Articles tagged "Inflammation"

2017 American Transplant Congress
Human IL-10 Transfection of Porcine Lungs Significantly Increases IL-10 Levels in Vascular Perfusate During Human Blood Perfusion.
C. Laird,¹ L. Burdorf,¹ X. Cheng,¹ N. O'Neill,¹ S. Sendil,¹ D. Parsell,¹ M. Cypel,² C. Phelps,³ D. Ayares,³ A. Azimzadeh,¹ R. Pierson.¹
¹University of Maryland School of Medicine, Baltimore, MD; ²Department of Surgery, Toronto, Canada; ³Revivicor, Inc, Blacksburg, VA
PurposePorcine organs are a potential source for clinical xenotransplantation. Pig lungs perfused with human blood exhibit inflammation and loss of vascular barrier function within hours.…
2017 American Transplant Congress
Preceeding the Rejection: Clinical Results of a Saliva Test After Renal Transplantation.
D. Abendroth,¹ M. Marzinzig,¹ M. Stangl.²
¹Dept. of Surgery, University of Ulm, Ulm, Germany; ²Dept. of Visceral and Transplant Surgery, Ludwigs-Maximilians-Universität, Munich, Germany
Introduction There remains a need for biomarker in transplantation for monitoring and early identification of rejection episodes (R). We developed a colorimetric assay to detect…
2017 American Transplant Congress
Human Islet-Derived Extracellular Vesicles Stimulate CD14+ Monocytes Resulting in Proinflammatory Cytokine Production.
A. Rutman, S. Negi, C. Hasilo, M. Gasparrini, J. Tchervenkov, S. Paraskevas.
Department of Surgery, McGill University Health Centre, Montreal, QC, Canada
Introduction: The cellular events involved in the generation of an auto and allo-reactive immune response in recipients of islet transplantation are not well understood. In…
2017 American Transplant Congress
Quantity and Functions of CD4^–CD8^– Double Negative (DN) αβ T Cells in Kidney Is MHC Dependent.
M. Sadasivam, S. Noel, S. Lee, A. Hamad, H. Rabb.
Johns Hopkins University, Baltimore, MD
Background: Prior studies have established important roles of CD4+ T cells, natural killer T cells, and CD4+CD25+FoxP3+ Tregs in kidney ischemia reperfusion injury (IRI) pathogenesis.…
2017 American Transplant Congress
Low Level Light Laser Treatment Reduces Macrophage Retention and ROS Levels Following Tissue Injury.
A. Paredes,¹ D. Benavidez,¹ R. Patil,¹ B. Khalil,¹ M. Mitchell,¹ J. Cheng,¹ S. Mangos,² A. Bartholomew.¹
¹University of Illinois, Chicago; ²Rush University, Chicago
Following ischemia reperfusion injury, inflamed macrophages switch from oxidative phosphorylation to glycolysis; in contrast, macrophages associated with tissue repair rely on oxidative phosphorylation. The triggers…
2017 American Transplant Congress
Normothermic Donor Lung Preservation with Portable EVLP Significantly Reduces Ischemia/Reperfusion Injury in Lung Recipients by Promoting Cytokine Antagonists.
C. Falk,¹ B. Wiegmann,² C. Neudörfl,¹ C. Kühn,² I. Tudorache,² M. Wvsar,² A. Haverich,² G. Warnecke.²
¹Institute of Transplant Immunology, IFB-Tx, Hannover Medical School, Hannover, Germany; ²Department of Cardiothoracic Transplant and Vascular Surgery, MHH, Hannover, Germany
ObjectivesThe INSPIRE trial revealed significant reduction of PGD grade 3 using the Organ Care System (OCS) compared to the standard of care (SOC) for lung…
2017 American Transplant Congress
Identification of NKG2D as Senescence Marker in Zero-Hour Kidney Biopsies Is Indicative for Clinical Outcome.
T. Resch,¹ J. Günther,¹ H. Hackl,² A. Sattler,³ S. Ebner,¹ P. Ritschl,³ M. Biebl,³ R. Öllinger,³ S. Schneeberger,¹ G. Brandacher,⁴ H. Schwelberger,¹ B. Zelger,⁵ D. Stauch,³ A. Pascher,³ J. Pratschke,³ K. Kotsch.³
¹Center of Operative Medicine, Department for Visceral, Transplant and Thoracic Surgery, Medical University of Innsbruck, Innsbruck, Austria; ²Division of Bioinformatics, Biocenter, Medical University of Innsbruck, Innsbruck, Austria; ³Department for General, Visceral and Transplantation Surgery, Charité-Universitätsmedizin Berlin, Berlin, Germany; ⁴Department of Plastic and Reconstructive Surgery, Vascularized Composite Allotransplantation Laboratory, John Hopkins University School of Medicine, Baltimore; ⁵Institute of Pathology, Medical University of Innsbruck, Innsbruck, Austria
The definition of biological donor organ age rather than chronological age seems an obvious factor for the establishment of valid pre-transplant risk assessment. We therefore…
2017 American Transplant Congress
AAV8 Delivery of TIMP-1 Prevents Hepatocyte Apoptosis After Liver Ischemia/Reperfusion Injury.
S. Duarte, P. Matian, M. Miller, R. Busuttil, A. Coito.
Dumont-UCLA Transplant Center, Los Angeles
Matrix metalloproteinase-9 (MMP-9) is a key mediator of leukocyte migration across vascular barriers in hepatic ischemia/reperfusion injury (IRI). Tissue inhibitor of metalloproteinase-1 (TIMP-1) is the…
2017 American Transplant Congress
Rapamycin Maintenance Therapy in Pediatric Liver Transplant Recipients Associated with Trend Toward Decreasing Th2 Cytokine Levels Compared to Tacrolimus Therapy.
R. Fischer,¹ A. Seng,² L. Gardner,² L. Steele,² L. Harvey,¹ H. Wasserkrug,¹ W. Andrews,¹ R. Hendrickson,¹ J. Daniel,¹ T. Yankee.²
¹Children's Mercy Hospital, Kansas City, MO; ²University of Kansas Medical Center, Kansas City, KS
Background: Maintenance immunosuppression after liver transplantation with tacrolimus (TAC) may have progressive fibrosis on serial allograft biopsies. mTOR inhibitors such as rapamycin (RAPA) may abrogate…
2017 American Transplant Congress
Kidney Injury Molecule-1 Mitigates Tissue Damage from Transplant Renal Ischemia Reperfusion Injury.
J. Lee,^1,2 X. Zhang,² A. Haig,³ D. Lian,² P. Anderson,² R. Navaratnam,² L. Gunaratnam.^1,2
¹Department of Microbiology and Immunology, Western University, London, ON, Canada; ²Matthew Mailing Centre for Translational Transplant Studies, London Health Sciences Centre, London, ON, Canada; ³Department of Pathology, Western University, London, ON, Canada
Ischemia reperfusion injury (IRI) at the time of organ harvesting is unavoidable, may cause delayed renal graft function, and is associated with premature graft loss.…