Articles tagged "Inflammation"

2018 American Transplant Congress
Inhibition of Neutrophil Recruitment and Activation Protects Airway Epithelium after Transplantation
R. Zhang,¹ H. Fang,¹ Q. Chen,² J. Ochando,³ Y. Ding,¹ J. Xu.¹
¹Department of Immunology, Capital Medical University, Beijing, China; ²Department of Thoracic Surgery, Chaoyang Hospital, Beijing, China; ³Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY.
Background: Obliterative bronchiolitis (OB) is the major obstacle limiting long-term allograft survival of lung transplantation. Airway epithelium is the primary target in obliterative airway diseases.…
2018 American Transplant Congress
Endothelial Cell Heterogeneity Governs Basal and Inducible Inflammatory Responses Relevant to Allograft Injury
N. Valenzuela.
Pathology and Laboratory Medicine, UCLA, Los Angeles, CA.
PurposeTransplanted tissues are differentially susceptible to ischemia/reperfusion and rejection. Endothelial cells (EC) are active regulators of inflammation. But model EC may not adequately reflect the…
2018 American Transplant Congress
Gene Silencing with p53 si-RNA Downregulates Inflammatory Markers in the Liver: Potential Utilization during Normothermic Machine Preservation
C. Moore,¹ M. Thijssen,^1,2 X. Wang,³ P. Mandrekar,³ E. Xiaofei,³ R. Abdi,⁴ R. Porte,² A. Bozorgzadeh,¹ H. Leuvenink,² T. Kowalik,³ P. Martins.¹
¹Dept of Surgery, University of Massachusetts, Worcester, MA; ²Dept of Surgery, Groningen University, Gronigen, Netherlands; ³Dept of Medicine, Univ. of Massachusetts, Worcester, MA; ⁴Transplant Research Institute, Harvard University, Boston, MA.
Background: RNA interference (RNAi) is a process through which RNA induces the activation of endogenous cellular pathways of RNA degradation, resulting in selective and potent…
2018 American Transplant Congress
Pro-Inflammatory B Cells Predict Progressive Minimal Early Renal Allograft Inflammation Which is Associated with Poor Graft Outcomes
A. Sharma, A. Cherukuri, D. Chittka, R. Mehta, S. Hariharan, D. Rothstein.
UPMC, Pittsburgh.
The clinical significance of minimal tubulointerstitial inflammation (MTI:'t'+'i'scores 0.5-1.5) and Banff Borderline changes (BBC:'t'+'i'scores 2-3) in early renal allograft biopsies is unclear. The rate and…
2018 American Transplant Congress
Hyperglycemia-Triggered ATF6-CHOP Pathway Exacerbates Liver Ischemia/Reperfusion Injury: Immunomodulation by Regulating β-Catenin Signaling
J. Rao,^1,2 C. Yang,¹ Y. Hu,¹ S. Yang,¹ Y. Xia,¹ F. Zhang,¹ X. Wang,¹ Y. Zhai,² L. Lu.^1,2
¹Department of Liver Surgery/Liver Transplantation Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China; ²Division of Liver and Pancreas Transplantation, Department of Surgery, David Geffen School of Medicine at University of California Los Angeles, Los Angeles.
Background & Aims: Hyperglycemia is a risk factor for hepatic ischemia/reperfusion injury (IRI) during liver transplantation or hepatectomy; however, the underlying mechanism remains unclear. Our…
2018 American Transplant Congress
Unraveling the Neuroimmunological Pathways Surrounding Brain Death: Systematic Study of Clinically Relevant Serum Biomarker Changes during Donor Management from Admission to Procurement
K. Bera, M. LoFaro, H. Huang, S. Maslau, R. Ploeg.
Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom.
Donation after brain death (BD) remains an important source of transplanted organs worldwide and it has been shown that BD causes a hostile environment with…
2018 American Transplant Congress
Type-1 Interferon Impairs the Immunoregulatory Activity of IL-10: Understanding the Mechanisms of Abrogation of Transplant Tolerance
M. Iglesias, A. Arun, M. Chicco, B. Lam, V. Ivanova, W. Lee, G. Brandacher, G. Raimondi.
Plastic Surgery, Johns Hopkins UIniversity, Baltimore, MD.
A growing body of evidence shows that induction of long term transplant survival by costimulation blockade (CoB) regimens is impaired by inflammatory responses (e.g. engagement…
2018 American Transplant Congress
IL-6 Inhibition with Tocilizumab to Promote Tregs and Control Renal Graft Inflammation: A Prospective Randomized Controlled Trial
S. Chandran, J. Leung, Z. Laszik, Q. Tang, C. Hu, M. Sarwal, F. Vincenti.
UCSF, San Francisco.
Background: IL-6, a proinflammatory cytokine & key regulator of Treg/Th17, is strongly associated with renal graft rejection. In theory, IL-6 blockade with tocilizumab (TCZ), a…
2018 American Transplant Congress
Human Urine-Derived Stem Cells Protect Renal Function by Releasing miR-129-5p Which Targets High-Mobility Group Box-1 (HMGB1) in Rat Ischemia Reperfusion Injury Model
L. Liu, X. Li, Q. Su, Z. Bi, H. Huang, C. Wang.
Organ Transplant Center, The First Affiliated Hospital of Sun Yet-sen University, New York, NY, China.
Objective: This study investigated the protective effect of human urine-derived stem cells (USCs) on renal ischemia reperfusion injury (IRI) in rats. Methods: Human USCs was…
2018 American Transplant Congress
Glycogen Synthase Kinase 3 beta Regulates Liver Inflammation Activation and Resolution by Controlling AMPK Activities
H. Wang,^1,2 M. Ni,^1,2 H. Zhou,² L. Lu,² R. Busuttil,¹ J. Kupiec-Weglinski,¹ Y. Zhai.¹
¹Surgery, David Geffen School of Medicine-UCLA, Los Angeles, CA; ²Liver Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
Background & Aims: Glycogen synthase kinase 3β (Gsk3β) is ubiquitously expressed with distinctive functions in different types of cells. Although its roles in regulating innate…