Articles tagged "Ischemia"

2016 American Transplant Congress
Hydrogen Sulfide Supplementation Helps Mitigate Effects of Ischemia Reperfusion Injury in a Murine Model of Donation After Cardiac Death Renal Transplantation.
J. Grewal,¹ I. Lobb,¹ M. Saha,² J. Jiang,² A. Haig,¹ A. Sener.^1,2
¹Microbiology & Immunology, University of Western Ontario, London, Canada; ²Matthew Mailing Centre for Translational Transplant Studies, London Health Sciences Centre, London, Canada.
Donation after cardiac death(DCD) renal grafts experience a combination of prolonged warm and cold ischemia leading to greater ischemia reperfusion injury(IRI) that results in higher…
2016 American Transplant Congress
SLPI in the Perfusion Liquid: A Predictor Marker of Short and Long Term Clinical Outcomes.
A. Dotta,¹ F. Caro,² K. Peña Ponce,¹ N. Ambrosi,² J. Salaberry,² X. García,¹ E. Minué,¹ L. León,¹ F. Sánchez,² F. Togniolo,¹ C. Incardona,³ E. Chuluyan,² D. Casadei.¹
¹Instituto de Nefrología, Caba, Argentina; ²CEFYBO-UBA, Caba, Argentina; ³Fundación GADOR, Caba, Argentina.
A lot of efforts have been done to identify the risk factors that tend to diminish the incidence of delayed graft function (DGF). Recently, the…
2016 American Transplant Congress
Recombinant TSGL-Ig Protects Liver Endothelial Cells Against Prolonged Cold Preservation Injury in Mouse Liver Transplantation.
C. Zhang,^1,2 H. Ji,¹ Y. Liu,^1,2 Y. Zhang,^1,2 X.-D. Shen,¹ F. Gao,¹ R. Busuttil, G. Shaw, J. Kupiec-Weglinski.
¹Dumont-UCLA Transplant Center, Division of Liver and Pancreas Transplantation, Department of Surgery, David Geffen School of Medicine at University of California-Los Angeles, Los Angeles, CA; ²Department of Surgery, Division of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
Background: Liver endothelial cells (LEC) suffer from ROS-mediated stress in the pathogenesis of liver ischemia-reperfusion injury (IRI). We used a novel recombinant form of soluble…
2016 American Transplant Congress
Markers of Activation of Microvascular Endothelial Cells Predict a Poor Long-Term Graft Outcome in Early Renal Graft Biopsies Displaying Acute Tubular Necrosis.
Y.-C. Dubois-Xu,¹ P. Ahmadpoor,¹ A. Corchia,¹ D. Buob,² P. Galichon,¹ I. Brochériou,¹ C. Suberbielle,³ A. Hertig,¹ E. Rondeau.¹
¹INSERM UMR_S1155, INSERM, Paris, France; ²Pathology, APHP, Hoptal Tenon, Paris, France; ³HLA Institute, INSERM_S940, Paris, France.
Acute tubular necrosis (ATN), is a histopathological feature frequently seen in the early post renal transplant biopsies taken from patients with delayed graft function (DGF).…
2016 American Transplant Congress
Defective Post-Reperfusion Metabolic Recovery Directly Associates with Incident Delayed Graft Function.
L. Wijermars, A. Schaapherder, J. Lindeman.
Department of Surgery, Leiden University Medical Center, Leiden, Netherlands.
Delayed graft function (DGF) following kidney transplantation detrimentally affects long-term graft function and survival. DGF is a manifestation of ischemia reperfusion (I/R) injury, yet up…
2016 American Transplant Congress
Tissue Inhibitor of Metalloproteinase-3 (TIMP-3) Protects Against Loss of Hepatic Integrity After Ischemia-Reperfusion Injury.
T. Fujii, S. Duarte, R. Busuttil, A. Coito.
Surgery, The Dumont-UCLA Transplant Center, Los Angeles, CA.
Liver ischemia-reperfusion injury (IRI) remains a challenging problem in clinical orthotopic liver transplantation (OLT). Tissue inhibitor of metalloproteinases-3 (TIMP-3) is an extracellular matrix (ECM)-associated protein…
2016 American Transplant Congress
Influence of Cold Ischemia Time in Kidney Transplants from Small Pediatric Donors.
L. Kayler,¹ M. Lubetzky,² P. Friedman.³
¹Erie County Medical Center, Buffalo; ²Montefiore Medical Center, Bronx; ³Montefiore Medical Center, Bronx.
Clinicians may be reluctant to transplant small pediatric kidneys that also have prolonged cold ischemia time (CIT) for fear of an additional deleterious effect since…
2016 American Transplant Congress
Matrix Metalloproteinase-9 in Human Orthotopic Liver Transplant Biopsies.
S. Duarte, N. Datta, J. Baber, R. Busuttil, A. Zarrinpar, A. Coito.
The Dumont-UCLA Transplant Center, Los Angeles.
Liver ischemia reperfusion injury (IRI) is an inflammatory event that contributes to graft dysfunction in orthotopic liver transplantation (OLT). Matrix Metalloproteinases (MMPs) are responsible for…
2016 American Transplant Congress
Ex-Vivo Normothermic Perfusion (EVNP) Attenuation of Kidney Ischemia-Reperfusion Injury (IRI): A Proposed Mechanism.
I. Palma,¹ S. Kabagambe,¹ Y. Smolin,¹ T. Boyer,¹ I. Palma,¹ O. Fiehn,² Y.-J. Chen,¹ J. Sageshima,¹ C. Santhanakrishnan,¹ C. Troppmann,¹ R. Perez.¹
¹Department of Surgery, University of California, Davis Medical Center, Sacramento, CA; ²Department of Molecular and Cellular Biology & Genome Center, University of California-Davis, Davis, CA.
Introduction: EVNP has the potential to repair deceased donor renal IRI. We hypothesize that EVNP may attenuate renal IRI via alteration of lipid metabolism.Methods: Eight…
2016 American Transplant Congress
The Impact of Total Ischaemic Time, Donor Age and the Pathway of Donor Death on Graft Outcomes After Deceased Donor Kidney Transplantation.
G. Wong,¹ A. Teixeira-Pinto,¹ C. Jeremy,¹ C. Jonathan,¹ M. Stephen,² L. Wai.³
¹University of Sydney, Sydney, Australia; ²University of Adelaide, Adelaide, Australia; ³University of Western Sydney, Perth, Australia.
Prolonged ischaemia is a known risk factor for delayed graft function and its interaction with donor characteristics, the pathways of donor death and graft outcomes…