2016 American Transplant Congress
Clinical Outcomes of Simplified Once-Daily Immunosuppressive Regimen for Kidney Recipients.
Background. Many of immunosuppressive drugs have been prescribed as twice-daily dosing. Simplified once-daily dosing of the entire drug regimen can enable patients to improve treatment…2016 American Transplant Congress
Achieving Timely Therapeutic Mycophenolic Acid Levels in Pediatric Lung Transplant Patients.
Texas Children's Hospital, Houston, TX.
The purpose of this study was to determine the appropriate initial dose of mycophenolate mofetil (MMF) in pediatric cystic fibrosis (CF) and non-CF lung transplant…2016 American Transplant Congress
The Effect of Immunosuppression Regimen on Iga Nephropathy Recurrence Post Kidney Transplantation.
Background: Steroid sparing immunosuppression is increasingly used in order to avoid the many well-known side effects of steroids. It has been argued that steroid use…2016 American Transplant Congress
Conversion to Belatacept as Rescue Therapy in Kidney Transplant Recipients with Severe Graft Dysfunction.
Belatacept is a fusion protein that prevents T cell co-stimulation via the CD28 receptor. If used as first-line therapy, immunosuppression with Belatacept is associated with…2016 American Transplant Congress
Marked Alterations in Gene Expression in Peripheral Blood Leukocytes of Kidney Transplant (tx) Recipients Following Mycophenolic Acid (MPA) Treatment.
1University of Minnestoa, Minneapolis; 2MMRC, Hennepin County Medical Center, Minneapolis; 3Rho.
MPA exerts its immunosuppressive activity by inhibiting IMPDH2 enzyme, halting DNA synthesis in T and B lymphocytes. Cell culture models have shown MPA effects on…2016 American Transplant Congress
Influence of the Tacrolimus Metabolism Rate on BKV Infection After Kidney Transplantation.
Introduction: BK virus (BKV) infection is a serious complication following renal transplantation (RTx). The minimization of risk factors that predict BKV infection might help to…2016 American Transplant Congress
Targeting IFN-g-Expressing TIM-4+ B Effector (Beff) Cells as a Novel Strategy to Prevent Allograft Rejection.
1University of Pittsburgh, Pittsburgh; 2Harvard Medical School, Boston.
B cell depletion can augment or inhibit auto- and allo- immune responses in humans and mice without altering Ig levels. This is likely due to…2016 American Transplant Congress
Induction Therapy with Depleting Antibodies in Low Immunological Risk Renal Transplant Patients Treated with a Steroid Free Regimen – Comparison of Alemtuzumab vs. Antithymocyte Globulin.
Induction therapy with depleting antibodies reduces rejection rate and potentially improves efficacy of steroid free regimens after renal transplantation.This prospective, single-centre, cohort study evaluated cumulative…2016 American Transplant Congress
Everolimus Plus Reduced-Exposure Cyclosporin versus Mycophenolic Acid Plus Cyclosporin: Seven-Year Follow-Up of Australia and New Zealand Kidney Transplant Recipients in the A2309 Study.
A2309 was a 2-year, phase III randomized controlled trial evaluating the effect on graft and patient outcomes of three groups:1.5mg everolimus plus low exposure cyclosporine…2016 American Transplant Congress
Donor HLA Specific IgM Antibody Measured on Day 14 Post-Transplantation Predicts Poor Graft Survival in HLA-Incompatible Renal Transplantation.
Introduction: Role of IgG antibodies against donor human leucocyte antigens (HLA) is established in renal transplant monitoring. Role of IgM donor HLA specific antibodies (DSA)…
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