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Articles tagged "Induction therapy"

  • 2018 American Transplant Congress

    Induction Agents and Post-Transplant Malignancies in Kidney Transplants: An Examination of Outcomes at a Large Volume Center over 20 Years

    D. Livingston-Rosanoff, X. Wang, G. Leverson, D. Kaufman, D. Foley.

    Division of Transplant Surgery, University of Wisconsin, Madison, WI.

    Introduction: Induction agents have a profound effect on the immune milieu at the time of kidney transplantation. However, evaluation of their long-term effects on graft…
  • 2018 American Transplant Congress

    Optimal Anti-Thymocyte Globulin Dose for Induction Immunosuppression in Kidney Transplantation

    A. Mitrokhin, J. Goldman, B. Trivedi, V. Vidyasagar, N. Vadivel, M. Hart.

    Organ Transplant Program, Swedish Medical Center, Seattle, WA.

    Anti-thymocyte globulin (ATG) is used as induction immunosuppression in kidney transplantation to prevent allograft rejection. ATG causes dose-dependent lymphocyte depletion, yet optimal dose is unknown.…
  • 2018 American Transplant Congress

    Hepatitis C Recurrence after Liver Transplant: A Comparison of Antibody Induction versus No Antibody Induction

    S. Patel, J. Jin, E. Benedetti, P. West-Thielke.

    University of Illinois Hospital and Health Sciences System, Chicago.

    Background: Hepatitis C virus (HCV) recurrence after orthotopic liver transplant (OLT) is universal and exhibits accelerated progression to cirrhosis. Progression can be mitigated by new…
  • 2018 American Transplant Congress

    Islet Xenotransplantation: A Quest for Clinically Available Immunosuppression Regimens

    Q. Gao, R. Davis, M. Mulvihill, M. Song, F. Leopardi, M. Ribeiro, T. How, G. Devi, B. Collins, A. Kirk.

    Department of Surgery, Duke University Medical Center, Durham, NC.

    IntroductionThe field of porcine islet xenotransplantation has made significant progress in non-human primate studies in recent years. However, one major barrier preventing clinical translation of…
  • 2018 American Transplant Congress

    T Cell Exhaustion in Kidney Transplant Patients

    M. Fribourg,1 C. Fischman,2 L. Anderson,2 B. Burrell,3 P. Heeger,2 P. Cravedi.2

    1Department of Neurology, Icahn School of Medicine, New York; 2Department of Medicine, Icahn School of Medicine, New York; 3Immune Tolerance Network, Bethesda.

    Background: T cell exhaustion is a dysfunctional state that arises during chronic infection and cancer in response to persistence of high antigenic load. Whether chronic…
  • 2018 American Transplant Congress

    Risk of Bacteremia According to Transplant Induction Immunosuppression Regimen

    E. Misch, S. Kelley, G. Leverson, B. Astor, D. Kaufman.

    University of Wisconsin School of Medicine and Public Health, Madison.

    Background: Transplant immune suppression is designed to suppress the adaptive immune response and ensure graft survival, but may have unintended effects on innate immunity. Few…
  • 2018 American Transplant Congress

    The BEST Trial: A Prospective Randomized Multicenter Trial of Belatacept-Based CNI- and Corticosteroid-Free Immunosuppression

    E. Woodle,1 D. Kaufman,2 A. Shields,1 J. Leone,3 A. Wiseman,4 A. Matas,5 P. West-Thielke,6 E. King,1 R. Alloway.1

    1U Cincinnati, Cincinnati; 2U Wisconsin, Madison; 3Tampa General, Tampa; 4U Colorado, Denver; 5U Minnesota, Minneapolis; 6UIC, Chicago.

    Previous large multicenter belatacept (BELA)-based CNI- and steroid-free immunosuppressive trials have not enrolled to completion due to safety concerns. The BEST Trial (Belatacept-based Early Steroid…
  • 2018 American Transplant Congress

    B Cell Reconstitution: 36-Month Analysis of Patients Post-Alemtuzumab Induction Followed by Belatacept-Based Immunosuppression

    Q. Gao,1 A. Mehta,2 A. Guasch,2 A. Ghali,2 A. Kirk,1 H. Xu.1

    1Department of Surgery, Duke University Medical Center, Durham, NC; 2Emory Transplant Center, Emory University School of Medicine, Atlanta, GA.

    Alemtuzumab induction combined with belatacept and rapamycin (ABR) maintenance immunotherapy effectively prevents costimulation blockade resistant rejection (CoBRR). We longitudinally investigated kinetics of repopulating B cell…
  • 2018 American Transplant Congress

    A Comparison of Alemtuzumab versus Antithymocyte Globulin Induction in High-Risk, Non-Sensitized Renal Transplant Recipients

    S. Patel, A. Lichvar, E. Benedetti, P. West-Thielke.

    University of Illinois Hospital and Health Sciences System, Chicago.

    Background: Lymphocyte depleting induction is routinely utilized in high immunologic risk renal transplant (RTx). African Americans (AA) have a relatively higher risk of rejection regardless…
  • 2018 American Transplant Congress

    Comparing Outcomes between Induction Immunosuppressive Therapies in Simultaneous Heart/Kidney Transplantation

    I. Moinuddin, J. Yu, L. Kang, C. Bhati, D. Bandyopadhyay, A. King, D. Kumar, L. Kamal, D. Tang, I. Yakubu, G. Gupta.

    Virginia Commonwealth University, Richmond.

    Introduction: There is no published data on the risks and benefits of Induction immunosuppression in simultaneous heart/kidney transplant (SHKT) patients.Methods: We analyzed all SHKT performed…
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