Articles tagged "Ischemia"

2016 American Transplant Congress
Gsk3β Regulates Macrophage Pro-Inflammatory Immune Activation via AMPK-Mediated Induction of Small Heterodimer Partner (SHP).
H. Zhou,^1,2 J. Zhu,^1,3 S. Yue,¹ R. Busuttil,¹ J. Kupiec-Weglinski,¹ X. Wang,² Y. Zhai.¹
¹Surgery, David Geffen School of Medicine-University of California-Los Angeles, LA, CA; ²Liver Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China; ³Liver Surgery, Renji Hospital, Shanghai, China.
Background & AimsAlthough glycogen synthase kinase 3 β (Gsk3β) has been found to play key roles in ischemia and reperfusion injuries (IRI) of different organs,…
2016 American Transplant Congress
Heparanase: A New Factor Involved in the Pro-Fibrotic Renal Biological Machinery Activated by the Ischemia/Reperfusion (I/R) Injury.
G. Zaza,¹ V. Masola,¹ G. Gambaro,² M. Onisto,³ G. Bellin,¹ I. Vlodavsky,⁴ Z. Abassi,⁵ A. Lupo.¹
¹Renal Unit, Department of Medicine, University of Verona, Verona, Italy; ²Division of Nephrology and Dialysis, Columbus-Gemelli Hospital Catholic University, Rome, Italy; ³Department of Biomedical Sciences, University of Padova, Padova, Italy; ⁴Cancer and Vascular Biology Research Center, Rappapor Faculty of Medicine, Technion, Haifa, Israel, Italy; ⁵Department of Physiology and Biophysics, Rappaport Faculty of Medicine, Technion, Haifa, Israel, Italy.
Ischemia/reperfusion (I/R) is an important cause of acute renal failure and delayed graft function, and it may induce chronic renal damage by activating epithelial to…
2016 American Transplant Congress
Bioinformatic Analysis of Pathways Mediating Clusterin Functions in Kidney Cells Under Normoxia and Hypoxia.
G. Dairi, Q. Guan, C. Collins, C. Ong, M. Gleave, C. Nguan, C. Du.
Department of Urologic Sciences, University of British Columbia, Vancouver, BC, Canada.
Background: Clusterin (CLU) is a chaperone-like protein and contributes to the resistance of the kidney to ischemia-reperfusion injury (IRI), however its pathways are not fully…
2016 American Transplant Congress
Factors Associated with Prolonged Warm Ischemia Time Among Deceased Donor Kidney Transplant Recipients.
A. Miller,¹ B. Kiberd,¹ I. Alwayn,² S. Kim,³ K. Tennankore.¹
¹Medicine, Division of Nephrology, Dalhousie University, Halifax, NS, Canada; ²Surgery, Multi Organ Transplant Program, Dalhousie University, Halifax, NS, Canada; ³Medicine, Division of Nephrology, University of Toronto, Toronto, ON, Canada.
Prolonged warm ischemia time (the time from organ removal from cold storage to reperfusion with warm blood) is associated with graft failure and mortality among…
2016 American Transplant Congress
Ischemia Reperfusion Induced Murine Heart Transplant Rejection Is Complement Dependent.
N. Chun,¹ M. Zhang,² R. Fairchild,³ P. Heeger.¹
¹Medicine, Icahn School of Medicine at Mount Sinai, NY, NY; ²Anesthesia, SUNY Downstate, NY, NY; ³Immunology, Cleveland Clinic, Cleveland, OH.
Increased posttransplant ischemia reperfusion injury (IRI) prevents costimulatory blockade induced heart graft survival but mechanisms linking innate and adaptive immunity are poorly understood. Based on…
2015 American Transplant Congress
Remote Ischemic Preconditioning Increases Transplantation of Abdominal Organs in Standard Criteria Neurological Death Donors
A. Bongu,¹ W. Washburn,² J. Oliver,¹ J. Nespral,³ A. Davidow,⁴ C. Kadric,³ G. Dikdan,¹ J. Lewis,² U. Pandit,¹ A.-K. Beidas,¹ C. Tourtellot,³ L. Brown,¹ B. Koneru.¹
¹Surgery, Rutgers-New Jersey Medical School, Newark, NJ; ²Surgery, University of Texas Health Science Center, San Antonio, TX; ³Texas Organ Sharing Alliance, San Antonio, TX; ⁴Preventive Medicine, Rutgers-New Jersey Medical School, Newark, NJ.
Background: Remote ischemic preconditioning (RIPC) induces innate protective mechanisms in remote organs. We hypothesized RIPC soon after neurological death (ND) would improve donor organ function…
2015 American Transplant Congress
Losartan Benefits Are Mediated Through SIRT1 Activation in Rat Reduced Size Orthotopic Liver Transplantation
E. Pantazi,¹ M. Bejaoui,¹ M. Zaouali,¹ E. Folch-Puy,¹ A. Rolo,^2,3 A. Panisello,¹ C. Palmeira,² J. Rosello-Catafau.¹
¹Experimental Pathology, Institute of Biomedical Research of Barcelona (IIBB-CSIC), Barcelona, Spain; ²Department of Life Sciences, Faculty of Science and Technology, University of Coimbra, Coimbra, Portugal; ³Center for Neurosciences and Cell Biology, Department of Zoology, University of Coimbra, Coimbra, Portugal.
Background: Silent Information Regulator 1 (SIRT1) is a histone deacetylase that has been associated with protective mechanisms against IRI, but its role in liver transplantation…
2015 American Transplant Congress
The Liver X Receptor Alpha (LXRα) Knockout Protect Liver Against Ischemia-Reperfusin Injury in Mice
T. Lu,¹ D. Li,¹ J. Zhang,¹ M. Zhang,¹ X. Cui,¹ H. Dai,¹ X. Liu,² Q. Xia.¹
¹Liver Surgery and Liver Transplantation Center, Renji Hospital, Shanghai, China; ²Cardiovascular, Shanghai First People's Hospital, Shanghai, China.
Background: Liver X Receptor Alpha (LXRα) is a transcription factor crucial for cholesterol, fatty acid, and glucose homeostasis. We hypothesize that LXRαKO may promote hepatocellular…
2015 American Transplant Congress
Kidney and Liver CIT Variations Across OPOs and Their Implications: US Experience Between 2003 and 2011
J. Melancon, N. Koizumi, C. Callender, D. DasGupta, T. Smith.
Surgery, George Washington University, Washington, DC; Public Policy, George Mason University, Arlington, VA; Surgery, Howard University, Washington, DC; Health Sciences, University of Indianapolis, Indianapolis, IN; School of Engineering, University of Pennsylvania, Philadelphia, PA.
Introduction: Significant variations in kidney and liver transplant outcomes across OPOs have been reported, but their causes remain largely unknown. This study investigated variations in…
2015 American Transplant Congress
A 10 Min “No-Touch” Time – Is It Enough in DCD? A DCD Animal Study
M. Sereinigg,¹ V. Stadlbauer,² T. Seifert-Held,³ F. Iberer,¹ P. Stiegler.¹
¹Department for Transplant Surgery, Medical University Graz, Graz, Austria; ²Department for Gastroenterology and Hepatology, Medical University Graz, Graz, Austria; ³Department for Neurology, Medical University Graz, Graz, Austria.
Introduction: DCD is under investigation due to the lack of human donor organs. Required times of cardiac arrest vary between 75 seconds and 27 min…