ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Inflammation"

  • 2020 American Transplant Congress

    Contamination of Acinar Cells Impairs Therapeutic Effect of Islet Transplantation Due to Induction of Inflammatory Reaction in Not Only Graft Islets but Also Hepatic Parenchyma

    K. Chinen, G. Yoshimatsu, N. Sakata, S. Kodama

    Regenerative Medicine and Transplantation, Fukuoka University, Fukuoka City, Japan

    *Purpose: Islet transplantation is a promising treatment option for type 1 diabetes. Edmonton protocol recommended that over 30 % purity of islets is essential for…
  • 2020 American Transplant Congress

    DEPTOR Expression within CD4+Foxp3+ T Regulatory Cells is Crucial for B Cell Activation Responses and Immunoregulation

    J. Wedel1, M. Maslyar1, S. Kong1, M. Laplante2, D. M. Briscoe1

    1Boston Children's Hospital, Boston, MA, 2Lavel University, Quebec, QC, Canada

    *Purpose: We have previously reported that the intracellular protein DEPTOR stabilizes Foxp3 expression, enhances suppressive Treg function and inhibits Treg dedifferentiation. Overexpression of DEPTOR within…
  • 2020 American Transplant Congress

    Allograft Parenchymal Cell Expression of Tlr9 is Required for Endogenous Donor-Reactive Memory Cd8 T Cell Activation within High-Risk Cardiac Allografts to Mediate Ctla-4 Ig Resistant Graft Rejection

    D. Ueda, H. Tsuda, S. Miyairi, R. L. Fairchild

    Lerner Reserch Institute, Cleveland Clinic, Cleveland, OH

    *Purpose: Increased ischemia-reperfusion graft inflammation provokes activation of endogenous donor-reactive memory CD8 T cells within complete MHC-mismatched cardiac allografts at 24 hrs after graft reperfusion…
  • 2020 American Transplant Congress

    Proinflammatory Cytokines Including IL-18 Correlate with Cytomegalovirus DNAemia in Solid Organ Transplant Recipients

    A. H. Karaba, A. Figueroa, S. C. Ray, R. K. Avery, A. L. Cox

    Division of Infectious Diseases, Department of Medicine, Johns Hopkins University, Baltimore, MD

    *Purpose: Human cytomegalovirus (CMV) is a common immunomodulatory virus that still causes significant morbidity and mortality in solid organ transplant (SOT) recipients despite prophylaxis. Cytokines…
  • 2020 American Transplant Congress

    Ikaros Regulates Macrophage Inflammation in Liver Ischemia-Reperfusion Injury: From Mouse-to-Human

    K. Kadono1, S. Kageyama1, K. Nakamura1, H. Hirao1, H. Kojima1, T. Ito1, K. J. Dery1, X. Li2, R. W. Busuttil1, F. Kaldas1, J. W. Kupiec-Weglinski1

    1Liver Transplant Surgery, UCLA, Los Angeles, CA, 2NIEHS, Durham, NC

    *Purpose: Hepatic ischemia-reperfusion injury (IRI) represents a major risk factor for early allograft dysfunction and rejection episodes in liver transplantation (LT). The impact of Ikaros,…
  • 2019 American Transplant Congress

    The Role of the T Regulatory Cell Compartment in Intestinal Transplant Patients: Helpful or Unhinged?

    L. Belyayev1, M. Sadat2, K. Loh3, S. Moturi2, K. Khan2, J. Hawksworth2, C. Matsumoto2, T. M. Fishbein2, A. Kroemer2

    1Surgery, Walter Reed National Military Medical Center, Bethesda, MD, 2Transplant, MedStar Georgetown Transplant Institute, Washington D.C., DC, 3Pediatrics, Children’s National Medical Center, Washington D.C., DC

    *Purpose: The T regulatory (Treg) cell compartment has now been established as a key player in dampening T helper 17 (Th17) mediated inflammation, managing self-tolerance,…
  • 2019 American Transplant Congress

    Islet Stress Leads to Increased Release of Exosomes That Stimulate Immune Cell Response

    S. Vasu1, C. Darden2, K. Kumano1, B. Naziruddin3, M. Lawrence3

    1Baylor Scott and White Research Institute, Dallas, TX, 2Institute of Biomedical Studies, Baylor University, Waco, TX, 3Baylor University Medical Ctr, Dallas, TX

    *Purpose: Islet dysfunction and death caused by isolation procedures, immune attack and hypoxia significantly affect islet transplantation outcomes. Non-invasive monitoring of islet stress and damage…
  • 2019 American Transplant Congress

    Hyperglycemia Aggravates Acute Liver Injury by Promoting Macrophage NLRP3 Activation via AMPK/mTOR-Dependent Autophagy Inhibition

    H. ZHOU, Q. Wang, R. Liu, S. Zhou, F. Cheng, X. Wang, L. Lu

    The First Affiliated Hospital of Nanjing Medical University, Nanjing, China

    *Purpose: The detrimental effects of diabetes mellitus/hyperglycemia include an increase in the oxidative stress response and an enhanced inflammatory response. Despite an increased understanding of…
  • 2019 American Transplant Congress

    Type-1 Interferons Impair the Key Immunoregulatory Activity of IL-10 in the Promotion of Transplant Tolerance

    M. Iglesias Lozano, M. Chicco, D. Bibicheff, G. Brandacher, G. Raimondi

    Plastic Surgery, Johns Hopkins University, Baltimore, MD

    *Purpose: Induction of long term transplant survival by “costimulation blockade” (CoB) regimens is impaired by inflammatory responses. Despite the identification of type-1 interferons (TI-IFN) as…
  • 2019 American Transplant Congress

    Galectin-3 Levels Are Associated with the Incidence and Severity of Chronic GVHD One Year after Allogeneic Hematopoietic Cell Transplantation

    N. Navarro-Alvarez1, A. R. Andrews1, Z. DeFilipp2, Y. A. Chen2, V. T. Ho3, J. Ritz3, T. R. Spitzer4, C. A. Huang5

    1Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, 2Blood and Marrow Transplant Program, Massachusetts General Hospital, Boston, MA, 3Hematologic Malignancies, Dana-Farber Cancer Institute, Boston, MA, 4Hematology/Oncology, Massachusetts General Hospital, Boston, MA, 5Plastic & Reconstructive Surgery and Transplant Surgery Divisions, University of Colorado, Denver, Aurora, CO

    *Purpose: Chronic graft-versus-host disease (cGVHD) is a frequent complication of allogeneic hematopoietic cell transplantation (HCT) and a leading cause of late morbidity and mortality. T-…
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