Articles tagged "Infection"

2021 American Transplant Congress
Impact of Bacterial Infection on HLA Allosensitization Among Kidney Recipients on the Waitlist
D. P. Cina¹, K. R. Sherwood², S. Dobrer², J. Wong³, F. Fenninger², M. Kadatz⁴, P. Keown⁴, J. Lan⁴
¹Department of Urologic Sciences, University of British Columbia, Vancouver, BC, Canada, ²University of British Columbia, Vancouver, BC, Canada, ³Department of Laboratory Medicine, Vancouver General Hospital, Vancouver, BC, Canada, ⁴Department of Nephrology, University of British Columbia, Vancouver, BC, Canada
*Purpose: The clinical relevance of HLA allosensitization associated with bacterial infection remains poorly defined. The primary objective of this study is to determine the incidence,…
2021 American Transplant Congress
Early Detection of SARS-CoV-2 and Other Infections in Solid Organ Transplant Recipients and Household Members Using Wearable Devices
E. H. Li¹, E. Mukhtar¹, E. D. Elftmann¹, F. R. Eweje¹, H. Gao¹, L. I. Ibrahim¹, R. G. Kathawate¹, A. C. Lee¹, K. A. Moore¹, N. Nair¹, S. Amaral², M. Snyder³, B. J. Keating¹
¹Department of Surgery, Penn Transplant Institute, Division of Transplantation, Philadelphia, PA, ²Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, PA, ³Department of Genetics, Stanford University, Palo Alto, CA
*Purpose: Wearable devices that measure physiological parameters have shown utility for detecting infections such as influenza and recently COVID-19 up to 10 days before clinical…
2021 American Transplant Congress
Lung Transplant Recipients with Severe Acute Respiratory Syndrome-Coronavirus 2 Infection and Asymptomatic Carriers Waiting for Lung Transplantation Induce Circulating Exosomes with Severe Acute Respiratory Syndrome-Coronavirus 2 Spike Protein S2
S. Bansal, S. Tokman, T. Fleming, M. Smith, R. Bremner, T. Mohanakumar
St. Joseph’s Hospital and Medical Center, Phoenix, AZ
*Purpose: Exosomes are vesicles released by cells into body fluids. We demonstrated increased circulating exosomes with lung self-antigens (Collagen V, Kα1 Tubulin) and viral antigens…
2021 American Transplant Congress
Dysregulation of Immune Cell Glycolysis and Oxidative Phosphorylation Correlates with Development of Pre-liver Transplant Immune Dysfunction and Post-transplant Mortality
G. Panayotova¹, L. Jin¹, A. Lemenze¹, S. Simonishvili¹, Y. Qin¹, L. Minze², G. Dikdan¹, F. Paterno¹, X. C. Li², M. Ghobrial², J. V. Guarrera¹, K. E. Lunsford¹
¹Transplant Surgery, Rutgers NJMS, Newark, NJ, ²Transplant Surgery, Houston Methodist Hospital, Houston, TX
*Purpose: Cirrhosis-related immune dysfunction contributes to early morbidity and mortality following liver transplant (LT). We have previously identified a pre-LT biomarker panel, the immune frailty…
2021 American Transplant Congress
Relationship Between Tacrolimus Blood Levels and Covid-19 Pandemic in Kidney Transplant Recipients
T. Inoue¹, K. Unagami,², A. Ishiwatari³, T. Kanzawa³, T. Shimizu³, K. Omoto³, M. Inui³, T. Suzuki¹, H. Ishida⁴, K. Tanabe³
¹Department of Nephrology, Kameda Medical Center, Chiba Kamogawa, Japan, ²Department of Organ Transplant Medicine, Tokyo Women’s Medical University, Tokyo, Japan, ³Department of Urology, Tokyo Women’s Medical University, Tokyo, Japan, ⁴Department of Organ transplant medicine, Tokyo Women’s Medical University, Tokyo, Japan
*Purpose: The novel coronavirus 2019 infection (COVID-19) caused a pandemic, prompting Tokyo, Japan, to restrict on the free movement of people in March 2020. Kidney…
2021 American Transplant Congress
Covid-19 Caseload and Management Practices Vary by Program-Level Factors: A Multinational Survey Study
S. Sandal¹, B. Boyarsky², P. Chiang², A. Massie², D. Segev², M. Cantarovich¹
¹McGill University, Montreal, QC, Canada, ²Johns Hopkins University, Baltimore, MD
*Purpose: During the pandemic, the COVID-19 patient caseload (CPC) is thought to be highly variable and likely dependant on the cumulative COVID-19 incidence (CCI) of…
2021 American Transplant Congress
Infectious Complications and Malignancy After Kidney Transplantation in the Elderly Population
L. Liriano-Ward, M. Parides, Y. Al Azzi, C. Pynadath, M. Ajaimy, P. Loarte, J. Graham, S. Greenstein, M. Le, H. Yaffe, M. Kinkhabwala, J. Rocca, E. Akalin
Montefiore Medical Center, New York, NY
*Purpose: All patients, regardless of age, may benefit from renal transplantation due to improved quality of life and decreased mortality. However, elderly patients are at…
2021 American Transplant Congress
The Impact of Fixed-Dose Alemtuzumab in Renal Transplant Recipients According to Weight
S. Mandala¹, N. Khodieva², A. Bigness¹, S. Mohamed², H. Mohammed¹, K. Robichaux², A. Brueckner³, R. Baliga⁴, J. Buggs⁵, A. Kumar¹, L. Bowman³
¹Morsani College of Medicine, University of South Florida, Tampa, FL, ²Honors College, University of South Florida, Tampa, FL, ³Transplant Pharmacy, Tampa General Hospital, Tampa, FL, ⁴Nephrology, Florida Kidney Physicians, Tampa, FL, ⁵Transplant Surgery, Tampa General Hospital, Tampa, FL
*Purpose: Alemtuzumab, a potent anti-CD52 monoclonal antibody is used for induction immunosuppression post-renal transplantation as a fixed 30mg dose regardless of the patient’s weight. The…
2021 American Transplant Congress
Wound Infection After Kidney Transplantation: A Single Center Study
A. Demirag, J. Oberholzer, A. Agarwal, B. Rawashdeh, E. McCraken, K. Brayman
Transplantation, University of Virginia Medical Cener, Charlottesville, VA
*Purpose: Wound complications (WC) following kidney transplantation (KTx) consume valuable resources and may be associated with inferior short and long term graft outcomes. Known risk…
2021 American Transplant Congress
COVID-19 in the Kidney Transplant Waitlist Population
A. C. Johnson¹, C. P. Larsen¹, H. Gebel², R. Bray²
¹Surgery, Emory University, Atlanta, GA, ²Pathology, Emory University, Atlanta, GA
*Purpose: Through banked serum samples from transplant candidates across Georgia, we characterize the prevalence, timing, and duration of SARS-CoV-2 seropositivity and investigate the impact on…