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American Transplant Congress abstracts

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Articles tagged "Inflammation"

  • 2022 American Transplant Congress

    Donor Kidney-Resident Passenger Macrophages Promote CCL8-CCR8 Mediated Early Allograft Inflammation

    A. Dangi1, I. Husain2, N. Natesh3, X. Shen3, J. Kwun4, X. Luo5

    1Medicine, Duke University Medical Center, Durham, NC, 2Duke University Medical Center, Durham, NC, 3Biomedical Engineering, Duke University, Durham, NC, 4Duke Transplant Center, Durham, NC, 5Duke University School of Medicine, Durham, NC

    *Purpose: Early intragraft infiltration of monocytes and macrophages has been associated with acute and chronic allograft rejections. Nevertheless, underlying mechanism remained poorly understood. In the…
  • 2022 American Transplant Congress

    Analysis of Tissue and Effluent Damage Associated Molecular Patterns Following Hypothermic Oxygenated Machine Perfusion vs Static Cold Storage in Liver Transplantation

    G. G. Panayotova, Y. Qin, S. Simonishvili, T. Ayorinde, F. Paterno, L. Brown, A. Amin, K. E. Lunsford, J. V. Guarrera

    Transplant Surgery, Rutgers New Jersey Medical School, Newark, NJ

    *Purpose: Hypothermic Oxygenated Machine Perfusion (HMP-O2) results in decreased ischemia/reperfusion injury (IRI) after liver transplantation; however, the molecular pathways of protection are largely unexplored. In…
  • 2022 American Transplant Congress

    Wide Spectrum of Molecular Injury Highlights Heterogeneity of Banff Tubulitis and Interstitial Inflammation Lesions

    M. J. Ellis1, T. Maw2, E. Huang3, E. Stites4, F. Shihab5, D. C. Brennan6, G. Shekhtman7, N. Agrawal7, J. Zeng7, S. Kung8

    1Duke University, Durham, NC, 2University of Southern California, Los Angeles, CA, 3Cedars-Sinai Medical Center, Los Angeles, CA, 4University of Colorado, Aurora, CO, 5University of Utah, Salt Lake City, UT, 6Johns Hopkins School of Medicine, Baltimore, MD, 7CareDx, Brisbane, CA, 8University of California, San Francisco, San Francisco, CA

    *Purpose: The pathological definition and clinical significance of borderline T cell-mediated rejection (BL-TCMR) remains an area of active debate, leading to inconsistencies in therapeutic strategy.…
  • 2022 American Transplant Congress

    Axl and MerTK Regulate the Activation of Liver Ischemia Reperfusion Injury by Upregulating Il-13 in Kupffer Cells

    J. Zhang1, M. Ni1, H. Zhang1, R. Busuttil1, J. Kupiec-Weglinski1, X. Wang2, J. Jin3, Y. Zhai1

    1Dumont-UCLA Transplant Center, Los Angeles, CA, 2The First Affiliated Hospital of Nanjing Medical University, Nanjing, China, 3Guilin Medical University, Guilin, China

    *Purpose: Ischemia reperfusion injury (IRI) remains an unresolved clinical problem. A sterile inflammatory response drives the disease pathogenesis. Although mechanisms of liver innate immune activation…
  • 2022 American Transplant Congress

    Targeting the Bet Family Protein Brd4 Inhibits Inflammatory Macrophages and Promotes Heart Allograft Tolerance

    X. Xiao

    Surgery, Houston Methodist Hospital, Houston, TX

    *Purpose: Infiltration of allografts by inflammatory macrophages is frequently associated with chronic graft loss In both animal models and clinical settings, but the mechanisms that…
  • 2022 American Transplant Congress

    Murine Intrahepatic Regulatory T Cells (TREGS) Modulate Acute Liver Inflammation by Promoting a Protective and Restorative Microenvironment

    A. S. Kurt1, K. Strobl2, P. Ruiz1, A. Sanchez-Fueyo1, M. Martinez-Llordella1

    1Inflammation Biology, King's College London, London, United Kingdom, 2Institute of Cancer Research, Medical University of Vienna, London, United Kingdom

    *Purpose: CD4+CD25+Foxp3+ Tregs are known to acquire tissue-specific features and develop cytoprotective and regenerative functions. The extent to which this applies to liver-resident Tregs is…
  • 2022 American Transplant Congress

    Cd47 Expression on Transplanted Human Neonatal Mesenchymal Stem Cells Inhibits Phagocytosis in Rat Myocardial Infarction Model

    M. Gunasekaran, R. Mishra, S. Sharma, P. Saha, L. Chen, S. Guru, A. Stefanowicz, A. Bilewska, S. Zarinebaf, G. Zhi-Dong, S. Kaushal

    Lurie Childrens Hospital, Chicago, IL

    *Purpose: Immune rejection of transplanted stem/progenitor cells is a major stumbling block in designing effective therapy for myocardial infarction (MI). Human neonatal mesenchymal stem cells…
  • 2022 American Transplant Congress

    Gsk3beta Regulates the Resolution of Liver Ischemia Reperfusion Injury via MerTK

    H. Zhang1, M. Ni2, J. Zhang1, R. Busuttil1, J. Kupiec-Weglinski1, W. Li3, X. Wang2, Y. E. Zhai1

    1Dumont-UCLA Transplant Center, Los Angeles, CA, 2The First Affiliated Hospital of Nanjing Medical University, Nanjing, China, 3China-Japan Union Hospital of Jilin University, JiLing, China

    *Purpose: We have shown previously that glycogen synthase kinase β (Gsk3β) regulates liver inflammatory activation against ischemia/reperfusion injury (IRI). The question of whether it also…
  • 2022 American Transplant Congress

    Type 1 Innate Lymphoid Cells Are Critical Pro-Inflammatory Effector Cells in a Fatty Liver Mouse Model of Ischemia-Reperfusion Injury

    J. Kang, J. Liggett, K. Oza, Y. Cui, K. Loh, D. Kwon, B. Kallakury, T. Fishbein, W. Cui, K. Kahn, A. Kroemer

    MedStar Georgetown Transplant Institute, Washington, DC

    *Purpose: Innate lymphoid cells (ILCs), the most recently described family of lymphoid cells, play fundamental roles in tissue homeostasis through the production of key cytokine…
  • 2022 American Transplant Congress

    Single-Cell RNA Sequencing Identifies the Changes of Human Normal Kidney After Transplantation

    G. Huang1, H. Zhang1, X. Chen1, G. Zhao1, J. Luo1, S. Yang2, J. Qiu1

    1Organ Transplant Center, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China, 2Department of Pathology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China

    *Purpose: We found that in all studies about kidney transplantation and single cell RNA sequencing (scRNA-seq), the native kidney rather than the transplanted kidney was…
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