ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Islets"

  • 2019 American Transplant Congress

    Withaferin A Shifts Circulating Lymphocytes toward Protective T Cell Subsets and Prolongs Islet Allograft Survival in a Mouse Transplant Model

    K. Kumano1, M. Kanak2, C. Darden3, S. Vasu1, Y. Liu4, M. C. Lawrence1, B. Naziruddin4

    1Baylor Scott and White Research Institute, Dallas, TX, 2Department of Surgery, Virginia Commonwealth University, Richmond, VA, 3Institute of Biomedical Studies, Baylor University, Waco, TX, 4Baylor Simmons Transplant Institute, Dallas, TX

    *Purpose: : Immunosuppression protocols improve the efficacy of allogeneic islet transplantation. However, decline in islet graft function and toxicities imposed by current immunosuppressant drugs remain…
  • 2019 American Transplant Congress

    Can Cxcl8 Inhibitor (reparixin) Improve Islet Engraftment And Clinical Outcomes After Islet Allotransplantation? University Of Chicago Preliminary Results From A Phase 3 Multicenter Randomized, Double-blinded, Prospective Study.

    P. Bachul1, K. Golab1, L. Basto1, L. Wang1, M. Tibudan1, J. Golebiewska2, M. Para1, L. Perea1, F. Antic1, J. Fung1, P. Witkowski1

    1University of Chicago Medicine, Chicago, IL, 2Medical University of Gdansk, Gdansk, Poland

    *Purpose: Reparixin is a novel CxCR1/2 chemokine receptor-blocking molecule, which has been shown improving islet engraftment in animal models. A multicenter trial was organized to…
  • 2019 American Transplant Congress

    Analysis of Islet Exosomal miRNAs Released Post-Transplant in Response to Inflammation

    P. Saravanan1, M. Kanak1, G. Yoshimatsu2, C. Darden2, M. Lawrence2, M. Levy1, B. Naziruddin3

    1Department of Surgery, Virginia Commonwealth University, VCU Health, Richmond, VA, 2Islet Cell Lab, Baylor Scott and White Research Institute, Dallas, TX, 3Simmons Transplant Institute, Baylor Scott and White Research Center, Dallas, TX

    *Purpose: Islets release miRNAs and other non-coding RNAs via exosomes under various pathological conditions, which are capable of regulating the genes of neighboring and/or distant…
  • 2019 American Transplant Congress

    Clinical Trial of Allogeneic Islet Transplantation in the Treatment of Diabetes after Renal Transplantation

    W. liang, M. Hu, G. Peng, D. Zhou, C. Zeng, W. Zhou, q. Ye, Z. Wang

    Zhongnan Hospital of Wuhan University, Institute of Hepatobiliary Diseases, Wuhan, China

    *Purpose: Diabetes after renal transplantation is one of the most serious complications after renal transplantation. It has a serious impact to the survival of kidney…
  • 2019 American Transplant Congress

    Microfluidic Study Analyzing the Effect of Immediate-Release and Extended-Release Tacrolimus on Islet Function

    P. West-Thielke1, J. Oberholzer2, Y. Wang3

    1University of Illinois, Chicago, IL, 2University of Virgina, Charlottesville, VA, 3University of Virginia, Charlottesville, VA

    *Purpose: The purpose of this analysis was to quantify the impact of 2 tacrolimus pharmacokinetic profiles on functional changes within human islet cells using a…
  • 2019 American Transplant Congress

    Prevention of Diabetes in the NOD Mice Reconstituted with Bone Marrow Cells from Allogeneic CD4 Knockout, CD8 Knockout or B-Cell Knockout B6 Mice

    Y. Huang, H. Xu, Y. Wen, S. Ildstad

    University of Louisville, Louisville, KY

    *Purpose: Type 1 diabetes (T1D) is an autoimmune disorder characterized by destruction of the pancreatic beta cells by both humoral- and cell-mediated immune mechanisms. Transplantation…
  • 2019 American Transplant Congress

    Islet Stress Leads to Increased Release of Exosomes That Stimulate Immune Cell Response

    S. Vasu1, C. Darden2, K. Kumano1, B. Naziruddin3, M. Lawrence3

    1Baylor Scott and White Research Institute, Dallas, TX, 2Institute of Biomedical Studies, Baylor University, Waco, TX, 3Baylor University Medical Ctr, Dallas, TX

    *Purpose: Islet dysfunction and death caused by isolation procedures, immune attack and hypoxia significantly affect islet transplantation outcomes. Non-invasive monitoring of islet stress and damage…
  • 2019 American Transplant Congress

    Xenorejection of Porcine Islets in Humanized Mice is Dominated by a Human Th17 Cytokine Immune Response

    F. T. Lee1, A. Dangi2, M. Burnette2, B. Hering3, X. Luo2

    1Transplant Surgery, Northwestern University, Chicago, IL, 2Nephrology, Duke University, Durham, NC, 3Diabetes Institute, University of Minnesota, Minneapolis, MN

    *Purpose: We have previously shown that interleukin(IL)-17 producing CD4 T cells (Th17 response) dominate in the early anti-donor immune responses of a pig-to-mouse xenogeneic model…
  • 2019 American Transplant Congress

    Pancreatic Extracellular Matrix Improves Human Islet Culture and Function In Vitro

    Y. Shindo, R. Pouillot, B. M. Young, P. Link, R. L. Heise, M. F. Levy, M. A. Kanak

    Virginia Commonwealth University, Richmond, VA

    *Purpose: Islet transplantation is a thriving therapy for patients with Chronic Pancreatitis and Type-1 Diabetes. Within the pancreas, the islets are surrounded by Extracellular Matrix…
  • 2019 American Transplant Congress

    Improvement of the Outcome of Clinical Islet Transplantation Depending on the Era in Japan

    Y. Akashi1, T. Kenmochi2, T. Ito3, K. Kurihara2, N. Aida2, A. Kawai2, M. Hayashi4, K. Kouketsu4

    1Faculty of Nursing, School of Health Sciences, Fujita Health University, Toyoake, Japan, 2Department of Transplantation and Regenerative Medicine, Fujita Health University, Toyoake, Japan, 31 Department of Transplantation and Regenerative Medicine,, Fujita Health University, Toyoake, Japan, 4Transplant medical support office, Fujita Health University Hospital, Toyoake, Japan

    *Purpose: Islet transplantation (ITX) is an ideal treatment for type 1 diabetic patients. In this paper, we compared the outcome of ITX depending on Era…
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