Articles tagged "Ischemia"

2016 American Transplant Congress
DNA Methylation Patterns and Association with Graft Injury Severity Post Liver Transplantation.
R. Gehrau, S. Bontha, V. Mas, D. Maluf.
UVA, Charlottesville.
Background: Epigenetics modifications in the graft may influence injury severity and function post liver transplantation (LT). This study aimed to interrogate the effect of different…
2016 American Transplant Congress
The mTORC2 Activation Is Critical for Hepato-Cytoprotection Against Ischemia and Reperfusion Injury.
H. Zhou,^1,2 J. Zhu,^1,3 S. Yue,¹ R. Busuttil,¹ J. Kupiec-Weglinski,¹ X. Wang,² Y. Zhai.¹
¹Surgery, David Geffen School of Medicine-University of California-Los Angeles, LA, CA; ²Liver Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China; ³Liver Surgery, Renji Hospital, Shanghai, China.
Background & AimsRapamycin and Everolimus have been used in liver transplant patients, particularly those with calcineurin inhibitor-related nephrotoxicity and hepatocellular carcinoma. Although designed as mTORC1…
2016 American Transplant Congress
Activating Transcription Factor 5 (ATF5) Regulates Liver Ischemia/Reperfusion Injury.
G.-Q. Shen,² M. Morita,¹ J. Fung,² L. Lu,^1,2 S. Qian.^1,2
¹Immunology, LernerResearch Institute, Cleveland Clinic, Cleveland, OH; ²General Surgery, Transplant Center, Digestive Disease Institute, Cleveland Clinic, Cleveland, OH.
Activating transcription factor 5 (ATF5), a member of the ATF/cAMP response element-binding proteins, is extremely highly expressed in the liver, the significance of which is…
2016 American Transplant Congress
Fractional Excretion of NGAL Instead of ^99mTcMAG₃Renography to Monitor Resolution of Delayed Graft Function.
J. Bank, M. Reinders, L. Noordermeer, M. Mallat, S. van der Kooij, C. van Kooten, J. de Fijter.
Nephrology, Leiden University Medical Center, Leiden, Netherlands.
Introduction: Kidneys transplanted from extended criteria donors have a higher prevalence of delayed graft function (DGF). Early identification of factors that prolong duration of DGF…
2016 American Transplant Congress
Gsk3β Regulates Macrophage Pro-Inflammatory Immune Activation via AMPK-Mediated Induction of Small Heterodimer Partner (SHP).
H. Zhou,^1,2 J. Zhu,^1,3 S. Yue,¹ R. Busuttil,¹ J. Kupiec-Weglinski,¹ X. Wang,² Y. Zhai.¹
¹Surgery, David Geffen School of Medicine-University of California-Los Angeles, LA, CA; ²Liver Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China; ³Liver Surgery, Renji Hospital, Shanghai, China.
Background & AimsAlthough glycogen synthase kinase 3 β (Gsk3β) has been found to play key roles in ischemia and reperfusion injuries (IRI) of different organs,…
2016 American Transplant Congress
Heparanase: A New Factor Involved in the Pro-Fibrotic Renal Biological Machinery Activated by the Ischemia/Reperfusion (I/R) Injury.
G. Zaza,¹ V. Masola,¹ G. Gambaro,² M. Onisto,³ G. Bellin,¹ I. Vlodavsky,⁴ Z. Abassi,⁵ A. Lupo.¹
¹Renal Unit, Department of Medicine, University of Verona, Verona, Italy; ²Division of Nephrology and Dialysis, Columbus-Gemelli Hospital Catholic University, Rome, Italy; ³Department of Biomedical Sciences, University of Padova, Padova, Italy; ⁴Cancer and Vascular Biology Research Center, Rappapor Faculty of Medicine, Technion, Haifa, Israel, Italy; ⁵Department of Physiology and Biophysics, Rappaport Faculty of Medicine, Technion, Haifa, Israel, Italy.
Ischemia/reperfusion (I/R) is an important cause of acute renal failure and delayed graft function, and it may induce chronic renal damage by activating epithelial to…
2016 American Transplant Congress
Bioinformatic Analysis of Pathways Mediating Clusterin Functions in Kidney Cells Under Normoxia and Hypoxia.
G. Dairi, Q. Guan, C. Collins, C. Ong, M. Gleave, C. Nguan, C. Du.
Department of Urologic Sciences, University of British Columbia, Vancouver, BC, Canada.
Background: Clusterin (CLU) is a chaperone-like protein and contributes to the resistance of the kidney to ischemia-reperfusion injury (IRI), however its pathways are not fully…
2016 American Transplant Congress
Factors Associated with Prolonged Warm Ischemia Time Among Deceased Donor Kidney Transplant Recipients.
A. Miller,¹ B. Kiberd,¹ I. Alwayn,² S. Kim,³ K. Tennankore.¹
¹Medicine, Division of Nephrology, Dalhousie University, Halifax, NS, Canada; ²Surgery, Multi Organ Transplant Program, Dalhousie University, Halifax, NS, Canada; ³Medicine, Division of Nephrology, University of Toronto, Toronto, ON, Canada.
Prolonged warm ischemia time (the time from organ removal from cold storage to reperfusion with warm blood) is associated with graft failure and mortality among…
2016 American Transplant Congress
Ischemia Reperfusion Induced Murine Heart Transplant Rejection Is Complement Dependent.
N. Chun,¹ M. Zhang,² R. Fairchild,³ P. Heeger.¹
¹Medicine, Icahn School of Medicine at Mount Sinai, NY, NY; ²Anesthesia, SUNY Downstate, NY, NY; ³Immunology, Cleveland Clinic, Cleveland, OH.
Increased posttransplant ischemia reperfusion injury (IRI) prevents costimulatory blockade induced heart graft survival but mechanisms linking innate and adaptive immunity are poorly understood. Based on…
2016 American Transplant Congress
ASC-Deficient Dendritic Cells Exhibit Activation Defects and a Reduced Ability to Stimulate Allogeneic T Cells.
A. Scheinok, A. Shigeoka, S. Kasimsetty, R. Elahimehr, D. McKay.
Medicine, University of California-San Diego, La Jolla, CA.
Donor dendritic cell (DC) activation causes adaptive immune responses that lead to rejection of transplanted allografts. Accumulating data suggest that inflammasome assembly within interstitial DCs…