Articles tagged "Inflammation"

2022 American Transplant Congress
Non-Invasive Assessment of Hepatic Ischemia-Reperfusion Injury Using Dynamic Contrast Enhanced-MRI and T2 Mapping
O. C. Rodriguez¹, J. R. Liggett², J. Kang², K. Loh², Y. Lee¹, N. Sang¹, B. He¹, Y. Cui², K. Oza², D. Kwon³, B. Kallakury³, T. Fishbein², W. Cui², K. Khan², C. Albanese¹, A. Kroemer²
¹Lombardi Comprehensive Cancer Center and the Center for Translational Imaging, Georgetown University Medical Center, Washington, DC, ²MedStar Georgetown Transplant Institute, Washington, DC, ³Pathology, MedStar Georgetown University Hospital, Washington, DC
*Purpose: Hepatic ischemia-reperfusion injury (IRI) is a consequence of liver transplantation and hepatectomy that varies in severity and clinical significance. The diagnosis is made based…
2022 American Transplant Congress
Cd137 on Host Dendritic Cells Fine-Tunes the Intesity of Donor T Cells in Systemic Alloinmmune Responses
S. Park¹, H. Cho², B. Kwon³, J. Lee⁴, H. Park¹, J. Park⁴, K. Park⁴, K. Yoo⁴
¹Department of Surgery, University of Ulsan College of Medicine, Ulsan, Korea, Republic of, ²University of Ulsan College of Medicine, Ulsan, Korea, Republic of, ³School of Biological Sciences, University of Ulsan, Ulsan, Korea, Republic of, ⁴Department of Internal Medicine, University of Ulsan College of Medicine, Ulsan, Korea, Republic of
*Purpose: CD137 is a potent costimulatory receptor for CD8+ T cells but it also regulates dendritic cells (DCs) to suppress immune responses. In this study,…
2022 American Transplant Congress
Anti-Fibrotic Property of Adipose Derived Regenerative Cells on Hydrogen Peroxide Induced Injury in Nrk-52e Cells
R. Chawangwongsanukun¹, R. Lathan¹, R. Pearson², M. Clancy², P. Mark¹
¹Institute of Cardiovascular and Medical Sciences, Glasgow, United Kingdom, ²Transplant Unit, Queen Elizabeth University Hospital, Glasgow, United Kingdom
*Purpose: Adipose derived regenerative cells (ADRCs) are a heterogenous cell population derived from adipose tissue. These cells are composed of endothelial progenitor cells, pericytes, and…
2022 American Transplant Congress
Plasma Galectin-3 is Predictive of Post-Transplant Infection in Pediatric Liver Transplant Recipients
D. Yoeli, A. Chaidez, Y. Luo, J. Huang, N. Limon De La Rosa, N. Nakra, Z. Wang, E. Cervantes-Alvarez, M. Adams, C. Mack, C. Huang, N. Navarro-Alvarez
University of Colorado Anschutz Medical, Aurora, CO
*Purpose: Galectin-3 (Gal3) is a beta-galactoside binding lectin that plays a key role in inflammation and immune response. Infectious complications are common among pediatric liver…
2022 American Transplant Congress
Deletion of AIF-1 Promotes Kidney Reparative Macrophages and Prevents Fibrosis
I. Husain, A. Dangi, X. Luo
Duke University School of Medicine, Durham, NC
*Purpose: A major etiology contributing to poor allograft survival is the inevitable ischemic insult it incurs during transplantation. Macrophages are key players in ischemia-reperfusion injury,…
2022 American Transplant Congress
HDAC Inhibitors Suppress Endothelial Inflammation but Alter Identity
N. M. Valenzuela
Pathology and Laboratory Medicine, UCLA, Los Angeles, CA
*Purpose: Histone modifications such as acetylation control gene expression. Histone deacetylases (HDACs) have been proposed as an attractive therapeutic approach to counteract detrimental gene expression,…
2022 American Transplant Congress
Adoptive Transfer OfMesenchymal Stem Cells Activates Hedgehog/SMO/Gli1 Signaling And Inhibits STING-mediated Innate Immune Response In Liver Transplant Inflammatory Injury
D. Xu¹, X. Qu¹, Y. Tian¹, M. Sheng¹, Y. Lin¹, Y. Zhan¹, F. M. Kaldas¹, R. W. Busuttil¹, D. G. Farmer¹, J. W. Kupiec-Weglinski¹, Q. Xia², B. Ke¹
¹Surgery, Dumont - UCLA Transplant Ctr, Los Angeles, CA, ²Liver Surgery, Shanghai Jiaotong University School of Medicine, Shanghai, China
*Purpose: The stimulator of interferon genes (STING) pathway has been recognized as a crucial signaling cascade of the innate immune system. Activation of the Hedgehog…
2022 American Transplant Congress
Myeloid Molecular Signature of Ischemia-Reperfusion Injury in Human Liver Transplantation
R. A. Sosa¹, R. Ahn², A. Terry¹, Z. Qian², F. Li¹, S. Sen¹, T. Ito³, B. V. Naini¹, F. Kaldas³, A. Hoffmann², R. W. Busuttil³, D. W. Gjertson¹, J. Kupiec-Weglinski³, E. F. Reed¹
¹Pathology and Lab Medicine, UCLA, Los Angeles, CA, ²Microbiology, Immunology and Molecular Genetics, UCLA, Los Angeles, CA, ³Surgery, UCLA, Los Angeles, CA
*Purpose: Ischemia reperfusion injury (IRI) is well-appreciated as a significant clinical concern for recipients of liver transplantation, yet there are still no diagnostic or therapeutic…
2022 American Transplant Congress
Utility of Urinary CTGF as a Biomarker of Progressive Allograft Dysfunction in Pediatric Renal Transplant Recipients
L. Sheward¹, J. Wedel¹, N. Rodig¹, A. Kho¹, T. Blydt-Hansen², R. B. Mannon³, D. M. Briscoe¹
¹Boston Children's Hospital, Boston, MA, ²BC Children's Hospital, Vancouver, BC, Canada, ³University of Nebraska Medical Center, Omaha, NE
*Purpose: Previous reports from a number of studies indicate that renal allograft recipients who have inflammatory infiltrates within areas of interstitial fibrosis with tubular atrophy…
2022 American Transplant Congress
Study of the Composition of the Inflammatory Burden on a Cohort of 125 Rejections by Multiplex Immunofluorescence
A. Mobio¹, M. Eloudzeri², L. Morin¹, J. Duong Van Huyen³, D. Anglicheau¹, M. Rabant³
¹Kidney transplantation, Necker-Enfants Malades Hospital, Paris, France, ²U1151, INEM, Paris, France, ³Pathology, Necker-Enfants Malades Hospital, Paris, France
*Purpose: The exact composition of the inflammatory burden during kidney transplant rejection has not been studied on large cohorts. Moreover, the determinants and impact of…