Articles tagged "Inflammation"

2015 American Transplant Congress
Delayed Graft Function (DGF) in Kidney Transplant Recipients (KTRs) Is Associated With Early Allograft Inflammation and Progressive Fibrosis Within 3 Months
A. Cherukuri, R. Mehta, P. Sood, S. Chen, G. Mour, A. Tevar, P. Randhava, S. Hariharan.
University of Pittsburgh, Pittsburgh.
DGF had been shown to be deleterious to KTR outcomes. Analysis of histological progression in KTRs with DGF was previously not attempted. In this prospective…
2015 American Transplant Congress
Antibody-Induced Platelet Activation Increases Allograft Hyaluronan Fragmentation
H.-H. Kuo,¹ R. Fan,¹ N. Dvorina,¹ C. De La Motte,² W. Baldwin.¹
¹Immunology, Lerner Research Istitute, Cleveland, OH; ²Pathobiology, Lerner Research Institute, Cleveland, OH.
Antibodies to MHC class I antigens have been shown to activate endothelial cells to release von Willebrand factor (vWf) and P-selectin from storage granules. These…
2015 American Transplant Congress
Kidney Double Negative TCR αβ + Cells: Newly Described Intra-Renal Kidney Lymphocytes That Respond to Ischemia Reperfusion in Mice
M. Martina,¹ S. Bandapalle,² S. Noel,² A. Saxena,¹ A. Hamad,¹ H. Rabb.²
¹Pathology, Johns Hopkins University, Baltimore, MD; ²Medicine, Johns Hopkins University, Baltimore, MD.
Background TCRαβ+CD4-CD8- double negative (DN) T cells with immunoregulatory function are a significant component of T cells residing in the kidney. The exact role of…
2015 American Transplant Congress
Differential Intragraft Gene Expression Profiles in Patients With Sterile Leukocyturia
M. Ajaimy,¹ P. O Broin,² Y. Bao,¹ J. Lindower,¹ A. Golden,² E. Akalin.¹
¹Transplantation, Einstein/Montefiore Transplant Center, Bronx; ²Computational Genomics Facility, Albert/Einstein College of Medicine, Bronx.
Objective: We aimed to investigate if sterile leukocyturia reflects increased intragraft immune activity and gene expression profiles of transplant kidney biopsies differ from patients without…
2015 American Transplant Congress
Association of IP-10 With Poor Islet Graft Function After Total Pancreatectomy With Islet Autotransplantation
M. Kanak,¹ M. Lawrence,² F. Kunnathodi,² G. Yoshimatsu,² R. Shahbazov,² M. Takita,² M. Levy,³ B. Naziruddin.³
¹Institute for Biomedical Studies, Baylor University, Waco, Tx; ²Islet Cell Laboratory, Baylor Research Institute, Dallas, TX; ³Baylor Annette C. and Harold C. Simmons Transplant Institute, Dallas, TX.
Introduction: Total pancreatectomy with islet autotransplantation (TPIAT) is an effective treatment for refractory chronic pancreatitis. The mechanisms underlying islet graft loss, however, remain unclear. Interferon…
2015 American Transplant Congress
Tandem P-Selectin Glycoprotein Ligand-Immunoglobulin (TSGL-Ig) Protects Liver Endothelial Cells Against Prolonged Cold Preservation Injury in Mouse Liver Transplantation
C. Zhang,¹ H. Ji,¹ Y. Liu,¹ X. Shen,¹ F. Gao,¹ R. Busuttil,¹ G. Shaw,² J. Kupiec-Weglinski.¹
¹Dept of Surgery, Dumont-UCLA Liver Transplant Center, Los Angeles, CA; ²Quell Pharma Inc., Half Moon Bay, CA.
Background: Liver endothelial cell (LEC) damage is central in the pathogenesis of hepatic ischemia-reperfusion injury (IRI). LEC detachment/progressed denudation are typical during cold storage and…
2015 American Transplant Congress
Isolated Microcirculation Inflammation Negatively Impacts Renal Graft Function at 5 Years
A. Chapelet,¹ M. Touzot,¹ M. Fournier,² A. Cesbron,³ K. Renaudin,⁴ A. Moreau,⁴ E. Morelon,⁵ D. Anglicheau,⁶ M. Giral.¹
¹Institut de Transplantation Urologie Néphrologie, CHU Nantes, Nantes, France; ²EA 4275 SPHERE—Biostatistics, Pharmacoepidemiology and Subjective Measures in Health Sciences, University of Nantes, Nantes, France; ³Etablissement Français du Sang (EFS), Nantes, France; ⁴Service d'Anatomie et Cytologie Pathologiques, CHU Nantes, Nantes, France; ⁵Service de Néphrologie, Transplantation et Immunologie Clinique, Hôpital Edouard Herriot, Lyon, France; ⁶Service de Transplantation Rénale et de Soins Intensifs, Hôpital Necker, Paris, France.
BACKGROUND: Microcirculation inflammation (MI, ie: glomerulitis (g) and peritubular capillaritis (ptc)) associated with anti-HLA Donor Specific Antibody (DSA) with or without C4d deposits in ptc…
2015 American Transplant Congress
Detection of Donor-Specific Anti-HLA Antibodies Is Associated With Changes in the Peripheral Distribution of NK Cell Subsets in Kidney Allograft Recipients
M. Crespo,¹ D. Redondo,¹ J. Yelamos,² A. Muntasell,² M. Pérez-Sáez,¹ M. Lopez-Montañes,³ C. Garcia,⁴ A. Torío,⁵ J. Hernandez,⁴ M. Mir,¹ M. Lopez-Botet,³ J. Pascual.¹
¹Nephrology, Hospital del Mar, Barcelona, Spain; ²Servicio de Inmunología, Institut Mar d'Investigacions Mediques, Barcelona, Spain; ³Grup de Investigacio en Immunologia, Universitat Pompeu Fabra, Barcelona, Spain; ⁴Laboratori de Referencia de Catalunya, Barcelona, Spain; ⁵Immunology Unit, Hospital de Alicante, Alicante, Spain.
Background: Microvascular damage has become the real protagonist involved in antibody-mediated rejection and NK-cell antibody-dependent cell mediated cytotoxicity (ADCC) has been proposed as a contributing…
2015 American Transplant Congress
Loss of RIPK3 and Caspase-8 Enhance Intrinsic Apoptosis in Tubular Epithelial Cell (TEC) Death and Contributes to Kidney Ischemia Reperfusion Injury (IRI)
B. Sung,¹ Y. Su,³ A. Lau,³ J. Jiang,³ A. Haig,² D. Green,⁴ Z. Zhang,² A. Jevnikar.¹
¹Microbiology and Immunology, Western University, London, ON, Canada; ²Pathology, Western University, London, ON, Canada; ³Matthew Mailing Centre for Translational Transplant Studies, London Health Sciences Centre, London, ON, Canada; ⁴St. Jude Children's Research Hospital, Memphis, TN.
[Background] Ischemia-reperfusion injury (IRI), a complex limiting factor in organ transplant survival, is related to multiple death pathways. Eliminating the key necroptotic molecule (RIPK3) improves…
2015 American Transplant Congress
IL-17 Production Influenced by Induction Therapy With ATG
D. Abendroth,¹ M. Marzinzig,¹ J. Kaden.²
¹Center of Surgery, University of Ulm, Ulm, Germany; ²Renal Transplant Center, Municipal Friedrichshain Hospital, Berlin, Germany.
Introduction Immune-mediated rejection remains the most important cause of graft failure. Recently, a newly identified CD4+ T cell subset, Th17, distinct from Th1 or Th2,…