Articles tagged "Ischemia"

2017 American Transplant Congress
The Use of a Furosemide Stress Test (FST) for Assessment of Discarded Deceased Donor Kidneys in an Ex-Vivo Normothermic Perfusion Model.
I. Palma, Y. Smolin, S. Kabagambe, A. Perry, I. Palma, J. Sageshima, R. Perez.
Department of Surgery, UC Davis Medical Center, Sacramento, CA
Studies have shown that Ex-Vivo Normothermic Perfusion (EVNP) has the potential to assess viability and function of high-risk deceased donor kidneys. A diuretic response to…
2017 American Transplant Congress
Effects of the Gut-Liver Axis on Ischemia-Mediated Hepatocellular Carcinoma Recurrence in the Mouse Liver.
L. Orci,¹ S. Lacotte,¹ V. Delaune,¹ G. Oldani,¹ F. Slits,¹ C. Rossetti,² L. Rubbia-Brandt,³ P. Morel,¹ C. Toso.¹
¹Hepato-pancreato-biliary Centre, Department of Surgery, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland; ²Dipartimento di Biotecnologie e Scienze della Vita, Università degli Studi dell'Insubria, Varese, Italy; ³Division of Clinical Pathology, Department of Pathology and Immunology, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland
Background: There is growing evidence that liver graft ischemia-reperfusion (I/R) is a risk factor for hepatocellular carcinoma (HCC) recurrence after liver transplantation, but the involved…
2017 American Transplant Congress
The Polymer Pro-Drug APP-103 Mitigates I/R Injury and Improves Graft Function in a Pre-Clinical Renal Transplant Model.
K. Minami,^1,3 H. Uehara,¹ A. Elkhal,¹ S. Bae,³ J. Reder,² B. Houser,² P. Kang,³ S. Tullius.¹
¹Transplant Surgery Division, Brigham and Women's Hospital, Boston, MA; ²Celdara Medical, LLC, Lebanon, NH; ³Beth Israel Deaconess Medical Center, Boston, MA
Purpose: Ischemia-reperfusion injury (IRI) is the strongest non-HLA factor that augments allogenicity of transplanted organs. Damage subsequent to IRI is critically linked to an abundance…
2017 American Transplant Congress
Kidney Injury Molecule-1 Mitigates Tissue Damage from Transplant Renal Ischemia Reperfusion Injury.
J. Lee,^1,2 X. Zhang,² A. Haig,³ D. Lian,² P. Anderson,² R. Navaratnam,² L. Gunaratnam.^1,2
¹Department of Microbiology and Immunology, Western University, London, ON, Canada; ²Matthew Mailing Centre for Translational Transplant Studies, London Health Sciences Centre, London, ON, Canada; ³Department of Pathology, Western University, London, ON, Canada
Ischemia reperfusion injury (IRI) at the time of organ harvesting is unavoidable, may cause delayed renal graft function, and is associated with premature graft loss.…
2017 American Transplant Congress
Direct Intrahepatic Delivery of Pegylated-Catalase Is Protective in a Rat Ischemia-Reperfusion Injury Model.
E. Beal,¹ S. Black,¹ J. Kim,¹ V. Velazquez,² K. Washburn,¹ D. Hayes Jr.,³ B. Whitson.¹
¹Department of Surgery, Division of Transplant, The Ohio State University Wexner Medical Center, Columbus, OH; ²Center for Vaccines and Immunity, The Research Institute at Nationwide Childrens Hospital, Columbus, OH; ³Departments of Pediatrics and Internal Medicine, The Ohio State University College of Medicine, Columbus, OH
Introduction: Ischemia-reperfusion injury (IRI) is characterized by cessation of blood flow to an organ or tissue leading to accumulation of toxic metabolites and free radicals,…
2017 American Transplant Congress
DNA Hypermethylation Caused by Ischemia in Kidney Transplants Predicts Future Chronic Injury to the Allograft.
L. Heylen,^1,2,3,4 B. Thienpont,^3,4 M. Naesens,^1,2 J. Depreeuw,^3,4 P. Busschaert,^3,4 D. Kuypers,^1,2 I. Jochmans,^2,5 D. Monbaliu,^2,5 J. Pirenne,^2,5 D. Lambrechts,^3,4 B. Sprangers.^1,2
¹Nephrology, University Hospitals Leuven, Leuven, Belgium; ²Microbiology and Immunology, KU Leuven, Leuven, Belgium; ³Oncology, KU Leuven, Leuven, Belgium; ⁴VIB, Leuven, Belgium; ⁵Abdominal Transplant Surgery, University Hospitals Leuven, Leuven, Belgium
Study Purpose: DNA demethylation results from hydroxymethylation and is inhibited by hypoxia. We investigated whether ischemia during kidney transplantation induces DNA methylation changes of the…
2017 American Transplant Congress
PPAR-γ Agonist Attenuates Hepatic Ischemia-Reperfusion Injury in a Mouse Model by Regulating Kupffer Cell Polarization.
I. Linares, K. Farrokhi, J. Echeverri, M. Kaths, D. Kollman, M. Hamar, P. Urbanellis, S. Ganesh, O. Adeyi, P. Yip, N. Selzner, M. Selzner.
Multi-Organ Transplant Program, Toronto General Hospital, University Health Network, Toronto, ON, Canada
PPAR-γ agonists have shown protective effect on ischemia-reperfusion injury (IRI) in cerebral and renal tissue. The effects of PPAR-γ on hepatic IRI is unclear. We…
2017 American Transplant Congress
Risk of Ischemic Biliary Injury Is Not Associated with Prolonged Hepatic Artery Ischemic Times During Liver Transplantation.
E. Armenia,¹ N. Schomaker,¹ A. Kalra,¹ J. Gralla,¹ A. Truesdale,¹ S. Biggins,² T. Nydam,¹ J. Burton.¹
¹Univ. Colorado, Aurora, CO; ²Univ. Washington, Seattle, WA
Biliary strictures after liver transplant (LT) are associated with increased patient morbidity and graft failure. AIM: To assess the association of duration of hepatic artery…
2017 American Transplant Congress
A Promising MyD88 Inhibitor TJ-M2010-2 Protects Heart from Myocardial Ischemia Reperfusion Injury.
Y. Miao, L. Xie, X. Zhang, Z.-C. Ding, M. Yang, Y. Yang, P. Zhou.
Institute of Qrgan Transplantation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology; Key Labrory of Organ Transplantation, Wuhan, Hubei, China
BACKGROUND: The activation of innate immunity via myeloid differentiation factor 88 (MyD88) contributes to myocardial ischemia reperfusion injury (IRI). This study is to investigate the…
2017 American Transplant Congress
TIMP-3 Plays a Key Regulatory Role in the Cleavage of E-Cadherin and Has an Essential Protective Function in Hepatic IRI.
T. Fujii, S. Duarte, R. Busuttil, A. Coito.
Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA
Liver ischemia-reperfusion injury (IRI) remains a challenging problem in clinical orthotopic liver transplantation. Tissue inhibitor of metalloproteinases-3 (TIMP-3), an extracellular matrix-associated protein, has been linked…