ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Inflammation"

  • 2017 American Transplant Congress

    Clinically Relevant Immunosuppression Promotes MCMV Reactivation and Dissemination Following Transplantation of Latently Infected Kidneys.

    Z. Zhang,1 S. Yan,1 L. Zhao,1 S. Kurian,2 M. Hummel,1 D. Salomon,2 M. Abecassis.1

    1Comprehensive Transplant Center, Northwestern University Feinberg School of Medicine, Chicago; 2Dept. of Molecular & Experimental Medicine, The Scripps Research Institute, La Jolla

    Reactivation of latent Cytomegalovirus (CMV) is an important problem facing clinical transplantation. We have previously described a model for murine CMV (MCMV) reactivation following kidney…
  • 2017 American Transplant Congress

    Myeloid HO-1 Regulates M2 Macrophage Activation in Liver Ischemia-Reperfusion Injury (IRI).

    K. Nakamura,1 M. Zhang,2 S. Kageyama,1 B. Ke,1 R. Sosa,3 E. Reed,3 A. Zarrinpar,1 R. Busuttil,1 J. Araujo,2 J. Kupiec-Weglinski.1

    1Surgery, Liver Transplant, UCLA, Los Angeles, CA; 2Department of Medicine, UCLA, Los Angeles, CA; 3Department of Pathology, UCLA, Los Angeles, CA

    Background/Aim: Although anti-inflammatory macrophage differentiation (M2) from pro-inflammatory (M1) phenotype is critical for heme oxygenase-1 (HO-1) cytoprotection, the role of cell type-specific HO-1 induction remains…
  • 2017 American Transplant Congress

    Course of Inflammatory Bowel Disease Activity in Primary Sclerosing Cholangitis Patients Undergoing Liver Transplantation.

    R. Parekh,1 M. Segovia,2 N. Kaur.1

    1Gastroenterology and Hepatology, Henry Ford Hospital, Detroit, MI; 2Gastroenterology and Hepatology, Duke University Medical Center, Durham, NC

    Aim: Primary sclerosing cholangitis (PSC) is associated with inflammatory bowel disease (IBD). We aimed to review disease activity of IBD in patients with PSC undergoing…
  • 2017 American Transplant Congress

    Extra-Renal Cardiac Injury Is Associated with Upregulation of NOD2 and Nlrp3 in the Heart After Renal IRI.

    A. Scheinok, S. Kasimsetty, E. Soo, C. Nelson, A. Shigeoka, D. McKay.

    Medicine, Division of Nephrology and Hypertension, University of California San Diego, La Jolla, CA

    Background: Recent studies show renal ischemia reperfusion injury (IRI) is associated with systemic release of danger associated molecular patterns (DAMPs). DMAPs induce significant extra-renal organ…
  • 2017 American Transplant Congress

    Mycophenolic Acid Needs Ca2+ to Exert Its Anti-inflammatory Action via Shedding of Toll-Like Receptor4 and Tumor Necrosis Factor Receptor 1.

    J. Kim,1 W. Yang,1 C. Baek,1 N. Han,2 S.-K. Park.1

    1Division of Nephrology, Department of Internal Medicine, Asan Medical Center, Seoul, Republic of Korea; 2Asan Institute for Life Science, Seoul, Republic of Korea

    Background Mycophenolic acid (MPA) has been used for many years to prevent transplantation rejection. Recently, it has been investigated for its anti-inflammatory effects. MPA can…
  • 2017 American Transplant Congress

    TIMP-3 Plays a Key Regulatory Role in the Cleavage of E-Cadherin and Has an Essential Protective Function in Hepatic IRI.

    T. Fujii, S. Duarte, R. Busuttil, A. Coito.

    Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA

    Liver ischemia-reperfusion injury (IRI) remains a challenging problem in clinical orthotopic liver transplantation. Tissue inhibitor of metalloproteinases-3 (TIMP-3), an extracellular matrix-associated protein, has been linked…
  • 2017 American Transplant Congress

    Predictive Value of Renal Poly (ADP-Ribose) Polymerase (PARP) Expression Both in Inflammation and Interstitial Fibrosis Processes in Recipients with Antibody-Mediated Rejection.

    B. Ozdemir,1 F. Ozdemir,2 E. Baskin,2 M. Haberal.3

    1Pathology, Baskent University, Ankara, Turkey; 2Nephrology, Baskent University, Ankara, Turkey; 3Transplant Surgery, Baskent University, Ankara, Turkey

    The activation of PARP is well considered to play an augmenting role in inflammation. However, its role in the development of fibrosis is not well…
  • 2017 American Transplant Congress

    Ischemia-Reperfusion Injury-Induced Innate Immune Signaling in Human Orthotopic Liver Transplantation.

    R. Sosa,1 A. Zarrinpar,2 M. Rossetti,1 C. Lassman,1 B. Naini,1 N. Datta,2 R. Busuttil,2 D. Gjertson,1 J. Kupiec-Weglinski,1,2 E. Reed.1

    1Pathology and Laboratory Medicine, University of California, Los Angeles, CA; 2Surgery, University of California, Los Angeles, CA

    Background: Ischemia-reperfusion injury (IRI) is a major risk factor in the development of acute and chronic graft rejection in orthotopic liver transplantation (OLT); however, no…
  • 2017 American Transplant Congress

    Immunosuppressive Ability of NFkB Inhibitor: Withaferin A.

    M. Kanak,1 Y. Shindo,1 M. Levy,1,2 B. Naziruddin.3

    1Transplant Surgery, Virginia Commonwealth University, Richmond, VA; 2Hume-Lee Transplant Center, VCU Health System, Richmond, VA; 3Simmons Transplant Institute, Baylor Scott and White Health, Dallas, TX

    BackgroundThe advent of steroid-free protocol by the Edmonton group encouraged islet transplant as a therapy for Type-1 Diabetes. However, long-term dysfunction in islet transplantation is…
  • 2017 American Transplant Congress

    Proteasome Modulation an Effective Strategy to Ameliorate Steatotic Liver Grafts Viability After Preservation.

    M. Zaouali,1 A. Panisello Roselló,1 T. Carbonell,2 A. Garcia-Gil,3 A. Lopez,4 R. Adam,4 J. Rosello-Catafau.1

    1Patología Experimental, Instituto de Investigaciones Biomédicas de Barcelona, CSIC, Barcelona, Spain; 2Phisiology, Fac. of Biology, Universitat de Barcelona, Barcelona, Spain; 3Transplantation, Hospital Clínico, Zaragoza, Spain; 4Hepato- Biliare Unit, Hôpital Paul Brousse, INSERM U-776, Université Paris Sud, Paris, France

    Recently we provided evidence for a possible protective role of proteasome inhibition during liver graft preservation. Although, several reported data confirmed that the proteolytic activity…
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