Articles tagged "Ischemia"

2015 American Transplant Congress
Type III Phosphodiesterase (PDE3) Inhibitor Improves Survival Rate After Ischemia Reperfusion Injury of the Liver in Rats
T. Fujii,¹ H. Obara,² N. Fujimura,² K. Matsubara,² Y. Kitagawa.²
¹Surgery, Inagi Municipal Hospital, Tokyo, Japan; ²Surgery, Keio University School of Medicine, Tokyo, Japan.
BackgroundPDE3 inhibitor (Cilostazol) has long been used as a potent inhibitor of platelet aggregation and thrombosis. Recently, there have been a report on the protective…
2015 American Transplant Congress
Impact of Cold Ischemic Time (CIT) and Distance Traveled (DT) on Shipped Kidneys in the OPTN/UNOS Kidney Paired Donation (KPD) Pilot Program (PP)
M. Aeder,¹ D. Stewart,² R. Leishman,² L. Robbins Callahan,² A. Kucheryavaya,² T. Sandholm,³ R. Formica.⁴
¹Univ Hosp Case Med Ctr, Cleveland, OH; ²UNOS, Richmond, VA; ³Carnegie Mellon Univ, Pittsburgh, PA; ⁴Yale Univ, New Haven, CT.
Background: The success of a national KPD program is predicated on excellent early kidney function and graft survival (GS). As other KPD programs have reported…
2015 American Transplant Congress
Impact of Donor Post-Extubation O2 Delivery on Recipient Hypoxic Cholangiopathy in Donation After Circulatory Death Liver Transplantation: The University of Colorado Experience
T. Chirichella,¹ C. Dunham,² M. Zimmerman,⁴ K. Conzen,¹ S. Kelley,³ E. Phelan,¹ T. Steinberg,¹ T. Nydam,¹ T. Bak,¹ I. Kam,¹ M. Wachs.¹
¹Transplant Surgery, University of Colorado Hospital, Aurora, CO; ²Department of Surgery, St. Elizabeth Health Center, Youngstown, OH; ³Donor Alliance Organ Procurement Organization, Denver, CO; ⁴Transplant Surgery, Medical College of Wisconsin, Milwaukee, WI.
The critical shortage of deceased organ donors has led to increased utilization of DCD liver grafts. The purpose of this study was to evaluate DCD…
2015 American Transplant Congress
Chemokine Receptor 5 Blockade Modulates Inflammation and Immunity in Renal Ischemic Reperfusion Injury
K. Yoo,¹ S. Han,¹ J. Park,¹ E. Bae,¹ J. Park,¹ J. An,¹ J. Lee,¹ D. Kim,¹ Y. Kim,^1,2 S. Yang.²
¹Internal Medicine, Seoul National University Hospital, Seoul, Korea; ²Kidney Research Institute, Seoul National University, Seoul, Korea.
Macrophages, which exhibit great pliability, are important components of renal ischemic reperfusion injury (IRI) and are closely correlated with loss of renal function. Chemokine Receptor…
2015 American Transplant Congress
Gender Differences in Kidney Transplant Delayed Graft Function Are Independent of Donor-Recpient Size Mismatch
M. Levine,¹ A. Thomasson,¹ D. Aufhauser,¹ R. Redfield,² P. Abt,¹ P. Reese.³
¹Surgery, University of Pennsylvania, Philadelphia, PA; ²Surgery, University of Wisconsin, Madison, WI; ³Medicine, University of Pennsylvania, Philadelphia, PA.
Introduction: Superior female tolerance of ischemia reperfusion injury (IRI) relative to males has been described in animal models, but little human data are available to…
2015 American Transplant Congress
Metabolomic Analysis of Remote Ischemic Preconditioning in Renal Ischemia Reperfusion Injury
A. Han,¹ S.-I. Min,¹ K. Cho,² C. Choi,¹ S.-K. Min,¹ S. Kim,³ M. Park,⁴ J.-Y. Cho,² J. Ha.¹
¹Department of Surgery, Seoul National University College of Medicine, Seoul, Republic of Korea; ²Depratment of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine, Seoul, Republic of Korea; ³Depratment of Surgery, Myongji Hospital, Goyang-si, Gyeonggi-do, Republic of Korea; ⁴Korean Organ Donation Agency, Seoul, Republic of Korea.
Background. Ischemic reperfusion injury (IRI), an inevitable process during kidney transplantation, can cause significant graft damage and may play a role in delayed graft function.…
2015 American Transplant Congress
The use of Donation After Cardiac Death Liver Allografts does not increase Recurrence of Hepatocellular Carcinoma
K. Croome, D. Lee, J. Burns, J. Nguyen, D. Perry, D. Harnois, C. Taner.
Transplant, Mayo Clinic, Jacksonville, FL.
Background: Previous studies examining the Scientific Registry of Transplant Recipients (SRTR) database for liver transplantation (LT) have demonstrated inferior survival for hepatocellular carcinoma (HCC) recipients…
2015 American Transplant Congress
Distinctive Roles of mTORC1 Vs. mTORC2 in Liver Ischemia-Reperfusion Injury
H. Zhou,^1,2 J. Zhu,^1,3 S. Yue,¹ M. Zhang,³ R. Busuttil,¹ Q. Xia,³ J. Kupiec-Weglinski,¹ Y. Zhai.¹
¹The Dumont-UCLA Transplant Center, UCLA, Los Angeles; ²Liver Transplant Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China; ³Liver Surgery, Renji Hospital, Shanghai Jiaotong University, Shanghai, China.
Mammalian target of rapamycin (mTOR) exists in two complexes to regulate diverse biological processes. Although mTOR complex 1, the canonical target of rapamycin, has been…
2015 American Transplant Congress
Inflammatory Profiling of Hypothermic Machine Pumped Kidney Allografts
J. Cohen, E. Ratigan, A. Shigeoka, R. Steiner, L. Stocks, D. McKay.
Medicine, University of California, San Diego, La Jolla, CA.
Background:Pulsatile Hypothermic Machine Perfusion (MP) offers an opportunity to define inflammatory molecules generated during renal ischemia. This study reports on allografts pumped at our OPO,…
2015 American Transplant Congress
Stem Cell and Novel Biologic Therapies to Enhance Functional Recovery in Limb Transplantation
K. Kniery, M. DeHart, T. Brown, S. Salgar.
Surgery/Clinical Investigation, Madigan Army Medical Center, Tacoma, WA.
Introduction: Unlike visceral organ transplants, vascular composite allotransplantation such as limb and face require successful nerve regeneration and reinnervation of graft motor and sensory targets…