ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Inflammation"

  • 2021 American Transplant Congress

    Clinically Evident Portal Hypertension (CEPH) is Associated with Low IGF-1 in Children with Chronic Liver Disease

    B. Whitehead1, S. Mohammad1, S. Kelly1, J. Josefson2, L. Mithal3, E. M. Alonso1

    1Division of Gastroenterology, Hepatology and Nutrition, Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, 2Division of Endocrinology, Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, 3Division of Infectious Disease, Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, IL

    *Purpose: Children with chronic liver disease exhibit growth hormone resistance which is an additional risk factor for sarcopenia and growth failure in this vulnerable population.…
  • 2021 American Transplant Congress

    Donor Kidney-Resident Macrophages Promote Allograft Inflammation and CD8 T Cell Response Post-Transplantation

    A. Dangi1, S. Yu2, I. Husain1, R. Geesala1, X. Luo1

    1Nephrology, Medicine, Duke University, Durham, NC, 2Division of Organ Transplantation, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China

    *Purpose: Kidney-resident macrophages play important roles in maintaining normal kidney function and promoting prompt repair following kidney injuries. Nevertheless, their fate and role in kidney…
  • 2021 American Transplant Congress

    Ex Situ Heart Perfusion and Standard of Care Cold Storage Differentially Affect the Ischemic Secretome of Donor Hearts in Perfusates but Not the Reperfusion Response in Recipient Plasma

    E. Chichelnitskiy1, B. Wiegmann2, N. Ledwoch1, F. Ius2, F. Wandrer1, J. Kühne1, K. Beushausen1, J. Keil1, S. V. Rojas2, W. Sommer2, C. Kühn2, I. Tudorache2, M. Avsar2, A. Haverich2, G. Warnecke2, C. S. Falk1

    1MHH, Institute of Transplant Immunology, Hannover, Germany, 2MHH, Department for Cardiothoracic, Transplantation and Vascular Surgery, Hannover, Germany

    *Purpose: Various allograft preservation procedures influence the donor organ status that may be reflected by the cytokine/chemokine microenvironment in heart transplant (HTx) recipients. In addition,…
  • 2021 American Transplant Congress

    Myeloid Foxo1-β-catenin Axis Regulates Hedgehog/Gli1 Signaling and Controls NLRP3-Mediated Innate Immune Responses in Sterile Inflammatory Liver Injury

    D. Xu, C. Li, M. Sheng, Y. Lin, Y. Tian, Y. Zhan, A. J. Coito, R. W. Busuttil, D. G. Farmer, J. W. Kupiec-Weglinski, B. Ke

    Surgery, Dumont - UCLA Transplant Center, Los Angeles, CA

    *Purpose: Foxo1 plays important roles in cell metabolism, oxidative stress, inflammation, and apoptosis. Activation of Hedgehog/Gli1 signaling regulates cell growth, differentiation, and immune function. However,…
  • 2021 American Transplant Congress

    CHBP Induces Stronger Immunosuppressive CD127+ M-MDSC via Erythropoietin Receptor

    C. Yang

    Urology, Zhongshan Hospital, Fudan University, Shanghai, China

    *Purpose: Erythropoietin (EPO) is not only an erythropoiesis hormone, but also an immune regulatory cytokine. The receptors of EPO, (EPOR)2 and tissue protective receptor (TPR),…
  • 2021 American Transplant Congress

    Peripheral Blood Inflammatory Chemokines Uncover Rejection in the Absence of Histological Lesions

    E. Van Loon1, T. Barba2, B. Lamarthée1, A. Senev1, O. Thaunat2, D. Schols3, M. Naesens1

    1Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium, 2Department of Transplantation, Nephrology and Clinical Immunology, Edouard Herriot Hospital Lyon, Lyon, France, 3Laboratory of Virology and Chemotherapy, KU Leuven, Leuven, Belgium

    *Purpose: Cytokines and chemokines play a critical role in the pathophysiology of allograft rejection, but the relation of peripheral blood cytokine expression profiles to clinical…
  • 2021 American Transplant Congress

    IL-10 Signaling in T Cells Modulates Costimulation-independent Activation and is Essential for Transplant Tolerance Induction

    M. Iglesias Lozano1, D. Bibicheff1, M. Chicco2, A. Komin1, G. Brandacher1, G. Raimondi1

    1Plastic Surgery, Johns Hopkins University, Baltimore, MD, 2Frimley Health NHS Foundation Trust, London, United Kingdom

    *Purpose: Costimulation blockade (CoB)-based immunotherapy remains a very promising approach for better management of transplant recipients. Understanding the mechanisms that impact the efficacy of CoB…
  • 2021 American Transplant Congress

    Propensity Matched Analysis of Death and Non-favorable Discharge Among Hospitalized Transplant Recipients with COVID-19

    J. T. Swan1, E. Rizk2, S. L. Jones1, N. Nwana1, J. C. Nicolas1, A. Tran1, T. Nisar1, T. Menser1, S. G. Yi2, L. W. Moore1, A. O. Gaber2, R. J. Knight2

    1Houston Methodist Research Institute, Houston, TX, 2Houston Methodist Hospital, Houston, TX

    *Purpose: This study compared death and non-favorable discharge following a hospital admission for Coronavirus Disease 2019 (COVID-19) management for patients with a history of solid…
  • 2021 American Transplant Congress

    HLA Mismatching and Subclinical Inflammation: An Association to be Considered in Kidney Transplant Patients with Low Immunological Risk

    T. Vazquez-Sanchez1, J. Alonso-Titos1, P. Ruiz-Esteban1, A. Caballero2, M. Leon3, V. Lopez1, E. Sola1, D. Hernández1

    1Nephrology, Instituto de Investigación Biomédica de Málaga (IBIMA). Hospital Universitario Regional de Málaga and University of Málaga. REDinREN (RD16/0009/0006). Málaga. (Spain), Málaga, Spain, 2Immunology, Instituto de Investigación Biomédica de Málaga (IBIMA). Hospital Universitario Regional de Málaga and University of Málaga. REDinREN (RD16/0009/0006). Málaga. (Spain), Málaga, Spain, 3Pathology, Instituto de Investigación Biomédica de Málaga (IBIMA). Hospital Universitario Regional de Málaga and University of Málaga. REDinREN (RD16/0009/0006). Málaga. (Spain), Málaga, Spain

    *Purpose: Subclinical inflammation (SCI) (
  • 2021 American Transplant Congress

    Impact of COVID-19 on Solid Organ Transplantation

    E. Sampson1, S. Hall2, K. Robichaux3, A. Kumar2, N. Kemmer4, J. Buggs5

    1Lake Erie College of Osteopathic Medicine, Tampa, FL, 2Morsani College of Medicine, University of South Florida, Tampa, FL, 3Honors College, University of South Florida, Tampa, FL, 4Transplant Hepatology, Tampa General Hospital, Tampa, FL, 5Transplant Surgery, Tampa General Hospital, Tampa, FL

    *Purpose: Patterns of racial disparities have been identified throughout the history of American medicine. In December 2019, COVID-19 was first detected and has had a…
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