2020 American Transplant Congress
Monitoring Inflammatory Cytokines in HLA-Sensitized Kidney Transplant Patients (HS KTx Pts) Desensitized with Clazakizumab (CLZ, Humanized Anti-IL-6 Monoclonal Antibody) Followed by Transplantation (Tx)
*Purpose: Chronic inflammation and HLA sensitization are burdens for end stage renal disease Pts awaiting for a KTx. IL-6 is a pro-inflammatory cytokine responsible for…2020 American Transplant Congress
B2-Adrenergic Receptor Activation in Donor Cells Inhibits T Cell Trafficking in Vascularized Composite Tissue Allotransplants
*Purpose: Transplantation of faces, hands, and limbs using vascularized composite allotransplantation (VCA) has faced significant challenges hindering its routine implementation in the clinic. One critical…2020 American Transplant Congress
Single Cell RNA Sequencing of Normal Kidney Allograft Surveillance Biopsies Show Evidence of Dynamic Glomerular Endothelial Cell Activation
University of Michigan, Ann Arbor, MI
*Purpose: Indication and surveillance biopsy studies show a high prevalence of post kidney transplant (KT) glomerular disease (ElZoghby 2009,Stegall 2017) that cannot be explained by…2019 American Transplant Congress
IL-10+ Plasma Cells Are Not Required for Breg Activity and Are Counterbalanced by Novel Pro-Inflammatory Plasma Cells
University of Pittsburgh, Pittsburgh, PA
*Purpose: Classically, B cells differentiate into Ab-secreting plasma cells (PCs; B220lowCD138hiBlimp1+Ig+) providing humoral immunity. B cells can also inhibit or promote immune responses through the…2019 American Transplant Congress
IFNAR Signaling Augments Plasmacytoid Dendritic Cell Activation during Costimulation Independent Rejection
Surgery, Emory University, Atlanta, GA
*Purpose: Costimulation blockade (CoB) is a promising new transplant immunosuppression strategy offering improved long-term patient and allograft survival without the nephrotoxicity of calcineurin inhibitors. However,…2019 American Transplant Congress
The Immunomodulatory Role of Type I Interferons in Alloimmunity
Medicine, Brigham and Women's Hospital, Boston, MA
*Purpose: Despite a growing body of work on type 1 interferon (IFNAR1) signaling, there is a lack of consensus on the immunological properties of type…2019 American Transplant Congress
A Potential Role for IgE-Mediated Immune Response in the Pathogenesis of Chronic Antibody-Mediated Rejection
*Purpose: Chronic antibody-mediated rejection (CAMR) is the main cause of graft loss and shares with systemic lupus erythematosus (SLE) the antibody-mediated kidney damage and the…2019 American Transplant Congress
Type-1 Interferons Impair the Key Immunoregulatory Activity of IL-10 in the Promotion of Transplant Tolerance
Plastic Surgery, Johns Hopkins University, Baltimore, MD
*Purpose: Induction of long term transplant survival by “costimulation blockade” (CoB) regimens is impaired by inflammatory responses. Despite the identification of type-1 interferons (TI-IFN) as…2019 American Transplant Congress
Human Adenovirus-Specific T Cell Response in Kidney Transplant Recipients Diagnosed with Adenovirus Infection
*Purpose: Cell-mediated immunity plays an important role in controlling human adenovirus (HAdV) infection after kidney transplantation (KT). We investigated T cell lymphocyte subsets and HAdV-specific…2019 American Transplant Congress
Murine Cytomegalovirus Infection Down-Regulates Receptor Tyrosine Kinase MerTK on Macrophages to Abrogate Allograft Tolerance
*Purpose: Cytomegalovirus (CMV) is one of the most common pathogens infecting solid organ transplant recipients. We recently showed that (1) CMV infection impairs the induction…
American Transplant Congress abstracts