2015 American Transplant Congress
MHC-Class-II Specific Sensitization in a Non-Human Primate Model of Sensitzation
1Emory University, Atlanta, GA; 2Medical University Vienna, Vienna, Austria.
[Background] Sensitization before transplantation and de novo alloantibodies affect a significant number of patients awaiting kidney transplantation. The type of anti-HLA antibody varies with subgroups…2015 American Transplant Congress
Serum Proteins Are Significantly Upregulated in Patients With Clinical Antibody-Mediated Rejection
Background: Antibody-mediated rejection (ABMR) is a major pathway associated with late graft loss. Although serum de novo donor-specific HLA antibodies are frequently observed in ABMR,…2015 American Transplant Congress
Delayed Graft Function (DGF) in Kidney Transplant Recipients (KTRs) Is Associated With Early Allograft Inflammation and Progressive Fibrosis Within 3 Months
University of Pittsburgh, Pittsburgh.
DGF had been shown to be deleterious to KTR outcomes. Analysis of histological progression in KTRs with DGF was previously not attempted. In this prospective…2015 American Transplant Congress
Antibody-Induced Platelet Activation Increases Allograft Hyaluronan Fragmentation
Antibodies to MHC class I antigens have been shown to activate endothelial cells to release von Willebrand factor (vWf) and P-selectin from storage granules. These…2015 American Transplant Congress
Kidney Double Negative TCR αβ + Cells: Newly Described Intra-Renal Kidney Lymphocytes That Respond to Ischemia Reperfusion in Mice
Background TCRαβ+CD4-CD8- double negative (DN) T cells with immunoregulatory function are a significant component of T cells residing in the kidney. The exact role of…2015 American Transplant Congress
Differential Intragraft Gene Expression Profiles in Patients With Sterile Leukocyturia
Objective: We aimed to investigate if sterile leukocyturia reflects increased intragraft immune activity and gene expression profiles of transplant kidney biopsies differ from patients without…2015 American Transplant Congress
Association of IP-10 With Poor Islet Graft Function After Total Pancreatectomy With Islet Autotransplantation
Introduction: Total pancreatectomy with islet autotransplantation (TPIAT) is an effective treatment for refractory chronic pancreatitis. The mechanisms underlying islet graft loss, however, remain unclear. Interferon…2015 American Transplant Congress
Tandem P-Selectin Glycoprotein Ligand-Immunoglobulin (TSGL-Ig) Protects Liver Endothelial Cells Against Prolonged Cold Preservation Injury in Mouse Liver Transplantation
Background: Liver endothelial cell (LEC) damage is central in the pathogenesis of hepatic ischemia-reperfusion injury (IRI). LEC detachment/progressed denudation are typical during cold storage and…2015 American Transplant Congress
Isolated Microcirculation Inflammation Negatively Impacts Renal Graft Function at 5 Years
BACKGROUND: Microcirculation inflammation (MI, ie: glomerulitis (g) and peritubular capillaritis (ptc)) associated with anti-HLA Donor Specific Antibody (DSA) with or without C4d deposits in ptc…2015 American Transplant Congress
Detection of Donor-Specific Anti-HLA Antibodies Is Associated With Changes in the Peripheral Distribution of NK Cell Subsets in Kidney Allograft Recipients
Background: Microvascular damage has become the real protagonist involved in antibody-mediated rejection and NK-cell antibody-dependent cell mediated cytotoxicity (ADCC) has been proposed as a contributing…
American Transplant Congress abstracts