2020 American Transplant Congress
IL-10 Signaling in T Cells is Essential for Induction of Transplant Tolerance
Plastic Surgery, Johns Hopkins University, Baltimore, MD
*Purpose: Induction of long term transplant survival by “costimulation blockade” (CoB) is achieved through deletion of abortively activated alloreactive T cells and generation of graft…2020 American Transplant Congress
Single-Cell RNA Sequencing to Assess the Effect of IL-6 Receptor Blockade in Kidney Transplantation
University of California San Francisco, San Francisco, CA
*Purpose: Prospective randomized study of IL-6R blockade with Tocilizumab for treatment of subclinical inflammation (SCI) in renal transplantation, reveals unique profiles of resting and stimulated…2020 American Transplant Congress
Time-Zero Histology Correlates with Donor Characteristics but Does Not Predict Short-Term Outcomes in Kidney Transplantation
University of Alabama School of Medicine, Birmingham, AL
*Purpose: Time-zero biopsies provide important information about baseline histology but their clinical utility compared to other non-invasive predictors is unclear. Our center performs universal time-zero…2020 American Transplant Congress
Targeting CD62 – CD162 Signaling with a Soluble Form of a Tandem-PSGL-1 in a Murine Model of Hindlimb Transplantation
*Purpose: Static cold storage (SCS) times for organs and tissues are currently limited to hours. Once outside the body, tissues lack oxygen and nutrient supply…2020 American Transplant Congress
Alum Elicited MDSCs Delay the Rejection of Fully Mistmatched Islets in Mice
1Boston Children's Hospital, Boston, MA, 2Massachusetts General Hospital, Boston, MA
*Purpose: Myeloid derived suppressor cells (MDSCs) have been demonstrated to be critical for the induction of tumor induced T cell tolerance and have also been…2019 American Transplant Congress
Characterization of Innate Lymphoid Cells in Full Facial and Limb Transplant Recipients
*Purpose: Vascular composite allotransplantation (VCA) transplantation is a life-transforming procedure with encouraging results. Despite the recent advances, the immunological response in these patients is still…2019 American Transplant Congress
Matrix Metalloproteinase-9 and Neutrophil Extracellular Traps in Human and Mouse Liver Ischemia and Reperfusion Injury
Dumont-UCLA Transplant Center, Los Angeles, CA
*Purpose: Neutrophils are key mediators of ischemia/reperfusion injury (IRI) in orthotopic liver transplantation (OLT). Once activated, they release nuclear DNA web-like structures called neutrophil extracellular…2019 American Transplant Congress
Microcirculation Inflammation with TCMR is Associated with Poor Graft Outcomes in Kidney Transplant Recipients (KTRs) without ABMR
*Purpose: Glomerulitis (g) and peritubular capillaritis (ptc), defined as microcirculation inflammation lesions (MI), are a hallmark of ABMR in KTRs. Their significance in KTRs with…2019 American Transplant Congress
Recipient Myeloid Notch1 Disruption Shifts Neutrophil towards Anti-Inflammatory Phenotype and Protects Liver Grafts from Ischemia-Reperfusion Injury
*Purpose: Liver ischemia-reperfusion injury (IRI) represents a major risk factor of early graft dysfunction and predisposes to rejection crises in orthotopic liver transplantation (OLT). We…2019 American Transplant Congress
Clazakizumab Acts on Endothelial Cells to Limit Antibody Mediated Damage
*Purpose: Human microvascular endothelial cell expression of HLA class II antigens is strongly increased, both in vitro and in vivo, under inflammatory conditions. HLA class…
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