Articles tagged "Ischemia"

2017 American Transplant Congress
Life Confocal Imaging of Murine Liver Biopsies as Novel Tool to Assess Graft Viability Prior to Transplantation.
R. Oberhuber, M. Fodor, B. Cardini, M. Maglione, M. Hermann, J. Troppmaier.
Visceral, Transplant and Thoracic Surgery, Medical University Innsbruck, Innsbruck, Austria
Prolonged ischemia time due to organ procurement and transport are main contributors to a decrease in organ quality, which is further enhanced during reperfusion. This…
2017 American Transplant Congress
Accumulating Mitochondrial DNA in Aging Augments Inflammatory Responses Subsequent to IRI.
M. Seyda,^1,2 M. Quante,¹ T. Heinbokel,¹ G. Liu,¹ H. Uehara,¹ J. Schuitenmaker,¹ R. Abdi,³ C. Falk,² A. Elkhal,¹ S. Tullius.¹
¹Division of Transplant Surgery and Transplant Surgery Research Laboratory, Brigham and Women's Hospital/Harvard Medical School, Boston; ²Institute of Transplant Immunology, Hannover Medical School, Hannover, Germany; ³Renal Division, Schuster Family Transplant Center, Brigham and Women's Hospital, Boston
Background: Older donor organs are increasingly utilized to close the gap between demand and supply. We submit that aging-associated kinetics of damage associated molecular patterns…
2017 American Transplant Congress
A Study on Gene Expression of the Protective Effect of Nitric Oxide Releasing Nanofiber in Rat Renal Ischemia-Reperfusion Injury.
H. Ahn,¹ S. Joo,¹ H. Ko,¹ K. Jung,¹ J. Shin.²
¹Kyung Hee University, Seoul, Korea; ²Kwanwoon University, Seoul, Korea
Objective: Renal ischemia-reperfusion injury (IRI) is very important issue in kidney transplantation. Nitric oxide (NO) was well known to be a protector of IRI. The…
2017 American Transplant Congress
Protective Effect of New Delivery System of Nitric Oxide Releasing Nanofiber in Rat Model of Renal Ischemia-Reperfusion Injury.
J. Kim,¹ H. Ahn,² D. Kim,¹ S. Jung,¹ E. Park,¹ T. Lee,¹ C. Ihm,¹ S. Lee,¹ J. Moon,¹ Y. Kim,¹ K. Jeong.¹
¹Nephrology, Kyung Hee University Medical Center, Seoul, Korea; ²Surgery, Kyung Hee University Medical Center, Seoul, Korea
Objective: Renal ischemia-reperfusion injury (IRI) is very important in various clinical setting including kidney transplantation. Nitric oxide (NO) is well known for having various protective…
2017 American Transplant Congress
CD4 T Cell Depletion Mitigates Ischemic Hepatocellular Damage and Promotes Immune Regulation in Mouse Liver Allografts.
S. Kageyama, K. Nakamura, R. Busuttil, J. Kupiec-Weglinski, Y. Zhai.
The Dumont-UCLA Transplant Center, Department of Surgery, David Geffen School of Medicine at University of California, Los Angeles, CA
Background: Extended cold preservation contributes to organ ischemia-reperfusion injury (IRI), which stimulates host allo-reactivity, leading to inferior clinical outcomes. We have shown that CD4+ T…
2017 American Transplant Congress
Donor Genetic Background Determines the Severity of Delayed Graft Function Following Kidney Transplantation in Mice.
L. Qiu, J.-J. Wang, X. Yeap, Z. Zheng, M. He, M. Abecassis, Z. Zhang.
Comprehensive Transplant Center, Department of Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL
Background: Delayed graft function (DGF) has been associated with poor clinical transplant outcomes. Current mouse models of kidney transplant or acute kidney injury induced by…
2017 American Transplant Congress
Lipid Catabolism Provides Alternative Energy Source and Compensates for Mitochondrial Dysfunction in Reperfused Rat Kidneys After Ischaemia.
H. Huang,^1,2 L. van Dullemen,³ M. Akhtar,¹ M. Lo Faro,^1,2 A. Dona,⁴ M. Kaisar,^1,2 H. Leuvenink,³ B. Kessler,² R. Ploeg.¹
¹Oxford Transplant Centre, NDS, University of Oxford, Oxford, United Kingdom; ²Target Discovery Institute, NDM, University of Oxford, Oxford, United Kingdom; ³Department of Surgery, University Medical Center Groningen, Groningen, Netherlands; ⁴Department of Surgery and Cancer, Imperial College London, London, United Kingdom
Introduction: To reduce morbidity and mortality on the wait list for kidney transplantation, centres are required to use older and higher risk organs including unstable…
2017 American Transplant Congress
Twelve Hour Ex Vivo Normothermic Perfusion for the Assessment of High-Risk Discarded Deceased Donor Kidneys.
I. Palma, I. Palma, Y. Smolin, S. Kabagambe, A. Perry, J. Sageshima, R. Perez.
Department of Surgery, UC Davis Medical Center, Sacramento, CA
Ex-Vivo Normothermic Perfusion (EVNP) has been shown to be useful to assess viability of high-risk deceased donor kidneys, with high renal blood flow and immediate…
2017 American Transplant Congress
AAV8 Delivery of TIMP-1 Prevents Hepatocyte Apoptosis After Liver Ischemia/Reperfusion Injury.
S. Duarte, P. Matian, M. Miller, R. Busuttil, A. Coito.
Dumont-UCLA Transplant Center, Los Angeles
Matrix metalloproteinase-9 (MMP-9) is a key mediator of leukocyte migration across vascular barriers in hepatic ischemia/reperfusion injury (IRI). Tissue inhibitor of metalloproteinase-1 (TIMP-1) is the…
2017 American Transplant Congress
Preservation Solution Affects the Immunological Milieu in Lung Transplantation and Alters the Inflammatory Balance.
R. Bellmàs Sanz,¹ M. Seyda,¹ B. Wiegmann,² C. Neudoerfl,¹ A. Haverich,^2,3 C. Falk,^1,4 G. Warnecke.^2,3
¹Institute of Transplant Immunology, IFB-Tx, Hannover Medical School, Hannover, Germany; ²Department for Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany; ³German Center for Lung Research (DZL), Hannover, Germany; ⁴German Center for Infection Research (DZIF), Hannover, Germany
Background: The pro-/ anti-inflammatory balance in lung transplantation is shaped by the pulmonary immune compartments, i.e. the T and NK cell repertoire. At present, it…