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Articles tagged "Islets"

  • 2017 American Transplant Congress

    IP-10 Monoclonal Antibody Treatment Suppresses Inflammatory Components of IBMIR and Improves Pancreatic Islet Graft Function.

    G. Yoshimatsu,1 C. Chang,1 C. Darden,1 P. Saravanan,1 B. Naziruddin,2 M. Lawrence.1

    1Baylor Scott and White Reseasrch Institute, Dallas, TX; 2Baylor Simmons Transplant Institute, Dallas, TX

    Introduction: An instant blood-mediated inflammatory response (IBMIR) causes acute loss of pancreatic islets. Interferon gamma-induced protein 10 (IP-10) is a key proinflammatory chemokine that may…
  • 2017 American Transplant Congress

    Islet Rejection in Autoimmune NOD Mouse Recipients: Implications for Stem Cell Therapies.

    R. Gill,1 M. Coulombe,1 T. Kupfer,1 K. Beard,1 A. Burrack.2

    1Surgery and Immunology, University of Colorado Denver, Aurora, CO; 2University of Minnesota, Minneapolis, MN

    Several efforts are ongoing to use stem cell precursors to generate islet-like tissues suitable for transplantation in autoimmune Type 1 diabetic (T1D) recipients. During the…
  • 2017 American Transplant Congress

    Thrombalexin and Mirococept Synergistically Reduce IBMIR in a Porcine to Rhesus Xenoislet Model.

    M. Manook,1,2 J. Kwun,1 J. Yoon,1 K. Samy,1 A. MacDonald,1 H. Xu,1 R. Smith,3 A. Dorling,3 A. Kirk,1 N. Mamode,2 S. Knechtle.1

    1Surgery, Duke Transplant Center, Durham, NC; 2Renal and Transplant, Guy's and St Thomas'NHS Foundation Trust, London, United Kingdom; 3MRC Centre for Transplantation, King's College, London, United Kingdom

    Introduction: Early activation of coagulation and complement are important factors in the initiation of instant blood mediated inflammation (IBMIR) in xenoislet models. Two novel 'cytotopic'…
  • 2017 American Transplant Congress

    Immunosuppressive Role of Pancreas Derived Mesenchymal Stem Cells.

    M. Kanak,1 F. Kunnathodi,2 M. Levy,1,3 M. Lawrence,2 B. Naziruddin.4

    1Transplant Surgery, Virginia Commonwealth University, Richmond, VA; 2Baylor Research Institute, Dallas, TX; 3Hume-Lee Transplant Center, VCU Health System, Richmond, VA; 4Simmons Transplant Institute, Baylor Scott and White Health, Dallas, TX

    BackgroundThe Edmonton protocol revived islet transplantation therapy for Type-1 Diabetic patients. However, Long-term islet function still remains a challenge. Immunosuppression used after islet transplantation contributes…
  • 2017 American Transplant Congress

    Long-Term Drug-Free Survival of Tiny Cynomolgus Islet Allografts.

    M. Koulmanda, V. Chipashivili, M. Duggan, T. Strom.

    Surgery and Medicine, Beth Israel Deaconess Medical Center, Boston, MA; Surgery, Massachusetts General Hospital, Boston, MA

    Following upon highly beneficial effects observed with short-term alpha 1-antitrypsin (AAT) treatment in the marginally sized autologous cynomolgus islet transplant model, we are testing the…
  • 2017 American Transplant Congress

    CD4+/CD8+ T Cell Ratio as a Predictive Marker for Early Graft Failure in Pig to Non-Human Primate Islet Xenotransplantation with Immunosuppression.

    S. Choi,1,3,4 H.-J. Kim,1,2,3,4 I.-H. Yoon,1,2 J.-S. Kim,1,2,6 S.-J. Kang,1,2,3,4 H.-Y. Nam,1,2 B.-H. Min,1 J.-S. Shin,1,6 J.-M. Kim,1,6 Y.-H. Kim,1,5 W.-W. Lee,1,2,3,4 C.-G. Park.1,2,3,4,6

    1Xenotransplantation Research Center, Seoul National University College of Medicine, Seoul, Korea; 2Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea; 3Department of Microbiology and Immunology, Seoul National University College of Medicine, Seoul, Korea; 4Department of Biomedical Sciences, Seoul National University Graduate School, Seoul, Korea; 5Department of Microbiology, Kyungpook National University School of Medicine, Daegu, Korea; 6Institute of Endemic Diseases, Seoul National University College of Medicine, Seoul, Korea

    Background: Outstanding results from nonhuman primate study put islet xenotransplantation with immunosuppression closer to the clinical application. To establish successful immune suppressive protocols, immune monitoring…
  • 2017 American Transplant Congress

    Next-Generation Sequencing-Based Exosome MicroRNA Profiling for Specific Identification of Islet Damage.

    P. Saravanan,1 J. Gu,1 X. Wang,1 P. Nguyen,1 G. Yoshimatsu,1 M. Lawrence,1 B. Naziruddin.2

    1Baylor Scott and White Research Institute, Dallas, TX; 2Baylor Simmons Transplant Institute, Dallas, TX

    Introduction: A significant mass of intraportally transplanted islets undergo damage due to various stress conditions including hypoxia and inflammation. Development of innovative ultrasensitive tests to…
  • 2016 American Transplant Congress

    Total Pancreatectomy with Islet Autotransplantation for Chronic Pancreatitis: Considerations for Early Intervention.

    J. Jolissaint,1 L. Langman,1 C. DeBolt,1 A. Wang,2 D. Strand,2 V. Zaydfudim,1 R. Adams,1 K. Brayman.1

    1Department of Surgery, University of Virginia, Charlottesville, VA; 2Department of Medicine, University of Virginia, Charlottesville, VA.

    Introduction: Total pancreatectomy with islet autotransplantation (TPIAT) provides pain relief for patients with chronic pancreatitis (CP) and the potential to ameliorate the resulting endocrine insufficiency.…
  • 2016 American Transplant Congress

    High Resolution Detection of Human Pancreatic Islet Damage During and After Isolation Procedure Using MicroRNAs.

    S. Prathab Balaji,1 M. Kanak,2 G. Yoshimatsu,1 C. Chang,1 M. Levy,2 M. Lawrence,1 P. Kim,3 N. Onaca,3 B. Naziruddin.3

    1Islet Cell Laboratory, Baylor Research Institute, Dallas, TX; 2Transplant Division, Department of Surgery, VCU Medical Center, Richmond, VA; 3Baylor Simmons Transplant Institute, Dallas, TX.

    Background: Pancreatic islets are subjected to stresses throughout isolation procedures that account for considerable variation in quality and yield. Multiparameter methods are needed to monitor…
  • 2016 American Transplant Congress

    Isolating High Islet Mass Even from Alcoholic Pancreatitis Pancreases Intended for Clinical Islet Auto-Transplantation: Improved Strategies to Human Islet Isolation Technique.

    A. Balamurugan, G. Loganathan, B. Tweed, W. Tucker, S. Mokshagundam, S. Williams, M. Hughes.

    Surgery, Clinical Islet Cell Laboratory, Cardiovascular Innovation Insitute, Louisville, KY.

    It has been reported in the literature that after pancreatic resection with planned islet auto-transplantation (IAT), islets isolated from alcoholic pancreatitis (AP) pancreases resulted in…
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