Articles tagged "Ischemia"

2016 American Transplant Congress
Anti-Inflammatory Effects of AAV-Mediated TIMP-1 Gene Transfer in Hepatic Ischemia-Reperfusion Injury.
S. Duarte, T. Fujii, G. Lipshutz, R. Busuttil, A. Coito.
The Dumont-UCLA Transplant Center, Los Angeles.
Matrix metalloproteinase-9 (MMP-9) is a key mediator of leukocyte migration across vascular barriers in hepatic ischemia/reperfusion injury (IRI). Tissue inhibitor of metalloproteinase1 (TIMP-1) is the…
2016 American Transplant Congress
The Effects of Brain Death and Ischemia on Tolerance Induction Are Organ-Specific.
S. Michel,^1,2 M. Madariaga,¹ G. LaMuraglia II,¹ R. Colvin,³ E. Farkash,³ J. Allan,^1,4 D. Sachs,¹ K. Yamada,¹ J. Madsen.^1,5
¹Center for Transplantation Sciences, Massachusetts General Hospital and Harvard Medical School, Boston, MA; ²Department of Cardiac Surgery, Ludwig-Maximilians-University, Munich, Germany; ³Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA; ⁴Division of Thoracic Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA; ⁵Division of Cardiac Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA.
Background. We have previously shown that 12 days of high-dose calcineurin inhibition induced tolerance in miniature swine transplanted with MHC mismatched lung or cotransplanted heart…
2016 American Transplant Congress
Hif-1α Stabilization in the Recipient Accelerates Cardiac Allograft Rejection.
Z. Ilyas, M. DeBerge, S. Dehn, J.-J. Wang, Z. Zhang, E. Thorp, M. Ansari.
Northwestern University, Chicago.
Introduction: Increased Hif-1α mRNA expression in deceased-donor organ transplant tissue prior to or soon after transplantation significantly correlated with primary graft dysfunction. HIF-1α is positioned…
2016 American Transplant Congress
Immunosuppressive Actions of CLI95 and CORM401 on TLR4 in Renal Ischemia Reperfusion Injury.
P. Luke,^1,2,5 G. Cepinskas,^1,4 H. Alharbi,^3,5 A. Haig,^3,5 R. Bhattacharjee.^1,2,5
¹Matthew Mailing Centre, London Health Sciences Centre, London, Canada; ²Surgery, Western University, London, Canada; ³Pathology and Laboratory Medicine, Western University, London, Canada.
Background: Kidneys from all donor sources are highly sensitive to ischemia-reperfusion injury (IRI). However, grafts donated after cardiac death (DCD) sustain an increased incidence of…
2016 American Transplant Congress
Anti-LG3 Antibodies Enhance Renal Microvascular Rarefaction, Fibrosis and Dysfunction Associated with Ischemia-Reperfusion Injury.
B. Yang,^1,3 K. Hamelin,^1,3 M. HÉnault-Rondeau,^1,3 N. Patey,^1,2,3 J. Turgeon,^1,3 S. Lan,^1,3 L. Pomerleau,¹ J. Peng,¹ J. Tremblay,¹ M. DieudÉ,^1,3 M.-J. HÉbert,^1,3 H. Cardinal.^1,3
¹Research Centre, Centre Hospitalier de l'Université de Montréal (CRCHUM), Montreal, QC, Canada; ²Department of Pathology, CHU Ste-Justine, Montreal, QC, Canada; ³Canadian National Transplant Research Program, CNTRP, Canada.
Delayed graft function (DGF) is associated with decreased kidney graft survival. We have shown that pre-transplant anti-LG3 autoantibodies were associated with increased risk of DGF…
2016 American Transplant Congress
Probability, Risk Factors, and Long-Term Outcomes of Biliary Complications After Hepatic Artery Thrombosis in Adult Liver Transplant Recipients: 20 Years Experience from a Single Center.
M. Fujiki, K. Hashimoto, T. Diago, C. Quintini, F. Aucejo, D. Kelly, B. Eghtesad, J. Fung, C. Miller.
General Surgery, Cleveland Clinic, Cleveland, OH.
Hepatic artery thrombosis (HAT) after liver transplantation (LT) is a devastating complication associated with ischemic biliary cholangiopathy (IBC) that can occur even after successful revascularization.…
2016 American Transplant Congress
Metabolic Dysregulation and Mitochondrial Dysfunction Are Key Features of Injury Profiles of Donor Kidneys After Brain Death.
M. Lo Faro,¹ M. Akhtar,¹ H. Huang,¹ M. Kaisar,¹ R. Robolledo,² K. Morten,¹ L. Heather,¹ A. Dona,³ H. Leuvenink,² S. Fuggle,¹ B. Kessler,¹ C. Pugh,¹ R. Ploeg.¹
¹University of Oxford, Oxford, United Kingdom; ²University of Groningen, Groningen, Netherlands; ³University of Sydney, Sydney, Australia.
Donation after brain death (DBD) organ donors remain an important source for kidney transplantation. However, brain death affects donor organs rendering them susceptible to ischemia…
2016 American Transplant Congress
Attenuation of Warm Hepatic Ischemia-Reperfusion Injury by Bruton's Tyrosine Kinase Inhibition.
A. Zarrinpar,¹ T. Palumbo,¹ K. Nakamura,¹ C. Lassman,² R. Busuttil,¹ J. Kupiec-Weglinski.¹
¹Surgery, Dumont-UCLA Translant Center, Los Angeles, CA; ²Pathology, UCLA, Los Angeles, CA.
Bruton's tyrosine kinase (Btk) is a central player in multiple signaling pathways in lymphoid and myeloid cells, including neutrophils. Neutrophils are crucial effectors in the…
2016 American Transplant Congress
Hypothermic Machine Perfusion Is Also Beneficial for Deceased Donor Kidneys When Cold Ischemic Time Is Short and a Short Cold Ischemic Time Is Also Beneficial When Kidneys Are Machine Perfused.
J. Kox,¹ C. Moers,² D. Monbaliu,³ A. Strelniece,⁴ J.-W. Treckmann,⁵ I. Jochmans,³ H. Leuvenink,² L. van Heurn,¹ J. Pirenne,³ A. Paul,⁵ R. Ploeg.^2,6
¹Dept. of Surgery, Maastricht University Medical Center, Maastricht, Netherlands; ²Dept. of Surgery, University Medical Center Groningen, Groningen, Netherlands; ³Abdominal Transplant Surgery, University Hospital Leuven, Leuven, Belgium; ⁴Eurotransplant, Leiden, Netherlands; ⁵General, Visceral and Transplantation Surgery, University Hospital Essen, Essen, Germany; ⁶Oxford Transplant Centre, Oxford, United Kingdom.
IntroductionHypothermic machine perfusion (HMP) of deceased donor kidneys is associated with better outcome compared to static cold storage (SCS). It is generally assumed that HMP…
2016 American Transplant Congress
Liver Ischemia Induces Kupffer Cell Necroptosis to Facilitate Liver Inflammatory Immune Activation.
S. Yue,¹ H. Zhou,^1,2 R. Busuttil,¹ J. Kupiec-Weglinski,¹ X. Wang,² Y. Zhai.¹
¹Surgery, David Geffen School of Medicine-University of California-Los Angeles, Los Angeles, CA; ²Liver Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China.
Background & AimsAlthough mechanisms of liver immune activation against ischemia reperfusion injury (IRI) have been studied extensively, cellular bases have yet to be fully defined…