2016 American Transplant Congress
Serelaxin Decreases the Severity of Cold Ischemia-Reperfusion Injury After Liver Transplantation in Mice.
The Dumont-UCLA Transplantation Center, UCLA, Los Angeles, CA.
Background. Extended cold preservation contributes to ischemia-reperfusion injury (IRI), which impairs graft function and leads to poor clinical outcomes. Serelaxin (SER), a recombinant form of…2016 American Transplant Congress
Multiplex Profiling of Plasma Proteins After Xenogenic Lung Exposure.
Background: Porcine lungs exhibit injury by human blood and are only partially protected in GalTKO organs with additional human membrane cofactor protein (hCD46). Residual injury…2016 American Transplant Congress
Allograft TLR4 Receptor Signaling Induces Specific Early Inflammatory Events in Promotes Allografts Subjected to Prolonged Cold Ischemic Storage.
Dept. Immunology and Glickman Urological Institute, Cleveland Clinic, Cleveland, OH.
Engagement of Toll-like receptors (TLR) by endogenous danger-associated molecular pattern ligands contributes to the intensity of tissue inflammation, including the inflammation generated during ischemia-reperfusion injury…2016 American Transplant Congress
Outcomes of Liver Grafts from Donors with Very High Transaminases.
Department of Surgery, Transplant Division, University of Massachusetts, Worcester, MA.
Introduction: Traditionally, elevation of transaminases has been broadly used as markers of hepatic ischemic injury and crucial parameters for liver graft assessment. We wanted to…2016 American Transplant Congress
Strategies to Prevent Ischemic Cholangiopathy After Donation After Circulatory Death Donor Liver Transplantation.
Background: Donation after circulatory death (DCD) donor pool remains underutilized for liver transplantation (LT). We describe optimizing the “modifiable risk factors”, such as CIT, recipient…2016 American Transplant Congress
Distinctive Roles of Gsk3 Inhibitory Phosphorylation in Liver Inflammatory Immune Response and Hepatocellular Injury Against Ischemia Reperfusion.
Background & AimsGlycogen synthase kinase 3 (Gsk3) a and b are ubiquitously expressed, constitutively active serine/threonine kinases, which play complex roles in cell activation, proliferation…2016 American Transplant Congress
Normothermic Ex-Vivo Perfusion of the Intestine: The Introduction of an Innovative Physiologic Model with Novel Biomarkers.
General Surgery, Transplant Center, Cleveland Clinic Foundation, Cleveland, OH.
Purpose: Ischemia reperfusion injury is a major risk factor for short and long-term functional survival after intestinal transplantation. Normothermic machine perfusion is an emerging biotechnology…2016 American Transplant Congress
Matrix Metalloproteinase-2 (MMP-2) Activity Protects Against Hepatic Ischemia Reperfusion Injury Through MMP-9-Dependent and MMP-9-Independent Mechanisms.
The Dumont-UCLA Transplant Center, Los Angeles.
Matrix Metalloproteinases (MMPs) are a family of proteinases with key roles in tissue homeostasis, inflammation and repair. We have recently shown that MMP-9 and MMP-2,…2016 American Transplant Congress
Short-Term Starvation Attenuates Liver Ischemia Reperfusion Injury by SIRT1-Autophagy Signaling in Mice.
Calorie restriction or starvation (fasting) has some beneficial effects on prolongation of life and increased resistance to stress. Calorie restriction has also been shown to…2016 American Transplant Congress
The First Impressions: A Study in Pre and Post-Implantation Renal Grafts for Early Detection Markers of Delayed Graft Function and Recovery.
1UVA, Charlottesville; 2VCU, Charlottesville; 3Northwestern University, Chicago.
Background: Delayed graft function (DGF) is mainly a consequence of ischemia and reperfusion injury (IRI) resulting in acute tubular necrosis. The degree of IRI is…
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