Articles tagged "Induction therapy"

2018 American Transplant Congress
Developing a Rationale for an Appropriate Immunosuppressive Regimen in Lung vs Kidney Transplant Recipients: Effects of Induction Therapy
P. Martin-Moreno,^1,2 H. Shin,^1,3 H. Goldberg,⁴ A. Chandraker.¹
¹Transplantation Research Center, Renal Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA; ²Nephrology Department, Clinica Universidad de Navarra, Pamplona, Spain; ³Renal Division, Department of Internal Medicine, Gospel Hospital, Kosin University College of Medicine, Busan, Korea; ⁴Pulmonary Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
IntroductionThe appropriate use of Thymoglobulin (ATG) or Basiliximab as induction therapy is not fully understood. We studied circulating cytokine profiles following kidney and lung transplantation…
2018 American Transplant Congress
Thymoglobulin Induction in HIV Positive Kidney Transplant Recipients: Report on Transplant and HIV Outcomes
E. Gibney, T. Ommert, R. Cross, A. Ray, J. Lizcano.
Piedmont Transplant Institute, Piedmont Atlanta Hospital, Atlanta, GA.
Introduction: Kidney transplant outcomes in HIV positive recipients are similar to HIV negative recipients. However, high published rates of acute rejection are a challenge. There…
2018 American Transplant Congress
Less Induction Therapy Means Fewer Early Readmissions with No Change in Rejection or Infection
S. Kush, K. Boyle, J. Gray, S. Rega, I. Feurer, A. Shah, J. Lindenfeld.
Vanderbilt University Medical Center, Nashville, TN.
PURPOSE:In heart transplant, induction may allow for delay of calcineurin inhibitor initiation and renal recovery. Literature comparing lymphocyte-depleting and non-depleting induction conflicts in rejection rate…
2018 American Transplant Congress
Adjusted Body Weight Dosing of Rabbit Antithymocyte Globulin in Obese Renal Transplant Recipients Preserves Excellent Clinical Outcomes at 3 Years and Improves the Value of Care
J. Dann, A. Agarwal, M. Bradley, W. Ally.
University of Virginia Health System, Charlottesville, VA.
There is significant variability in antithymocyte globulin (ATG) dosing practices among centers. In the obese population, use of total body weight (TBW) vs. adjusted body…
2018 American Transplant Congress
Effect of Induction Therapy on CD4 Cell Count Recovery Following Renal Transplantation in HIV Positive Recipients – A Single Center Experience
J. Chique Figueroa, M. Prendergast, H. Wadei, M. Mai, K. Oshel, D. Leonard.
Department of Transplantation, Mayo Clinic College of Medicine, Jacksonville, FL.
The feasibility, complications and outcomes of solid organ transplantation in the HIV positive population are well documented and have had excellent outcomes with a slight…
2018 American Transplant Congress
Effect of rATG on Monocytic Myeloid-Derived Suppressor Cells and Its Associated Mechanisms in Kidney Transplantation Recipients
Y. Jiang, X. Zhang.
Beijing Chao-Yang Hospital, Beijing, China.
Myeloid-derived suppressor cells (MDSCs) consist of heterogeneous myeloid progenitors and precursors that was first defined in cancer patients and are characterized by a regulatory ability…
2018 American Transplant Congress
Age Stratified Efficacy and Safety Outcomes of Induction Immunosuppression in Renal Transplantation
D. McKimmy,¹ H. Kuzaro,² S. Sakya,³ K. Belfield,¹ E. Cohen.¹
¹Solid Organ Transplant, Yale New Haven Hospital, New Haven, CT; ²University of St. Joseph School of Pharmacy, West Hartford, CT; ³University of Connecticut School of Pharmacy, Storrs, CT.
Purpose: Rejection and infection remain a leading concern for decreased graft survival after renal transplant (RT). Induction immunosuppression is associated with a decreased risk of…
2018 American Transplant Congress
Clinical and Pathological Findings in Hepatitis C Positive Renal Transplant Recipients Following Alemtuzumab Induction
S. Jonchhe, J. Husson, A. Haririan, B. Ravichandran.
University of Maryland Medical Center, Baltimore.
BackgroundHistorically, renal transplant recipients (RTRs) with chronic hepatitis C (HCV) have worse long-term outcomes. Induction with alemtuzumab (ALM) in HCV positive RTRs has been postulated…
2018 American Transplant Congress
Induction Type and Outcomes in HLA-DR Mismatch Kidney Transplantation
K. Sureshkumar, S. Hussain, B. Chopra.
Nephrology and Hypertension, Allegheny General Hospital, Pittsburgh, PA.
In kidney transplantation, donor-recipient HLA-DR mismatch is considered high immunologic risk portending inferior outcomes. We sought to explore the impact of induction type used on…
2018 American Transplant Congress
Successful Transplantation in a Sensitized Patient Allergic to Commercially Available Antibody Induction Agents
K. Venkatachalam, A. Malone.
Transplant Nephrology, Washington University, St. Louis, MO; Transplant Nephrology, Washington University, St. Louis, MO.
Antibody induction in renal transplantation has increased to over 80%. Rabbit anti-thymocyte globulin (rATG) is the most commonly used agent. Hypotension, rash, dyspnea with rATG…