Articles tagged "Ischemia"

2019 American Transplant Congress
Quantitative Proteomics Analysis of Ischemia Reperfusion Injured Liver Tissue Provides Insight into Liver Allograft Quality Evaluation
M. Chen, M. Han, W. Ju, Q. Zhao, D. Wang, Z. Guo, X. He
Transplant Center, Sun Yat-sen University, Guangzhou, China
*Purpose: Successful orthotopic liver transplantation (OLT) surgery mostly depends on good and functional liver donor, besides of mature transplant technology. The molecular basis of different…
2019 American Transplant Congress
Organ-Specific Injury and Recovery Mechanisms in Post-Transplant Ischemia Reperfusion Injury
S. Bontha¹, A. Bajwa¹, L. Gallon², J. Eason³, D. Maluf¹, V. Mas⁴
¹UTHSC, Memphis, TN, ²Northwestern University, Chicago, IL, ³Director of Transplant Institute UTHSC, Memphis, TN, ⁴Director of Transplant Research Institute, Memphis, TN
*Purpose: Ischemia reperfusion (I/R) injury is a major contributor to short-term graft function. Dissecting organ specific and common molecular pathways associated with I/R injury among…
2019 American Transplant Congress
Accelerating Kidney Allocation: Simultaneously Expiring Offers
M. Kosztowski¹, M. Mankowski², S. Raghavan³, J. Garonzik-Wang¹, D. Axelrod⁴, D. L. Segev¹, S. E. Gentry¹
¹Johns Hopkins University, Baltimore, MD, ²King Abdullah University of Science and Technology, Thuwal, Saudi Arabia, ³University of Maryland, College Park, MD, ⁴University of Iowa, Iowa City, IA
*Purpose: Placing kidneys quickly might reduce discard. Additionally, a faster allocation system that reduces cold ischemia time would yield benefits: decreased delayed graft function, shorter…
2019 American Transplant Congress
Visceral Arterial Embolization – An Important Tool For Managing Blood Loss In Multivisceral Transplant Candidates With Portomesenteric Thrombosis
D. P. Borle, J. A. Shah, R. Kadiyala Venkata, D. Vikraman, B. Collins, S. Knechtle, A. Rege, A. Barbas, C. Kim, T. Smith, P. Sohocki, D. L. Sudan
Duke University Medical Center, Durham, NC
*Purpose: Organ explant in multivisceral transplant (MVT) candidates is technically demanding associated with high volume blood loss. Visceral arterial embolisation (VAE) may reduce bleeding, but…
2019 American Transplant Congress
CD38 Inhibition: A Novel Target for Hepatic Ischemia Reperfusion Injury
C. Akateh¹, B. F. Reader¹, Y. Lee¹, J. Kim¹, K. Maynard¹, K. W. Washburn¹, J. L. Zweier², B. A. Whitson¹, S. M. Black¹
¹Surgery, The Ohio State University Wexner Medical Center, Columbus, OH, ²The Ohio State University Wexner Medical Center, Columbus, OH
*Purpose: Ischemia/reperfusion injury (IRI) is a major source of injury during many surgical procedures on the liver, and severe IRI can lead to post-hepatectomy liver…
2019 American Transplant Congress
Role of Mitochondria, Metabolism and Inflammation: Pathways Influencing Short Term Outcomes Post-Renal Transplantation
S. Bontha¹, A. Bajwa¹, G. Lorenzo², J. Eason³, D. Maluf⁴, V. Mas⁵
¹Surgery, UTHSC, Memphis, TN, ²Northwestern University, Chicago, IL, ³Director of Transplant Institute UTHSC, Memphis, TN, ⁴UTHSC, Memphis, TN, ⁵Director of Transplant Research Institute, Memphis, TN
*Purpose: Preconditioning of donor kidneys and clinical assessment for need of dialysis early post-transplant vary per each case and are crucial for improving transplant outcomes.…
2019 American Transplant Congress
Early Allograft Dysfunction in the Setting of Histologic Ischemia Reperfusion Injury Following Liver Transplantation: Analysis of Predictors and Outcomes
T. Ito, J. Aziz, V. G. Agopian, S. Younan, J. DiNorcia, H. Yersiz, D. G. Farmer, R. W. Busuttil, F. M. Kaldas
Department of Surgery, The Dumont-UCLA Transplant Center, Los Angeles, CA
*Purpose: Hepatic ischemia-reperfusion injury (IRI) in Liver Transplantation (LT) is believed to contribute to Early Allograft Dysfunction (EAD). However, the relationship between IRI and EAD…
2019 American Transplant Congress
Prevention of Graft Ischemia-Reperfusion Injury in Ischemia-Free Liver Transplantation
Z. Guo, X. He, Q. Zhao, S. Huang, Z. Zhang, L. Wang, W. Ju, G. Chen
Organ Transplant Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
*Purpose: Graft ischemia-reperfusion injury (IRI) is an inevitable event in organ transplantation, which often leads to a number of complications and even patient deaths. We…
2019 American Transplant Congress
Circulating Donor T and NK Cells in Lung Transplantation Recipients Are Derived from the Donor Lung Parenchyma and Represent Tissue-Resident Memory Cells
J. F. Kuehne¹, R. Ballmàs Sanz¹, A. Hitz¹, B. Wiegmann², K. A. Bläsing¹, F. Ius², A. Knoefel², I. Tudorache², M. Avsar², D. Jonigk³, A. Haverich², G. Warnecke², C. Falk¹
¹Institute of Transplant Immunology, Hannover Medical School (MHH), Hannover, Germany, ²Department for Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School (MHH), Hannover, Germany, ³Institute of Pathology, Hannover Medical School (MHH), Hannover, Germany
*Purpose: We previously identified donor lymphocytes in peripheral blood of recipients directly after transplantation and persisting at least three weeks that were characterized by the…
2019 American Transplant Congress
Multi-omic Analysis Of Hepatic Ischemia/reperfusion Injury Identifies Novel Targets To Mitigate Hepatocellular Damage
S. Duarte¹, V. Boominathan², Z. Huo³, A. Kobayashi², U. Kim², Y. Lai², A. Coito¹, A. Zarrinpar²
¹Surgery, UCLA, Los Angeles, CA, ²Surgery, University of Florida, Gainesville, FL, ³Biostatistics, University of Florida, Gainesville, FL
*Purpose: Hepatic ischemia/reperfusion injury (IRI) is a major risk factor for acute rejection and early graft dysfunction in liver transplantation. The large and complex landscape…