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American Transplant Congress abstracts

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Articles tagged "Inflammation"

  • 2022 American Transplant Congress

    Sting but Not Mtor Signaling Regulates Exogenous Mitochondrion-Induced Endothelial Cell Mitophagy

    H. Xu, L. Wang, A. D. Kirk, H. Xu

    Duke University School of Medicine, Durham, NC

    *Purpose: We have previously demonstrated activation and increasing mitophagy of human endothelial cells (ECs) following exogenous mitochondrion-stimulation. The objectives of this study were to evaluate…
  • 2022 American Transplant Congress

    Evs from Patients with Amr Induce Tubular Senescence and Endmt Through Horizontal Transfer of Mirnas

    R. Franzin1, A. Stasi1, F. Sallustio1, S. Bruno2, G. Merlotti3, M. Quaglia3, G. Grandaliano4, P. Pontrelli1, J. Thurman5, G. Camussi2, G. Stallone6, V. Cantaluppi3, L. Gesualdo1, G. Castellano7

    1DETO, University of Bari, Bari, Italy, 2University of Turin, Turin, Italy, 3University of Piemonte Orientale, Novara, Italy, 4Università Cattolica Sacro Cuore, Rome, Italy, 5University of Colorado School of Medicine, Aurora, CO, 6University of Foggia, Foggia, Italy, 7University of Milan, Milan, Italy

    *Purpose: Extracellular vesicles (EV) are emerging mediators in several diseases; however, their role in antibody-mediated allograft rejection (AMR) has been poorly investigated.*Methods: Plasma EVs from…
  • 2022 American Transplant Congress

    Post-Operative Day 1 Galectin-3 is Predictive of Early Allograft Dysfunction in Liver Transplantation

    D. Yoeli, T. Ferrell, I. Rodriguez, N. Limon De La Rosa, N. Nakra, Z. Wang, E. Cervantes-Alvarez, R. Choudhury, M. Adams, T. Nydam, E. Pomfret, C. Huang, N. Navarro Alvarez, H. Moore

    University of Colorado Anschutz Medical, Aurora, CO

    *Purpose: Early allograft dysfunction (EAD) is an important outcome measure in liver transplantation that is predictive of graft failure, but the mechanism behind it remains…
  • 2022 American Transplant Congress

    Non-Invasive Assessment of Hepatic Ischemia-Reperfusion Injury Using Dynamic Contrast Enhanced-MRI and T2 Mapping

    O. C. Rodriguez1, J. R. Liggett2, J. Kang2, K. Loh2, Y. Lee1, N. Sang1, B. He1, Y. Cui2, K. Oza2, D. Kwon3, B. Kallakury3, T. Fishbein2, W. Cui2, K. Khan2, C. Albanese1, A. Kroemer2

    1Lombardi Comprehensive Cancer Center and the Center for Translational Imaging, Georgetown University Medical Center, Washington, DC, 2MedStar Georgetown Transplant Institute, Washington, DC, 3Pathology, MedStar Georgetown University Hospital, Washington, DC

    *Purpose: Hepatic ischemia-reperfusion injury (IRI) is a consequence of liver transplantation and hepatectomy that varies in severity and clinical significance. The diagnosis is made based…
  • 2022 American Transplant Congress

    Cd137 on Host Dendritic Cells Fine-Tunes the Intesity of Donor T Cells in Systemic Alloinmmune Responses

    S. Park1, H. Cho2, B. Kwon3, J. Lee4, H. Park1, J. Park4, K. Park4, K. Yoo4

    1Department of Surgery, University of Ulsan College of Medicine, Ulsan, Korea, Republic of, 2University of Ulsan College of Medicine, Ulsan, Korea, Republic of, 3School of Biological Sciences, University of Ulsan, Ulsan, Korea, Republic of, 4Department of Internal Medicine, University of Ulsan College of Medicine, Ulsan, Korea, Republic of

    *Purpose: CD137 is a potent costimulatory receptor for CD8+ T cells but it also regulates dendritic cells (DCs) to suppress immune responses. In this study,…
  • 2022 American Transplant Congress

    Anti-Fibrotic Property of Adipose Derived Regenerative Cells on Hydrogen Peroxide Induced Injury in Nrk-52e Cells

    R. Chawangwongsanukun1, R. Lathan1, R. Pearson2, M. Clancy2, P. Mark1

    1Institute of Cardiovascular and Medical Sciences, Glasgow, United Kingdom, 2Transplant Unit, Queen Elizabeth University Hospital, Glasgow, United Kingdom

    *Purpose: Adipose derived regenerative cells (ADRCs) are a heterogenous cell population derived from adipose tissue. These cells are composed of endothelial progenitor cells, pericytes, and…
  • 2022 American Transplant Congress

    Plasma Galectin-3 is Predictive of Post-Transplant Infection in Pediatric Liver Transplant Recipients

    D. Yoeli, A. Chaidez, Y. Luo, J. Huang, N. Limon De La Rosa, N. Nakra, Z. Wang, E. Cervantes-Alvarez, M. Adams, C. Mack, C. Huang, N. Navarro-Alvarez

    University of Colorado Anschutz Medical, Aurora, CO

    *Purpose: Galectin-3 (Gal3) is a beta-galactoside binding lectin that plays a key role in inflammation and immune response. Infectious complications are common among pediatric liver…
  • 2022 American Transplant Congress

    Deletion of AIF-1 Promotes Kidney Reparative Macrophages and Prevents Fibrosis

    I. Husain, A. Dangi, X. Luo

    Duke University School of Medicine, Durham, NC

    *Purpose: A major etiology contributing to poor allograft survival is the inevitable ischemic insult it incurs during transplantation. Macrophages are key players in ischemia-reperfusion injury,…
  • 2022 American Transplant Congress

    HDAC Inhibitors Suppress Endothelial Inflammation but Alter Identity

    N. M. Valenzuela

    Pathology and Laboratory Medicine, UCLA, Los Angeles, CA

    *Purpose: Histone modifications such as acetylation control gene expression. Histone deacetylases (HDACs) have been proposed as an attractive therapeutic approach to counteract detrimental gene expression,…
  • 2022 American Transplant Congress

    Adoptive Transfer OfMesenchymal Stem Cells Activates Hedgehog/SMO/Gli1 Signaling And Inhibits STING-mediated Innate Immune Response In Liver Transplant Inflammatory Injury

    D. Xu1, X. Qu1, Y. Tian1, M. Sheng1, Y. Lin1, Y. Zhan1, F. M. Kaldas1, R. W. Busuttil1, D. G. Farmer1, J. W. Kupiec-Weglinski1, Q. Xia2, B. Ke1

    1Surgery, Dumont - UCLA Transplant Ctr, Los Angeles, CA, 2Liver Surgery, Shanghai Jiaotong University School of Medicine, Shanghai, China

    *Purpose: The stimulator of interferon genes (STING) pathway has been recognized as a crucial signaling cascade of the innate immune system. Activation of the Hedgehog…
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