2017 American Transplant Congress
Infusion of Polyclonal Tregs Modulates Subclinical Kidney Transplant Inflammation: Final Report of TASK Pilot Trial.
Purpose:Treg therapy can reverse established inflammation in animal models. We conducted a pilot safety & feasibility trial of Treg therapy for subclinical kidney transplant inflammation.Methods:Peripheral…2017 American Transplant Congress
Inflammasome, Unfolded Protein Response, and T Cell Immunity in DAIH.
Background: Regulatory T cells (Tregs) of patients with de novo autoimmune hepatitis (DAIH) secrete IL-17A & IFN-g; display TH1 & TH17 pehnotypes & are functionally…2017 American Transplant Congress
Improvement in Inflammatory Response Follows Clearance of BKVN.
Intro: Development of BKV nephropathy (BKVN) is a significant risk factor for graft loss. Proximate cause of graft loss is commonly attributed to acute/chronic rejection…2017 American Transplant Congress
The Immunophenotype of Peritubular Capillaritis in Renal Transplant Biopsies.
Background: Peritubular capillaritis (ptc) is a feature of acute antibody-mediated rejection (ABMR) in the renal allograft. However, it is not an specific feature for ABMR…2017 American Transplant Congress
Impact of Antihypertensive (AHT) Choice and Advagraf® Dose on Immunologic Events in Renal Allografts 24 Months Post-Transplantation (Tx).
Renal allograft inflammation may be modulated by ACEi- or ARB-type AHTs (renin-angiotensin system (RAS)-targeting drugs that may inhibit calcineurin) or by optimizing tacrolimus (TAC) exposure.…2017 American Transplant Congress
The Role of Toll-Like Receptor 4 in Islet Transplantation and a Novel Method of Protection Using Chemical Surface Modification.
Toll-like Receptor 4 (TLR4) is the canonical receptor for lipopolysaccharide (LPS), however recent evidence reveals that TLR4 also plays an important role in ischemia-reperfusion injury…2017 American Transplant Congress
Effect of Bone Marrow Derived Mesenchymal Stem Cells on Renal Ischemia-Reperfusion Injury in Rabbit.
Background: We succeeded to set up a rabbit model of Ischemia-Reperfusion (I/R) injury to test future candidate substance or plant extract that may have anti-oxidant…2017 American Transplant Congress
Beneficial Effects of Hydrogen Sulfide (H2S) on Renal Ischemia-Reperfusion Injury (IRI) in CLAWN Miniature Swine.
Center for Advanced Biomedical Science and Swine Research, Kagoshima University, Kagoshima, Japan
Objective: The prevention of IRI is important for both early and long-term graft function, especially when using extended-criteria or donation after cardiac donors. H2S has…2017 American Transplant Congress
Nucleic Acid Scavenging Microfiber Mesh Inhibits Trauma Induced Inflammation and Thrombosis After Organ Transplantation.
[Introduction] Trauma patients produce a host of danger signals and high levels of damage-associated molecular patterns (DAMPs) after cellular injury and tissue damage. Organs from…2017 American Transplant Congress
Cibinetide (ARA 290), the Innate Repair Receptor Ligand, Improves Engraftment in Pancreatic Islet Transplantation by Protecting Islets and Reducing Inflammatory Reactions.
Purpose. Cibinetide, an innate repair receptor ligand, exerts anti-inflammatory, anti-apoptotic, and cytoprotective effects. We have shown that cibinetide protected mouse pancreatic islets from cytokine-induced damage…
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