2015 American Transplant Congress
Everolimus Plus Reduced-Exposure Calcineurin Inhibitor Versus Mycophenolate Mofetil Plus Standard-Exposure Calcineurin Inhibitor: 2-Year Results in Living Donor Kidney Transplant Recipients
Purpose: To evaluate the long-term efficacy and safety of everolimus (EVR) plus reduced cyclosporine (rCsA) compared to mycophenolate mofetil (MMF) plus standard cyclosporine at 24…2015 American Transplant Congress
Eosinophilic Gastrointestinal Disease in Pediatric Liver and Kidney Transplant Recipients
1Pediatrics, Northwestern University, Chicago; 2Pathology, Northwestern University, Chicago.
Eosinophilic gastrointestinal disease (EGID) has been associated with immunosuppression use in solid organ transplant recipients. However, its relationship to the post-transplant clinical course is unknown.…2015 American Transplant Congress
Sequential Monitoring and Stability of Ex Vivo-Expanded Autologous and Non-Autologous Regulatory T Cells Following Infusion in Non-Human Primates
1University of Pittsburgh, pittsburgh, PA; 2University of Wisconsin, Madison.
Ex vivo-expanded cynomolgus monkey CD4+CD25+CD127- regulatory T cells (Treg) maintained Foxp3 demethylation status at the Treg-Specific Demethylation Region (TSDR), and potently suppressed T cell proliferation…2015 American Transplant Congress
Cyclosporine Nephrotoxicity Is Associated With Diminished Expression of Heat Shock Protein 27 (HSP27) and Loss of Claudin-2-Dependent Intercellular Adhesion
1Medicine, University of Alabama at Birmingham, Birmingham, AL; 2INSERM U1082, Poitiers, France.
Although Cyclosporine A (CsA), a calcineurin inhibitor (CNI), is an effective immunosuppressant used to prevent kidney allograft rejection, prolonged administration is frequently associated with kidney…2015 American Transplant Congress
Allogeneic Mature Human Monocyte-Derived Dendritic Cells Generate Superior Alloreactive Regulatory T Cells in an IL-2-Independent Manner
IntroductionExpansion of antigen (Ag)-specific natural occurring regulatory T cells (nTregs) is required to obtain sufficient numbers of cells for cellular immunotherapy. In this study, different…2015 American Transplant Congress
Thymoglobulin Dosing Efficacy: The Role of ALC on Infection and Rejection
University of Minnesota, Minneapolis, MN.
There are varied Thymoglobulin® (Thymo) induction regimens accepted among transplant programs. Our center uses five doses of Thymo at 1.25mg/kg, yielding a total goal of…2015 American Transplant Congress
Treatment Patterns, Healthcare Resource Utilization, and Costs in Kidney Transplant Recipients Using a Fixed Source Regimen of Tacrolimus Vs. a Variable Source Regimen
BackgroundTacrolimus (TAC) has evolved to be the foundation of kidney transplant immunosuppressant protocols. However, the implications of switching between multiple formulations of TAC have not…2015 American Transplant Congress
Everolimus With Low Dose Tacrolimus in Intestinal Transplantation
Miami Transplant Institute, University of Miami Miller School of Medicine, Miami, FL.
Introduction: Renal dysfunction is a well-known complication after organ transplant given immunosuppression (ISP) with calcineurin inhibitors. This is especially true after intestinal transplant (ITx) given…2015 American Transplant Congress
Comparison of Pharmacokinetics and Pharmacogenomics of Once-Daily Extended-Release MeltDose® Tacrolimus Tablets (Envarsus® XR) Vs. Twice-Daily Tacrolimus Capsules in Stable African American Kidney Transplant Patients: A Randomized Cross-Over Study
The CYP3A5 genotype is the most significant genetic factor impacting tacrolimus (tac) metabolism; expresser's of this genotype require higher tac doses to achieve therapeutic tac…2015 American Transplant Congress
mTOR Inhibitors Reduce the Endothelial Transmigration of Leukocytes After Ischemia
ObjectivemTOR inhibitors Everolimus and Sirolimus are currently used as maintenance immunosuppressive agents to prevent rejection of solid transplanted organs. Episodes of transplant rejection and graft…
American Transplant Congress abstracts