2018 American Transplant Congress
Significant Difference between Proteasome and Immunoproteasome Inhibition in Acute Kidney Injury
The proteasome inhibitor bortezomib has successful administrated in kidney transplant recipients with acute or chronic antibody-mediated rejection, but there were some unfavorable cases which arised…2018 American Transplant Congress
Preoperative Antibiotics Treatment Decreases Endoplasmic Reticulum Stress and Protects Liver Transplant from Ischemia-Reperfusion Injury
Department of Surgery, The Dumont-UCLA Transplant Center, Los Angeles, CA.
Ischemia-reperfusion injury (IRI) represents a major risk factor of graft dysfunction in liver transplantation (LT). We have reported a critical role of endoplasmic reticulum (ER)…2018 American Transplant Congress
Senolytic Drug Treatment Attenuates mtDNA-Mediated Inflammatory Injury in Old Donors and Prolongs Cardiac Allograft Survival
Introduction: Solid organ transplantation has seen a increase in the utilization of older organs. Here, we investigate how aging-associated kinetics of damage associated molecular patterns…2018 American Transplant Congress
Tax1bp3 is Upregulated in the Ischemia/Reperfusion Injury of Kidney
Department of Urology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Objective The ischemia/reperfusion (I/R) injury plays an important role in delayed graft function (DGF) after kidney transplantation, however, the mechanism is not fully understood. Therefore,…2018 American Transplant Congress
Histone Deacetylase-6 Inhibition Mitigates Liver Ischemia-Reperfusion Injury and Acetaminophen Toxicity in Mice
Introduction: Ischemia/reperfusion injury (IRI) leads to poor outcomes and early graft loss in liver transplantation. Understanding the mechanisms of liver IRI may aid in prevention…2018 American Transplant Congress
Protective Effect of Ceria-Nanoparticle on Renal Ischemia Reperfusion Injury in Rats
Introduction: Ischemia-reperfusion injury (IRI) is a commonly encountered problem in organ transplantation. IRI is associated with delayed graft function and acute rejection; therefore IRI adversely…2018 American Transplant Congress
Graft Dendritic Cell p40 Homodimers Activate Donor-Reactive Endogenous Memory CD8 T Cells within Higher Risk Allografts
Immunology, Cleveland Clinic, Cleveland, OH.
Memory T cells with donor-reactivity pose a major barrier to successful allograft transplantation and tolerance induction. Longer cold ischemic storage (CIS) prior to transplantation promotes…2018 American Transplant Congress
Assessment of Hepatic Ischemia-Reperfusion Injuries by NRF2-Dependent Transcriptional Activities of Bile Transporters in Rats
Background: The effect of hepatic ischemia and reperfusion injury (IRI) on bile transporter (BT) gene expression and the role of Nrf2 in BT regulation during…2018 American Transplant Congress
Cold Ischemia Time is an Important Risk Factor for Post-Liver Transplant Prolonged Length of Stay
Background: Cold ischemia time (CIT) is often viewed as a categorical risk factor in liver transplantation. We hypothesize that the risk for adverse outcomes increases…2018 American Transplant Congress
Normothermic Ex Vivo Liver Perfusion Prior to Liver Transplantation Can Prevent Platelet Aggregation and Platelet Induced Sinusoidal Cell Injury
Background. Normothermic ex vivo liver perfusion (NEVLP) is a novel method for graft-preservation applied alternatively to static cold storage (SCS). We examined the impact of…
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