Articles tagged "Islets"

2017 American Transplant Congress
Total Pancreatectomy and Islet Autotransplantation into the Liver of a Patient with Previous Hepatitis C Infection.
A. Rajab,¹ J. Buss,¹ P. Hart,² D. Conwell,² S. Black,¹ K. Washburn.¹
¹Transplant Surgery, The Ohio State Wexner Medical Center, Columbus, OH; ²Internal Medicine, The Ohio State Wexner Medical Center, Columbus, OH
Hepatic parenchymal disease such as hepatitis has been considered a relative contraindication to islet transplantation as the islets are infused into the liver. Islet transplantation…
2017 American Transplant Congress
Maintenance of the Phenotype and Abundance of Islet-Resident Macrophages Promotes Islet Graft Survival and Appears to Prevent Type 1 Diabetes.
P. Kyriazis, T. Thornley, K. Agarwal, L. Ma, T. Strom, M. Koulmanda.
Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA
Immunoregulatory tissue resident macrophage subsets have been reported in skin, heart, lung and adipose tissue.We now demonstrate the existence of a functionally immunoregulatory population of…
2017 American Transplant Congress
Hypoxia Induces Tissue Factor Upregulation in Isolated Human Islets.
B. Sandhu,¹ M. Prendecki,¹ G. Rutter,¹ A. Martinez-Sanchez,¹ N. Kanda,¹ N. Galloway-Phillips,¹ R. Smith,² C. Pusey,¹ V. Papalois.¹
¹Imperial College, London, United Kingdom; ²King's College, London, United Kingdom
Purpose: Early islet loss post-infusion remains a significant problem in islet transplantation, despite the use of heparinised media to abrogate the effects of Tissue Factor…
2017 American Transplant Congress
Safety and Decreased Inflammation of Early Double Cytokine Blockade (IL-1β and TNF-α) Facilitates Engraftment in Islet Allotransplantation.
N. Onaca,¹ M. Takita,² M. Levy,³ B. Naziruddin.¹
¹Simmons Transplant Institute, Baylor University Medical Center, Dallas; ²Baylor Scott and White Research Institute, Dallas; ³Hume Lee Transplant Center, Virginia Commonwealth University, Richmond
Enhanced early islet engraftment offers the potential for improved graft function after islet allotransplantation (IT). Nine patients underwent IT under a fully completed prospective research…
2017 American Transplant Congress
Assessment of Islet Damage During Isolation Utilizing miRNAs and Its Significance with Post-Transplant Outcome in TPIAT.
P. Saravanan,¹ M. Kanak,² G. Yoshimatsu,¹ M. Lawrence,¹ B. Naziruddin.³
¹Baylor Scott and White Research Institute, Dallas, TX; ²Virginia Commonwealth University, Richmond, VA; ³Baylor Simmons Transplant Institute, Dallas, TX
Background: Pancreatic islets with high quality are essential for better endocrine function and post-transplant outcome in total pancreatectomy with islet autotransplantation (TPIAT). The islets are…
2017 American Transplant Congress
Ex-Vivo Mitomycin-C Exposure Reduced Immunogenicity and Prolonged Survival of Islets by Suppressing the Secretion of Multiple Chemotaxis Factors.
N. Sato,¹ T. Anazawa,² A. Kenjyo,¹ T. Kimura,¹ R. Okada,¹ T. Ishigame,¹ Y. Kofunato,¹ J. Watanabe,¹ M. Muto,¹ A. Nishimagi,¹ M. Gotoh,¹ S. Marubashi.¹
¹Department of Surgery, Division of Hepato-Biliary-Pancreatic and Transplant, Fukushima Medical University, Fukushima, Japan; ²Department of Surgery, Graduate School of Midicine, Kyoto University, Kyoto, Japan
Background. Strategies to reduce immunogenicity of islets, and to prevent activation of pro-inflammatory events are essential to successful islet engraftment. We previously demonstrated that ex-vivo…
2017 American Transplant Congress
Combination Therapy of iNKT Cell Ligand and CD40-CD154 Signal Blockade Establishes Islet Allograft Tolerance in Non-Myeloablative Bone Marrow Transplant Recipients.
T. Kanzawa,¹ T. Hirai,¹ R. Ishii,¹ M. Okumi,¹ H. Ishida,¹ Y. Ishii,² K. Tanabe.¹
¹Department of Urology, Tokyo Women's Medical University, Tokyo, Japan; ²Cluster for Industry Partnerships (CIP), RIKEN, Tokyo, Japan
Background: Allogeneic islet transplantation is an effective therapeutic option for type 1 diabetes. Toxicity associated with chronic use of immunosuppressants still remains an obstacle for…
2016 American Transplant Congress
Utilization of Plasmapheresis and High Dose of Immunoglobulins in the Treatment of the High Level of De Novo Donor Specific Antibodies for the Successful Islet Allotransplantation.
J. Solomina,¹ Z. Tekin,¹ S. Matosz,¹ K. Golab,¹ C. Thomas,² J. Golebiewska,³ S. Ramachandran,¹ L. Schenck,¹ W. Chon,¹ M. Tibudan,¹ N. Marek-Trzonkowska,⁴ J. Millis,¹ P. Witkowski.¹
¹Surgery, University of Chicago, Chicago, IL; ²Medicine, University of Chicago, Chicago, IL; ³Internal Medicine, Medical University of Gdansk, Gdansk, Poland; ⁴Family Medicine, Medical University of Gdansk, Gdansk, Poland.
Background.Development of donor specific antibodies (DSA) after islet transplantation has been a poor prognostic factor for graft survival, while no intervention is implemented. Here, we…
2016 American Transplant Congress
Citrate-Based Thermoresponsive Hydrogel as a Versatile Platform for Extrahepatic Islet Transplantation.
Y. Zhu,¹ X. Zhang,² A. Guillermo,¹ X. Luo.²
¹McCormick School of Engineering, Northwestern University, Chicago, IL; ²Comprehensive Transplant Center, Northwestern University, Chicago, IL.
Introduction: Islets transplantation in the liver often results in limited islets survival presumably due to abnormal blood flow dynamics and acute inflammatory response. The objective…
2016 American Transplant Congress
Low Risk of Cytomegalovirus (CMV) Transmission in Clinical Islet Transplantation.
D. Kabbani,¹ K. Cheung,² P. Senior,² C. Cervera,¹ K. Doucette,¹ J. Preiksaitis.¹
¹Infectious Diseases, University of Alberta, Edmonton, AB, Canada; ²Clinical Islet Transplant Program, University of Alberta, Edmonton, AB, Canada.
Background:In solid organ transplantation (SOT), CMV is commonly transmitted from seropositive organ donors (D+) to seronegative recipients (R-), despite the use of antiviral prophylaxis. The…