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American Transplant Congress abstracts

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Articles tagged "Intestinal transplantation"

  • 2019 American Transplant Congress

    A National Survey of Immunosuppression Strategies in Intestinal Transplantation

    M. Segovia1, T. Beduschi2, J. Boike3, D. Farmer4, S. Horslen5, K. Iyer6, S. Jafri7, A. Langnas8, C. Matsumoto9, A. Mavis1, G. Mazariegos10, S. Nagai7, J. O'Leary11, Y. Patel1, D. Sudan1, N. Sulejmani7, B. Summers7, T. Schiano6

    1Duke, Durham, NC, 2Univ Miami, Miami, FL, 3NWU, Chicago, IL, 4UCLA, Los Angeles, CA, 5Seattle Child, Seattle, WA, 6Mt Sinai, NY, NY, 7Henry Ford, Detroit, MI, 8UNMC, Omaha, NE, 9Georgetown, Washington, DC, 10UPMC, Pittsburgh, PA, 11Dallas VAMC, Dallas, TX

    *Purpose: Review the management of immunosuppression (IS) for intestinal transplantation (IT) in the USA*Methods: A survey was created and sent via email to surgical directors…
  • 2019 American Transplant Congress

    First Report and Mechanistic Analysis of Operational Tolerance after Intestinal Transplant

    J. Weiner1, S. Moturi1, C. Ashokkumar2, K. Khan1, S. Kaufman1, R. Sindhi2, C. Matsumoto1, T. Fishbein1, A. Kroemer1

    1MedStar Georgetown Transplant Institute, Washington, DC, 2University of Pittsburgh, Pittsburgh, PA

    *Purpose: Transplantation tolerance is a highly sought and rarely achieved state in clinical medicine. Defined as long-term stable and acceptable graft tolerance without immunosuppression and…
  • 2019 American Transplant Congress

    Promotion of Chimerism by Lymphohematopoietic Graft-versus-Host Responses in Patients Receiving Intestinal Transplantation

    J. Fu1, J. Zuber1, B. Shonts1, A. Obradovic1, K. Frangaj1, E. E. Waffarn1, S. Lau1, T. M. Savage1, S. Yang1, K. Rogers1, P. Satwani2, S. Ho1, Y. Shen3, A. Griesemer4, M. Martinez2, T. Kato4, M. Sykes1

    1Columbia Center for Translational Immunology, Department of Medicine, Columbia University, New York, NY, 2Department of Pediatrics, Columbia University, New York, NY, 3Department of Systems Biology, Columbia University, New York, NY, 4Department of Surgery, Columbia University, New York, NY

    *Purpose: Long-term multilineage chimerism often appears in blood following intestinal transplantation (ITx), usually without graft-versus-host disease (GVHD). Patients with donor T cell macrochimerism (≥4%) in…
  • 2019 American Transplant Congress

    Central Role of Graft Resident Memory T Cells in Pathogenesis of GVHD after Bowel Transplantation

    J. Weiner, N. Svetlicky, J. Schmidt, S. Moturi, O. Aguirre, J. Kang, M. Sadat, K. Khan, J. Hawksworth, C. Matsumoto, T. Fishbein, A. Kroemer

    MedStar Georgetown Transplant Institute, Washington, DC

    *Purpose: Graft-versus-host disease (GVHD) is a relatively common and highly morbid complication after intestinal transplantation. Its pathophysiology remains poorly understood. Resident memory T cells (TRM)…
  • 2019 American Transplant Congress

    Deceased Donor Vascularized Abdominal Wall Allograft Procurement – Lessons Learned from Early Experiences

    J. A. Shah, D. L. Sudan, D. Erdmann, K. V. Ravindra

    Abdominal Transplant Surgery, Duke University Medical Center, Durham, NC

    *Purpose: Vascularized abdominal wall allografts (AWA), which protect solid organs in patients with loss of abdominal domain or extensive abdominal wall damage, remain an essential…
  • 2019 American Transplant Congress

    De Novo Glomerulonephritis after Non Renal Abdominal Organ Transplantation

    C. Farkas1, R. B. Ettenger1, J. Zuckerman2, R. S. Venick3, P. Weng1

    1Pediatric Nephrology, UCLA, Los Angeles, CA, 2Pathology, UCLA, Los Angeles, CA, 3Pediatric Gastroenterology, UCLA, Los Angeles, CA

    *Purpose: Pediatric recipients of non renal abdominal organs may develop renal abnormalities of uncertain etiology. We describe for the first time de novo lupus-like glomerulonephritis…
  • 2019 American Transplant Congress

    Predicting Risk of Cytomegalovirus with Viral-Antigen-Specific CD154+ T-cells after Liver or Intestine Transplantation

    C. Ashokkumar, K. Soltys, M. Green, G. Mazariegos, G. Bond, K. Jones, A. Rzempoluch, M. Zaccagnini, P. Sethi, B. W. Higgs, R. Sindhi

    Childrens Hospital of Pittsburgh of UPMC, Pittsburgh, PA

    *Purpose: Cytomegalovirus (CMV)-specific T-cells express IFNγ, measure cell-mediated immunity to CMV and can guide the timing and duration of antiviral therapy. CMV-specific T-cells also co-express…
  • 2019 American Transplant Congress

    Anti-Xa Level Monitoring for Treatment Dose Enoxaparin in Liver/Intestine Transplant Recipients

    J. Sullivan, J. Jebrock, J. Revollo, M. Perez, J. Garcia, T. Beduschi

    Jackson Memorial Hospital, Miami, FL

    *Purpose: Evaluate the use of anti-Xa levels in therapeutic enoxaparin dosing in liver/intestine transplant recipients.*Methods: A single-center retrospective chart review was conducted on liver/intestine transplant…
  • 2019 American Transplant Congress

    First Report and Mechanistic Analysis of Chronic GVHD after Solid Organ Transplantation

    J. Weiner, N. Svetlicky, J. Schmidt, J. Kang, M. Sadat, A. Karaballa, S. Moturi, O. Aguirre, J. Hawksworth, C. Matsumoto, T. Fishbein, A. Kroemer

    Georgetown University Hospital, Washington, DC

    *Purpose: Chronic graft-versus-host disease (cGVHD) occurs late after bone marrow transplantation and is associated with a characteristic lichenoid rash (cutaneous sclerosis) and effects on multiple…
  • 2019 American Transplant Congress

    Ninety-Day Complications in 214 Intestinal Transplant Patients: A Calvien-Dindo Analysis and Assessment of Long Term Outcomes

    A. Zimmerman, J. Hawksworth, A. Kroemer, P. Radkani, K. Khan, S. Kaufman, N. Yazigi, S. Subramanian, T. Fishbein, C. Matsumoto

    Georgetown Transplant Institute, MedStar Georgetown University Hospital, Washington, DC

    *Purpose: The purpose of this study was to examine the 90-day complications that occurred after intestinal transplantation and to determine whether they effect 5-year patient…
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