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American Transplant Congress abstracts

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Articles tagged "Inflammation"

  • 2022 American Transplant Congress

    DEPTOR: A Novel Endothelial-Specific Regulator of Cell-Intrinsic Anti-Inflammation Following Transplantation

    C. Testini1, S. Bose1, K. Liu1, S. Kong1, E. Flynn1, M. Miovski1, J. Leyva-Rangel1, M. Laplante2, J. Wedel1, D. M. Briscoe1

    1Boston Children's Hospital and Harvard Medical School, Boston, MA, 2Laval University, Quebec, QC, Canada

    *Purpose: Recent studies have highlighted a paradigm whereby the maintenance of normal tissue homeostasis and the prevention of chronic inflammation is dependent on the active…
  • 2022 American Transplant Congress

    Ikaros-SIRT1 Signaling Axis Regulates Macrophage Pyroptosis and Ischemia-Reperfusion Injury (IRI) in Mouse and Human Liver Transplantation

    K. Kadono1, H. Hirao1, H. Kojima1, K. J. Dery1, X. Li2, J. Kupiec-Weglinski1

    1UCLA Medical Center, Los Angeles, CA, 2NIEHS, Durham, NC

    *Purpose: Although Ikaros is a well-established regulator of lymphopoiesis, its role in myeloid cells and organ IRI remains unclear. We recently reported that the SIRT1-mediated…
  • 2022 American Transplant Congress

    P2X7R Signaling Controls Exosome Release by Macrophages and Donor MHC Cross-Dressing After Skin Transplantation

    H. H. Lancia1, N. Carnel2, A. G. Lellouch1, C. Cetrulo1, G. Benichou2

    1Division of Plastic and Reconstructive Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 2Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA

    *Purpose: Exosomes released by transplanted organs play an important role in the host's immune response leading to their rejection. Donor exosomes contribute to alloimmunity by…
  • 2022 American Transplant Congress

    Bcl6 Regulates NFκB-Controlled Endothelial Inflammation and Apoptosis

    A. Franco Acevedo, N. Valenzuela

    Pathology and Laboratory Medicine, UCLA, Los Angeles, CA

    *Purpose: Endothelial cells (EC) centrally regulate leukocyte access to peripheral tissue and immune cell activation, and exhibit remarkable tissue-specific diversity. However, the molecular mechanisms underlying…
  • 2022 American Transplant Congress

    Disulfide HMGB1 Reprograms Macrophages to Induce Alloimmunity via TLR4 and TLR9 Pathways Following Ischemia-Reperfusion Injury in Human Orthotopic Liver Transplantation

    A. Q. Terry1, R. A. Sosa1, F. Kaldas2, R. Busuttil3, D. Gjertson1, J. Kupiec-Weglinski1, E. Reed1

    1Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA, 2University of California Los Angeles (Multi-organ), Los Angeles, CA, 3Surgery, University of California, Los Angeles, Los Angeles, CA

    *Purpose: Human hepatocellular damage caused by ischemia reperfusion injury (IRI) generates the disulfide form of HMGB1 (diS HMGB1), eliciting myeloid cell activation and proinflammatory cytokine…
  • 2022 American Transplant Congress

    IL-15 Signaling is Required for the Maintenance of Tissue Resident Memory T Cells in Chronic Allograft Rejection

    R. Tieu1, Q. Zeng1, D. Zhao1, A. Williams1, J. Yun Tso2, F. Lakkis1, J. Yun Tso2

    1Starzl Transplantation Institute, Pittsburgh, PA, 2JN Biosciences, Mountain View, CA

    *Purpose: Currently, no immunotherapies have been clinically proven to prevent or treat chronic rejection. IL-15 is known to support memory T cell homeostasis. However, it…
  • 2022 American Transplant Congress

    Higher Proinflammatory Cytokines Are Associated with Increased Antibody Titer After a Third Dose of SARS-CoV-2 Vaccine in Solid Organ Transplant Recipients

    A. H. Karaba1, X. Zhu1, S. E. Benner1, O. Akinde1, Y. Eby1, K. H. Wang1, S. Saraf2, J. M. Garonzik-Wang3, S. L. Klein1, J. R. Bailey1, A. L. Cox1, J. N. Blankson1, C. M. Durand1, D. L. Segev1, W. A. Werbel1, A. A. Tobian1

    1Johns Hopkins University, Baltimore, MD, 2National Institute of Allergy and Infectious Diseases, Bethesda, MD, 3University of Wisconsin School of Medicine and Health, Madison, WI

    *Purpose: Solid organ transplant recipients (SOTRs) are at increased risk for severe COVID-19 and exhibit lower antibody responses to SARS-CoV-2 vaccines. This study aimed to…
  • 2022 American Transplant Congress

    Donor Kidney-Resident Passenger Macrophages Promote CCL8-CCR8 Mediated Early Allograft Inflammation

    A. Dangi1, I. Husain2, N. Natesh3, X. Shen3, J. Kwun4, X. Luo5

    1Medicine, Duke University Medical Center, Durham, NC, 2Duke University Medical Center, Durham, NC, 3Biomedical Engineering, Duke University, Durham, NC, 4Duke Transplant Center, Durham, NC, 5Duke University School of Medicine, Durham, NC

    *Purpose: Early intragraft infiltration of monocytes and macrophages has been associated with acute and chronic allograft rejections. Nevertheless, underlying mechanism remained poorly understood. In the…
  • 2022 American Transplant Congress

    Analysis of Tissue and Effluent Damage Associated Molecular Patterns Following Hypothermic Oxygenated Machine Perfusion vs Static Cold Storage in Liver Transplantation

    G. G. Panayotova, Y. Qin, S. Simonishvili, T. Ayorinde, F. Paterno, L. Brown, A. Amin, K. E. Lunsford, J. V. Guarrera

    Transplant Surgery, Rutgers New Jersey Medical School, Newark, NJ

    *Purpose: Hypothermic Oxygenated Machine Perfusion (HMP-O2) results in decreased ischemia/reperfusion injury (IRI) after liver transplantation; however, the molecular pathways of protection are largely unexplored. In…
  • 2022 American Transplant Congress

    Wide Spectrum of Molecular Injury Highlights Heterogeneity of Banff Tubulitis and Interstitial Inflammation Lesions

    M. J. Ellis1, T. Maw2, E. Huang3, E. Stites4, F. Shihab5, D. C. Brennan6, G. Shekhtman7, N. Agrawal7, J. Zeng7, S. Kung8

    1Duke University, Durham, NC, 2University of Southern California, Los Angeles, CA, 3Cedars-Sinai Medical Center, Los Angeles, CA, 4University of Colorado, Aurora, CO, 5University of Utah, Salt Lake City, UT, 6Johns Hopkins School of Medicine, Baltimore, MD, 7CareDx, Brisbane, CA, 8University of California, San Francisco, San Francisco, CA

    *Purpose: The pathological definition and clinical significance of borderline T cell-mediated rejection (BL-TCMR) remains an area of active debate, leading to inconsistencies in therapeutic strategy.…
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