2022 American Transplant Congress
Gsk3beta Regulates the Resolution of Liver Ischemia Reperfusion Injury via MerTK
*Purpose: We have shown previously that glycogen synthase kinase β (Gsk3β) regulates liver inflammatory activation against ischemia/reperfusion injury (IRI). The question of whether it also…2022 American Transplant Congress
Type 1 Innate Lymphoid Cells Are Critical Pro-Inflammatory Effector Cells in a Fatty Liver Mouse Model of Ischemia-Reperfusion Injury
MedStar Georgetown Transplant Institute, Washington, DC
*Purpose: Innate lymphoid cells (ILCs), the most recently described family of lymphoid cells, play fundamental roles in tissue homeostasis through the production of key cytokine…2022 American Transplant Congress
Single-Cell RNA Sequencing Identifies the Changes of Human Normal Kidney After Transplantation
*Purpose: We found that in all studies about kidney transplantation and single cell RNA sequencing (scRNA-seq), the native kidney rather than the transplanted kidney was…2022 American Transplant Congress
Vitamin D Status and Sars-cov-2 Infection in a Cohort of Renal Transplanted Patients
Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico Milano, Milano, Italy
*Purpose: Immunomodulatory and anti-inflammatory properties have been hypothesized for native vitamin D (nVD). Very little is reported about nVD and risk of Sars-CoV-2 infection (COV)…2022 American Transplant Congress
Histologic Predictors of Graft Loss in Early Clinically Indicated Biopsies After Kidney Transplantation
*Purpose: We aimed to investigate histopathological predictors of graft lost in patients who underwent clinically indicated biopsies for worsening kidney function and/or proteinuria within 3…2022 American Transplant Congress
HCK is a Key Regulator for Macrophage Polarization in Kidney Fibrosis
Icahn School of Medicine at Mount Sinai, New York, NY
*Purpose: Interstitial fibrosis and tubular atrophy (IF/TA) is common histological abnormality in biopsy of kidney transplants. Our previous study from a prospective human kidney transplant…2022 American Transplant Congress
P2X7R Inhibition Impairs In Vitro Training of Macrophages
*Purpose: Macrophage training and ATP-mediated P2X7R signaling are unrelated key elements of the innate immune response associated with allotransplant rejection. In the present study, we…2022 American Transplant Congress
Ficoll-Based Isolation Alters the Immunogenicity of Islets That Leads to Enhanced Rejection in Allogeneic Hosts
*Purpose: The purification of pancreatic islets has long relied on the time-consuming density gradient separation method. We herein report a filtration method as an efficient,…2022 American Transplant Congress
QSant, a Novel Urine Test Monitors Recovery of Allograft Injury After DGF
1Nephrosant, Brisbane, CA, 2Hospital do Rim, Sao Paolo, Brazil
*Purpose: We evaluate urine QSant assay to non-invasively monitor recovery of allograft injury, post delayed graft function(DGF).*Methods: 65 HLA-DR matched, renal allograft recipients, on TAC/MMF/prednisone…2022 American Transplant Congress
Type 1 Innate Lymphoid Cells Alleviate Acute Liver Injury Following Transplantation via Interferon-γ Mediated Pathway
Dumont-UCLA Transplant Center, Los Angeles, CA
*Purpose: Innate lymphoid cells (ILCs), a heterogeneous population of non-B non-T lymphocytes, have been found in recent years to plays key regulatory roles in tissue…
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