2022 American Transplant Congress
An Immune-Modulatory Strategy to Mitigate Hepatic Ischemia Reperfusion Injury in a Murine Model
University of Florida, Gainesville, FL
*Purpose: Hepatic ischemia/reperfusion injury (IRI) is the leading cause of early graft dysfunction and contributes to the shortage of donor liver grafts. However, despite its…2022 American Transplant Congress
Circulating Donor-Derived Cell-Free DNA: A Novel Non-Invasive Biomarker for Immune Surveillance in Vascularized Composite Allotransplantation
*Purpose: The purpose of this study is to evaluate whether circulating donor-derived cell-free DNA (dd-cfDNA) could be used as a noninvasive biomarker to detect rejection…2022 American Transplant Congress
Adenosine A2A Receptor (A2AR) Agonist Apadenoson Promotes Survival in K28-hACE2 Mice and Syrian Hamsters Infected with Sars-CoV-2
*Purpose: To determine if Apadenoson or Regadenoson has a therapeutic effect in attenuating hyper-inflammation and improving survival rate in K18-hACE2mice or Syrian hamsters infected with…2022 American Transplant Congress
Inflammation After Kidney Transplantation Is Associated With Overall- And Death-censored Graft Loss
Department of Transplantational Medicine, Oslo University Hospital, Rikshospitalet, Oslo, Norway
*Purpose: Early graft loss after kidney transplantation (KT) is mainly a result of acute rejection, while long-term graft loss episodes are often dependent on multifactorial…2022 American Transplant Congress
Dual Therapy with Esculin and Erythropoietin Attenuates Renal Ischemia-Reperfusion Injury via P2x7 Receptor and Nlrp3 Inflammasome Inhibition, and Pi3k/akt Activation
*Purpose: Renal ischemia/reperfusion (RI/R) is an inevitable condition during renal transplantation with critical clinical outcomes. Accordingly, effective therapies are crucially required.*Methods: In this study, the…2022 American Transplant Congress
Kinetic Analysis of Post-Clearance Phase Inflammation in Kidney Biopsies After BK Viremia
1University of Michigan, Ann Arbor, MI, 2Dept. of Pathology, University of Michigan, Ann Arbor, MI
*Purpose: During the post-clearance phase of BK polyomavirus nephropathy, tubulointerstitial inflammation can persist despite resolution of BK viremia. This inflammation is indistinguishable from low grade…2022 American Transplant Congress
Normothermic Machine Perfusion of the Liver Supports Protein Translation and Mitochondrial Function While Reducing Protein Degradation and Metabolic Imbalance: A Proteomics Study
*Purpose: Liver preservation by normothermic machine perfusion (NMP) involves perfusion of the graft with oxygenated blood and nutrients. The NMP Liver trial by the Consortium…2022 American Transplant Congress
Impact of Total Parenteral Nutrition on Donor Kidneys During Oxygenated Preservation at 22ºC Ex Vivo
1London Health Sciences Centre, London, ON, Canada, 2Western University, London, ON, Canada
*Purpose: Recent studies have shown that ex vivo preservation at 37 º C can reduce kidney injury compared to current clinical practice. However, to mitigate…2022 American Transplant Congress
Abnormal Kidney T Cell Metabolism During Ischemia Reperfusion Injury Can Be Modified to Improve Organ Structure and Function
Johns Hopkins University School of Medicine, Baltimore, MD
*Purpose: T cells play an important role in the pathophysiology of kidney ischemia reperfusion injury (IRI). Metabolic programming of T cells, a rapidly evolving field,…2022 American Transplant Congress
Intraoperative Kinetics of Pro-Inflammatory Markers and Delayed-Graft Function During Kidney Transplantation
University of Texas Medical Branch, Galveston, TX
*Purpose: Detailed molecular changes associated with allograft reperfusion have been poorly defined and current methods of predicting delayed graft function (DGF) after kidney transplantation are…
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