ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Ischemia"

  • 2021 American Transplant Congress

    P40 Homodimers Induce Il-15 to Promote Endogenous Donor-reactive Memory Cd8 T Cell Activation within High-risk Cardiac Allografts

    H. Tsuda, A. Valujskikh, R. Fairchild

    Inflammation and Immunity, Cleveland Clinic, Cleveland, OH

    *Purpose: Longer cold ischemic storage (CIS) time prior to transplant results in increased proliferation of endogenous donor-reactive memory CD8 T cells within complete MHC-mismatched cardiac…
  • 2021 American Transplant Congress

    Augmented Responses of Donor Kidney Tubular Cells to TLR Signaling Correlate with Ameliorated Ischemia/reperfusion Injury and Long-term Allograft Protection

    X. Lai1, J. Wang1, L. Qiu2, S. Han1, K. Shen1, Z. Zhang1

    1Comprehensive Transplant Center, Microsurgery core, Northwestern University, Chicago, IL, 2University of California, San Francisco, San Francisco, CA

    *Purpose: We have previously demonstrated that donor genetic background and kidney-intrinsic innate immunity were key determinants of delayed graft function in kidney transplantation. However, the…
  • 2021 American Transplant Congress

    Ikaros-SIRT1 Signaling Axis Regulates Macrophage Polarization and Ischemia Reperfusion Injury in Mouse and Human Liver Transplantation

    K. Kadono1, H. Hirao1, H. Kojima1, K. J. Dery1, X. Li2, J. W. Kupiec-Weglinski1

    1The Dumont-UCLA Transplant Center, Los Angeles, CA, 2NIEHS, Durham, NC

    *Purpose: Although Ikaros is a well-established transcriptional regulator of lymphopoiesis and differentiation of leukocyte lineage, its role in myeloid cells and ischemia reperfusion injury remain…
  • 2021 American Transplant Congress

    Caspase-3 is a Predominant Regulator of Microvascular Dysfunction and Aki-ckd Transition Post Renal Ischemia-reperfusion Injury

    S. Lan, F. Migneault, J. Turgeon, M. Bourgault, M. Dieudé, N. Patey, H. Cardinal, M. Hébert

    CRCHUM, University of Montreal, Montreal, QC, Canada

    *Purpose: Ischemia-reperfusion injury (IRI) is a major risk factor for chronic renal failure. Caspase-3, an effector responsible for apoptosis execution, is activated within tubular epithelial…
  • 2021 American Transplant Congress

    Superior Post-transplant Clinical Outcomes Using Portable Normothermic Perfusion and Assessment with the Organ Care System (ocs) Liver System: 1-year Outcomes of the Ocs Liver Protect Randomized Controlled Trial

    J. Markmann1, M. Abouljoud2, M. Ghobrial3, C. Bhati4, S. Pelletier5, J. Magliocca6, T. Pruett7, A. Lu8, M. Rizzari9, S. Ottmann10, T. Klair11, C. Eymard12, G. Roll13, G. Reyes14, S. Black15, S. Florman16, S. Mirani17, C. Marsh18, G. Schnickel19, M. Kinkhabwala20, A. Demetris21, H. Yeh22, P. Vagefi23, M. MacConmara23

    1MGH, Boston, MA, 2Henry Ford, Detroit, MI, 3Houston Methodist, Houston, TX, 4Virginia Commonwealth, Richmond, VA, 5UVA, Charlottesville, VA, 6Emory, Atlanta, GA, 7U. Minnesota, Minneapolis, MN, 8Tampa General, Tampa, FL, 9Henry Ford, Detriot, MI, 10Johns Hopkins, Baltimore, MD, 11University of Texas HSC, San Antonio, TX, 12University of Tennessee HSC, Memphis, TN, 13UCSF, San Francisco, CA, 14U. Washington, Seattle, WA, 15Ohio State, Columbus, OH, 16Mt. Sinai, New York, NY, 17U. Nebraska, Omaha, NE, 18Scripps Clinic, San Diego, CA, 19U. San Diego, San Diego, CA, 20Montefiore, New York, MA, 21UPMC, Pittsburgh, PA, 22Massachusetts General Hospital, Boston, MA, 23UT Southwestern, Dallas, TX

    *Purpose: The OCS Liver PROTECT Trial was the first U.S. randomized controlled trial for liver perfusion and was designed to evaluate the impact of portable…
  • 2021 American Transplant Congress

    Tubastatin-a Mediated Protection from Liver Injury is Preserved in a Lymphocyte Deficient Model

    C. S. O'Brien1, P. Hernandez1, Z. Wang1, G. Ge1, A. Kozikowski2, W. Hancock1, M. H. Levine1

    1University of Pennsylvania, Philadelphia, PA, 2University of Illinois at Chicago, Chicago, IL

    *Purpose: Liver Ischemia reperfusion injury (IRI) and Acetaminophen (APAP) toxicity are important causes of acute liver failure in the United States, that lack effective therapy.…
  • 2021 American Transplant Congress

    Role of Ferroptosis Inhibitors in Mitigating Ischemia-Reperfusion Injury in Marginal Livers Using a Novel Protect Model

    M. D. Nazzal, J. Van Nispen, A. Armstrong, V. Murali, E. Song, M. Voigt, A. Samaddar, E. Madsen, C. Manithody, J. Krebs, D. Blackall, D. Carpenter, C. Varma, J. Teckman, A. Jain

    Saint Louis University, Saint Louis, MO

    *Purpose: The discard rate of deceased donor livers (DDL) remains high at nearly 9% and incudes livers that are steatotic, old in age, and from…
  • 2021 American Transplant Congress

    Myeloid YAP-HSF1 Signaling Inhibits NLRP3 Function and RIPK3-mediated Hepatocyte Necroptosis in Liver Ischemia and Reperfusion Injury

    Y. Tian, D. Xu, M. Sheng, Y. Zhan, Y. Lin, C. Li, A. J. Coito, R. W. Busuttil, D. G. Farmer, J. W. Kupiec-Weglinski, B. Ke

    Surgery, Dumont - UCLA Transplant Ctr, Los Angeles, CA

    *Purpose: Yes-associated protein (YAP), a downstream effector of the Hippo pathway, tightly regulates cell growth, survival, and tissue inflammation. Activation of heat shock factor 1…
  • 2021 American Transplant Congress

    Double Negative T Cells Mediate Cd39-Dependent Protection in Hepatic Ischemia and Reperfusion Injury

    H. Jin, M. Li, C. Zhang, G. Sun, D. Zhang

    Beijing Key Laboratory of Tolerance Induction and Organ Protection in Transplantation, Beijing Friendship Hospital, Capital Medical University, Beijing, China

    *Purpose: Hepatic ischemia and reperfusion injury (HIRI) is a significant cause of morbidity and mortality following liver transplantation and major hepatic resections. Double negative T…
  • 2021 American Transplant Congress

    Galectin-3 Blockade Can Decrease Reperfusion Injury in Response to Ischemia in a Rat Hind Limb Transplant Model

    Z. Wang1, Y. Wang1, D. Yoeli1, B. Li1, A. Su1, D. Mathes1, K. Washington1, E. Farkash2, C. A. Huang1

    1University of Colorado, Aurora, CO, 2University of Michigan, Ann Arbor, Ann Arbor, MI

    *Purpose: Vascularized composite allograft (VCA) transplant is technically feasible and results in successful clinical outcomes. However, skin and muscle containing VCA is highly susceptible to…
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