Articles tagged "Inflammation"

2018 American Transplant Congress
Gr1^– Macrophages Play Critical Roles in Liver Inflammation Resolution after IRI via Efferocytosis
M. Ni,^1,2 H. Wang,^1,2 R. Busuttil,¹ J. Kupiec-Weglinski,¹ X. Wang,² Y. Zhai.¹
¹Surgery, David Geffen School of Medicine-UCLA, Los Angeles, CA; ²Liver Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiansu, China.
Inflammation resolution is an integral part of liver ischemia reperfusion injury (IRI), which affects not only the severity of tissue damage, but more importantly its…
2018 American Transplant Congress
Monitoring of Small Bowel Allografts with Kynurenine Serum Levels
M. Stangl,¹ D. Koliogiannis,¹ J. Bucher,¹ M. Guba,¹ D. Abendroth.²
¹Transplant Center Munich, Klinikum Großhadern, LMU Munich, Munich, Germany; ²Department of Surgery, University of Ulm, Ulm, Germany.
Long-term success in intestinal transplantation could be significantly improved by the development of a reliable noninvasive marker of rejection, allowing early diagnosis and treatment without…
2018 American Transplant Congress
Deceased Donor Urinary Biomarker Signature and the Effectiveness of Peritransplant Lymphocyte Depletion on Early Renal Allograft Function
S. Bernd,² P. Heeger,¹ T-.P. Heather,³ I. Hall,⁷ M. Doshi,⁴ F. Weng,⁵ P. Reese,⁶ C. Parikh.³
¹Icahn School of Medicine Mount Sinai, New York, NY; ²University of Ulm, Ulm, Germany; ³Yale University School of Medicine, New Haven, CT; ⁴Wayne State University, Detroit, MI; ⁵Barnabas Health, Livingston, NJ; ⁶University of Pennsylvania, Philadelphia, PA; ⁷University of Utah School of Medicine, Salt Lake City, UT.
Purpose: Delayed graft function (DGF) is associated with increased allogaft immunogenicity and decreased long-term survival. We hypothesized that high levels of donor urinary biomarkers for…
2018 American Transplant Congress
In Vivo Allograft Exposure to Mitochondrial DAMPs Prior to Organ Procurement Increases Graft Rejection in Mice
L. Lin, J. Wang, L. Cendales, A. Kirk, T. Brennan.
Surgery, Duke University, Durham, NC.
Mitochondria released in the setting of tissue injury are a source of damage associated molecular patterns (DAMPs) that initiate innate immune responses. We hypothesized that…
2018 American Transplant Congress
Daptomycin Minimum Inhibitory Concentration (MIC) of Vancomycin Resistant Enterococcal (VRE) Blood Isolates Correlates with Allograft Failure in Orthotopic Liver Transplant (OLT) Recipients
R. Lee,¹ G. Haidar,² J. Lewis,³ S. Arif,⁴ J. Hand,⁵ E. Holaday,⁶ H. Clauss,⁶ J. Goldman,⁷ A. Nellore.¹
¹University of Alabama at Birmingham, Birmingham, AL; ²University of Pittsburgh Medical Center, Birmingham, AL; ³University of Virginia, Charlottesville, VA; ⁴Duke University, Durham, NC; ⁵Oschner Medical Center, New Orleans, LA; ⁶Department of Internal Medicine, Temple University, Philadelphia, PA; ⁷Temple University, Philadelphia, PA; ⁸Swedish Medical Center, Seattle, WA.
Background: Enterococci are one of the leading causes of nosocomial infection in after OLT. Unfortunately, treatment options for enterococci that are resistant to first-line agents…
2017 American Transplant Congress
Infusion of Polyclonal Tregs Modulates Subclinical Kidney Transplant Inflammation: Final Report of TASK Pilot Trial.
S. Chandran, Q. Tang, M. Sarwal, Z. Laszik, A. Putnam, T. Sigdel, E. Tavares, J. Bluestone, F. Vincenti.
UCSF, San Francisco
Purpose:Treg therapy can reverse established inflammation in animal models. We conducted a pilot safety & feasibility trial of Treg therapy for subclinical kidney transplant inflammation.Methods:Peripheral…
2017 American Transplant Congress
Inflammasome, Unfolded Protein Response, and T Cell Immunity in DAIH.
A. Arterbery,¹ M. Martinez,³ S. Lobritto,³ Y. Avitzur,² U. Ekong.¹
¹Ped Gastro. and Hep., Yale University, New Haven, CT; ²Gastro., Hep., and Nutr., Hospital for Sick Children, Toronto, ON, Canada; ³Ped. Gastro., Hep., and Nutr., Columbia University, New York, NY
Background: Regulatory T cells (Tregs) of patients with de novo autoimmune hepatitis (DAIH) secrete IL-17A & IFN-g; display TH1 & TH17 pehnotypes & are functionally…
2017 American Transplant Congress
Improvement in Inflammatory Response Follows Clearance of BKVN.
E. Abuhelaiqa,¹ S. Salvatore,² J. Lee,¹ J. Lee,¹ T. Muthukumar,¹ S. Seshan,² D. Dadhania.¹
¹Transplant Medicine, Weill Cornell Medicine, NY, NY; ²Dept. of Pathology, Weill Cornell Medicine, NY, NY
Intro: Development of BKV nephropathy (BKVN) is a significant risk factor for graft loss. Proximate cause of graft loss is commonly attributed to acute/chronic rejection…
2017 American Transplant Congress
The Immunophenotype of Peritubular Capillaritis in Renal Transplant Biopsies.
T. Chen,¹ L. Rasch,¹ T. Al Johani,² H. McPhail,¹ M. Willicombe,³ A. McLean,³ J. Galliford,³ T. Cook,¹ C. Roufosse.¹
¹Centre for Complement and Inflammation Research, Imperial College, London, United Kingdom; ²Cellular Pathology, King Saud University, Riyadh, Saudi Arabia; ³Dept Renal Medicine, Imperial College Healthcare NHS Trust, London, United Kingdom
Background: Peritubular capillaritis (ptc) is a feature of acute antibody-mediated rejection (ABMR) in the renal allograft. However, it is not an specific feature for ABMR…
2017 American Transplant Congress
Impact of Antihypertensive (AHT) Choice and Advagraf^® Dose on Immunologic Events in Renal Allografts 24 Months Post-Transplantation (Tx).
D. Rush,¹ S. Cockfield,² S. Wilson,³ J. Howell,⁴ FKC-014 Study Group.
¹Health Sciences Centre, Winnipeg, MB, Canada; ²University of Alberta Hospital, Edmonton, AB, Canada; ³Astellas Pharma Global Development, Northbrook, IL; ⁴Astellas Pharma Global Development, Markham, ON, Canada
Renal allograft inflammation may be modulated by ACEi- or ARB-type AHTs (renin-angiotensin system (RAS)-targeting drugs that may inhibit calcineurin) or by optimizing tacrolimus (TAC) exposure.…