2022 American Transplant Congress
Vitamin D Status and Sars-cov-2 Infection in a Cohort of Renal Transplanted Patients
Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico Milano, Milano, Italy
*Purpose: Immunomodulatory and anti-inflammatory properties have been hypothesized for native vitamin D (nVD). Very little is reported about nVD and risk of Sars-CoV-2 infection (COV)…2022 American Transplant Congress
Histologic Predictors of Graft Loss in Early Clinically Indicated Biopsies After Kidney Transplantation
*Purpose: We aimed to investigate histopathological predictors of graft lost in patients who underwent clinically indicated biopsies for worsening kidney function and/or proteinuria within 3…2022 American Transplant Congress
HCK is a Key Regulator for Macrophage Polarization in Kidney Fibrosis
Icahn School of Medicine at Mount Sinai, New York, NY
*Purpose: Interstitial fibrosis and tubular atrophy (IF/TA) is common histological abnormality in biopsy of kidney transplants. Our previous study from a prospective human kidney transplant…2022 American Transplant Congress
P2X7R Inhibition Impairs In Vitro Training of Macrophages
*Purpose: Macrophage training and ATP-mediated P2X7R signaling are unrelated key elements of the innate immune response associated with allotransplant rejection. In the present study, we…2022 American Transplant Congress
Ficoll-Based Isolation Alters the Immunogenicity of Islets That Leads to Enhanced Rejection in Allogeneic Hosts
*Purpose: The purification of pancreatic islets has long relied on the time-consuming density gradient separation method. We herein report a filtration method as an efficient,…2022 American Transplant Congress
QSant, a Novel Urine Test Monitors Recovery of Allograft Injury After DGF
1Nephrosant, Brisbane, CA, 2Hospital do Rim, Sao Paolo, Brazil
*Purpose: We evaluate urine QSant assay to non-invasively monitor recovery of allograft injury, post delayed graft function(DGF).*Methods: 65 HLA-DR matched, renal allograft recipients, on TAC/MMF/prednisone…2022 American Transplant Congress
Type 1 Innate Lymphoid Cells Alleviate Acute Liver Injury Following Transplantation via Interferon-γ Mediated Pathway
Dumont-UCLA Transplant Center, Los Angeles, CA
*Purpose: Innate lymphoid cells (ILCs), a heterogeneous population of non-B non-T lymphocytes, have been found in recent years to plays key regulatory roles in tissue…2022 American Transplant Congress
Alloimmune Recognition Blocks Recipient Macrophage Differentiation into Reparative Subsets
*Purpose: Monocytes differentiate into macrophage subsets that orchestrate tissue repair in response to damage signals and local cytokines. After heart transplant (Tx), graft IL-33 acts…2022 American Transplant Congress
Prevention of the Progression in Chronic Calcineurin Inhibitors Nephrotoxicity via Steroids Anti-Inflammatory Effects
*Purpose: Calcineurin inhibitors (CNI) lead to an excellent short-term kidney allograft outcome. However, chronic nephrotoxicity is a major concern, which affects a long-term allograft survival.…2022 American Transplant Congress
Allo-Sensitization is Increased in Liver Transplant Recipients Following Ischemia-Reperfusion Injury
*Purpose: Recipient sensitization to donor HLA antigens remains an important clinical problem in transplantation, leading to increased wait times to find a compatible donor and…
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