ARA 290), the Innate Repair Receptor Ligand, Improves Engraftment in Pancreatic Islet Transplantation by Protecting Islets and Reducing Inflammatory Reactions.
M. Watanabe,¹ M. Han Yao,¹ H. Zemack,¹ B.-G. Ericzon,¹ A. Cerami,² M. Brines,² T. Lundgren,¹ M. Kumagai-Braesch.¹
¹Department of Transplantation Surgery, CLINTEC, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden; ²Araim Pharmaceuticals, Tarrytown, NY
Purpose. Cibinetide, an innate repair receptor ligand, exerts anti-inflammatory, anti-apoptotic, and cytoprotective effects. We have shown that cibinetide protected mouse pancreatic islets from cytokine-induced damage…
2017 American Transplant Congress
Improved Method to Obtain High Islet Mass from Severely Fibrotic Pancreatitis Pancreases Intended for Clinical Islet Auto-Transplantation.
A. Balamurugan, G. Loganathan, W. Tucker, M. Dhanasekaran, S. Narayanan, A. Patel, S. Mokshagundam, S. Williams, M. Hughes.
Clinical Islet Laboratory, Dept. of Surgery, Cardiovascular Innovation Institute, University of Louisville, KY
A total pancreatectomy and islet autotransplant (TPIAT) offers substantial pain relief and improved quality of life for pancreatitis patients. Isolating a large quantity of islet…
2016 American Transplant Congress
Distinct Effects of Chronic Hyperglycemia on Cellular and Humoral Alloresponses In Vivo.
N. Bishop,¹ K. Beard,² R. Gill.²
¹Immunology and Microbiology, University of Colorado Denver, Aurora, CO; ²Surgery, University of Colorado Denver, Aurora, CO; ³Surgery, University of Colorado Denver, Aurora, CO.
Background: Diabetes constitutes a significant problem in the transplant recipient. Diabetes is associated with impaired immunity to pathogens but its effect on alloimmunity remains ambiguous.…
2016 American Transplant Congress
Enhanced IL-6 Production Impedes Transplant Tolerance Induction in Lupus-Prone Mice.
B. Stocks, C. Wilson, M. Seto, A. Marshall, D. Moore.
Pediatrics and Pathology, Microbiology, and Immunology, Vanderbilt University, Nashville, TN.
Significance: Autoimmunity is a significant barrier to transplantation. Based on previous studies, it is apparent that there are separate genetic regions that control susceptibility to…
2016 American Transplant Congress
Long-Term Islet Xenograft Survival Requires Effective Control of Early Xenogeneic IL-17 Response and Late Xenogeneic IFN-γ Response.
H. Kang,¹ S. Wang,² X. Zhang,³ A. Singh,⁵ L. Zhang,¹ W. Suarez-Pinzon,⁵ S. Miller,⁴ B. Hering,⁵ X. Luo.^1,3,4
¹Medicine, Northwestern University, Chicago, IL; ²Surgery, Tianjin Union Medical Center, Tianjin, China; ³Comprehensive Transplant Center, Northwestern University, Chicago, IL; ⁴Microbiology and Immunology, Northwestern University, Chicago, IL; ⁵Schulze Diabetes Institute, University of Minnesota, Minneapolis, MN.
Introduction: Tolerance induction for xenogeneic islet transplant remains a challenge. We have previously shown that peri-transplant infusion of donor cells treated with 1-ethyl-3-(3'-dimethylaminopropyl)-carbodiimide (ECDI) is…