Articles tagged "Immunosuppression"

2020 American Transplant Congress
Medication Non-Adherence (MNA) Mitigation Practices and Health Care Professional (HCP) Perceptions at U.S. Transplant Centers
S. J. Patel¹, J. L. Descourouez², B. Hofmeyer³, C. A. Moore⁴, D. Nguyen⁵, E. Graviss⁵, D. J. Taber⁶
¹Veloxis Pharmaceuticals, Cary, NC, ²UW Health, Madison, WI, ³Mercy Hospital, Iowa City, IA, ⁴UPMC Presbyterian Hospital, Pittsburgh, PA, ⁵Houston Methodist, Houston, TX, ⁶MUSC, Charleston, SC
*Purpose: Extensive literature exists on risk factors and mitigating strategies for MNA, however information on MNA management within U.S. transplant centers is scarce. This survey…
2020 American Transplant Congress
Practice Patterns and Provider Adherence to Long Term Management Guidelines in the Post Liver Transplant (LT) Patient
F. Pradhan¹, P. Kang², A. Seetharam¹, S. Mehta¹, R. Nathan¹, M. Fallon¹, N. Patel¹
¹Department of Gastroenterology and Hepatology, Banner University Medical Center, Phoenix, AZ, ²Department of Epidemiology and Biostatistics, University of Arizona, Phoenix, AZ
*Purpose: Long-term use of immunosuppression is associated with increased risks of cardiovascular disease, chronic kidney disease, and cancer. We assessed practice patterns and provider adherence…
2020 American Transplant Congress
Ten Year Results of a Single Center Study of Rabbit Anti-Thymocyte Globulin Compared to Alemtuzumab Induction in Simultaneous Pancreas-Kidney Transplantation
V. Gurram, K. Gurung, G. Orlando, A. Farney, J. Rogers, C. Jay, W. Doares, S. Kaczmorski, A. Reeves-Daniel, A. Mena-Gutierrez, M. Gautreaux, R. Stratta
Abdominal Transplant Surgery, Wake Forest Baptist Health, Winston Salem, NC
*Purpose: The study purpose was to analyze 10-year outcomes of depleting antibody induction agents in simultaneous pancreas-kidney transplant (SPKT) at a single center*Methods: From 2/02…
2020 American Transplant Congress
New-Onset Diabetes after Adult Liver Transplantation in the Korean Organ Transplantation Registry Study
J. Kim¹, S. Hwang², K. Lee³, J. Lee⁴, J. Ryu⁵, B. Kim⁶, D. Choi⁷, Y. You⁸, D. Kim⁹, Y. Nah¹⁰, K. Kang¹¹, M. Kim⁴
¹Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea, Republic of, ²Department of Surgery, Asan Medical Center, College of Medicine University of Ulsan, Seoul, Korea, Republic of, ³Department of Surgery, Seoul National University College of Medicine, Seoul, Korea, Republic of, ⁴Department of Surgery, Yonsei University College of Medicine, Seoul, Korea, Republic of, ⁵Department of Surgery, Pusan National University College of Medicine, Busan, Korea, Republic of, ⁶Department of Liver Transplantation and Hepatobiliary Surgery, Ajou University School of Medicine, Suwon, Korea, Republic of, ⁷Department of Surgery, Catholic University of Daegu College of Medicine, Daegu, Korea, Republic of, ⁸Department of Surgery, College of Medicine, Catholic University of Korea, Seoul, Korea, Republic of, ⁹Division of HBP Surgery and Liver Transplantation, Department of Surgery, Korea University College of Medicine, Seoul, Korea, Republic of, ¹⁰Department of Surgery, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Korea, Republic of, ¹¹Department of Surgery, Keimyung University School of Medicine, Daegu, Korea, Republic of
*Purpose: New-onset diabetes after transplantation (NODAT) is a serious complication following liver transplantation (LT). The present study aimed to investigate the incidence of and risk…
2020 American Transplant Congress
ESAT-6, A Novel Protein Originally Produced by M. Tuberculosis, Inhibits Central Memory CD8+ T Cell Generation and Allograft Rejection
F. Qiu, S. Ye, H. Liu, Z. Dai
Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China
*Purpose: Allospecific memory T cells pose a threat to long-term allograft survival since they are somewhat resistant to immunosuppression. The objective of this study is…
2020 American Transplant Congress
Management of Adenovirus Enteritis after Intestinal Transplantation
E. Sherman¹, N. Beltran², Y. Muszkat³, S. Jafri³
¹Wayne State University School of Medicine, Detroit, MI, ²Department of Surgery, Henry Ford Hospital, Detroit, MI, ³Division of Gastroenterology and Hepatology, Henry Ford Hospital, Detroit, MI
*Purpose: Solid organ transplant recipients are at risk for infection, in part due to immunosuppression. Adenovirus enteritis (AE) is one possible clinical presentation of infection…
2020 American Transplant Congress
Treg Use PD-1 for Lymphatic Migration
W. Piao¹, L. Li¹, K. Hippen², Y. Zhang³, Y. Xiong¹, V. Saxena¹, C. Paluskievicz¹, M. WillsonShirkey¹, B. Blazar⁴, L. Riella⁵, J. Bromberg⁶
¹Surgery, U of Maryland, Baltimore, MD, ²U of Minnesota, Minneapolis, MN, ³U of Maryland, Minneapolis, MD, ⁴U of Minnesota, Minneapolis, MA, ⁵Harvard U, Boston, MA, ⁶Surgery and Microbiology and Immunology, U of Maryland, Baltimore, MD
*Purpose: Regulatory T cell (Treg) lymphatic migration is important for immune tolerance. Treg express both programmed death-1 (PD-1) and its ligand PD-L1, which are important…
2020 American Transplant Congress
De Novo NAFLD Post-Liver Transplant is Defined by Altered Lipid Metabolism and Mitochondrial Dysfunction
M. Bhat¹, E. Pasini¹, M. Angeli¹, J. Allard², A. Humar¹
¹Multi-Organ Transplant, UHN, Toronto, ON, Canada, ²Division of Gastroenterology and Hepatology, UHN, Toronto, ON, Canada
*Purpose: De Novo Non-alcoholic Fatty Liver Disease (NAFLD) affects up to 35% of liver transplant (LT) recipients transplanted for non-NAFLD indications. Non-alcoholic steatohepatitis (NASH), the…
2020 American Transplant Congress
Selective Dual Co-Stimulatory Blockade of CD28/CD80-86 and PD1-PL2 with a Novel Recombinant Bi-Specific Fusion Protein (Hybri-2) Promotes Successful Humoral Desensitization in a Stringent Sensitized Rat Model
A. Torija, E. Crespo, M. Jarque, N. Bolaños, M. Meneghini, A. Favà, J. Torras, J. Grinyo, O. Bestard
Kidney Transplantation Unit, Bellvitge University Hospital- IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain
*Purpose: Humoral Alloimmune memory is a main barrier for successful kidney transplantation and is orchestrated by a compartmentalized cellular immune response driven by bone-marrow LLPCs…
2020 American Transplant Congress
Patterns of Belatacept Use and Risk of Post-Transplant Lymphoproliferative Disorder (PTLD) in US Kidney Transplant Recipients – Analysis of Organ Procurement and Transplantation Network (OPTN) Database
W. S. Cherikh¹, T. Kou², J. Foutz¹, A. Gomez-Caminero²
¹United Network for Organ Sharing (UNOS), Richmond, VA, ²Bristol-Myers Squibb, Princeton, NJ
*Purpose: Belatacept, a selective T-cell costimulation blocker, was approved in 2011 for the prophylaxis of organ rejection in Epstein-Barr virus (EBV)-seropositive kidney transplant recipients. PTLD…