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Articles tagged "Inflammation"

  • 2017 American Transplant Congress

    Circulating Inflammatory Factors in Deceased Organ Donors Result in Innate Immune Activation.

    T. Brennan, L. Lin, J. Pollara.

    Surgery, Duke University, Durham, NC

    Background: Superior outcomes of living-donor compared to deceased-donor transplants may be related to increased graft immunogenicity at the time of transplant. Donor brain death results…
  • 2017 American Transplant Congress

    Suppression of Inflammation by Withaferin A in Cerulein-Induced Pancreatitis Model Results in Improved Syngeneic Islet Engraftment.

    G. Yoshimatsu,1 M. Kanak,2 C. Chang,1 C. Darden,1 M. Lawrence,1 B. Naziruddin.3

    1Baylor Scott and White Research Institute, Dallas, TX; 2Virginia Commonwellth University, Richmond, VA; 3Baylor Simmons Transplant Institute, Dallas, TX

    Introduction: Chronic pancreatitis (CP) is characterized by inflammatory damage to acinar cells followed by islets. In clinical islet autotransplantation, patients with advanced stages of CP…
  • 2017 American Transplant Congress

    IL-3 Contributes to Development of Basophil-Triggered Cardiac Allograft Fibrosis Development.

    G. Schiechl-Brachner,1 M. Rodriguez Gomez,1 K. Renner,1 S. Buchtler,1 K. Schmidbauer,1 D. Halbritter,1 S. Neumayer,1 Y. Talke,1 H. Bruehl,2 M. Mack.1

    1Department of Internal Medicine II, University Hospital / Medical Center, Regensburg, Germany; 2Department of Internal Medicine I, University Hospital / Medical Center, Regensburg, Germany

    Introduction: Organ fibrosis and vasculopathy are major causes of chronic cardiac allograft failure. Resident (donor-derived) fibroblasts are thought to be mainly responsible for excessive production…
  • 2017 American Transplant Congress

    Human IL-10 Transfection of Porcine Lungs Significantly Increases IL-10 Levels in Vascular Perfusate During Human Blood Perfusion.

    C. Laird,1 L. Burdorf,1 X. Cheng,1 N. O'Neill,1 S. Sendil,1 D. Parsell,1 M. Cypel,2 C. Phelps,3 D. Ayares,3 A. Azimzadeh,1 R. Pierson.1

    1University of Maryland School of Medicine, Baltimore, MD; 2Department of Surgery, Toronto, Canada; 3Revivicor, Inc, Blacksburg, VA

    PurposePorcine organs are a potential source for clinical xenotransplantation. Pig lungs perfused with human blood exhibit inflammation and loss of vascular barrier function within hours.…
  • 2017 American Transplant Congress

    Preceeding the Rejection: Clinical Results of a Saliva Test After Renal Transplantation.

    D. Abendroth,1 M. Marzinzig,1 M. Stangl.2

    1Dept. of Surgery, University of Ulm, Ulm, Germany; 2Dept. of Visceral and Transplant Surgery, Ludwigs-Maximilians-Universität, Munich, Germany

    Introduction There remains a need for biomarker in transplantation for monitoring and early identification of rejection episodes (R). We developed a colorimetric assay to detect…
  • 2017 American Transplant Congress

    Human Islet-Derived Extracellular Vesicles Stimulate CD14+ Monocytes Resulting in Proinflammatory Cytokine Production.

    A. Rutman, S. Negi, C. Hasilo, M. Gasparrini, J. Tchervenkov, S. Paraskevas.

    Department of Surgery, McGill University Health Centre, Montreal, QC, Canada

    Introduction: The cellular events involved in the generation of an auto and allo-reactive immune response in recipients of islet transplantation are not well understood. In…
  • 2017 American Transplant Congress

    Quantity and Functions of CD4–CD8– Double Negative (DN) αβ T Cells in Kidney Is MHC Dependent.

    M. Sadasivam, S. Noel, S. Lee, A. Hamad, H. Rabb.

    Johns Hopkins University, Baltimore, MD

    Background: Prior studies have established important roles of CD4+ T cells, natural killer T cells, and CD4+CD25+FoxP3+ Tregs in kidney ischemia reperfusion injury (IRI) pathogenesis.…
  • 2017 American Transplant Congress

    Low Level Light Laser Treatment Reduces Macrophage Retention and ROS Levels Following Tissue Injury.

    A. Paredes,1 D. Benavidez,1 R. Patil,1 B. Khalil,1 M. Mitchell,1 J. Cheng,1 S. Mangos,2 A. Bartholomew.1

    1University of Illinois, Chicago; 2Rush University, Chicago

    Following ischemia reperfusion injury, inflamed macrophages switch from oxidative phosphorylation to glycolysis; in contrast, macrophages associated with tissue repair rely on oxidative phosphorylation. The triggers…
  • 2017 American Transplant Congress

    Normothermic Donor Lung Preservation with Portable EVLP Significantly Reduces Ischemia/Reperfusion Injury in Lung Recipients by Promoting Cytokine Antagonists.

    C. Falk,1 B. Wiegmann,2 C. Neudörfl,1 C. Kühn,2 I. Tudorache,2 M. Wvsar,2 A. Haverich,2 G. Warnecke.2

    1Institute of Transplant Immunology, IFB-Tx, Hannover Medical School, Hannover, Germany; 2Department of Cardiothoracic Transplant and Vascular Surgery, MHH, Hannover, Germany

    ObjectivesThe INSPIRE trial revealed significant reduction of PGD grade 3 using the Organ Care System (OCS) compared to the standard of care (SOC) for lung…
  • 2017 American Transplant Congress

    Identification of NKG2D as Senescence Marker in Zero-Hour Kidney Biopsies Is Indicative for Clinical Outcome.

    T. Resch,1 J. Günther,1 H. Hackl,2 A. Sattler,3 S. Ebner,1 P. Ritschl,3 M. Biebl,3 R. Öllinger,3 S. Schneeberger,1 G. Brandacher,4 H. Schwelberger,1 B. Zelger,5 D. Stauch,3 A. Pascher,3 J. Pratschke,3 K. Kotsch.3

    1Center of Operative Medicine, Department for Visceral, Transplant and Thoracic Surgery, Medical University of Innsbruck, Innsbruck, Austria; 2Division of Bioinformatics, Biocenter, Medical University of Innsbruck, Innsbruck, Austria; 3Department for General, Visceral and Transplantation Surgery, Charité-Universitätsmedizin Berlin, Berlin, Germany; 4Department of Plastic and Reconstructive Surgery, Vascularized Composite Allotransplantation Laboratory, John Hopkins University School of Medicine, Baltimore; 5Institute of Pathology, Medical University of Innsbruck, Innsbruck, Austria

    The definition of biological donor organ age rather than chronological age seems an obvious factor for the establishment of valid pre-transplant risk assessment. We therefore…
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