Articles tagged "Ischemia"

2018 American Transplant Congress
Deceased Donor Urinary Biomarker Signature and the Effectiveness of Peritransplant Lymphocyte Depletion on Early Renal Allograft Function
S. Bernd,² P. Heeger,¹ T-.P. Heather,³ I. Hall,⁷ M. Doshi,⁴ F. Weng,⁵ P. Reese,⁶ C. Parikh.³
¹Icahn School of Medicine Mount Sinai, New York, NY; ²University of Ulm, Ulm, Germany; ³Yale University School of Medicine, New Haven, CT; ⁴Wayne State University, Detroit, MI; ⁵Barnabas Health, Livingston, NJ; ⁶University of Pennsylvania, Philadelphia, PA; ⁷University of Utah School of Medicine, Salt Lake City, UT.
Purpose: Delayed graft function (DGF) is associated with increased allogaft immunogenicity and decreased long-term survival. We hypothesized that high levels of donor urinary biomarkers for…
2018 American Transplant Congress
CCAAT-Enhancer-Binding Protein Homologous Protein Promotes Liver Ischemia and Reperfusion Injury by Inhibiting Beclin-1-Mediated Autophagy in Hepatocytes
H. Zhou,¹ Z. Rao,¹ Y. Xia,¹ R. Liu,¹ S. Zhou,¹ X. Wang,¹ Y. Zhai,¹ L. Lu.¹
¹First Affiliated Hospital of Nanjing Medical University, Nanjing, China; ²David Geffen School of Medicine at University of California-Los Angeles, Los Angeles.
Background and Aims:Critical role of endoplasmic reticulum (ER) stress has been found in ischemia and reperfusion(IR) injury models. However, the role of CCAAT-Enhancer-Binding Protein Homologous…
2018 American Transplant Congress
The Aggressive Phenotype: Center-Level Characteristics in the Use of Suboptimal Lungs
M. Kosztowski, E. Bush, X. Luo, A. Thomas, M. Bowring, D. Segev, J. Garonzik Wang.
Johns Hopkins, Baltimore, MD.
The disparity between organ supply and demand has led some centers to expand their criteria for donor selection. We explored utilization of suboptimal lungs to…
2018 American Transplant Congress
Serelaxin-Notch1 Signaling Promotes Macrophage M2 Differentiation and Alleviates Hepatocellular Damage in Orthotopic Liver Transplantation: From Mouse-to-Human
S. Kageyama,¹ K. Nakamura,¹ B. Ke,¹ R. Sosa,² E. Reed,² F. Kaldas,¹ R. Busuttil,¹ J. Kupiec-Weglinski.¹
¹Surgery, Liver Transplant, UCLA, Los Angeles, CA; ²Pathology, UCLA, Los Angeles, CA.
Background/Aim: We have documented crucial role of macrophage Notch1 signaling in a mouse warm hepatic ischemia-reperfusion injury (IRI) model. However, its clinical relevance or therapeutic…
2018 American Transplant Congress
TGR5-Mediated AMPK/mTOR Signaling Regulates Macrophage Migration and Polarization in Liver Ischemia Reperfusion
S. Zhou, H. Zhou, R. Liu, F. Zhang, X. Wang, L. Lu.
Liver Transplantation Center, First Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu, China.
Background: Although the plasma membrane-bound G protein–coupled bile acid receptor (TGR5) exerts protective roles in various inflammatory diseases, little is known about the effects and…
2018 American Transplant Congress
Assessing Necroptosis in Brain Dead Kidney Donors: Implications for Predicting Recipient Outcomes
A. Zmijewska, J. Murphy, J. Chen, J. Zmijewski, R. Mannon.
Medicine, University of Alabama at Birmingham, Birmingham, AL.
Introduction: Kidney graft transplant obtained from Brain Dead Donors (BDD) is more frequently associated with development of delayed graft function (DGF) and higher risk of…
2018 American Transplant Congress
Histone Deacetylase Inhibition Mitigates Limb Ischemia Reperfusion Injury
S. Concors,¹ D. Aufhauser,¹ D. Murken,¹ Z. Wang,¹ G. Ge,¹ T. Bhatti,⁴ W. Hancock,^3,4 M. Levine.^1,2
¹Surgery, University of Pennsylvania, Philadelphia, PA; ²Surgery, Children's Hospital of Philadelphia, Philadelphia, PA; ³Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA; ⁴Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA.
Introduction: Vascular composite allotransplantation (VCA) of the limb involves cold and warm ischemia, further limiting organ availability beyond the constraints of blood type, HLA compatibility,…
2018 American Transplant Congress
Double Deficiency of Gelatinase-A and Gelatinase-B Does Not Protect against Hepatic Ischemia Reperfusion Injury
S. Duarte, P. Matian, S. Ma, R. Busuttil, A. Coito.
Dumont-UCLA Transplant Center, Los Angeles.
Gelatinases, consisting of gelatinase A (MMP-2; 72 KDa) and gelatinase B (MMP-9; 92KDa), are a subgroup of matrix metalloproteinases (MMPs) with key roles in a…
2018 American Transplant Congress
Comparison of Temperatures for Optimal Preservation of Donor Kidneys during Oxygenated Pulsatile Perfusion
R. Bhattacharjee,¹ M. Richard-Mohamed,² A. Ruthirakanthan,³ R. Mayer,² S. Luke,³ H. Sharma,² M. TunAbraham,² B. Alharbi,² A. Haig,² P. Luke.^1,2,3
¹Matthew Mailing Centre for Translational Transplant Studies, London Health Sciences Centre, London, ON, Canada; ²Multi-Organ Transplant Program, London Health Sciences Centre, London, ON, Canada; ³Western University, Canada, London, ON, Canada.
Background. The current methods of preserving DCD renal allografts in either static cold solution or hypothermic pulsatile perfusion are unable to adequately protect the kidney…
2018 American Transplant Congress
Recombinant Thrombomodulin alpha Attenuates Kidney Graft Damage after Long Cold Ischemia Time in a Rat Kidney Transplant Model
S. Tamaki,¹ K. Shinoda,¹ M. Shimoda,² S. Morita,¹ H. Asanuma,¹ M. Oya.¹
¹Urology, Keio University School of Medicine, Tokyo, Japan; ²Pathology, Keio University School of Medicine, Tokyo, Japan.
Objectives: Thrombomodulin (TM) extensively expresses on the endothelial cells in the steady state and is known to prevent hypercoagulation via combining with thrombin and inactivating…