ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Immunosuppression"

  • 2020 American Transplant Congress

    Treatment of De Novo Renal Transplant Recipients with Calcineurin Inhibitor (CNI)-Free, Belatacept+Everolimus-Based Immunosuppression

    V. R. Peddi1, B. Marder2, L. Gaite3, J. Oberholzer4, R. Goldberg5, T. Pearson6, H. Yang7, L. Allamassey8, S. Gao8, M. Polinsky8, R. N. Formica9

    1California Pacific Medical Center, San Francisco, CA, 2Colorado Kidney Care, Denver, CO, 3Hospital Marqués de Valdecilla, Cantabria, Spain, 4UVA Health, Charlottesville, VA, 5Saint Barnabas Medical Center, Livingston, NJ, 6Emory University School of Medicine, Atlanta, GA, 7UPMC Pinnacle, Harrisburg, PA, 8Bristol-Myers Squibb, Princeton, NJ, 9Yale University School of Medicine, New Haven, CT

    *Purpose: Compared with CNI-based immunosuppression, kidney transplant recipients receiving belatacept-based treatment present with a favorable metabolic profile, reduced chronic allograft nephropathy, and improved renal function,…
  • 2020 American Transplant Congress

    Medication Knowledge Retention and Adherence Following Transplant: Is There Room for Improvement?

    M. H. Cooper1, A. W. Rogers1, T. L. Menser2, J. C. Krisl1

    1Department of Pharmacy, Houston Methodist Hospital, Houston, TX, 2Houston Methodist Research Institute, Houston Methodist Hospital, Houston, TX

    *Purpose: Transplant recipients’ complex medication regimens following transplant can lead to non-adherence, which has been linked to increased rates of acute rejection and graft loss.…
  • 2020 American Transplant Congress

    Clinical Outcomes in Kidney Transplant Recipients Following Implementation of a Strategic Maintenance Reduction Protocol

    H. Perkins, K. Foster, N. Patel, H. Meadows, F. Bartlett, C. Perez, J. McGillicuddy, N. Pilch, M. Casey, M. A. Posadas-Salas, D. Taber

    Pharmacy, Medical University of South Carolina, Charleston, SC

    *Purpose: Post-transplant complications are commonly due to over-immunosuppression, particularly as it relates to infections. The purpose of this study was to assess clinical outcomes in…
  • 2020 American Transplant Congress

    Association of Discharge Immunosuppressive Regimen with Treated Acute Rejection and Bronchiolitis Obliterans Syndrome in Adult Lung Transplantation: An Analysis of Organ Procurement and Transplantation Network Data

    W. S. Cherikh1, B. J. Plucinski1, S. Palmer2, W. E. Fitzsimmons3

    1United Network for Organ Sharing, Richmond, VA, 2Duke University Hospital, Durham, NC, 3Fitzsimmons LLC, Vernon Hills, IL

    *Purpose: The optimal immunosuppressive (IS) regimen after lung (LU) transplant is unknown. We conducted the current analysis to compare the effect of four different discharge…
  • 2020 American Transplant Congress

    Quantitative Analysis of Humoral Immunity by Flow-Cytometric Crossmatch Using Molecules of Equivalent Soluble Fluorochromosome (FCXM-MESF)

    H. Ishida, M. Furusawa, T. Shimizu, M. Okumi, Y. Kakuta, K. Omoto, K. Tanabe

    Tokyo Womens, Tokyo, Japan

    *Purpose: In this study, we examined the quantitative significance of humoral immunity by flow-cytometric crossmatch using molecules of equivalent soluble fluorochromosome (FCXM-MESF) in recipients of…
  • 2020 American Transplant Congress

    Precision Dosing for Tacrolimus Using Genotypes and Clinical Factors

    M. Al-Kofahi1, W. Oetting1, A. Israni2, D. Schladt3, W. Guan4, B. Wu4, C. Dorr5, R. Remmel6, R. Mannon7, N. Pankratz8, A. Matas9, P. Jacobson1

    1Experimental and Clinical Pharmacology, Univ of MN, College of Pharmacy, Minneapolis, MN, 2Nephrology, Univ of MN and Hennepin HealthCare, Minneapolis, MN, 3Hennepin HealthCare Research Institute, Hennepin HealthCare, Minneapolis, MN, 4Biostatistics, Univ of MN, Minneapolis, MN, 5Nephrology, Hennepin HealthCare, Minneapolis, MN, 6Medicinal Chemistry, Univ of MN, College of Pharmacy, Minneapolis, MN, 7Nephrology, Univ of Alabama, Minneapolis, MN, 8Lab Medicine Pathology, Univ of MN, Minneapolis, MN, 9Surgery, Univ of MN, Minneapolis, MN

    *Purpose: Variants in CYP3A4/5 genes, clinical factors and drug-drug interactions are associated with tacrolimus (TAC) clearance and dose. This results in high intra- and inter-…
  • 2020 American Transplant Congress

    Lymphycyte Subset Test as a Determinant of Cytomegalovirus Prophylaxis in Renal Transplant Recipients

    M. Kim, Y. Park, S. Mok, K. Jun, S. Kim, J. Kim, S. Yun, I. Moon, S. Park

    Surgery, The Catholic University of Korea, Seoul, Korea, Republic of

    *Purpose: Cytomegalovirus (CMV) infection is an important complication after kidney transplantation (KT). Anti-thymocyte globulin (ATG) increases a risk of CMV infection and the American society…
  • 2020 American Transplant Congress

    Incident Malignancies among Post Kidney-Transplant Patients by Type of Induction Immunosuppression and by Age

    L. Wang, J. Motter, S. Bae, D. Segev, M. McAdams DeMarco

    Johns Hopkins University, Baltimore, MD

    *Purpose: Adult kidney-transplant (KT) recipients have a differential risk of malignancies based on their induction immunosuppression (IS) therapy. However, older recipients are more likely to…
  • 2020 American Transplant Congress

    Stability of T Reg with Combination of mTOR Inhibitors with Belatacept in Reducing Risk of Acute Rejection in Kidney Transplant

    J. Shoji, J. Leung, Q. Tang, F. Vincenti

    University of California San Francisco (UCSF), San Francisco, CA

    *Purpose: Belatacept is a costimulatory blocker that is used as de novo maintenance immunosuppression in kidney transplantation to avoid toxic effects of calcineurin inhibitors and…
  • 2020 American Transplant Congress

    ATHENA – Patient and Allograft Outcome Differences after Kidney Transplantation – Germany vs. France

    F. Thaiss1, C. Sommerer1, B. Suwelack1, D. Dragun1, I. A. Hauser1, O. Witzke1, C. Hugo1, P. Schenker1, N. Kamar2, P. Merville2, I. Kroeger3, M. Junge3, B. Nashan1

    1Athena, Study Group, Germany, 2Athena, Study Group, France, 3Novartis Pharma GmbH, Nürnberg, Germany

    *Purpose: In the ATHENA trial [NCT01843348], efficacy and safety of everolimus in combination with tacrolimus [EVR+TAC] or cyclosporine A [EVR+CyA] vs. TAC and mycophenolic acid…
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