Articles tagged "Immunosuppression"

2020 American Transplant Congress
Simultaneous Pancreas-Kidney Transplant: – The Effects of Early Steroid Withdrawal, Donor and Recipient Variables on Patient Survival
D. Kloda¹, M. McLeod², M. Romine¹, J. Ladowski², J. Locke¹, C. Young¹
¹Department of Surgery - Division of Transplantation, University of Alabama, Birmingham, AL, ²Department of Surgery, University of Alabama, Birmingham, AL
*Purpose: Simultaneous pancreas-kidney transplantation (SPK) improves survival in type I diabetic patients with end stage renal disease (ESRD). Corticosteroids have traditionally been an integral component…
2020 American Transplant Congress
Sparing the Nephron in Liver Transplant Recipients with Antithymocyte Bridging: A Four Year Experience
N. Wilson, H. Kuzaro, N. Parrish, S. A. Shah, N. Anwar, R. R. Alloway, S. Tremblay, T. E. Kaiser
U Cincinnati, Cincinnati, OH
*Purpose: Renal function decline after liver transplant (LT) remains a significant issue. Using antithymocyte globulin (rATG) to delay tacrolimus (TAC) initiation may impact renal deterioration;…
2020 American Transplant Congress
Depletional Profiles of Human and Rhesus Specific Anti-Thymocyte Globulins in Rhesus Macaques
B. I. Shaw¹, R. Schmitz¹, D. M. Magnani², F. Leopardi¹, A. D. Kirk¹
¹Surgery, Duke University, Durham, NC, ²Medicine, MassBiologics of the University of Massachusetts Medical School, Boston, MA
*Purpose: Rabbit anti-human ATG (rATG; Thymoglobulin®) is the most commonly used formulation for depletional induction therapy in the United States. However, given that it is…
2020 American Transplant Congress
Adenovirus Infection in Pediatric Liver Transplant Recipients: A Single Center Experience
S. Hassan¹, K. R. Mysore¹, M. E. Faraone², D. Cerminara³, K. Hosek⁴, E. Moulton⁵, C. Bocchini⁵, R. Sigereddi⁶, R. Ackah⁶, F. Muñoz⁵, A. Rana⁷, J. Goss⁷, D. H. Leung¹, T. Galvan⁷
¹Pediatric Gastroenterology, Hepatology and Nutrition, Baylor College of Medicine/ Texas Children's Hospital, Houston, TX, ²Department of Surgery, Baylor College of Medicine/ Texas Children's Hospital, Houston, TX, ³Department of Pharmacy, Baylor College of Medicine/ Texas Children's Hospital, Houston, TX, ⁴Outcomes and Impact Service, Baylor College of Medicine/ Texas Children's Hospital, Houston, TX, ⁵Department of Pediatrics, Infectious Diseases, Baylor College of Medicine/ Texas Children's Hospital, Houston, TX, ⁶Baylor College of Medicine/ Texas Children's Hospital, Houston, TX, ⁷Michael E. DeBakey Department of Surgery, Division of Abdominal Transplantation, Baylor College of Medicine/ Texas Children's Hospital, Houston, TX
*Purpose: Immunosuppression predisposes children to primary viral or latent infections after liver transplantation (LT). The impact of adenovirus infections on morbidity and mortality remains largely…
2020 American Transplant Congress
Laminin Alpha5 Regulates T Cell Entry and Distribution in Lymph Nodes in Immunity
L. Li¹, M. Shirkey¹, W. Piao¹, Y. Xiong¹, V. Saxena¹, T. Zhang¹, C. Paluskievicz¹, J. Zhao², R. Abdi², J. S. Bromberg¹
¹UMB, Baltimore, MD, ²Harvard University, Boston, MA
*Purpose: Laminin α5 (Lama5) and α4 (Lama4) are lymph node (LN) stromal fibers whose expression ratio influences CD4+ T cell migration and stimulation. We hypothesized…
2020 American Transplant Congress
Risk Factors for Antibody-Mediated Rejection after Adult Liver Transplantation with Preformed Donor-Specific Antibodies: A Single Center Experience
T. Tajima, K. Hata, J. Kusakabe, H. Miyauchi, T. Anazawa, T. Ito, S. Uemoto
Div. of HBP Surgery and Transplantation, Dept. of Surgery, Kyoto University, Kyoto, Japan
*Purpose: In general, preformed donor-specific antibodies (pDSAs) can lead to an increased risk of antibody-mediated rejection (AMR); however, their prevalence, risk factors, and the efficacy…
2020 American Transplant Congress
Donor-Derived DCREG Infusion Prolongs Kidney Allograft Survival in Rhesus Monkeys Treated with Co-Stimulation Blockade and Calcineurin Inhibition
Y. Wang, S. Kazuki, L. Lu, A. Zahorchak, H. Dai, A. Ganoza, M. Wijkstrom, A. Humar, M. Ezzelarab, A. Thomson
Thomas E. Starzl Transplantation Institute, Pittsburgh, PA
*Purpose: We have shown previously that pre-transplantation (Tx) infusion of donor-derived regulatory dendritic cells (DCreg) safely prolongs MHC-mismatched renal allograft survival and regulates donor-reactive T…
2020 American Transplant Congress
Plasma Microbiome Profiles of Liver Transplant Patients with Operational Tolerance
C. Kuscu¹, J. Pierre², I. Lies¹, C. Kuscu¹, A. Bajwa¹, A. Wolen¹, J. Eason¹, B. Ramaswami³, D. Maluf¹, G. Mazariegos³, G. Chalasani³, V. Mas¹
¹James D. Eason Transplant Institute, Department of Surgery, UTHSC, Memphis, TN, ²Department of Pediatrics, UTHSC, Memphis, TN, ³Thomas E. Starzl Transplantation Institute, Children's Hospital of Pittsburgh, UPMC, Pittsburgh, PA
*Purpose: Microbiome has emerged as a key modulator of organ homeostasis and immune system function with altered microbiota and microbiome - host interactions contributing to…
2020 American Transplant Congress
The Use of Cell-Free MicroRNAs for the Diagnosis of Allograft Rejection in Liver Transplant Recipients Using Standard and Novel Direct Detection Platforms
T. Kohut¹, B. Chang², J. Wen¹, A. Shaked², B. Keating²
¹Division of Gastroenterology, Hepatology & Nutrition, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, PA, ²Hospital of the University of Pennsylvania, Penn Transplant Institute, Philadelphia, PA
*Purpose: Standard immunosuppression therapy (IST) in liver transplant (LTx) recipients requires a delicate balance to prevent side effects and allograft rejection (AR). There is no…
2020 American Transplant Congress
Graft versus Host Disease in Liver Transplant Recipients: A Case Series
N. Joiner, J. Dietz, K. Nava-Estevanott, L. Kerbe
Cleveland Clinic Florida, Weston, FL
*Purpose: Graft Versus Host Disease (GvHD) is a serious and potentially fatal disease that is rarely observed in solid organ transplant recipients; however, we report…