2021 American Transplant Congress
The Contribution of Disulfide-hmgb1 Released During Ischemia-reperfusion Injury to Pro-inflammatory Macrophage Polarization Following Liver Transplantation
Pathology and Lab Medicine, UCLA, Los Angeles, CA
*Purpose: Ischemia-reperfusion injury (IRI) during liver transplantation (LT) is a pro-inflammatory response linked to poorer outcomes, including increased alloimmunity, post-LT. We previously showed that post-reperfusion…2020 American Transplant Congress
Frailty-Inflammatory Index & Mortality after Kidney Transplantation: Development & Validation
*Purpose: Frailty is associated with poor outcomes like delirium, delayed graft function, and mortality, that may result from inflammation after kidney transplant (KT). Despite a…2020 American Transplant Congress
Rat Hind Limb Transplant Model to Assess Vascularized Composite Allograft (VCA) Inflammation and Ischemia Reperfusion Injury
*Purpose: Vascularized composite allografts are potential surgical solutions for patients with traumatic or disfiguring injuries but are highly immunogenic and require elevated levels of immunosuppression.…2020 American Transplant Congress
Multimodal Theranostic Nanocolloid Platform for Imaging, Targeted Drug Delivery and Organ Preservation in Transplantation
*Purpose: The goal of this project design and development of multifunctional nanomedicines to address unique and complex therapeutic outcomes in transplantation and organ preservation. Presented…2020 American Transplant Congress
Dual Donor-Recipient Intervention with Recombinant Human C1 Inhibitor Prevents Delayed Graft Function and Reduces Antibody-Mediated Rejection after Kidney Transplantation in Non-Human Primates
*Purpose: Patients with delayed graft function (DGF) are at increased risk for rejection and inferior graft survival. Complement activation during brain death and ischemia reperfusion…2020 American Transplant Congress
Inhibiting NLRP3 Inflammasome Ameliorates Glucose Fluctuation Through Reducing Apoptosis and Infiltration of Inflammatory Cells after Intraportal Islet Transplantation in Rodent Model
*Purpose: Islet transplantation is a useful treatment option for insulin dependent diabetes mellitus with severe hypoglycemic event. However, intraportal islet transplantation is known to induce…2020 American Transplant Congress
DAMPs and NLRP3 Inflammasome Response in Fatty Liver Grafts Preservation in Different Preservation Solutions
*Purpose: Preservation solutions (UW, HTK and IGL-1) are widely used in clinical liver transplantation. It is well known that the composition of the preservation solution…2020 American Transplant Congress
IL-33 is a Potent Injury Signal That Programs Graft Macrophage Metabolism Toward That Required for Reparative and Regulatory Functions
*Purpose: Sequestered self-molecules, such as HMGB1 or haptoglobin, are appreciated to stimulate the pro-inflammatory response of infiltrating innate immune cells by targeting TLR4 after their…2020 American Transplant Congress
Contamination of Acinar Cells Impairs Therapeutic Effect of Islet Transplantation Due to Induction of Inflammatory Reaction in Not Only Graft Islets but Also Hepatic Parenchyma
Regenerative Medicine and Transplantation, Fukuoka University, Fukuoka City, Japan
*Purpose: Islet transplantation is a promising treatment option for type 1 diabetes. Edmonton protocol recommended that over 30 % purity of islets is essential for…2020 American Transplant Congress
DEPTOR Expression within CD4+Foxp3+ T Regulatory Cells is Crucial for B Cell Activation Responses and Immunoregulation
1Boston Children's Hospital, Boston, MA, 2Lavel University, Quebec, QC, Canada
*Purpose: We have previously reported that the intracellular protein DEPTOR stabilizes Foxp3 expression, enhances suppressive Treg function and inhibits Treg dedifferentiation. Overexpression of DEPTOR within…
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