Articles tagged "Islets"

2017 American Transplant Congress
Next-Generation Sequencing-Based Exosome MicroRNA Profiling for Specific Identification of Islet Damage.
P. Saravanan,¹ J. Gu,¹ X. Wang,¹ P. Nguyen,¹ G. Yoshimatsu,¹ M. Lawrence,¹ B. Naziruddin.²
¹Baylor Scott and White Research Institute, Dallas, TX; ²Baylor Simmons Transplant Institute, Dallas, TX
Introduction: A significant mass of intraportally transplanted islets undergo damage due to various stress conditions including hypoxia and inflammation. Development of innovative ultrasensitive tests to…
2017 American Transplant Congress
Phase 3 Trial of Transplantation of Human Islets in Type 1 Diabetes (T1D) Post Renal Transplantation.
J. Markmann, R. Alejandro, M. Bellin, N. Bridges, W. Clarke, T. Eggerman, E. Foster, B. Hering, D. Kaufman, O. Korsgren, X. Luo, A. Naji, J. Oberholzer, A. Posselt, M. Rickels, C. Ricordi, M. Robien, P. Senior, A. Shapiro, N. Turgeon.
CIT Consortium
Introduction: From a risk-benefit perspective, patients with type 1 diabetes (T1D) who are already obligated to long-term immunosuppression to support a kidney transplant and who…
2017 American Transplant Congress
A Multicenter, Prospective and Randomized Trial Comparing Pancreas versus Islet Transplantation: Should We Do It Now?
D. Cantarovich, P.-Y. Benhamou.
ITUN, Nantes University Hospital, Nantes, France; Endocrinology, Grenoble University Hospital, Grenoble, France
Patients suffering from type 1 diabetes are at high risk of death. Our aim is to design a multicenter, prospective and randomized study comparing pancreas…
2017 American Transplant Congress
The Beneficial Effect of Janus Kinase 3 Inhibitor on Transplanted Islet via Protection from Oxidative Stress-Induced β Cell Death.
S.-J. Kang,^1,2,3,4 H. Chung,^1,2,3,4 S. Lee,^1,2,3,4 J.-S. Shin,^1,3,5 H.-J. Kim,^1,2,3,4 J.-M. Kim,^1,3,5 B.-H. Min,^1,3,5 S. Choi,^1,2,3,4 C.-G. Park.^1,2,3,4,5
¹Department of Microbiology and Immunology, Seoul National University College of Medicine, Seoul, Korea; ²Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea; ³Xenotransplantation Research Center, Seoul National University College of Medicine, Seoul, Korea; ⁴Department of Biomedical Sciences, Seoul National University, Seoul, Korea; ⁵Institute of Endemic Diseases, Seoul National University College of Medicine, Seoul, Korea
Janus kinase 3 (JAK3) is one of the molecules that make up the JAK-STAT signaling pathway that regulates numerous 40 cytokines. Thus, this cascade can…
2017 American Transplant Congress
Beta Cell-Specific Free Circulating DNA May Predict the Outcome After Clinical Islet Transplantation.
B. Gala-Lopez,¹ D. Neiman,² T. Kin,¹ D. O'Gorman,¹ A. Pepper,¹ A. Malcolm,¹ B. Glaser,³ R. Shemer,² Y. Dor,² J. Shapiro.¹
¹Department of Surgery, Clinical Islet Transplant Program, University of Alberta, Edmonton, AB, Canada; ²Department of Developmental Biology and Cancer Research, The Hebrew University-Hadassah Medical School, Jerusalem, Israel; ³Endocrinology and Metabolism Service, Department of Internal Medicine, Hadassah-Hebrew University Medical Center, Jerusalem, Israel
Optimizing engraftment and early survival of human beta cells after clinical islet transplantation is critical to long-term function, but there are no reliable, quantifiable measures…
2017 American Transplant Congress
The Role of Toll-Like Receptor 4 in Islet Transplantation and a Novel Method of Protection Using Chemical Surface Modification.
C. Chang,¹ G. Yoshimatsu,² B. Akinbobuyi,⁴ M. Lawrence,² R. Kane,¹ B. Naziruddin.³
¹Institute of Biomedical Studies, Baylor University, Waco, TX; ²Baylor Scott and White Research Institute, Dallas, TX; ³Baylor Simmons Transplant Institute, Dallas, TX; ⁴Department of Chemistry and Biochemistry, Baylor University, Waco, TX
Toll-like Receptor 4 (TLR4) is the canonical receptor for lipopolysaccharide (LPS), however recent evidence reveals that TLR4 also plays an important role in ischemia-reperfusion injury…
2017 American Transplant Congress
Patterns and Associated Risk Factors for Early Readmissions Post Total Pancreatectomy and Islet Auto-Transplantation(TP-IAT).
V. Kirchner, A. Bagdiwala, D. Vock, M. Bellin, G. Beilman, L. Berry, S. Chinnakotla, T. Dunn, M. Freeman, D. Sutherland, T. Pruett.
University of Minnesota, Minneapolis
Introduction: For four decades, TP-IAT has been performed to provide pain relief and preserve insulin function in patients(pts) with chronic/acute relapsing pancreatitis. Despite advances in…
2017 American Transplant Congress
Antioxidant Thermoresponsive Hydrogel as a Versatile Islets Scaffolds for Treating Type I Diabetes.
Y. Zhu,¹ X. Zhang,² G. Ameer,¹ X. Luo.²
¹McCormick School of Engineering, Northwestern University, Evanston, IL; ²Feinberg School of Medicine, Northwestern University, Chicago, IL
Introduction: Hepatic islets transplantation procedure to treat type I diabetes often results in limited islets survival presumably due to uneven islet distribution, acute inflammatory response…
2017 American Transplant Congress
Intraomental Non-Purified Islet Transplantation Isolated from DCD Donor Pancreas.
S. Wang, G. Pei, Y. Liu, Z. Wang, B. Zhang, Y. Xie, J. Wang, Z. Shen.
Transplant Center, Tianjin First Center Hospital, Tianjin, China
Objective: We have proved that omentum was a more efficient site to perform non-purified islet transplantation with more safety in Beagle dog islet auto-transplantation model.…
2017 American Transplant Congress
Cibinetide (ARA 290), the Innate Repair Receptor Ligand, Improves Engraftment in Pancreatic Islet Transplantation by Protecting Islets and Reducing Inflammatory Reactions.
M. Watanabe,¹ M. Han Yao,¹ H. Zemack,¹ B.-G. Ericzon,¹ A. Cerami,² M. Brines,² T. Lundgren,¹ M. Kumagai-Braesch.¹
¹Department of Transplantation Surgery, CLINTEC, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden; ²Araim Pharmaceuticals, Tarrytown, NY
Purpose. Cibinetide, an innate repair receptor ligand, exerts anti-inflammatory, anti-apoptotic, and cytoprotective effects. We have shown that cibinetide protected mouse pancreatic islets from cytokine-induced damage…