Articles tagged "Inflammation"

2017 American Transplant Congress
Predictive Value of Renal Poly (ADP-Ribose) Polymerase (PARP) Expression Both in Inflammation and Interstitial Fibrosis Processes in Recipients with Antibody-Mediated Rejection.
B. Ozdemir,¹ F. Ozdemir,² E. Baskin,² M. Haberal.³
¹Pathology, Baskent University, Ankara, Turkey; ²Nephrology, Baskent University, Ankara, Turkey; ³Transplant Surgery, Baskent University, Ankara, Turkey
The activation of PARP is well considered to play an augmenting role in inflammation. However, its role in the development of fibrosis is not well…
2017 American Transplant Congress
Ischemia-Reperfusion Injury-Induced Innate Immune Signaling in Human Orthotopic Liver Transplantation.
R. Sosa,¹ A. Zarrinpar,² M. Rossetti,¹ C. Lassman,¹ B. Naini,¹ N. Datta,² R. Busuttil,² D. Gjertson,¹ J. Kupiec-Weglinski,^1,2 E. Reed.¹
¹Pathology and Laboratory Medicine, University of California, Los Angeles, CA; ²Surgery, University of California, Los Angeles, CA
Background: Ischemia-reperfusion injury (IRI) is a major risk factor in the development of acute and chronic graft rejection in orthotopic liver transplantation (OLT); however, no…
2017 American Transplant Congress
Immunosuppressive Ability of NFkB Inhibitor: Withaferin A.
M. Kanak,¹ Y. Shindo,¹ M. Levy,^1,2 B. Naziruddin.³
¹Transplant Surgery, Virginia Commonwealth University, Richmond, VA; ²Hume-Lee Transplant Center, VCU Health System, Richmond, VA; ³Simmons Transplant Institute, Baylor Scott and White Health, Dallas, TX
BackgroundThe advent of steroid-free protocol by the Edmonton group encouraged islet transplant as a therapy for Type-1 Diabetes. However, long-term dysfunction in islet transplantation is…
2017 American Transplant Congress
Proteasome Modulation an Effective Strategy to Ameliorate Steatotic Liver Grafts Viability After Preservation.
M. Zaouali,¹ A. Panisello Roselló,¹ T. Carbonell,² A. Garcia-Gil,³ A. Lopez,⁴ R. Adam,⁴ J. Rosello-Catafau.¹
¹Patología Experimental, Instituto de Investigaciones Biomédicas de Barcelona, CSIC, Barcelona, Spain; ²Phisiology, Fac. of Biology, Universitat de Barcelona, Barcelona, Spain; ³Transplantation, Hospital Clínico, Zaragoza, Spain; ⁴Hepato- Biliare Unit, Hôpital Paul Brousse, INSERM U-776, Université Paris Sud, Paris, France
Recently we provided evidence for a possible protective role of proteasome inhibition during liver graft preservation. Although, several reported data confirmed that the proteolytic activity…
2017 American Transplant Congress
Maintenance of the Phenotype and Abundance of Islet-Resident Macrophages Promotes Islet Graft Survival and Appears to Prevent Type 1 Diabetes.
P. Kyriazis, T. Thornley, K. Agarwal, L. Ma, T. Strom, M. Koulmanda.
Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA
Immunoregulatory tissue resident macrophage subsets have been reported in skin, heart, lung and adipose tissue.We now demonstrate the existence of a functionally immunoregulatory population of…
2017 American Transplant Congress
Contribution of γδ T-Cell Subsets and IL-17A Release to Ischemia Reperfusion Injury (IRI) and Kidney Allograft Rejection in Mice.
A. Thorenz,¹ S. Rong,¹ N. Völker,¹ R. Chen,¹ J. Bräsen,² H. Haller,¹ C. Klemann,³ F. Gueler.¹
¹Nephrology, Hannover Medical School, Hannover, Germany; ²Pathology, Hannover Medical School, Hannover, Germany; ³Pediatric Surgery, Hannover Medical School, Hannover, Germany
Ischemia reperfusion injury (IRI) contributes to acute allograft injury and to delayed graft function (DGF) which is a trigger for acute rejection after kidney transplantation…
2017 American Transplant Congress
Prolonged Liver Ischemia Triggers Necrotic Depletion of TIM4+ Kupffer Cells to Facilitate Tissue Inflammatory Immune Activation in Liver Ischemia-Reperfusion Injury.
H. Wang,¹ S. Yue,¹ M. Ni,¹ R. Busittil,¹ J. Kupiec-Weglinski,¹ L. Lu,² Y. Zhai.¹
¹Surgery, David Geffen School of Medicine, UCLA, Los Angeles, CA; ²Liver Surgery, The First affiliated Hospital of Nanjing Medical University, Nanjing, Jiansu Province, China
Although mechanisms of immune activation against liver ischemia-reperfusion injury (IRI) have been studied extensively, questions regarding liver resident Kupffer cells vs. infiltrating macrophages (iM[Oslash]s) remain…
2017 American Transplant Congress
Proteomic Profiles of Deceased Donor Kidney Biopsies Obtained Prior to Transplantation Correlate with Allograft Function at One Year.
M. Kaisar,^1,2 L. van Dullemen,¹ Z. Akhtar,¹ H. Huang,¹ B. Kessler,² R. Ploeg.¹
¹Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom; ²Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom
Introduction:Cerebral injury during Donation after Brain Death (DBD) will induce a systemic inflammatory response affecting immediate kidney function and survival posttransplantation. Assessment of donor organ…
2017 American Transplant Congress
Role of Protease Activated Receptor 1 and Sphingosine-1-Phospate Receptor 1 in Mice Hepatic Ischemia-Reperfusion Injury for Targeting Cell Signal Pathways of Activated Protein C.
T. Ito, N. Kuriyama, H. Kato, Y. Iizawa, A. Tanemura, Y. Murata, Y. Azumi, M. Kishiwada, S. Mizuno, M. Usui, H. Sakurai, S. Isaji.
Hepatobiliary Pancreatic and Transplant Surgery, Mie University Graduate School of Medicine, Tsu, Japan
Introduction: Hepatic ischemia-reperfusion injury (IRI) is a serious comlication during liver surgery. As for therapeutic strategies on hepatic IRI, we previously demonstrated that activated protein…
2017 American Transplant Congress
Binding of Human Neutrophils to Activated Porcine Endothelium Is Mediated by E-Selectin.
C. Laird,¹ B. French,¹ L. Burdorf,¹ X. Cheng,¹ W. Fogler,² J. Magnani,² C. Phelps,³ D. Ayares,³ A. Azimzadeh,¹ R. Pierson.¹
¹University of Maryland SOM, Baltimore; ²GlycoMimetics, Inc, Rockville; ³Revivicor, Inc, Blacksburg
Purpose: Shortage of transplantable human organs motivates research into alternatives, including xenotransplantation. When porcine lungs are perfused with human blood, a majority of human neutrophils…