ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Ischemia"

  • 2017 American Transplant Congress

    The mTOR Signal Regulates Myeloid Derived Suppressor Cells Differentiation and Immunosuppressive Function in Acute Kidney Injury.

    C. Yang, C. Zhang, R. Rong, T. Zhu.

    Urology, Zhongshan Hospital, Fudan University, Shanghai, China

    The mammalian target of rapamycin (mTOR) is a serine–threonine kinase that senses various environmental stimuli. The mTOR signal controls innate and adaptive immune response in…
  • 2017 American Transplant Congress

    Effect of Bone Marrow Derived Mesenchymal Stem Cells on Renal Ischemia-Reperfusion Injury in Rabbit.

    J. Jang, H. Ri, I. Hong.

    Agriculture & Life Science, Pyongyang University of Science & Technology, Pyongyang, Democratic Peoples Republic of Korea

    Background: We succeeded to set up a rabbit model of Ischemia-Reperfusion (I/R) injury to test future candidate substance or plant extract that may have anti-oxidant…
  • 2017 American Transplant Congress

    Life Confocal Imaging of Murine Liver Biopsies as Novel Tool to Assess Graft Viability Prior to Transplantation.

    R. Oberhuber, M. Fodor, B. Cardini, M. Maglione, M. Hermann, J. Troppmaier.

    Visceral, Transplant and Thoracic Surgery, Medical University Innsbruck, Innsbruck, Austria

    Prolonged ischemia time due to organ procurement and transport are main contributors to a decrease in organ quality, which is further enhanced during reperfusion. This…
  • 2017 American Transplant Congress

    Accumulating Mitochondrial DNA in Aging Augments Inflammatory Responses Subsequent to IRI.

    M. Seyda,1,2 M. Quante,1 T. Heinbokel,1 G. Liu,1 H. Uehara,1 J. Schuitenmaker,1 R. Abdi,3 C. Falk,2 A. Elkhal,1 S. Tullius.1

    1Division of Transplant Surgery and Transplant Surgery Research Laboratory, Brigham and Women's Hospital/Harvard Medical School, Boston; 2Institute of Transplant Immunology, Hannover Medical School, Hannover, Germany; 3Renal Division, Schuster Family Transplant Center, Brigham and Women's Hospital, Boston

    Background: Older donor organs are increasingly utilized to close the gap between demand and supply. We submit that aging-associated kinetics of damage associated molecular patterns…
  • 2017 American Transplant Congress

    A Study on Gene Expression of the Protective Effect of Nitric Oxide Releasing Nanofiber in Rat Renal Ischemia-Reperfusion Injury.

    H. Ahn,1 S. Joo,1 H. Ko,1 K. Jung,1 J. Shin.2

    1Kyung Hee University, Seoul, Korea; 2Kwanwoon University, Seoul, Korea

    Objective: Renal ischemia-reperfusion injury (IRI) is very important issue in kidney transplantation. Nitric oxide (NO) was well known to be a protector of IRI. The…
  • 2017 American Transplant Congress

    Protective Effect of New Delivery System of Nitric Oxide Releasing Nanofiber in Rat Model of Renal Ischemia-Reperfusion Injury.

    J. Kim,1 H. Ahn,2 D. Kim,1 S. Jung,1 E. Park,1 T. Lee,1 C. Ihm,1 S. Lee,1 J. Moon,1 Y. Kim,1 K. Jeong.1

    1Nephrology, Kyung Hee University Medical Center, Seoul, Korea; 2Surgery, Kyung Hee University Medical Center, Seoul, Korea

    Objective: Renal ischemia-reperfusion injury (IRI) is very important in various clinical setting including kidney transplantation. Nitric oxide (NO) is well known for having various protective…
  • 2017 American Transplant Congress

    CD4 T Cell Depletion Mitigates Ischemic Hepatocellular Damage and Promotes Immune Regulation in Mouse Liver Allografts.

    S. Kageyama, K. Nakamura, R. Busuttil, J. Kupiec-Weglinski, Y. Zhai.

    The Dumont-UCLA Transplant Center, Department of Surgery, David Geffen School of Medicine at University of California, Los Angeles, CA

    Background: Extended cold preservation contributes to organ ischemia-reperfusion injury (IRI), which stimulates host allo-reactivity, leading to inferior clinical outcomes. We have shown that CD4+ T…
  • 2017 American Transplant Congress

    Donor Genetic Background Determines the Severity of Delayed Graft Function Following Kidney Transplantation in Mice.

    L. Qiu, J.-J. Wang, X. Yeap, Z. Zheng, M. He, M. Abecassis, Z. Zhang.

    Comprehensive Transplant Center, Department of Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL

    Background: Delayed graft function (DGF) has been associated with poor clinical transplant outcomes. Current mouse models of kidney transplant or acute kidney injury induced by…
  • 2017 American Transplant Congress

    Lipid Catabolism Provides Alternative Energy Source and Compensates for Mitochondrial Dysfunction in Reperfused Rat Kidneys After Ischaemia.

    H. Huang,1,2 L. van Dullemen,3 M. Akhtar,1 M. Lo Faro,1,2 A. Dona,4 M. Kaisar,1,2 H. Leuvenink,3 B. Kessler,2 R. Ploeg.1

    1Oxford Transplant Centre, NDS, University of Oxford, Oxford, United Kingdom; 2Target Discovery Institute, NDM, University of Oxford, Oxford, United Kingdom; 3Department of Surgery, University Medical Center Groningen, Groningen, Netherlands; 4Department of Surgery and Cancer, Imperial College London, London, United Kingdom

    Introduction: To reduce morbidity and mortality on the wait list for kidney transplantation, centres are required to use older and higher risk organs including unstable…
  • 2017 American Transplant Congress

    Twelve Hour Ex Vivo Normothermic Perfusion for the Assessment of High-Risk Discarded Deceased Donor Kidneys.

    I. Palma, I. Palma, Y. Smolin, S. Kabagambe, A. Perry, J. Sageshima, R. Perez.

    Department of Surgery, UC Davis Medical Center, Sacramento, CA

    Ex-Vivo Normothermic Perfusion (EVNP) has been shown to be useful to assess viability of high-risk deceased donor kidneys, with high renal blood flow and immediate…
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