Articles tagged "Ischemia"

2015 American Transplant Congress
Activation of FXR Protects Against Liver Ischemia and Reperfusion Injury (IRI) in Mice Via the PI 3-Kinase/Akt (PI3K/Akt) Pathway
J. Zhang,¹ X. Liu,² D. Li,¹ H. Dai,¹ J. Zhang,¹ T. Lu,¹ Q. Xia.¹
¹Liver Transplantation Center, Renji Hospital, Shanghai, China; ²Cardiovascular, Shanghai First People/s Hospital, Shanghai, China.
Background: FXR is a ligand-dependent transcription factor belonging to the nuclear hormone receptor superfamily, which plays important roles in lipid metabolism, glucose homeostasis, inflammatory responses…
2015 American Transplant Congress
Engagement of the Vasopressin Receptor On Hepatocytes Protects Liver from Ischemia-Reperfusion Injury Via the WNT-β-Catenin-SGK1-FOXO Pathway
X. Liu,¹ T. Billiar,² R. Tao.¹
¹Department of Hepatobiliary-Pancreatic Surgery, Zhejiang Provincial Peoples' Hospital, Hangzhou, Zhejiang Province, China; ²Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA.
The synthetic vasopressin analogue, terlipressin, has been extensively used in the management of certain complications associated with end-stage liver diseases (ESLDs), however concerns have been…
2015 American Transplant Congress
Mesenchymal Stem Cells Prevent Cold Ischemia-Reperfusion Injury in Lung Transplants
H. Wang,^1,2 W. Tian,¹ Y. Liu,³ X. Dai,¹ G. Li,³ T. Liu,^1,2 Z. Zhang,^1,2 C. Du.⁴
¹Department of General Surgery, Tianjin Medical University General Hospital, Tianjin, China; ²Tianjin General Surgery Institute, Tianjin, China; ³Department of Biology, Tianjin Medical University, Tianjin, China; ⁴Department of Urologic Sciences, The University of British Columbia, Vancouver, BC, Canada.
Background: Cold ischemia-reperfusion injury (IRI) is a major cause of graft failure in lung transplantation. Despite therapeutic benefits of mesenchymal stem cells (MSCs) in attenuating…
2015 American Transplant Congress
Macrophage Specific β-Catenin Controls ROCK/PTEN Function and Regulates Innate Immunity in Liver Inflammation
S. Yue,¹ X. Zhou,² M. Zhou,¹ Y. Zhai,¹ R. Busuttil,¹ Q. Ying,² J. Kupiec-Weglinski,¹ B. Ke.¹
¹Dumont-UCLA Transplant Center, Dept. of Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA; ²Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at USC, Dept. of Stem Cell Biology & Regenerative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA.
Background: It has been shown that β-catenin is an important regulator of cell development, regeneration, and carcinogenesis. Our previous studies demonstrated the key role of…
2015 American Transplant Congress
Galectin-9 Protects Mouse Liver Transplants Against Ischemia-Reperfusion Injury
H. Ji, Y. Liu, Y. Zhang, X. Shen, F. Gao, R. Busuttil, J. Kupiec-Weglinski.
Dept of Surgery, Dumont-UCLA Liver Transplant Center, Los Angeles, CA.
Background:Although Galecin 9 (Gal-9) negatively regulates Th1-type alloimmunity by binding to T-cell Immunoglobulin Mucin-3 (TIM-3) on activated Th1 cells, its role in liver ischemia-reperfusion injury…
2015 American Transplant Congress
Delivery of Heme Oxygenase-1-Cell Penetrating Peptide (HO-1-CPP) Into Hepatocytes, Kupffer and Islet Cells in In Vitro and Ex Vivo Models of Cold Ischemia
A. Venkatachalam,¹ C. Wood,¹ Q. Hu,¹ I. Alwayn.²
¹Surgery, Dalhousie University, Halifax, NS, Canada; ²Surgery, Pathology, Microbiology & Immunology, Surgical Lead Multi Organ Transplant Program, QEII Health Sciences Center, Dalhousie University, Halifax, NS, Canada.
In an attempt to increase the number of donor organs available to transplantation extended criteria donor (ECD) organs are more frequently considered. Unfortunately, ECD organs…
2015 American Transplant Congress
Cellular Mechanism of Enhanced Alloimmunity by Ischemia Reperfusion Injury
Z. Solhjou, M. Uehara, S. Ohori, M. McGrath, J. Azzi, S. Tullius, R. Abdi.
Transplant Research Center, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
Ischemia reperfusion injury of transplanted organs represents a key pathogenic inflammatory process, which increases their allogenicity; subsequently augmenting the rate of acute and chronic rejection.…
2015 American Transplant Congress
Allograft Class II MHC and CD40 Expression Are Required for Endogenous Memory CD8 T Cell Proliferation in Cardiac Allografts Subjected to Prolonged Cold Ischemic Storage
T. Tanaka,^1,2 H. Tsuda,^1,3 N. Kohei,^1,4 D. Kish,¹ W. Baldwin,¹ A. Valujskikh,¹ R. Fairchild.¹
¹Immunology, Cleveland Clinic, Cleveland, OH; ²Urology, Sapporo Medical University, Sapporo, Japan; ³Urology, Osaka University, Osaka, Japan; ⁴Urology, Kidney Center, Tokyo Women's Medical University, Tokyo, Japan.
Endogenous memory CD8 T cells infiltrate MHC-mismatched cardiac allografts and produce IFN-γ in response to donor class І MHC within 24 hrs after graft reperfusion…
2015 American Transplant Congress
Ischemia-Induced Endoplasmic Reticulum Stress Regulates Autophagy to Determine the Severity of Liver Ischemia Reperfusion Injury
H. Zhou,^1,2 J. Zhu,¹ S. Yue,¹ R. Busuttil,¹ J. Kupiec-Weglinski,¹ Y. Zhai.¹
¹The Dumont-UCLA Transplant Center, UCLA, Los Angeles, CA; ²Liver Transplant Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
Both endoplasmic reticulum (ER) stress and autophagy have been implicated in the pathogenesis of ischemia and reperfusion injury (IRI). As essential cellular stress responses against…
2015 American Transplant Congress
Recipient Myelomonocytic Cells With Activated Hypoxia-Inducible Factor Alleviate Ischemia-Reperfusion Injury in Mouse Heart Allografts
A. Raissadati, M. Keränen, E. Rouvinen, R. Krebs, K. Lemström.
Transplantation Laboratory and Department of Cardiac Surgery, University of Helsinki, Haartman institute and Helsinki University Central Hospital, Heart and Lung Center, Helsinki, Finland.
Aim: To investigate the effect of HIF-1α and -2α activation in myelomonocytic cells during the early phase after ischemia-reperfusion (IRI) injury of mouse allogenic heart…