Articles tagged "Inflammation"

2018 American Transplant Congress
Identification of Exosomal Isletokines Released by Pancreatic Islets in Response to Inflammatory Stress
P. Saravanan,¹ G. Yoshimatsu,¹ R. Bhattacharjee,¹ C. Chang,¹ C. Darden,¹ B. Naziruddin,² M. Lawrence.¹
¹Islet Cell Lab, Baylor Scott & White Research Institute, Dallas, TX; ²Transplantation, Baylor Simmons Transplant Institute, Dallas, TX.
Purpose: To identify isletokines released by exosomes from human islets that have been exposed to hypoxic or inflammatory conditions and define stress signaling pathways that…
2018 American Transplant Congress
Brain Death Conditions Intensify Inflammation and Impair Metabolic Gene Expression
L. Zitur, P. Chlebeck, S. Odorico, T. Zens, J. Danobeitia, M. Eerhart, J. Reyes, A. D'Alessandro, K. Brunner, S. Capuano, L. Fernandez.
University of Wisconsin, Madison.
Rationale: Inflammation observed in Brain Death (BD) donors is linked to reduced graft function and survival compared to living donors (LD). Detailed analyses of non-human…
2018 American Transplant Congress
Pre-Kidney Transplant Inflammation and Post-Transplant Outcomes.
H. Ying, M. McAdams DeMarco, D. Segev.
Department of Surgery, Johns Hopkins School of Medicine, Baltimore, MD.
Background: Patients with ESRD have higher inflammation levels, which may cause adverse outcomes after they receive a kidney transplant (KT). In this study, we quantified…
2018 American Transplant Congress
Kidney Transplant Rejection is Associated with Robust and Prolonged Bioenergetic Reprogramming and Metabolic Maladaptation
A. Zmijewska, J. Zmijewski, J. Chen, R. Mannon.
Medicine, University of Alabama at Birmingham, Birmingham, AL.
Introduction: Metabolic plasticity and mitochondrial bioenergetic homeostasis are altered due to a organ ischemia. However, the impact of the alloimmune response on the allograft is…
2018 American Transplant Congress
Rictor mTORC2 Signaling Protects Ischemic Liver Injury by Targeting Both Liver Parenchymal and Non-Parenchymal Cells
H. Zhou,¹ Z. Rao,¹ R. Liu,¹ S. Zhou,¹ J. Rao,¹ J. Gu,¹ H. Lu,¹ Y. Xia,¹ X. Wang,¹ Y. Zhai,² L. Lu.¹
¹First Affiliated Hospital of Nanjing Medical University, Nanjing, China; ²David Geffen School of Medicine at University of California-Los Angeles, Los Angeles.
Background and Aims:Mammalian target of rapamycin (mTOR) signaling controls many essential cellular functions. However, the role and its underlying mechanism of Rictor/mTOR complex 2 (mTORC2)…
2018 American Transplant Congress
Neutrophil to Lymphocyte Ratio (NLR) Does Not Predict Outcomes after Liver Transplant (LT) for Hepatocellular Carcinoma (HCC)
E. Harding-Theobald, N. Mehta, F. Yao.
Hepatology, UCSF, San Francisco.
Background: A high preoperative NLR ≥5 has been reported to predict poor outcomes following LT for HCC, and NLR has been incorporated into several prognostic…
2018 American Transplant Congress
Ischemia Reperfusion Injury in Liver Transplantation is Associated with Acute Kidney Injury: Role of Inflammatory Mediators
P. Mihaylov,^1,2 P. Li,¹ J. Skill,¹ L. Timsina,¹ J. Fridell,¹ B. Ekser,¹ R. Mangus,¹ C. Kubal.¹
¹Surgery, Indiana University, Indianapolis; ²Surgery, University of Pavia, Pavia, Italy.
Background: The impact of liver allograft ischemia/reperfusion injury (IRI) on native renal function remains to be characterized. We hypothesized that elevated levels of circulating inflammatory…
2018 American Transplant Congress
Hyperglycemia Aggravates Hepatic Ischemia and Reperfusion Injury by Inhibiting Liver Resident Macrophage M2 Polarization via C/EBP-Homologous Protein-Mediated Endoplasmic Reticulum Stress
Z. Rao, J. Sun, X. Pan, Z. Chen, H. Sun, P. Zhang, M. Gao, Z. Ding, C. Liu.
Anesthesiology, First Affiliated Hospital with Nanjing Medical University, Nanjing, China.
Background:Aggravated liver ischemia and reperfusion (IR) injury has been observed in hyperglycemic hosts, but its underlying mechanism remains undefined. The aim of the study was…
2018 American Transplant Congress
Parathyroid Cell Xenotransplantation with Ultrapure Alginate Based Microencapsulation Technique
B. Goncu,¹ E. Yucesan,² H. Basoglu,³ M. Celikten,¹ O. Huseyinbas,¹ B. Ozdemir,¹ N. Ozten Kandas,⁴ F. Akbas,⁵ Y. Ersoy,⁶ E. Aysan.⁶
¹Bezmialem Vakif University, Experimental Research Center, Istanbul, Turkey; ²Bezmialem Vakif University, Institute of Life Sciences and Biotechnology, Istanbul, Turkey; ³Bezmialem Vakif University, Faculty of Medicine, Department of Biophysics, Istanbul, Turkey; ⁴Bezmialem Vakif University, Faculty of Pharmacy, Department of Pharmaceutical Toxicology, Istanbul, Turkey; ⁵Bezmialem Vakif University, Faculty of Medicine, Department of Medical Biology, Istanbul, Turkey; ⁶Bezmialem Vakif University, Faculty of Medicine, Department of General Surgery, Istanbul, Turkey.
Permanent hypoparathyroidism (PH) is a serious clinical condition and unique treatment option is parathyroid allotransplantation (PA). The most important obstacle for PA is an immune…
2018 American Transplant Congress
SIRT1-Ikaros Axis Promotes Macrophage M2 Polarization and Protects Liver Graft from Ischemia-Reperfusion Injury
K. Nakamura,¹ S. Kageyama,¹ X. Li,² A. Aziz,¹ R. Sosa,³ E. Reed,³ F. Kaldas,¹ R. Busuttil,¹ J. Kupiec-Weglinski.¹
¹Surgery, Liver Transplant, UCLA, Los Angeles, CA; ²NIEHS, Durham, NC; ³Pathology, UCLA, Los Angeles, CA.
Although pre-clinical studies have reported the efficacy of Sirtuin 1 (SIRT1) to protect livers from ischemia-reperfusion injury, its clinical relevance in liver transplantation (LT) has…