Articles tagged "Islets"

2019 American Transplant Congress
Role of NF-kB in Release of Isletokines via Exosomes in Response to Islet Stress
P. Saravanan¹, M. Kanak¹, J. Kalivarathan¹, M. Lawrence², M. Levy¹, B. Naziruddin³
¹Department of Surgery, Virginia Commonwealth University, VCU Health, Richmond, VA, ²Islet Cell Lab, Baylor Scott and White Research Institute, Dallas, TX, ³Simmons Transplant Institute, Baylor Scott and White Medical Center, Dallas, TX
*Purpose: Human islets are exposed to a range of inflammatory stimuli upon transplantation that leads to poor graft survival. Identifying the various signaling events may…
2019 American Transplant Congress
Blockade of IL-1β and TNF-α Does Not Significantly Pose Risk or Affect Outcomes in Patients Infused with Microbial-Positive Autologous Islet Preparations
K. Kumano¹, C. Darden², S. Vasu¹, M. Lawrence¹, B. Naziruddin³, A. Gupta³, E. Beecherl³, N. Onaca³
¹Baylor Scott and White Research Institute, Dallas, TX, ²Baylor University, Waco, TX, ³Baylor Simmons Transplant Institute, Dallas, TX
*Purpose: We recently demonstrated that the combined use of anakinra (IL-1β blocker) and etanercept (TNF-α blocker) improved outcomes of islet autotransplantation after total pancreatectomy (TPIAT).…
2019 American Transplant Congress
B Cell IL-4 Signaling Induces the IL-10 Secreting TIM-1+ Bregs and Suppresses T Cell Inflammatory Cytokines
Z. Song, K. Mohib, D. M. Rothstein
Surgery, Starzl Transplantation Institute, Pittsburgh, PA
*Purpose: TIM-1+ identifies the majority (~75%) of IL-10+ B regulatory cells (Bregs). However, TIM-1+ B cells are also enriched for IL-4+ B effector 2 cells…
2019 American Transplant Congress
Fibrosis Scoring Correlates with Progression of Chronic Pancreatitis, Islet Isolation Yields and Transplant Outcomes in Patients Undergoing Islet Autotransplantation
Y. Liu¹, J. SoRelle², K. Kumano³, S. Vasu³, M. Lawrence⁴, A. Gupta¹, N. Onaca¹, E. Beecherl¹, B. Naziruddin⁴
¹Baylor Simmons Transplant Institute, Dallas, TX, ²UTSouthwestern Medical Center, Dallas, TX, ³Baylor Scott and White Research Institute, Dallas, TX, ⁴Baylor University Medical Ctr, Dallas, TX
*Purpose: Total pancreatectomy with autologous islet transplantation (TPIAT) is a promising procedure for alleviating pain and maintaining glucose homeostasis in chronic pancreatitis (CP) patients. However,…
2019 American Transplant Congress
Long Term Renal Function Following Islet Transplantation in the Clinical Islet Transplantation Consortium
L. G. Hunsicker¹, T. L. Eggerman², M. R. Rickels³, t. Clinical Islet Transplantation (CIT) Consortium⁴
¹Internal Medicine, U. Iowa, Iowa City, IA, ²NIDDK/NIH, Bethesda, MD, ³Internal Medicine, U. Pennsylvania, Philadelphia, PA, ⁴Internal Medicine, University of Iowa, Iowa City, IA
*Purpose: Islet transplantation (IsletTp) is safe and effective treatment of Type 1 diabetes complicated by severe hypoglycemia (Diabetes Care 2016, 39:1230). But the requirement for…
2019 American Transplant Congress
Outcomes of Total Pancreatectomyand Islet Autotransplantation, a Single Center Experience
A. Rajab¹, J. Buss¹, L. F. Lara², S. Meng³, K. Kuntz⁴, D. Conwell², P. A. Hart², K. Washburn¹
¹Transplant Surgery, The Ohio State University, Columbus, OH, ²Gastroenterology, Hepatology and Nutrition, The Ohio State University, Columbus, OH, ³Endocrinology, Diabetes and Metabolism, The Ohio State University, Columbus, OH, ⁴Psychiatry and Behavioral Health, The Ohio State University, Columbus, OH
*Purpose: Patients with chronic pancreatitis (CP) suffer from severe pain that greatly reduces their quality of life and often leads to long-term narcotic therapy to…
2019 American Transplant Congress
Withaferin A Shifts Circulating Lymphocytes toward Protective T Cell Subsets and Prolongs Islet Allograft Survival in a Mouse Transplant Model
K. Kumano¹, M. Kanak², C. Darden³, S. Vasu¹, Y. Liu⁴, M. C. Lawrence¹, B. Naziruddin⁴
¹Baylor Scott and White Research Institute, Dallas, TX, ²Department of Surgery, Virginia Commonwealth University, Richmond, VA, ³Institute of Biomedical Studies, Baylor University, Waco, TX, ⁴Baylor Simmons Transplant Institute, Dallas, TX
*Purpose: : Immunosuppression protocols improve the efficacy of allogeneic islet transplantation. However, decline in islet graft function and toxicities imposed by current immunosuppressant drugs remain…
2019 American Transplant Congress
Can Cxcl8 Inhibitor (reparixin) Improve Islet Engraftment And Clinical Outcomes After Islet Allotransplantation? University Of Chicago Preliminary Results From A Phase 3 Multicenter Randomized, Double-blinded, Prospective Study.
P. Bachul¹, K. Golab¹, L. Basto¹, L. Wang¹, M. Tibudan¹, J. Golebiewska², M. Para¹, L. Perea¹, F. Antic¹, J. Fung¹, P. Witkowski¹
¹University of Chicago Medicine, Chicago, IL, ²Medical University of Gdansk, Gdansk, Poland
*Purpose: Reparixin is a novel CxCR1/2 chemokine receptor-blocking molecule, which has been shown improving islet engraftment in animal models. A multicenter trial was organized to…
2019 American Transplant Congress
Analysis of Islet Exosomal miRNAs Released Post-Transplant in Response to Inflammation
P. Saravanan¹, M. Kanak¹, G. Yoshimatsu², C. Darden², M. Lawrence², M. Levy¹, B. Naziruddin³
¹Department of Surgery, Virginia Commonwealth University, VCU Health, Richmond, VA, ²Islet Cell Lab, Baylor Scott and White Research Institute, Dallas, TX, ³Simmons Transplant Institute, Baylor Scott and White Research Center, Dallas, TX
*Purpose: Islets release miRNAs and other non-coding RNAs via exosomes under various pathological conditions, which are capable of regulating the genes of neighboring and/or distant…
2019 American Transplant Congress
Clinical Trial of Allogeneic Islet Transplantation in the Treatment of Diabetes after Renal Transplantation
W. liang, M. Hu, G. Peng, D. Zhou, C. Zeng, W. Zhou, q. Ye, Z. Wang
Zhongnan Hospital of Wuhan University, Institute of Hepatobiliary Diseases, Wuhan, China
*Purpose: Diabetes after renal transplantation is one of the most serious complications after renal transplantation. It has a serious impact to the survival of kidney…

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