ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Inflammation"

  • 2022 American Transplant Congress

    Myeloid Molecular Signature of Ischemia-Reperfusion Injury in Human Liver Transplantation

    R. A. Sosa1, R. Ahn2, A. Terry1, Z. Qian2, F. Li1, S. Sen1, T. Ito3, B. V. Naini1, F. Kaldas3, A. Hoffmann2, R. W. Busuttil3, D. W. Gjertson1, J. Kupiec-Weglinski3, E. F. Reed1

    1Pathology and Lab Medicine, UCLA, Los Angeles, CA, 2Microbiology, Immunology and Molecular Genetics, UCLA, Los Angeles, CA, 3Surgery, UCLA, Los Angeles, CA

    *Purpose: Ischemia reperfusion injury (IRI) is well-appreciated as a significant clinical concern for recipients of liver transplantation, yet there are still no diagnostic or therapeutic…
  • 2022 American Transplant Congress

    Utility of Urinary CTGF as a Biomarker of Progressive Allograft Dysfunction in Pediatric Renal Transplant Recipients

    L. Sheward1, J. Wedel1, N. Rodig1, A. Kho1, T. Blydt-Hansen2, R. B. Mannon3, D. M. Briscoe1

    1Boston Children's Hospital, Boston, MA, 2BC Children's Hospital, Vancouver, BC, Canada, 3University of Nebraska Medical Center, Omaha, NE

    *Purpose: Previous reports from a number of studies indicate that renal allograft recipients who have inflammatory infiltrates within areas of interstitial fibrosis with tubular atrophy…
  • 2022 American Transplant Congress

    Study of the Composition of the Inflammatory Burden on a Cohort of 125 Rejections by Multiplex Immunofluorescence

    A. Mobio1, M. Eloudzeri2, L. Morin1, J. Duong Van Huyen3, D. Anglicheau1, M. Rabant3

    1Kidney transplantation, Necker-Enfants Malades Hospital, Paris, France, 2U1151, INEM, Paris, France, 3Pathology, Necker-Enfants Malades Hospital, Paris, France

    *Purpose: The exact composition of the inflammatory burden during kidney transplant rejection has not been studied on large cohorts. Moreover, the determinants and impact of…
  • 2022 American Transplant Congress

    Apheresis of Deceased Donors: A New Source of Mobilized Peripheral Blood Hematopoietic Stem Cells for Transplant Tolerance

    R. A. Sosa1, T. Mone2, B. V. Naini1, D. B. Kohn3, E. F. Reed1, K. Wheeler2, B. Campo-Fernandez3, A. Davila3, D. J. Chaffin4, J. DiNorcia5, F. M. Kaldas5, A. Cohen2, E. Lum6, J. L. Veale7, N. M. Kogut7

    1Pathology and Lab Medicine, UCLA, Los Angeles, CA, 2One Legacy, Los Angeles, CA, 3Microbiology, Immunology and Molecular Genetics, UCLA, Los Angeles, CA, 4LifeStream Blood Bank, San Bernadino, CA, 5Surgery, UCLA, Los Angeles, CA, 6Medicine, UCLA, Los Angeles, CA, 7Urology, UCLA, Los Angeles, CA

    *Purpose: Solid organ transplantation is the therapy of choice for many patients with end-stage organ failure, but recipients must remain on lifelong immune suppression, leaving…
  • 2022 American Transplant Congress

    Galectin-3 Discriminates Patients with Advanced Cirrhosis and Predicts Post-Liver Transplant Infectious Complications

    E. Cervantes-Alvarez1, M. Vilatobá1, J. Argemi2, N. Limon-de la Rosa1, O. Mendez-Guerrero1, C. Huang3, D. Kershenobich1, R. Bataller4, A. Torre5, N. Navarro-Alvarez1

    1Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico, 2Liver Unit, Clinica Universidad de Navarra, Hepatology Program, Center for Applied Medical Research, Pamplona, Spain, Pamplona, Spain, 3University of Colorado Anschutz Medical Campus, Denver, CO, 4University of Pittsburgh Medical Center, Pittsburgh, PA, 5Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico city, Mexico

    *Purpose: An increased demand for liver transplantation (LT) prevails. Galectin-3 is a lectin implicated in inflammation, immunoregulation, and liver fibrosis. In this study we assessed…
  • 2022 American Transplant Congress

    Nebulized Mitochondria Localize to Transplanted Allografts and Improve Outcomes Following Lung Transplantation

    D. Nord1, Z. Tu2, L. Langerude1, A. McQuiston1, J. Kwon3, S. Nadig4, T. Machuca5, C. Atkinson1

    1Pulmonary Medicine, University of Florida, Gainesville, FL, 2University of Florida, Gaineville, FL, 3MUSC College of Medicine, Charleston, SC, 4Northwestern University, Charleston, SC, 5Department of Surgery, University of Florida, Gainesville, FL

    *Purpose: Mitochondrial transplantation therapy is an innovative strategy for the treatment of mitochondrial dysfunction. The approach has shown efficacy in the treatment of cardiac ischemic…
  • 2022 American Transplant Congress

    Discordant Histological Findings During Acute Rejection in a Combined Face and Hand Transplant Recipient

    O. C. Onuh1, J. Trilles1, W. J. Rifkin1, H. Brydges1, B. F. Chaya1, R. Rodriguez Colon1, D. Boczar1, D. J. Ceradini1, E. D. Rodriguez1, B. E. Gelb2

    1Hansjörg Wyss Department of Plastic Surgery, NYU Langone Health, New York, NY, 2Transplant Institute, NYU Langone Health, New York, NY

    *Purpose: The purpose of this study is to evaluate histologic findings in a face and bilateral hand transplant recipient that was monitored with multi-site allograft…
  • 2022 American Transplant Congress

    NecroX-7 Ameliorate FK506-Induced Nephrotoxicity in LLC-PK1 Cells (Pig Kidney Epithelial Cells)

    H. J. Jang

    Surgery, University of Ulsan, Gangneung Asan Hospital, Gangneung, Korea, Republic of

    *Purpose: Tacrolimus (FK506) is an immunosuppressant agent that is frequently used to prevent rejection of solid organs upon transplant. However, nephrotoxicity due to apoptosis and…
  • 2022 American Transplant Congress

    Variability of Serum Klotho and FGF-23 Levels During the First Two Years After Kidney Transplantation

    T. Vazquez-Sanchez1, M. Sanchez-Niño2, P. Ruiz-Esteban1, V. López1, J. Delgado1, A. Ortiz3, D. Hernández1

    1Nephrology Department, Regional University Hospital (IBIMA), REDinREN (RD16/0009/0006), Malaga (España), Malaga, Spain, 2Nephrology Department, Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz, Universidad Autónoma de Madrid. REDINREN, Madrid, Spain, 3Nephrology Department, Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz, Universidad Autónoma de Madrid. REDINREN, Madrid, Spain, Madrid, Spain

    *Purpose: Klotho is a protein produced in renal tubular cells with nephroprotective actions which acts as a co-receptor for phosphaturic factor FGF-23. The natural history…
  • 2021 American Transplant Congress

    Exosomal DAMP Proteins Released During Islet Isolation Affects TPIAT Outcomes

    P. Saravanan, J. Kalivarathan, M. Levy, M. Kanak

    Hume Lee Islet Cell Transplantation Lab, Department of Surgery, VCU Health, Richmond, VA

    *Purpose: Isolation of islets cause significant stress that results in the release of immunogenic factors called damage-associated molecular patterns (DAMPs) which can induce inflammatory signaling…
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