Articles tagged "Inflammation"

2016 American Transplant Congress
Immunosuppressive Actions of CLI95 and CORM401 on TLR4 in Renal Ischemia Reperfusion Injury.
P. Luke,^1,2,5 G. Cepinskas,^1,4 H. Alharbi,^3,5 A. Haig,^3,5 R. Bhattacharjee.^1,2,5
¹Matthew Mailing Centre, London Health Sciences Centre, London, Canada; ²Surgery, Western University, London, Canada; ³Pathology and Laboratory Medicine, Western University, London, Canada.
Background: Kidneys from all donor sources are highly sensitive to ischemia-reperfusion injury (IRI). However, grafts donated after cardiac death (DCD) sustain an increased incidence of…
2016 American Transplant Congress
The Effect of the Use of a TNF-Alpha Inhibitor in Hypothermic Machine Perfusion on Kidney Function After Transplantation.
P. Diuwe,¹ P. Domagala,¹ R. Kieszek,¹ M. Wszola,¹ M. Serwanska-Swietek,¹ L. Paczek,² M. Durlik,³ A. Chmura,¹ A. Kwiatkowski.¹
¹Department of General Surgery and Transplantology, Medical University of Warsaw, Warsaw, Poland; ²Department of Immunology, Transplantology and Internal Medicine, Medical University of Warsaw, Warsaw, Poland; ³Department of Transplantology and Nephrology, Medical University of Warsaw, Warsaw, Poland.
Organ damage associated with processes occurring during the ischaemic period as well as during and after organ reperfusion is an important problem of transplantation medicine.The…
2016 American Transplant Congress
HO-1/SIRT1/p53 Axis Regulates Macrophage Activation and Attenuates Liver Ischemia-Reperfusion Injury in Mice.
K. Nakamura,¹ M. Zhang,² B. Ke,¹ S. Kageyama,¹ R. Busuttil,¹ J. Araujo,² J. Kupiec-Weglinski.¹
¹Surgery, Liver Transplant, University of California-Los Angeles, Los Angeles, CA; ²Medicine, Division of Cardiology, University of California-Los Angeles, Los Angeles, CA.
Background/Aim: The mechanism by which macrophage heme oxygenase-1 (HO-1)-Sirtuin1 (SIRT1) signaling promotes resistance against inflammation response in liver ischemia-reperfusion injury (IRI) remains elusive. As tumor…
2016 American Transplant Congress
Deceased Donor Urine C5a Predicts Donor and Recipient Acute Kidney Injury.
B. Schroppel,¹ P. Heeger,² I. Hall,³ M. Doshi,⁴ F. Weng,⁵ P. Reese,⁶ C. Parikh.³
¹University Hospital, Ulm, Germany; ²Mount Sinai School of Medicine, New York; ³Program of Applied Translational Research, Yale University School of Medicine, New Haven; ⁴Wayne State University, Detroit; ⁵Barnabas Health, Livingston; ⁶University of Pennsylvania, Philadelphia.
Anti-complement therapies are currently being tested in human kidney transplantation to prevent DGF. In this large prospective, cohort study of 469 deceased organ donors, we…
2016 American Transplant Congress
Metabolic Dysregulation and Mitochondrial Dysfunction Are Key Features of Injury Profiles of Donor Kidneys After Brain Death.
M. Lo Faro,¹ M. Akhtar,¹ H. Huang,¹ M. Kaisar,¹ R. Robolledo,² K. Morten,¹ L. Heather,¹ A. Dona,³ H. Leuvenink,² S. Fuggle,¹ B. Kessler,¹ C. Pugh,¹ R. Ploeg.¹
¹University of Oxford, Oxford, United Kingdom; ²University of Groningen, Groningen, Netherlands; ³University of Sydney, Sydney, Australia.
Donation after brain death (DBD) organ donors remain an important source for kidney transplantation. However, brain death affects donor organs rendering them susceptible to ischemia…
2016 American Transplant Congress
Effect of Inflammation on Concentration of Intracellular Tacrolimus.
E. Bae,¹ S. Yang,² S. Han,¹ J.-Y. Park,¹ H. Lee,¹ Y. Kim.¹
¹Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea; ²Kidney Research Institute, Seoul National University, Seoul, Republic of Korea.
Background: The use of calcineurin inhibitors improved the outcome for transplant recipients. However, acute rejection (AR) and infection remained still an unsolved problem. We evaluated…
2016 American Transplant Congress
Cold Storage Stabilization of Gap Junctions Reduces Post Transplant Ischemia Reperfusion Injury.
R. Finnegan,¹ P. Zhu,¹ S. Stephenson,¹ K. Patel,² S. Nadig,^1,2,3 C. Atkinson.^1,2,3
¹Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC; ²Department of Surgery, Medical University of South Carolina, Charleston, SC; ³South Carolina Investigators in Transplantation, Medical University of South Carolina, Charleston, SC.
Purpose: Organ procurement, cold storage and ischemia reperfusion injury (IRI) promote inflammation, which induces endothelial cell (EC) activation and dysfunction post transplantation. EC gap junctions…
2016 American Transplant Congress
The Urine Common Rejection Module (uCRM) Is a Sentinal Assay for Graft Rejection.
T. Sigdel,¹ T. Tran,¹ O. Bestard,² F. Vincenti,¹ M. Sarwal.¹
¹Surgery, UCSF, San Francisco, CA; ²Nephrology, Bellevitage Hospital, Barcelona, Spain.
Background: A common rejection module (CRM) consisting of 11 genes are expressed in solid organ transplant rejection in kidney, heart, liver and lung transplantation (Khatri,…
2016 American Transplant Congress
Liver Ischemia Induces Kupffer Cell Necroptosis to Facilitate Liver Inflammatory Immune Activation.
S. Yue,¹ H. Zhou,^1,2 R. Busuttil,¹ J. Kupiec-Weglinski,¹ X. Wang,² Y. Zhai.¹
¹Surgery, David Geffen School of Medicine-University of California-Los Angeles, Los Angeles, CA; ²Liver Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China.
Background & AimsAlthough mechanisms of liver immune activation against ischemia reperfusion injury (IRI) have been studied extensively, cellular bases have yet to be fully defined…
2016 American Transplant Congress
Serial Peripheral Blood Mononuclear Cell Expression Profiling Reveals Inflammatory Genomic Storm Following Mechanical Circulatory Support Surgery.
G. Godoy,¹ G. Bondar,¹ A. Esmaeili,¹ E. Arellano,¹ E. Chang,¹ M. Bakir,¹ J. Chittoor,¹ R. Togashi,¹ N. Fazli,¹ C. Starling,¹ E. Oh,¹ S. Toluie,¹ Z. Yang,² D. Tran,¹ M. Cadeiras,¹ N. Wisniewski,¹ M. Kwon,¹ J. Schaenman,¹ Y. Korin,¹ M. Rosetti,¹ E. Reed,¹ M. Deng.¹
¹University of California, Los Angeles, Los Angeles, CA; ²Shanxi Medical University First Hospital, Taiyuan, Shanxi, China.
Introduction: The main cause of death in patients with Advanced Heart Failure (AdHF) is the Multi-Organ Dysfunction (MOD) Syndrome. Immune system aberrancy after Mechanical Circulatory…