Articles tagged "Islets"

2017 American Transplant Congress
Combination Therapy of iNKT Cell Ligand and CD40-CD154 Signal Blockade Establishes Islet Allograft Tolerance in Non-Myeloablative Bone Marrow Transplant Recipients.
T. Kanzawa,¹ T. Hirai,¹ R. Ishii,¹ M. Okumi,¹ H. Ishida,¹ Y. Ishii,² K. Tanabe.¹
¹Department of Urology, Tokyo Women's Medical University, Tokyo, Japan; ²Cluster for Industry Partnerships (CIP), RIKEN, Tokyo, Japan
Background: Allogeneic islet transplantation is an effective therapeutic option for type 1 diabetes. Toxicity associated with chronic use of immunosuppressants still remains an obstacle for…
2017 American Transplant Congress
Assessment of Simple Indices Based on a Single Fasting Blood Sample in Search for an Optimal Tool to Estimate Beta Cell Function After Islet Transplantation.
J. Golebiewska,¹ J. Solomina,² E. Konsur,² K. Cieply,² L. Basto,² A. Kotukhov,² K. Golab,² C. Thomas,³ A. Debska-Slizien,¹ P. Witkowski.²
¹Department of Nephrology, Medical University of Gdansk, Gdansk, Poland; ²Departemt of Surgery, University of Chicago, Chicago; ³Department of Medicine, University of Chicago, Chicago
Background:Precise yet logistically feasible evaluation of beta-cell function is extremely important after islet allotransplantation. We investigated the utility and possible limitations of indices using only…
2017 American Transplant Congress
Measurement of Dissolved Oxygen by ¹⁹F MRI of Microcapsules Implanted IP in Non-Human Primates.
S. Safley,¹ M. Graham,² M. Garwood,³ K. Papas,⁵ B. Weegman,^3,4 G. Barber,¹ E. Lin,¹ J. Leisen,⁷ A. Sambanis,⁶ B. Hering,² C. Weber.¹
¹Surgery, Emory University, Atlanta, GA; ²Surgery, University of Minnesota, Minneapolis, MN; ³Radiology, University of Minnesota, Minneapolis, MN; ⁴Sylvatica Biotech, Inc., Charleston, SC; ⁵Surgery, University of Arizona, Tucson, AZ; ⁶School of Chemical and Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA; ⁷School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA
Since our encapsulated NHP islet allografts and porcine islet xenografts fail after i.p. transplantation in immunosuppressed NHPs without a cellular or humoral immune response, we…
2017 American Transplant Congress
Dendritic Cells That Highly Express SOCS1 Induce T-Cell Hypo-Responsiveness and Prolong Islet Allograft Survival.
R. Deng, X. Lu, M. Chen, Z. Xue, X. Zhang, J. Xu, L. Wu, Y. Ma.
Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
The capability of dendritic cells (DCs) to induce an immune response or immune tolerance is dependent on their status. Suppressor of cytokine signaling 1 (SOCS1)…
2017 American Transplant Congress
Bioengineering Human Islets to Form Peri-Islet Vessels from Intraislet Endothelial Cells for Improving Human Islet Function.
G. Loganathan, S. Narayanan, M. Dhanasekaran, A. Patel, W. Tucker, M. Hughes, S. Williams, A. Balamurugan.
Clinical Islet Laboratory, Dept. of Surgery, Cardiovascular Innovation Institute, University of Louisville, KY
Native islets in the pancreas have a rich vascular supply however, the current islet isolation technique completely severs the vasculature to islets. As such, these…
2017 American Transplant Congress
Recognition of Islet Xenografts In Vivo by Non-Obese Diabetic (NOD) Insulin-Specific CD4 T Cells.
R. Gill, W. Dale, M. Crawford.
Surgery and Immunology, University of Colorado Denver, Aurora, CO
Xenogeneic islet transplantation has been one ongoing goal for treating autoimmune Type 1 diabetes. Autoimmune diabetes involves a T cell response restricted to the host…
2017 American Transplant Congress
IP-10 Monoclonal Antibody Treatment Suppresses Inflammatory Components of IBMIR and Improves Pancreatic Islet Graft Function.
G. Yoshimatsu,¹ C. Chang,¹ C. Darden,¹ P. Saravanan,¹ B. Naziruddin,² M. Lawrence.¹
¹Baylor Scott and White Reseasrch Institute, Dallas, TX; ²Baylor Simmons Transplant Institute, Dallas, TX
Introduction: An instant blood-mediated inflammatory response (IBMIR) causes acute loss of pancreatic islets. Interferon gamma-induced protein 10 (IP-10) is a key proinflammatory chemokine that may…
2017 American Transplant Congress
Islet Rejection in Autoimmune NOD Mouse Recipients: Implications for Stem Cell Therapies.
R. Gill,¹ M. Coulombe,¹ T. Kupfer,¹ K. Beard,¹ A. Burrack.²
¹Surgery and Immunology, University of Colorado Denver, Aurora, CO; ²University of Minnesota, Minneapolis, MN
Several efforts are ongoing to use stem cell precursors to generate islet-like tissues suitable for transplantation in autoimmune Type 1 diabetic (T1D) recipients. During the…
2017 American Transplant Congress
Thrombalexin and Mirococept Synergistically Reduce IBMIR in a Porcine to Rhesus Xenoislet Model.
M. Manook,^1,2 J. Kwun,¹ J. Yoon,¹ K. Samy,¹ A. MacDonald,¹ H. Xu,¹ R. Smith,³ A. Dorling,³ A. Kirk,¹ N. Mamode,² S. Knechtle.¹
¹Surgery, Duke Transplant Center, Durham, NC; ²Renal and Transplant, Guy's and St Thomas'NHS Foundation Trust, London, United Kingdom; ³MRC Centre for Transplantation, King's College, London, United Kingdom
Introduction: Early activation of coagulation and complement are important factors in the initiation of instant blood mediated inflammation (IBMIR) in xenoislet models. Two novel 'cytotopic'…
2017 American Transplant Congress
Immunosuppressive Role of Pancreas Derived Mesenchymal Stem Cells.
M. Kanak,¹ F. Kunnathodi,² M. Levy,^1,3 M. Lawrence,² B. Naziruddin.⁴
¹Transplant Surgery, Virginia Commonwealth University, Richmond, VA; ²Baylor Research Institute, Dallas, TX; ³Hume-Lee Transplant Center, VCU Health System, Richmond, VA; ⁴Simmons Transplant Institute, Baylor Scott and White Health, Dallas, TX
BackgroundThe Edmonton protocol revived islet transplantation therapy for Type-1 Diabetic patients. However, Long-term islet function still remains a challenge. Immunosuppression used after islet transplantation contributes…