Articles tagged "Inflammation"

2017 American Transplant Congress
Donor-Derived Nonclassical Monocytes Produce MIP-2 to Recruit Recipient Neutrophils and Cause Ischemia Reperfusion Injury After Lung Transplant.
S. Chiu,¹ Z. Zheng,¹ M. Akbarpour,¹ R. Fernandez,¹ A. McQuattie-Pimentel,¹ P. Reyfman,¹ K. Anekalla,¹ D. Kreisel,² H. Perlman,¹ G. Budinger,¹ A. Misharin,¹ A. Bharat.¹
¹Northwestern University, Chicago; ²Washington University, St Louis
Purpose: Primary graft dysfunction (PGD), the primary cause of early mortality after lung transplant, is mediated by neutrophils. However, neutrophil depletion may not be clinically…
2017 American Transplant Congress
Down-Regulation of Nuclear HMGB1 by Small Interfering RNA Protects Against Liver Ischemia-Reperfusion Injury.
G. Zhao, C. Fu, L. Wang, L. Zhu, S. Chen, G. Chen.
Institute of Organ Transplantation, Tongji Hospital, Tongji Medical College, HUST, Wuhan, Hubei, China
Background:High mobility group box 1 (HMGB1) was found to have both a beneficial intracellular role and injurious extracellular role after a sterile inflammatory insult.Hepatocyte-specific HMGB1…
2017 American Transplant Congress
Safety and Decreased Inflammation of Early Double Cytokine Blockade (IL-1β and TNF-α) Facilitates Engraftment in Islet Allotransplantation.
N. Onaca,¹ M. Takita,² M. Levy,³ B. Naziruddin.¹
¹Simmons Transplant Institute, Baylor University Medical Center, Dallas; ²Baylor Scott and White Research Institute, Dallas; ³Hume Lee Transplant Center, Virginia Commonwealth University, Richmond
Enhanced early islet engraftment offers the potential for improved graft function after islet allotransplantation (IT). Nine patients underwent IT under a fully completed prospective research…
2017 American Transplant Congress
Accumulating Mitochondrial DNA in Aging Augments Inflammatory Responses Subsequent to IRI.
M. Seyda,^1,2 M. Quante,¹ T. Heinbokel,¹ G. Liu,¹ H. Uehara,¹ J. Schuitenmaker,¹ R. Abdi,³ C. Falk,² A. Elkhal,¹ S. Tullius.¹
¹Division of Transplant Surgery and Transplant Surgery Research Laboratory, Brigham and Women's Hospital/Harvard Medical School, Boston; ²Institute of Transplant Immunology, Hannover Medical School, Hannover, Germany; ³Renal Division, Schuster Family Transplant Center, Brigham and Women's Hospital, Boston
Background: Older donor organs are increasingly utilized to close the gap between demand and supply. We submit that aging-associated kinetics of damage associated molecular patterns…
2017 American Transplant Congress
Protective Effect of Crepidiastrum denticulatum Extract Pretreatment Against Hepatic Ischemia-Reperfusion Injury in Mice.
H. Jang, H. Lee, C. Park, D. Eom, J. Lee, M. Oh, J. Yoo, C. Rho.
Surgery, University of Ulsan, Gangneung Asan Hospital, Gangneung, Gangwon, Korea; Anesthesia, University of Ulsan, Gangneung Asan Hospital, Gangneung, Gangwon, Korea; Surgery, University of Ulsan, Gangneung Asan Hospital, Gangneung, Gangwon, Korea; Pathology, University of Ulsan, Gangneung Asan Hospital, Gangneung, Gangwon, Korea; Surgery, University of Ulsan, Gangneung Asan Hospital, Gangneung, Gangwon, Korea; Surgery, University of Ulsan, Gangneung Asan Hospital, Gangneung, Gangwon, Korea; Natural Medicine Center, Korea Institute of Science and Technology, Gangneung, Gangwon, Korea; Natural Medicine Center, Korea Institute of Science and Technology, Gangneung, Gangwon, Korea
Crepidiastrum denticulatum (CD) is a well-known, traditionally consumed vegetable in Korea, which was recently reported to have bioactive compounds with detoxification and antioxidant properties. Ischemia-reperfusion…
2017 American Transplant Congress
IP-10 Monoclonal Antibody Treatment Suppresses Inflammatory Components of IBMIR and Improves Pancreatic Islet Graft Function.
G. Yoshimatsu,¹ C. Chang,¹ C. Darden,¹ P. Saravanan,¹ B. Naziruddin,² M. Lawrence.¹
¹Baylor Scott and White Reseasrch Institute, Dallas, TX; ²Baylor Simmons Transplant Institute, Dallas, TX
Introduction: An instant blood-mediated inflammatory response (IBMIR) causes acute loss of pancreatic islets. Interferon gamma-induced protein 10 (IP-10) is a key proinflammatory chemokine that may…
2017 American Transplant Congress
Inflammatory Cytokines Are Associated with Angiotensin II Type 1 Receptor Antibodies and Vascular Inflammation in Pediatric Renal Transplantation.
M. Pearl,¹ J. Grotts,¹ M. Rossetti,¹ Q. Zhang,¹ M. Palma Diaz,¹ D. Gjertson,¹ P. Weng,¹ E. Reed,¹ E. Tsai.²
¹University of California, Los Angeles, CA; ²Duke University, Durham, NC
Background: We recently found that angiotensin II type 1 receptor antibody (AT1R-Ab) was associated with decreased renal function in pediatric renal transplant recipients independent of…
2017 American Transplant Congress
Tissue Transcriptional Profile of Portal Inflammation with Interface Activity in Pediatric Liver Transplant (LT) Recipients with Normal Liver Tests Closely Resembles T Cell Mediated Rejection (TCMR).
A. Sanchez-Fueyo, S. Feng, A. Demetris, J. Bucuvalas, J. Lozano, J. Magee, K. Spain, S. Kanaparthi, iWITH Investigators.
KCL, London, United Kingdom; UCSF, SF; Pittsburgh, Pittsburgh; Cincinnati, Cincinnati; CiberEHD, Barcelona, Spain; Michigan, Ann Arbor; Rho, Chapel Hill; ITN, Bethesda; NIDDK/NIAID/NIH, Bethesda
Background: Significant inflammation±fibrosis is frequently seen in biopsies (bxs) of pediatric LT recipients with normal liver tests assessed for immunosuppression withdrawal. The pathogenesis of these…
2017 American Transplant Congress
Ischemia Reperfusion Injury (IRI) Causes Local Release of Free Heme Which Aggravates Inflammation and Contributes to Delayed Graft Function.
F. Gueler,¹ R. Chen,¹ A. Thorenz,¹ K. Madyaningrana,² J. Bräsen,³ H. Haller,¹ S. Immenschuh,³ V. Vijayan.³
¹Nephrology, Hannover Medical School, Hannover, Germany; ²Transfusion Medicine, Hannover Medical School, Hannover, Germany; ³Pathology, Hannover Medical School, Hannover, Germany
Ischemia reperfusion injury (IRI) is relevant in solid organ transplantation and contributes to delayed graft function (DGF). In this study, release of free heme after…
2017 American Transplant Congress
Identification of Plasma Protein Biomarkers of Acute Renal Allograft Rejection.
M. Rossetti,¹ C. Fitzpatrick,¹ N. Harre,¹ Y. Zheng,¹ N. Mercer,² G. Sunga,¹ D. Gjertson,¹ E. Reed.¹
¹Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA; ²Department of Biostatistics, University of California Los Angeles, Los Angeles, CA
Background & Aim: Upon presentation of clinical symptoms, renal transplant recipients routinely undergo needle core biopsy to diagnose acute graft rejection. This procedure is invasive…