ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Inflammation"

  • 2016 American Transplant Congress

    Microfluidics to Characterize Leukocyte Trafficking into Allografts and the Resolution of Inflammation.

    L. Boneschansker,1,2 D. Irimia,2 D. Briscoe.1

    1Transplant Research Program, Boston Children's Hospital, Boston; 2MGH, Boston.

    Pro-resolution mediators such as resolvins and axonal guidance receptor-ligand interactions are increasingly recognized to regulate leukocyte trafficking into sites of inflammation. The implication of this…
  • 2016 American Transplant Congress

    The Immunologic Profile of Brain Death in Humans: A Whole-Body Analysis.

    D. Carpenter,1,2 N. Matsuoka,1 J. Thome,1,3 T. Granot,1,3 C. Gordon,1,3 B. Kumar,1,3 T. Senda,1,3 M. Miron,1,3 J. Weiner,2 A. Griesemer,1,2 D. Farber.1,2,3

    1Columbia Center for Translational Immunology, Columbia University Medical Center, New York City, NY; 2Surgery, Columbia University Medical Center, New York City, NY; 3Microbiology and Immunology, Columbia University Medical Center, New York City, NY.

    Transplantation outcomes are believed to be influenced by a generalized inflammatory state caused by brain death itself or events in the peri-transplant period. Studies on…
  • 2016 American Transplant Congress

    Optimizing the Immunogenicity and Immunomodulatory Properties of MSC for Cellular Therapy.

    S. de Witte,1 M. Franquesa,1 T. Strini,1 S. Korevaar,1 F. Luk,1 S. Elliman,2 P. Newsome,3 M. Gargesha,4 D. Roy,4 A. Merino,1 C. Baan,1 M. Hoogduijn.1

    1ErasmusMC, Rotterdam, Netherlands; 2Orbsen Therapeutics, Galway, Ireland; 3University of Birmingham, Birmingham, United Kingdom; 4Bioinvision, Mayfield Village.

    Mesenchymal stromal cells (MSC) are candidates for immunotherapy after transplantation. MSC have shown to be immunomodulatory and low immunogenic, which is favorable for cellular therapy…
  • 2016 American Transplant Congress

    Rapamycin Nanotherapy Delays Heart Transplant Rejection.

    M. Braza,1 M. Lameijer,1 C. Perez-Medina,1 T. Reiner,3 M. Nahrendorf,4 Z. Fayad,1 R. Duivenvoorden,1 J. Ochando,2 W. Mulder.1

    1Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York; 2Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York; 3Radiology, Memorial Sloan-Kettering Cancer Center, New York; 4Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston.

    Background:In patients, allograft survival requires a cocktail of immunosuppressive drugs, while experimentally antibodies targeting the innate immune system have been shown to induce long-term tolerance,…
  • 2015 American Transplant Congress

    Enhanced Production of Macrophage Chemoattractant Protein-1 (MCP-1) Within the Kidney in Brain Death Donors Predicts Recipient Allograft Function

    J. Chen, S. Antipenko, A. Zmijewska, R. Reed, J. Locke, R. Mannon.

    Medicine/Surgery, University of Alabama at Birmingham, Birmingham, AL.

    Brain death (BD) induces an intense pro-inflammatory state, which may impact recipient immunity and graft function after kidney transplantation. The identification of biomarkers predictive of…
  • 2015 American Transplant Congress

    Donor Organ Resident M2 Type Myeloid Cells Protect Murine Orthotropic Liver Transplants from Ischemia and Reperfusion Injury

    S. Yue, X. Shen, F. Gao, R. Busuttil, J. Kupiec-Weglinski, Y. Zhai.

    The Dumont-UCLA Transplant Ctr., UCLA, Los Angeles, CA.

    Liver ischemia reperfusion injury (lRI) is mediated by a pro-inflammatory immune response initiated by the activation of liver non-parenchymal innate immune cells, such as Kupffer…
  • 2015 American Transplant Congress

    Predictive Value of Postoperative CRP and Procalctonin in Kidney Donors Experiencing Surgical Complications

    Z. Ahmed, R. Tamburrini, J. Wright, N. Kessaris, N. Mamode.

    Renal and Pancreatic Transplantation, Guy's Hospital, London, United Kingdom.

    Introduction: Patients undergoing donor nephrectomy are fit and well individuals. Despite this, 1 in 5 will suffer a perioperative complication causing significant morbidity. Recent published…
  • 2015 American Transplant Congress

    Perfusion Disturbances and Local Infarctions After Experimental Kidney Transplantation Corralte With the Duration of Cold Ischemia Time

    S. Rong,1 R. Chen,1 M. Meier,4 B. Hensen,2 H. Haller,1 K. Hueper,2 F. Gueler.1

    1Nephrology, Hannover Medical School, Hannover, Germany; 2Radiology, Hannover Medical School, Hannover, Germany; 3Laboratory Medicine and Pathology, University of Alberta, Edmonton, Canada; 4Imaging Center, Hannover Medical School, Hannover, Germany.

    Background: Kidney transplantation in mice is challenging but offers good translational models to study mechanisms of disease. In this study allogenic and isogenic kidney transplantation…
  • 2015 American Transplant Congress

    Galectin-9 Protects Mouse Liver Transplants Against Ischemia-Reperfusion Injury

    H. Ji, Y. Liu, Y. Zhang, X. Shen, F. Gao, R. Busuttil, J. Kupiec-Weglinski.

    Dept of Surgery, Dumont-UCLA Liver Transplant Center, Los Angeles, CA.

    Background:Although Galecin 9 (Gal-9) negatively regulates Th1-type alloimmunity by binding to T-cell Immunoglobulin Mucin-3 (TIM-3) on activated Th1 cells, its role in liver ischemia-reperfusion injury…
  • 2015 American Transplant Congress

    AAV-Mediated TIMP-1 Gene Therapy Ameliorates Hepatic Ischemia/Reperfusion Injury

    S. Duarte, T. Fujii, G. Lipshutz, R. Busuttil, A. Coito.

    The Dumont-UCLA Transplant Center, Los Angeles.

    Matrix metalloproteinase-9 (MMP-9) is a key mediator of leukocyte migration across vascular barriers in hepatic ischemia/reperfusion injury (IRI). Tissue inhibitor of metalloproteinase-1 (TIMP-1) is the…
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