Articles tagged "Inflammation"

2022 American Transplant Congress
Deletion of AIF-1 Promotes Kidney Reparative Macrophages and Prevents Fibrosis
I. Husain, A. Dangi, X. Luo
Duke University School of Medicine, Durham, NC
*Purpose: A major etiology contributing to poor allograft survival is the inevitable ischemic insult it incurs during transplantation. Macrophages are key players in ischemia-reperfusion injury,…
2022 American Transplant Congress
HDAC Inhibitors Suppress Endothelial Inflammation but Alter Identity
N. M. Valenzuela
Pathology and Laboratory Medicine, UCLA, Los Angeles, CA
*Purpose: Histone modifications such as acetylation control gene expression. Histone deacetylases (HDACs) have been proposed as an attractive therapeutic approach to counteract detrimental gene expression,…
2022 American Transplant Congress
Adoptive Transfer OfMesenchymal Stem Cells Activates Hedgehog/SMO/Gli1 Signaling And Inhibits STING-mediated Innate Immune Response In Liver Transplant Inflammatory Injury
D. Xu¹, X. Qu¹, Y. Tian¹, M. Sheng¹, Y. Lin¹, Y. Zhan¹, F. M. Kaldas¹, R. W. Busuttil¹, D. G. Farmer¹, J. W. Kupiec-Weglinski¹, Q. Xia², B. Ke¹
¹Surgery, Dumont - UCLA Transplant Ctr, Los Angeles, CA, ²Liver Surgery, Shanghai Jiaotong University School of Medicine, Shanghai, China
*Purpose: The stimulator of interferon genes (STING) pathway has been recognized as a crucial signaling cascade of the innate immune system. Activation of the Hedgehog…
2022 American Transplant Congress
Myeloid Molecular Signature of Ischemia-Reperfusion Injury in Human Liver Transplantation
R. A. Sosa¹, R. Ahn², A. Terry¹, Z. Qian², F. Li¹, S. Sen¹, T. Ito³, B. V. Naini¹, F. Kaldas³, A. Hoffmann², R. W. Busuttil³, D. W. Gjertson¹, J. Kupiec-Weglinski³, E. F. Reed¹
¹Pathology and Lab Medicine, UCLA, Los Angeles, CA, ²Microbiology, Immunology and Molecular Genetics, UCLA, Los Angeles, CA, ³Surgery, UCLA, Los Angeles, CA
*Purpose: Ischemia reperfusion injury (IRI) is well-appreciated as a significant clinical concern for recipients of liver transplantation, yet there are still no diagnostic or therapeutic…
2022 American Transplant Congress
Utility of Urinary CTGF as a Biomarker of Progressive Allograft Dysfunction in Pediatric Renal Transplant Recipients
L. Sheward¹, J. Wedel¹, N. Rodig¹, A. Kho¹, T. Blydt-Hansen², R. B. Mannon³, D. M. Briscoe¹
¹Boston Children's Hospital, Boston, MA, ²BC Children's Hospital, Vancouver, BC, Canada, ³University of Nebraska Medical Center, Omaha, NE
*Purpose: Previous reports from a number of studies indicate that renal allograft recipients who have inflammatory infiltrates within areas of interstitial fibrosis with tubular atrophy…
2022 American Transplant Congress
Study of the Composition of the Inflammatory Burden on a Cohort of 125 Rejections by Multiplex Immunofluorescence
A. Mobio¹, M. Eloudzeri², L. Morin¹, J. Duong Van Huyen³, D. Anglicheau¹, M. Rabant³
¹Kidney transplantation, Necker-Enfants Malades Hospital, Paris, France, ²U1151, INEM, Paris, France, ³Pathology, Necker-Enfants Malades Hospital, Paris, France
*Purpose: The exact composition of the inflammatory burden during kidney transplant rejection has not been studied on large cohorts. Moreover, the determinants and impact of…
2022 American Transplant Congress
Apheresis of Deceased Donors: A New Source of Mobilized Peripheral Blood Hematopoietic Stem Cells for Transplant Tolerance
R. A. Sosa¹, T. Mone², B. V. Naini¹, D. B. Kohn³, E. F. Reed¹, K. Wheeler², B. Campo-Fernandez³, A. Davila³, D. J. Chaffin⁴, J. DiNorcia⁵, F. M. Kaldas⁵, A. Cohen², E. Lum⁶, J. L. Veale⁷, N. M. Kogut⁷
¹Pathology and Lab Medicine, UCLA, Los Angeles, CA, ²One Legacy, Los Angeles, CA, ³Microbiology, Immunology and Molecular Genetics, UCLA, Los Angeles, CA, ⁴LifeStream Blood Bank, San Bernadino, CA, ⁵Surgery, UCLA, Los Angeles, CA, ⁶Medicine, UCLA, Los Angeles, CA, ⁷Urology, UCLA, Los Angeles, CA
*Purpose: Solid organ transplantation is the therapy of choice for many patients with end-stage organ failure, but recipients must remain on lifelong immune suppression, leaving…
2022 American Transplant Congress
Galectin-3 Discriminates Patients with Advanced Cirrhosis and Predicts Post-Liver Transplant Infectious Complications
E. Cervantes-Alvarez¹, M. Vilatobá¹, J. Argemi², N. Limon-de la Rosa¹, O. Mendez-Guerrero¹, C. Huang³, D. Kershenobich¹, R. Bataller⁴, A. Torre⁵, N. Navarro-Alvarez¹
¹Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico, ²Liver Unit, Clinica Universidad de Navarra, Hepatology Program, Center for Applied Medical Research, Pamplona, Spain, Pamplona, Spain, ³University of Colorado Anschutz Medical Campus, Denver, CO, ⁴University of Pittsburgh Medical Center, Pittsburgh, PA, ⁵Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico city, Mexico
*Purpose: An increased demand for liver transplantation (LT) prevails. Galectin-3 is a lectin implicated in inflammation, immunoregulation, and liver fibrosis. In this study we assessed…
2022 American Transplant Congress
Nebulized Mitochondria Localize to Transplanted Allografts and Improve Outcomes Following Lung Transplantation
D. Nord¹, Z. Tu², L. Langerude¹, A. McQuiston¹, J. Kwon³, S. Nadig⁴, T. Machuca⁵, C. Atkinson¹
¹Pulmonary Medicine, University of Florida, Gainesville, FL, ²University of Florida, Gaineville, FL, ³MUSC College of Medicine, Charleston, SC, ⁴Northwestern University, Charleston, SC, ⁵Department of Surgery, University of Florida, Gainesville, FL
*Purpose: Mitochondrial transplantation therapy is an innovative strategy for the treatment of mitochondrial dysfunction. The approach has shown efficacy in the treatment of cardiac ischemic…
2022 American Transplant Congress
Discordant Histological Findings During Acute Rejection in a Combined Face and Hand Transplant Recipient
O. C. Onuh¹, J. Trilles¹, W. J. Rifkin¹, H. Brydges¹, B. F. Chaya¹, R. Rodriguez Colon¹, D. Boczar¹, D. J. Ceradini¹, E. D. Rodriguez¹, B. E. Gelb²
¹Hansjörg Wyss Department of Plastic Surgery, NYU Langone Health, New York, NY, ²Transplant Institute, NYU Langone Health, New York, NY
*Purpose: The purpose of this study is to evaluate histologic findings in a face and bilateral hand transplant recipient that was monitored with multi-site allograft…