ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Inflammation"

  • 2020 American Transplant Congress

    IL-10 Signaling in T Cells is Essential for Induction of Transplant Tolerance

    M. Iglesias Lozano, D. Bibicheff, M. Chicco, G. Brandacher, G. Raimondi

    Plastic Surgery, Johns Hopkins University, Baltimore, MD

    *Purpose: Induction of long term transplant survival by “costimulation blockade” (CoB) is achieved through deletion of abortively activated alloreactive T cells and generation of graft…
  • 2020 American Transplant Congress

    Single-Cell RNA Sequencing to Assess the Effect of IL-6 Receptor Blockade in Kidney Transplantation

    A. Zarinsefat, P. Rashmi, A. Da Silva, T. Sigdel, S. Chandran, Q. Tang, J. Ye, F. Vincenti, M. Sarwal

    University of California San Francisco, San Francisco, CA

    *Purpose: Prospective randomized study of IL-6R blockade with Tocilizumab for treatment of subclinical inflammation (SCI) in renal transplantation, reveals unique profiles of resting and stimulated…
  • 2020 American Transplant Congress

    Time-Zero Histology Correlates with Donor Characteristics but Does Not Predict Short-Term Outcomes in Kidney Transplantation

    S. Raza, G. Agarwal, D. Anderson, M. Deierhoi, H. Fatima, M. Hanaway, J. Locke, P. MacLennan, B. Orandi, C. Young, R. Mannon, M. Seifert

    University of Alabama School of Medicine, Birmingham, AL

    *Purpose: Time-zero biopsies provide important information about baseline histology but their clinical utility compared to other non-invasive predictors is unclear. Our center performs universal time-zero…
  • 2020 American Transplant Congress

    Targeting CD62 – CD162 Signaling with a Soluble Form of a Tandem-PSGL-1 in a Murine Model of Hindlimb Transplantation

    K. Kadono1, F. Messner2, Y. Guo2, B. Oh2, G. Brandacher2, J. W. Kupiec-Weglinski1

    1Liver Transplant Surgery, UCLA, Los Angeles, CA, 2Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, MD

    *Purpose: Static cold storage (SCS) times for organs and tissues are currently limited to hours. Once outside the body, tissues lack oxygen and nutrient supply…
  • 2020 American Transplant Congress

    Alum Elicited MDSCs Delay the Rejection of Fully Mistmatched Islets in Mice

    A. Cuenca1, N. Feeney2, J. Ge1, K. Deng2, Q. Fu2, G. Huai2, K. Lee2, C. Rickert2, J. Markmann2

    1Boston Children's Hospital, Boston, MA, 2Massachusetts General Hospital, Boston, MA

    *Purpose: Myeloid derived suppressor cells (MDSCs) have been demonstrated to be critical for the induction of tumor induced T cell tolerance and have also been…
  • 2019 American Transplant Congress

    Characterization of Innate Lymphoid Cells in Full Facial and Limb Transplant Recipients

    T. J. Borges1, J. T. O’Malley2, B. Kollar3, B. Pomahac3, S. G. Talbot3, L. V. Riella1

    1Schuster Transplantation Research Center, Brigham & Women's Hospital, Harvard Medical School, Boston, MA, 2Department of Dermatology, Brigham & Women's Hospital, Harvard Medical School, Boston, MA, 3Division of Plastic Surgery, Department of Surgery, Brigham & Women's Hospital, Harvard Medical School, Boston, MA

    *Purpose: Vascular composite allotransplantation (VCA) transplantation is a life-transforming procedure with encouraging results. Despite the recent advances, the immunological response in these patients is still…
  • 2019 American Transplant Congress

    Matrix Metalloproteinase-9 and Neutrophil Extracellular Traps in Human and Mouse Liver Ischemia and Reperfusion Injury

    S. Duarte, A. Zarrinpar, R. W. Busuttil, A. J. Coito

    Dumont-UCLA Transplant Center, Los Angeles, CA

    *Purpose: Neutrophils are key mediators of ischemia/reperfusion injury (IRI) in orthotopic liver transplantation (OLT). Once activated, they release nuclear DNA web-like structures called neutrophil extracellular…
  • 2019 American Transplant Congress

    Microcirculation Inflammation with TCMR is Associated with Poor Graft Outcomes in Kidney Transplant Recipients (KTRs) without ABMR

    A. Cherukuri, S. Tandukar, S. Hariharan, R. Mehta

    UPMC, Pittsburgh, PA

    *Purpose: Glomerulitis (g) and peritubular capillaritis (ptc), defined as microcirculation inflammation lesions (MI), are a hallmark of ABMR in KTRs. Their significance in KTRs with…
  • 2019 American Transplant Congress

    Recipient Myeloid Notch1 Disruption Shifts Neutrophil towards Anti-Inflammatory Phenotype and Protects Liver Grafts from Ischemia-Reperfusion Injury

    S. Kageyama1, H. Hirao1, K. Kadono1, K. Nakamura1, K. J. Dery1, T. Ito2, D. Oncel1, J. Aziz1, B. Ke1, F. M. Kaldas2, R. W. Busuttil2, J. W. Kupiec‐Weglinski1

    1Dumont-UCLA Transplant Center, UCLA, Los Angeles, CA, 2Surgery, Ronald Reagan UCLA Medical Center, UCLA, Los Angeles, CA

    *Purpose: Liver ischemia-reperfusion injury (IRI) represents a major risk factor of early graft dysfunction and predisposes to rejection crises in orthotopic liver transplantation (OLT). We…
  • 2019 American Transplant Congress

    Clazakizumab Acts on Endothelial Cells to Limit Antibody Mediated Damage

    J. Lion1, K. Poussin1, E. Chong2, D. Glotz3, N. A. Mooney1

    1Alloimmunité-Autoimmunité-Transplantation, INSERM, Paris, France, 2Vitaeris, Vancouver, BC, Canada, 3Nephrology and Transplantation, Hôpital Saint Louis, Paris, France

    *Purpose: Human microvascular endothelial cell expression of HLA class II antigens is strongly increased, both in vitro and in vivo, under inflammatory conditions. HLA class…
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