ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Inflammation"

  • 2022 American Transplant Congress

    Abnormal Kidney T Cell Metabolism During Ischemia Reperfusion Injury Can Be Modified to Improve Organ Structure and Function

    K. Lee, E. A. Thompson, C. H. Patel, S. Gharaie, J. T. Kurzhagen, S. Noel, P. M. Pierorazio, B. S. Slusher, H. Rabb

    Johns Hopkins University School of Medicine, Baltimore, MD

    *Purpose: T cells play an important role in the pathophysiology of kidney ischemia reperfusion injury (IRI). Metabolic programming of T cells, a rapidly evolving field,…
  • 2022 American Transplant Congress

    Intraoperative Kinetics of Pro-Inflammatory Markers and Delayed-Graft Function During Kidney Transplantation

    P. A. Wadsworth, H. L. Stevenson, M. L. Kueht

    University of Texas Medical Branch, Galveston, TX

    *Purpose: Detailed molecular changes associated with allograft reperfusion have been poorly defined and current methods of predicting delayed graft function (DGF) after kidney transplantation are…
  • 2022 American Transplant Congress

    Cell-free Amniotic Fluid Reduces Liver Inflammation And Fibrosis

    F. Ditmars1, C. Bowen1, N. Liu1, K. L. Pereira de Castro1, J. Johnson1, M. Kueht1, A. Saad2, H. L. Stevenson3, J. Fair1, W. S. Fagg1

    1Surgery, University of Texas Medical Branch, Galveston, TX, 2Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, TX, 3Pathology, University of Texas Medical Branch, Galveston, TX

    *Purpose: Effective interventions for hepatic inflammation and fibrosis remain a dire unmet need in transplant medicine. Cell-free amniotic fluid (AF) represents a potential alternative to…
  • 2022 American Transplant Congress

    Novel Immune Checkpoint Molecule TIGIT Mediates Experimental Kidney Ischemia Reperfusion Injury

    S. Noel, K. Lee, S. Gharaie, J. T. Kurzhagen, H. Rabb

    Medicine, Johns Hopkins University, Baltimore, MD

    *Purpose: T cells play both pathogenic and reparative roles in kidney ischemia reperfusion injury (IRI) but the molecular mechanisms regulating kidney T cell functions are…
  • 2022 American Transplant Congress

    Internal Validation of a Pre-Transplant Biomarker Panel to Predict Post-Transplant Mortality: The Liver Immune Frailty Index

    G. G. Panayotova1, D. T. Nguyen2, E. A. Graviss2, L. J. Minze2, S. Simonishvili1, Y. Qin1, T. Ayorinde1, G. Prakash1, F. Paterno1, L. Brown1, A. Amin1, X. C. Li2, R. M. Ghobrial2, J. V. Guarrera1, K. E. Lunsford1

    1Rutgers New Jersey Medical School, Newark, NJ, 2Houston Methodist Hospital, Houston, TX

    *Purpose: Infection and sepsis are the greatest contributors to early post-liver transplant (LT) mortality. These often result from ongoing immune dysfunction, or “Immune Frailty”. We…
  • 2022 American Transplant Congress

    DEPTOR: A Novel Endothelial-Specific Regulator of Cell-Intrinsic Anti-Inflammation Following Transplantation

    C. Testini1, S. Bose1, K. Liu1, S. Kong1, E. Flynn1, M. Miovski1, J. Leyva-Rangel1, M. Laplante2, J. Wedel1, D. M. Briscoe1

    1Boston Children's Hospital and Harvard Medical School, Boston, MA, 2Laval University, Quebec, QC, Canada

    *Purpose: Recent studies have highlighted a paradigm whereby the maintenance of normal tissue homeostasis and the prevention of chronic inflammation is dependent on the active…
  • 2022 American Transplant Congress

    Ikaros-SIRT1 Signaling Axis Regulates Macrophage Pyroptosis and Ischemia-Reperfusion Injury (IRI) in Mouse and Human Liver Transplantation

    K. Kadono1, H. Hirao1, H. Kojima1, K. J. Dery1, X. Li2, J. Kupiec-Weglinski1

    1UCLA Medical Center, Los Angeles, CA, 2NIEHS, Durham, NC

    *Purpose: Although Ikaros is a well-established regulator of lymphopoiesis, its role in myeloid cells and organ IRI remains unclear. We recently reported that the SIRT1-mediated…
  • 2022 American Transplant Congress

    P2X7R Signaling Controls Exosome Release by Macrophages and Donor MHC Cross-Dressing After Skin Transplantation

    H. H. Lancia1, N. Carnel2, A. G. Lellouch1, C. Cetrulo1, G. Benichou2

    1Division of Plastic and Reconstructive Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 2Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA

    *Purpose: Exosomes released by transplanted organs play an important role in the host's immune response leading to their rejection. Donor exosomes contribute to alloimmunity by…
  • 2022 American Transplant Congress

    Bcl6 Regulates NFκB-Controlled Endothelial Inflammation and Apoptosis

    A. Franco Acevedo, N. Valenzuela

    Pathology and Laboratory Medicine, UCLA, Los Angeles, CA

    *Purpose: Endothelial cells (EC) centrally regulate leukocyte access to peripheral tissue and immune cell activation, and exhibit remarkable tissue-specific diversity. However, the molecular mechanisms underlying…
  • 2022 American Transplant Congress

    Disulfide HMGB1 Reprograms Macrophages to Induce Alloimmunity via TLR4 and TLR9 Pathways Following Ischemia-Reperfusion Injury in Human Orthotopic Liver Transplantation

    A. Q. Terry1, R. A. Sosa1, F. Kaldas2, R. Busuttil3, D. Gjertson1, J. Kupiec-Weglinski1, E. Reed1

    1Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA, 2University of California Los Angeles (Multi-organ), Los Angeles, CA, 3Surgery, University of California, Los Angeles, Los Angeles, CA

    *Purpose: Human hepatocellular damage caused by ischemia reperfusion injury (IRI) generates the disulfide form of HMGB1 (diS HMGB1), eliciting myeloid cell activation and proinflammatory cytokine…
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