Articles tagged "Islets"

2017 American Transplant Congress
Improved Method to Obtain High Islet Mass from Severely Fibrotic Pancreatitis Pancreases Intended for Clinical Islet Auto-Transplantation.
A. Balamurugan, G. Loganathan, W. Tucker, M. Dhanasekaran, S. Narayanan, A. Patel, S. Mokshagundam, S. Williams, M. Hughes.
Clinical Islet Laboratory, Dept. of Surgery, Cardiovascular Innovation Institute, University of Louisville, KY
A total pancreatectomy and islet autotransplant (TPIAT) offers substantial pain relief and improved quality of life for pancreatitis patients. Isolating a large quantity of islet…
2017 American Transplant Congress
CXCL12 Modulation of Localized Immune Responses to Subcutaneous Islet Macrocapsulation.
M. Penson, M. Sremac, R. Sirbulescu, T. Brauns, F. Harrington, M. Poznansky.
Infectious Disease, Massachusetts General Hospital, Boston, MA
Purpose:To determine the impact of CXCL12 on vascularization and immune response to xeno islets transplanted into TheraCyte macroencapsulation device in diabetic C57BL/6 mice.Materials and Methods:Three…
2017 American Transplant Congress
Impact of Pancreatic Texture Assessment on Islet Isolation and Metabolic Outcome After TPIAT.
G. Yoshimatsu,¹ M. Khadka,¹ M. Lawrence,¹ B. Appakalai,² B. Naziruddin.³
¹Baylor Scott and White Research Institute, Dallas, TX; ²University of Louisville, Louisville, KY; ³Baylor Simmons Transplant Institute, Dallas, TX
Introduction: Total pancreatectomy with islet autotransplantation (TPIAT) is an effective treatment for refractory chronic pancreatitis (CP). Chronic inflammation leads to fibrosis formation in pancreas and…
2017 American Transplant Congress
Suppression of Inflammation by Withaferin A in Cerulein-Induced Pancreatitis Model Results in Improved Syngeneic Islet Engraftment.
G. Yoshimatsu,¹ M. Kanak,² C. Chang,¹ C. Darden,¹ M. Lawrence,¹ B. Naziruddin.³
¹Baylor Scott and White Research Institute, Dallas, TX; ²Virginia Commonwellth University, Richmond, VA; ³Baylor Simmons Transplant Institute, Dallas, TX
Introduction: Chronic pancreatitis (CP) is characterized by inflammatory damage to acinar cells followed by islets. In clinical islet autotransplantation, patients with advanced stages of CP…
2017 American Transplant Congress
Total Pancreatectomy with Islet Autotransplantation Improves Quality of Life Allowing for the Resolution of the Intractable Pain with Good Glucose Control in Properly Selected Patients with Chronic Pancreatitis.
A. Kotukhov,¹ J. Solomina,¹ E. Konsur,¹ K. Cieply,¹ L. Basto,¹ L.-J. Wang,¹ K. Golab,¹ M. Tibudan,¹ A. Gelrud,² C. Thomas,² J. Matthews,¹ P. Witkowski.¹
¹Surgery, University of Chicago, Chicago, IL; ²Medicine, University of Chicago, Chicago, IL
Background: There is a group of Total pancreatectomy (TP) is offered as a last option to patients with chronic pancreatitis (CP) who despite optimal treatment…
2017 American Transplant Congress
Human Islet-Derived Extracellular Vesicles Stimulate CD14+ Monocytes Resulting in Proinflammatory Cytokine Production.
A. Rutman, S. Negi, C. Hasilo, M. Gasparrini, J. Tchervenkov, S. Paraskevas.
Department of Surgery, McGill University Health Centre, Montreal, QC, Canada
Introduction: The cellular events involved in the generation of an auto and allo-reactive immune response in recipients of islet transplantation are not well understood. In…
2017 American Transplant Congress
Initial Experince with Total Pancreatectomy-Islet Auto-Transplantation (TP-IAT) for Chronic Pancreatitis at the University of Louisville.
M. Hughes,¹ E. Davis,¹ S. Mokshagundam,² W. Tucker,¹ G. Logananthan,¹ S. Williams,³ B. Appakalai.¹
¹Surgery, University of Louisville, Louisville, KY; ²Medicine, University of Louisville, Louisville, KY; ³Physiology, University of Louisville, Louisville, KY
Chronic pancreatitis (CP) represents a highly significant healthcare challenge in Kentucky. To address this need, we created a TP-IAT program to cure patients of this…
2016 American Transplant Congress
Validation of the Newly Developed North America Islet Donor Scoring System in the Medium Volume Islet Transplant Center.
J. Solomina,¹ S. Matosz,¹ M. Sledzinski,² J. Golebiewska,³ O. Savaril,¹ L.-J. Wang,⁴ T. Kin,⁵ K. Golab,¹ S. Ramachandran,¹ M. Tibudan,¹ L. Schenck,¹ W. Chon,⁶ C. Thomas,⁶ P. Witkowski.¹
¹Surgery, University of Chicago, Chicago, IL; ²Surgery, Medical University of Gdansk, Gdansk, Poland; ³Internal Medicine, Medical University of Gdansk, Gdansk, Poland; ⁴Surgery, University of Illinois, Chicago, IL; ⁵Surgery, University of Alberta, Edmonton, AB, Canada; ⁶Medicine, University of Chicago, Chicago, IL.
Background.North America Islet Donor Scoring (NAIDS) system has been recently developed for selection of the optimal pancreas donor based on analysis of the results from…
2016 American Transplant Congress
B Lymphocytes Prevent Transplantation Tolerance in NOD Mice by Limiting CD4 Treg Function.
B. Stocks, C. Wilson, D. Meehan, A. Marshall, D. Moore.
Pediatrics, Vanderbilt University, Nashville, TN.
IntroductionType 1 Diabetes is a significant barrier to islet transplant as grafts are subject to both alloimmunity and recurrent autoimmunity. No better is this clinical…
2016 American Transplant Congress
The IFN-Gamma-Inducible Protein (IP-10/CXCL10) Is a Promising Target to Improve Endocrine Function Following Islet Transplantation.
G. Yoshimatsu,¹ M. Kanak,² P. Balaji S,¹ C. Chang,³ C. Darden,³ M. Takita,¹ M. Lawrence,¹ B. Naziruddin.⁴
¹Islet Cell Laboratory, Baylor Research Institute, Dallas, TX; ²Transplant Division, Department of Surgery, VCU Medical Center, Richmond, VA; ³Transplant Services, Baylor Simmons Transplant Institute, Dallas, TX.
A significant mass of transplanted islets is lost very early due to an inflammatory reaction. CXCL10 is a chemokine that is highly expressed in islets…