2016 American Transplant Congress
A Systematic Over View of Five Year Results of Serial Protocol Kidney Transplant Biopsies.
Surgery, UCSF, San Francisco, CA.
Background: Protocol biopsies can detect sub-clinical rejection. With declining rates of clinical acute rejection, a systematic review of protocol biopsies can provide clues about other…2016 American Transplant Congress
Vascular Endothelial Cell Activation by Mitochondria Links Innate and Adaptive Immune Responses to Allograft Injury.
Surgery, Duke University Medical Center, Durham, NC.
Vascular endothelial cells (ECs) are an initial barrier between allografts and the host immune system and play an important role in initiating allograft rejection. Increasing…2016 American Transplant Congress
Re-Examining the Role of B-1 Cells in a Murine Model of Renal Ischemia Reperfusion Injury.
We propose a reexamination of the currently underappreciated role of B-1 cells in IRI. Ischemia reperfusion injury (IRI) is a two phase insult composed of…2016 American Transplant Congress
Fecal Microbiota Transplant Results in Durable Changes to Host Microbiota That Correlate with Allograft Outcome.
CVID and IGS, University of Maryland School of Medicine, Baltimore, MD.
Hypothesis: We previously presented highly significant differences in the bacterial community structures of human renal allograft recipients over time. Likewise, murine normal, colitic, and pregnant…2015 American Transplant Congress
Molecular Correlates of Atrophy-Fibrosis in Human Kidney Transplants Provides a New Model of Renal Fibrosis
University of Alberta, Edmonton, Canada.
We studied the effect of time post-transplant on atrophy-fibrosis (AF) and the molecular associations with AF in 703 kidney transplant indication biopsies (bx) 3 days…2015 American Transplant Congress
Histology of Renal Allografts With DGF Provides Limited Prognostic Information
DGF has been shown to be associated with adverse graft outcomes in renal transplantation. However DGF is heterogeneous histologically and the impact of various histological…2015 American Transplant Congress
Macrophage Specific β-Catenin Controls ROCK/PTEN Function and Regulates Innate Immunity in Liver Inflammation
Background: It has been shown that β-catenin is an important regulator of cell development, regeneration, and carcinogenesis. Our previous studies demonstrated the key role of…2015 American Transplant Congress
Intra-Allograft Common Rejection Module (CRM) Expression in Kidney Transplants Diagnoses Acute Rejection and Predicts Long Term Graft Prognosis
Surgery, UC San Francisco, San Francisco, CA.
Background: Previous studies with cross-organ transcriptional analysis of 794 allograft biopsies from kidney, liver, heart and lung transplant patients identified a common rejection module (CRM)…2015 American Transplant Congress
Microvascular (MIA) and Interstitial (i) Inflammation Influence Late Death-Censored Graft Failure (DCGF) After Kidney Transplantation
We and others have shown late DCGF is due to ongoing, most often immune, injury. Though there is general agreement that antibody-mediated injury is a…2015 American Transplant Congress
An Orchestrated Sequence of Innate and Adaptive Immune Responses Is Associated With Rejection After Pediatric Liver Transplantation
The concept of a coordinated immune response initiated by innate and sustained by adaptive immune cells and their soluble mediators is well established for infection…
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